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高频超声检查在小儿肠套叠鉴别诊断中的应用价值

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医学影像学杂志 2024年第7期34卷 86-88页

作者：江华刘慧张文芳王璇张波山东省东营市东营区人民医院儿内科山东东营257000 山东省胜利油田中心医院儿内科山东东营257000 山东省东营市东营区人民医院超声科山东东营257000 山东第一医科大学附属省立医院超声科山东济南250000

目的探讨高频超声检查对小儿肠套叠的鉴别诊断价值。方法选取126例小儿肠套叠患儿,均行高频超声检查,根据临床诊断结果将患儿分为甲组(一过性小儿肠套叠)69例与乙组(持续性小儿肠套叠)57例,比较两组患儿的影像学表现。结果所有患儿... 详细信息

目的探讨高频超声检查对小儿肠套叠的鉴别诊断价值。方法选取126例小儿肠套叠患儿,均行高频超声检查,根据临床诊断结果将患儿分为甲组(一过性小儿肠套叠)69例与乙组(持续性小儿肠套叠)57例,比较两组患儿的影像学表现。结果所有患儿高频超声检查显示小肠包块横切面呈“同心圆征”、纵切面呈“套筒征”。甲组套叠部位的直径与深度分别为(16.14±3.35)mm、(19.59±4.26)mm,乙组套叠部位的直径与深度分别为(18.87±3.68)mm、(27.83±6.37)mm,乙组套叠部位的直径与深度均高于甲组,差异有统计学意义(P<0.05)。乙组套叠肠壁蠕动情况正常/活跃的概率(68.42%)低于甲组(98.55%),套叠肠壁水肿率(15.79%)高于甲组(0%),差异有统计学意义(P<0.05)。结论两组高频超声检查特征存在差异,甲组通常伴有包块直径小、深度低、肠壁蠕动正常/活跃、无水肿等特征,有持续性小儿肠套叠危险。

关键词：小儿肠套叠一过性持续性肠壁蠕动超声检查

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双眼渐进性坏死性黄色肉芽肿1例

中华眼科杂志 2024年第5期60卷 447-450页

作者：杨文钰陈辉任若昕谢伊王君慧吴丝季敏南通大学附属医院眼科南通226000

1例主诉为双眼睁眼困难半年的55岁男性患者就诊眼科,查体发现患者双眼眼睑、胸部多发性黄瘤样斑块和结节,并伴有角膜炎和葡萄膜炎。胸部皮损组织病理学检查示真皮内黄色瘤性肉芽肿伴渐进性坏死。骨髓活检示套细胞淋巴瘤。结合病史,确诊... 详细信息

1例主诉为双眼睁眼困难半年的55岁男性患者就诊眼科,查体发现患者双眼眼睑、胸部多发性黄瘤样斑块和结节,并伴有角膜炎和葡萄膜炎。胸部皮损组织病理学检查示真皮内黄色瘤性肉芽肿伴渐进性坏死。骨髓活检示套细胞淋巴瘤。结合病史,确诊为渐进性坏死性黄色肉芽肿伴套细胞淋巴瘤。患者全身应用苯达莫司汀联合利妥昔单抗治疗6个月后眼部症状有所缓解。

关键词：渐进性坏死性黄肉芽肿淋巴瘤,膜细胞

Microrod structure and properties of Sb-doped Ti/SnO_2 anodes prepared by magnetron sputtering

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Science Bulletin 2015年第24期60卷 2135-2139页

作者： bo Yan Aqing chen Cairu Shao Kaigui Zhu Department of Physics Beihang University College of Materials and Environmental Engineering Hangzhou Dianzi University

Cyclic voltammetry and chronopotentiometry have been used to study the Sb-doped Ti/SnO2 anodes prepared by magnetron sputtering. The results showed that magnetron sputtering condition influenced the surface morphology and the properties of the anodes. After the Ti substrate was tempered in Ar at 600 ℃ for 1 h, Till1.5 on the surface generated from the acid etching was replaced by needle-like TiO2. The SnO2 coating on the above Ti substrate by magnetron sputtering with post-annealing was comprised of microrod and different with the traditional Ti/ SnO2 anode. The accelerated service life test showed that the microrod SnO2 anode gained the longest service time. The anode exhibited oscillations in the chronopotentiometry curves, and the microrod SnO2 coating almost dissolved after the life test. A model of layer-by-layer degradation mechanism for the anode was proposed.

关键词： Sb-doped SnO2 Anode Microrod Degradation Service life test

Evolution in physiochemical and cloud condensation nuclei activation properties of crop residue burning particles during photochemical aging

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Journal of Environmental Sciences 2019年第3期31卷 43-53页

作者： Yan Ma Chao chen Junfeng Wang Youling Jiang Zewen Zheng hui chen Jun Zheng Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and Technology Harvard-NUIST Joint Laboratory for Air Quality and Climate (JLAQC) Nanjing University of Information Science and Technology NUIST Reading Academy Nanjing University of Information Science and Technology

As a main form of biomass burning in agricultural countries, crop residue burning is a significant source of atmospheric fine particles. In this study, the aging of particles emitted from the burning of four major crop residues in China was investigated in a smog *** particle size distribution, chemical composition and cloud condensation nuclei(CCN)activity were simultaneously measured. The properties of crop residue burning particles varied substantially among different fuel types. During aging, the particle size and mass concentration increased substantially, suggesting condensational growth by formation of secondary aerosols. The particle composition was dominated by organics. Aging resulted in considerable enhancement of organics and inorganics, with enhancement ratios of 1.24–1.44 and 1.33–1.76 respectively, as well as a continuous increase in the oxidation level of organics. Elevated CCN activity was observed during aging, with the hygroscopicity parameter κ varying from 0.16 to 0.34 for fresh particles and 0.19 to 0.40 for aged *** on the volume mixing rule, the hygroscopicity parameter of organic components(κorg) was derived. κorgexhibited an increasing tendency with aging, which was generally consistent with the tendency of the O:C ratio, indicating that the oxidation level was related to the hygroscopicity and CCN activity of organic aerosols from crop residue burning. Our results indicated that photochemical aging could significantly impact the CCN activation of crop burning aerosols, not only by the production of secondary aerosols, but also by enhancing the hygroscopicity of organic components, thereby contributing to the aerosol indirect climate forcing.

关键词： Crop residue burning Aging Cloud condensation nuclei activity Hygroscopicity Organic aerosol

Mismatched feature detection with finer granularity for emotional speaker recognition

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第10期15卷 903-916页

作者： Li chen Ying-chun YANG Zhao-hui WU College of Computer Science & Technology Zhejiang University

The shapes of speakers' vocal organs change under their different emotional states, which leads to the deviation of the emotional acoustic space of short-time features from the neutral acoustic space and thereby the degradation of the speaker recognition performance. Features deviating greatly from the neutral acoustic space are considered as mismatched features, and they negatively affect speaker recognition systems. Emotion variation produces different feature deformations for different phonemes, so it is reasonable to build a finer model to detect mismatched features under each phoneme. However, given the difficulty of phoneme recognition, three sorts of acoustic class recognition—phoneme classes, Gaussian mixture model(GMM) tokenizer, and probabilistic GMM tokenizer—are proposed to replace phoneme recognition. We propose feature pruning and feature regulation methods to process the mismatched features to improve speaker recognition performance. As for the feature regulation method, a strategy of maximizing the between-class distance and minimizing the within-class distance is adopted to train the transformation matrix to regulate the mismatched features. Experiments conducted on the Mandarin affective speech corpus(MASC) show that our feature pruning and feature regulation methods increase the identification rate(IR) by 3.64% and 6.77%, compared with the baseline GMM-UBM(universal background model) algorithm. Also, corresponding IR increases of 2.09% and 3.32% can be obtained with our methods when applied to the state-of-the-art algorithm i-vector.

关键词： Emotional speaker recognition Mismatched feature detection Feature regulation

APT-联合DCE-MRI术前预测成人型弥漫性胶质瘤病理分级及IDH基因突变型

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放射学实践 2024年第8期39卷 1021-1025页

作者：陈世煌黄日升林慧宇丁增兴卢丽梅福建医科大学附属泉州市第一医院影像科福建泉州362000 福建医科大学附属泉州市第一医院放疗科福建泉州362000 泉州市儿童医院影像科福建泉州362000

目的:探讨氨基质子转移(APT)成像联合DCE-MRI对成人型弥漫性胶质瘤病理分级和IDH基因型的术前预测价值。方法:将2020年10月-2023年10月在本院诊治且经病理证实的78例脑胶质瘤患者纳入本研究。患者手术前均进行APT成像和DCE-MRI检查。依... 详细信息

目的:探讨氨基质子转移(APT)成像联合DCE-MRI对成人型弥漫性胶质瘤病理分级和IDH基因型的术前预测价值。方法:将2020年10月-2023年10月在本院诊治且经病理证实的78例脑胶质瘤患者纳入本研究。患者手术前均进行APT成像和DCE-MRI检查。依据肿瘤的组织病理学分级将患者分为2组:低级别组(Ⅱ~Ⅲ级)36例,高级别组(Ⅳ级)42例;依据患者IDH基因表达情况将患者分为2组:IDH野生型组31例,IDH突变型组47例。比较高、低病理分级组及不同IDH分型组之间病灶的APT图像信号等级(分为1~5级)和DCE-MRI参数(K_(trans)、V_(e)、rCBV、V_(p)、K_(ep)和rCBF)值的差异,对组间差异有统计学意义的指标,采用ROC曲线分析其诊断效能。结果:IDH突变型和野生型组之间年龄、性别、主诉、神经系统体征差异均无统计学意义(P>0.05);高级别组和低级别组之间年龄、性别、主诉、神经系统体征差异均无统计学意义(P>0.05),但是高级别组中IDH野生型占比更高(P<0.05)。78例病灶的APT信号分级:1级有19例,2级3例,3级14例,4级6例,5级36例。高级别组APT图像上肿瘤的信号等级高于低级别组,IDH野生型组患者APT图像等级高于突变型组,差异有统计学意义(P<0.05)。DCE-MRI参数的组间比较结果显示,高级别组与低级别组之间,以及IDH突变型与IDH野生型之间,K_(trans)、V_(e)和rCBV值的差异均有统计学意义(P<0.05)。APT信号等级鉴别高、低级别胶质瘤及IDH状态的AUC分别为0.782和0.714,K_(trans)、V_(e)和rCBV鉴别高、低级别胶质瘤的AUC分别为0.982、0.793和0.898,鉴别IDH状态的AUC分别为0.963、0.803和0.873。结论:APT成像联合DCE-MRI定量参数能在术前较准确地预测成人型弥漫性胶质瘤的病理分级和IDH基因分型。

关键词：氨基质子转移成像动态对比增强磁共振成像脑肿瘤弥漫性胶质瘤肿瘤分级 IDH基因型

人参皂甙Rg3抑制卵巢癌SKOV3细胞生长的机制研究

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湖北科技学院学报（医学版） 2024年第5期38卷 369-373,379页

作者：黄璐吴辰施玲李梅蔡慧兰湖北科技学院医学部临床医学院湖北咸宁437100 咸宁市中心医院产科

目的探讨人参皂甙Rg3抑制卵巢癌细胞生长可能存在的分子机制。方法采用细胞克隆实验检测人参皂甙Rg3对人卵巢癌SKOV3细胞增殖的抑制效果;四氮唑蓝(MTT)比色法、流式凋亡、划痕实验、Transwell实验分别检测人参皂甙Rg3对SKOV3细胞凋亡、... 详细信息

目的探讨人参皂甙Rg3抑制卵巢癌细胞生长可能存在的分子机制。方法采用细胞克隆实验检测人参皂甙Rg3对人卵巢癌SKOV3细胞增殖的抑制效果;四氮唑蓝(MTT)比色法、流式凋亡、划痕实验、Transwell实验分别检测人参皂甙Rg3对SKOV3细胞凋亡、侵袭、迁移的影响;qRT-PCR法和Western blot法分别检测Rg3不同浓度作用下卵巢癌细胞中Zeste基因增强子同源物2(EZH2)基因和蛋白的表达。结果人参皂甙Rg3对SKOV3细胞增殖抑制率升高(P<0.05),凋亡率显著上升(P<0.01),侵袭、迁移能力均显著下降(P<0.01),SKOV3细胞中EZH2的基因和蛋白随着Rg3浓度的增加表达量呈现明显的下降(P<0.01)。结论人参皂甙Rg3可能通过抑制EZH2的表达,促进卵巢癌细胞的凋亡,抑制卵巢癌SKOV3细胞增殖、侵袭以及迁移的能力,为卵巢癌的临床治疗提供新思路。

关键词：人参皂甙Rg3 EZH2 卵巢癌 SKOV3细胞

雅鲁藏布江下游鮡科鱼类分类整理及三新种和中国一新记录种

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水生生物学报 2024年第6期48卷 920-949页

作者：陈咏霞谭慧敏林鹏程张驰王琳何德奎河北大学生命科学学院保定071002 中国科学院水生生物研究所武汉430072 西藏自治区农牧科学院水产科学研究所拉萨850000

基于形态学和分子系统学方法,对1974、2019—2023年间采自雅鲁藏布江下游(我国实际控制区内,下同)的403尾鮡科鱼类标本进行分类整理。标本检视结果及结合历史记录表明,雅鲁藏布江下游共分布有鮡科鱼类6属10种,即黑斑原鮡Glyptosternon m... 详细信息

基于形态学和分子系统学方法,对1974、2019—2023年间采自雅鲁藏布江下游(我国实际控制区内,下同)的403尾鮡科鱼类标本进行分类整理。标本检视结果及结合历史记录表明,雅鲁藏布江下游共分布有鮡科鱼类6属10种,即黑斑原鮡Glyptosternon maculatum(Regan 1905)、穴形纹胸鮡Glyptothorax cavia(Hamilton1822)、墨脱纹胸鮡*** chen&He ***.、疑似细体纹胸鮡***(Günther 1864)、稀有纹胸鮡*** chen&He ***.、西仁褶鮡Pseudecheneis sirenica Vishwanath&Darshan 2007、扁头异鮡Creteuchiloglanis kamengensis(Jayaram 1966)、细尾鰋Exostoma tenuicaudatum Tamang,Sinha&Gurumayun2015、西藏鰋*** Gong,Lin,Liu&Liu 2018和无斑平唇鮡Parachiloglanis immaculata chen&He ***.。新种墨脱纹胸鮡是安氏纹胸鮡*** Hora 1923种名的修订,其偶鳍具羽状皮褶,项背骨前突与上枕骨棘相离,腹鳍起点位于背鳍基后缘垂直下方之后,腹鳍末端远离臀鳍起点,更细的尾柄,以及更长的头长等联合特征区别于同属其他物种。新种稀有纹胸鮡其偶鳍腹面光滑,无羽状皮褶;胸部吸着器心形,皮纹向前延伸至咽部,附着器后缘中部微陷、开放,皮纹不明显;臀鳍不分枝鳍条11根;项背骨前突与上枕骨棘间隔距离远;上颌须延伸超过胸鳍基末端,达胸鳍长的1/2处,其长为头长的134.2%等特征区别于同属其他种。新种无斑平唇鮡是霍氏平唇鮡***(Hora 1923)种名修订,其上颌齿带两侧向后延伸,内侧内凹,呈弯月形,横向宽约为纵向深的2倍;下颌齿带前缘和后缘中部微凹,左右两块紧靠,无明显间隔;鳃孔下角限于胸鳍基前1/3处;脂鳍末端游离,与尾鳍起点有一缺刻;胸鳍分枝鳍条16—17根;尾鳍末端明显内凹;侧线明显,侧线孔周围具白色稀疏圆点,体表和各鳍无明显的斑纹等特征有别于同属其他物种。穴形纹胸鮡为我国新记录种。西仁褶鮡为黄斑褶鮡***(McClelland 1842)种名的修订。文章对10种鮡科鱼类的主要鉴别特征进行了描述,并编制了属种分类检索表。

关键词：西藏喜马拉雅地区鮡科种名修订鉴别特征新种系统发育

局部晚期鼻咽癌同步放化疗加或不加尼妥珠单抗的临床研究

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中华放射肿瘤学杂志 2024年第2期33卷 103-109页

作者：杨志左权段和新刘蓉吴慧陈佳熊莉贾洁琦向志碧湘西土家族苗族自治州人民医院肿瘤科吉首416000 湘西土家族苗族自治州人民医院耳鼻咽喉科吉首416000

目的比较新辅助化疗后同步放化疗加或不加尼妥珠单抗治疗局部晚期鼻咽癌的疗效及不良反应。方法采用前瞻性研究方法,将符合入组条件的100例Ⅲ-Ⅳa期(T3N0M0期除外)局部晚期鼻咽癌患者采用随机数字表法分为试验组和对照组,两组均先行紫... 详细信息

目的比较新辅助化疗后同步放化疗加或不加尼妥珠单抗治疗局部晚期鼻咽癌的疗效及不良反应。方法采用前瞻性研究方法,将符合入组条件的100例Ⅲ-Ⅳa期(T3N0M0期除外)局部晚期鼻咽癌患者采用随机数字表法分为试验组和对照组,两组均先行紫杉醇脂质体+顺铂+氟尿嘧啶(TPF)方案新辅助化疗2个周期。化疗后2周,试验组行同步放化疗加尼妥珠单抗靶向治疗,对照组行同步放化疗。主要观察指标为无远处转移生存(DMFS)率,主要采用log-rank检验及多因素Cox回归分析进行比较。结果试验组和对照组的客观缓解率为100%∶98%(P=1.000),完全缓解率为92.0%∶80%(P=0.084)。试验组和对照组3年DMFS率为91.4%∶76.1%,(P=0.043),3年PFS、OS、LRFS率分别为87.3%∶74.1%(P=0.097)、94.5%∶85.6%(P=0.227)、90.5%∶85.2%(P=0.444)。年龄<60岁(HR=0.34,95%CI为0.12~0.94,P=0.037),中性粒细胞/淋巴细胞比值(NLR)≤4(HR=0.34,95%CI为0.13~0.89,P=0.028)的局部晚期鼻咽癌新辅助化疗后同步放化疗加尼妥珠单抗靶向治疗的PFS更好。多因素分析发现,NLR是局部晚期鼻咽癌疾病进展(HR=5.94,95%CI为1.18~29.81,P=0.030)、远处转移(HR=13.76,95%CI为1.52~124.36,P=0.020)的独立危险因素。结论局部晚期鼻咽癌新辅助化疗后同步放化疗加用尼妥珠单抗,比不加显著提高了DMFS率,两者的不良反应发生率相当。新辅助化疗后同步放化疗加尼妥珠单抗治疗方案可能是局部晚期鼻咽癌的一个优选的治疗策略。

关键词：鼻咽肿瘤新辅助化学疗法同步放化疗尼妥珠单抗