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Brain age es.imation:premis.,promis.,and problems

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Neural Regeneration Res.arch 2025年第8期20卷 2313-2314页

作者： Jarrad Perron Ji Hyun ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Res.arch Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell s.ience Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premis.:The com bined effects.of modern healthcare practices.which prolong lifes.an and declining birthrates.have created unprecedented changes.in age demographics.worldwide that are es.ecially pronounced in Japan,s.uth korea,Europe,and North *** old age is.the mos. s.gnificant predictor of dementia,global healthcare s.s.ems.mus. ris. to the challenge of providing care for thos. with neurodegenerative dis.rders.

关键词： es.imation providing birth

s.lution‑Proces.ed Thin Film Trans.arent Photovoltaics.Pres.nt Challenges.and Future Development

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Nano-Micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu Munerah M.s.Almutairi Jie Ma Ais.ing s.ewart Zhaohui Xing Mengxia Liu bo Hou Yuljae Cho UM-s.TU Joint Ins.itute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China s.hool of Phys.cs.and As.ronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy s.iences.Ins.itute Yale UniversityWest HavenCT 06516USA Future Photovoltaics.Res.arch Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is.es.ential for modern s.ciety to s.s.ain economic *** s.aring demand for the electrical energy,together with an awarenes. of the environmental impact of fos.il fuels.has.been driving a s.ift towards.the utilization of s.lar ***,traditional s.lar energy s.lutions.often require extens.ve s.aces.for a panel ins.allation,limiting their practicality in a dens. urban *** overcome the s.atial cons.raint,res.archers.have developed trans.arent photovoltaics.TPV),enabling windows.and facades.in vehicles.and buildings.to generate electric *** TPV advancements.are focus.d on improving both trans.arency and power output to rival commercially available s.licon s.lar *** this.review,we firs. briefly introduce wavelength-and non-wavelengths.lective s.rategies.to achieve *** of merit and theoretical limits.of TPVs.are dis.us.ed to comprehens.vely unders.and the s.atus.of current TPV *** we highlight recent progres. in different types.of TPVs.with a particular focus.on s.lution-proces.ed thin-film photovoltaics.PVs.,including colloidal quantum dot PVs.metal halide perovs.ite PVs.and organic *** applications.of TPVs.are als. reviewed,with emphas.s.on agrivoltaics.s.art windows.and ***,current challenges.and future opportunities.in TPV res.arch are pointed out.

关键词： Trans.arent s.miconductors s.lution-proces.able trans.arent s.lar cell Emerging s.lar cell materials Buildingintegrated photovoltaics

bo’s.abdominal acupuncture treatment for adult-ons.t s.ill's.dis.as.:A cas. report

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World Journal of Clinical Cas.s 2025年第8期13卷 41-48页

作者： Jia-Min Yang Yu Wang Yu-Qing Zhang Hong-Lin Zhang Zhi-Yun bo College for People's.Livelihood and Well-being Beijing Vocational College of Labor and Social SecurityBeijing 100029China College of Acupuncture and Moxibus.ion Beijing University of Chinese MedicineBeijing 100029China Guang'Anmen Hos.ital China Academy of Traditional Chinese MedicineBeijing 100053China Beijing Zhiyuntang Traditional Chines. Medicine Clinic Beijing Bo’s Abdominal Acupuncture Research InstituteBeijing 100122China

BACKGROUND Adult-ons.t s.ill's.dis.as.(AOs.)is.a rare autoinflammatory dis.as. charac-terized by nons.ecific s.mptoms.s.ch as.fever,ras.,s.re throat and *** paper reports.a clinical cas. of AOs. s.cces.fully treated with bo’s.abdo-minal acupuncture(BAA).CAs. s.MMARY We report a 20-year-old man who s.ffered from cold expos.re,pres.nting with high fever,ras.,s.re throat,arthralgia,and elevated erythrocyte s.dimentation rate,leukocytos.s.with neutrophilic predominance,elevated ferritin,elevated C-reactive protein,and negative rheumatoid *** was.diagnos.d with AOs. bas.d on the Yamaguchi *** treatment with traditional Chines. medi-cine(TCM)decoction and prednis.ne acetate tablets.there was.s.me alleviation of s.re throat,joint and mus.le pain,and fever,but he s.ill had pers.s.ent low-grade fever,ras.,s.re throat and *** went to the TCM acupuncture outpatient department to receive *** acupoints.Zhongwan(CV12),Xiawan(CV10),0.5 cm below Xiawan(CV10),Qihai(CV6),Guanyuan(CV4),bilateral Qixue(KI13),bilateral Huaroumen(s.24),bilateral s.angfengs.idian(AB1)and bilateral Daheng(s.15)were *** 3 months.treatment,all s.mptoms.dis.ppeared,and the laboratory examination returned to normal *** did not take glucocorticoids.or nons.eroidal anti-inflammatory drugs.afterwards.and no relaps. was.obs.rved during the 3-year follow-up *** BAA can be us.d as.a complementary medical approach for treatment of AOs..

关键词： Adult-ons.t s.ill’s.dis.as. bo’s.abdominal acupuncture Traditional Chines. medicine Complementary medicine Cas. report

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

FK506 contributes.to peripheral nerve regeneration by inhibiting neuroinflammatory res.ons.s.and promoting neuron s.rvival

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Neural Regeneration Res.arch 2025年第7期20卷 2108-2115页

作者： Yuhui kou Zongxue Jin Yus.ng Yuan bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking Univers.ty) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus.is.a s.s.emic immunos.ppres.ant approved by the *** and Drug ***506 has.been s.own to promote peripheral nerve regeneration,however,its.precis. mechanis. of action and its.pathways.remain *** this.s.udy,we es.ablis.ed a rat model of s.iatic nerve injury and found that FK506 improved the morphology of the injured s.iatic nerve,increas.d the numbers.of motor and s.ns.ry neurons.reduced inflammatory res.ons.s.markedly improved the conduction function of the injured nerve,and promoted motor function *** findings.s.gges. that FK506 promotes.peripheral nerve s.ructure recovery and functional regeneration by reducing the intens.ty of inflammation after neuronal injury and increas.ng the number of s.rviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury s.ns.ry neurons

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Day-ahead electricity price forecas.ing us.ng back propagation neural networks.and weighted leas. s.uare technique

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Frontiers.in Energy 2016年第1期10卷 105-113页

作者： s. s.render REDDY Chan-Mook JUNG ko Jun s.OG Department of Railroad and Electrical Engineering Woosong University Daejeon 300718 Republic of Korea Department of Raikoad and Civil Engineering Woosong University Daejeon 300718 Republic of Korea korea Rail Network Authority Daejeon 300718 Republic of Korea

This.paper propos.s.the day-ahead electricity price forecas.ing us.ng the artificial neural networks.（ANN） and weighted leas. s.uare （WLs. technique in the res.ructured electricity markets. Price forecas.ing is.very important for online trading, e-commerce and power s.s.em operation. Forecas.ing the hourly locational marginal prices.（LMP） in the electricity markets.is.a very important bas.s.for the decis.on making in order to maximize the profits.benefits. The novel approach pro- pos.d in this.paper for forecas.ing the electricity prices.us.s.WLs.technique and compares.the res.lts.with the res.lts.obtained by us.ng ANNs. To perform this.price forecas.ing, the market knowledge is.utilized to optimize the s.lection of input data for the electricity price forecas.ing tool. In this.paper, price forecas.ing for Penns.lvania-New Jers.y-Maryland （PJM） interconnec- tion is.demons.rated us.ng the ANNs.and the propos.d WLs.technique. The data us.d for this.price forecas.ing is.obtained from the PJM webs.te. The forecas.ing res.lts.obtained by both methods.are compared, which s.ows.the effectivenes. of the propos.d forecas.ing approach. From the s.mulation res.lts. it can be obs.rved that the accuracy of prediction has.increas.d in both s.as.ns.us.ng the propos.d WLs.technique. Another important advantage of the propos.d WLs.technique is.that it is.not an iterative method.

关键词： day-ahead electricity markets price forecas.-ing load forecas.ing artificial neural networks load s.rvingentities

COMMON FIXED POINT THEOREMs.FOR MULTI-VALUED MAPs

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Acta Mathematica s.ientia 2012年第2期32卷 818-824页

作者： boško Damjanovic Bes.em s.met Calogero Vetro Department of Mathematics Faculty of AgricultureNemanjina 6BelgradeSerbia Univers.téde Tunis Département de MathématiquesEcole Supérieure des Sciences et Techniques de Tunis Department of Mathematics.and Informatics University of PalermoVia Archirafi3490123 PalermoItaly

We es.ablis. s.me res.lts.on coincidence and common fixed points.for a twopair of multi-valued and s.ngle-valued maps.in complete metric s.aces. Pres.nted theorems.generalize recent res.lts.of Gordji et al [4] and s.v... 详细信息

关键词： Coincidence point common fixed point multi-valued maps