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Biosafety and Health 2024年第3期6卷 186-190页

作者： yuan Fang Fuchun Wang Taiyi Jiang Junyi Duan Tao Huang Hao Liu Lin Jia Han Jia Benyong Yan Mei zhang Wen Wang Caiping Guo Lifeng Liu Yuening zhang Tong zhang Beijing Youan Hospital Capital Medical UniversityBeijing 100069China

Mpox is a zoonotic infectious disease caused by the mpox virus(MPXV).Historically,the majority of mpox cases have been documented in Central ***,since May 2022,there has been a notable rise in reported cases from regions beyond ***,over 110 countries spanning Europe,North America,South America,Asia,and other territories have reported mpox *** report details a case involving a patient who identifies as a man who has sex with men(MSM)and is concurrently infected with MPXV,human immunodeficiency virus type 1(HIV-1),Pneumocystis jiroveci,as well as extensively drug-resistant tuberculosis(XDR-TB).This patient had also received a vaccination for smallpox in the ***,we provide photographic documentation charting the progression of dermatological manifestations associated with *** case highlights the significance of sexual intercourse as a crucial mode of transmission for *** rapid and widespread dissemination of the MPXV across various regions,especially among MSM communities,underscores the importance of enhancing preventive education efforts targeted at high-risk populations.

关键词： Mpox Mpox virus(MPXV) Human immunodeficiency virus type 1 (HIV-1)Extensively drug-resistant tuberculosis(XDR-TB)

A study of novel real-time power balance strategy with virtual asynchronous machine control for regional integrated electric-thermal energy systems

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Science China(Technological Sciences) 2024年第7期67卷 2074-2086页

作者： WANG Rui LI Ming-Jia WANG Yibo SUN QiuYe zhang PinJia College of Information Science and Engineering Northeastern UniversityShenyang 110819China School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

The development of regional integrated electric-thermal energy systems(RIETES) is considered a promising direction for modern energy supply systems. These systems provide a significant potential to enhance the comprehensive utilization and efficient management of energy resources. Therein, the real-time power balance between supply and demand has emerged as one pressing concern for system stability operation. However, current methods focus more on minute-level and hour-level power optimal scheduling methods applied in RIETES. To achieve real-time power balance, this paper proposes one virtual asynchronous machine(VAM) control using heat with large inertia and electricity with fast response speed. First, the coupling timescale model is developed that considers the dynamic response time scales of both electric and thermal energy systems. Second, a real-time power balance strategy based on VAM control can be adopted to the load power variation and enhance the dynamic frequency response. Then, an adaptive inertia control method based on temperature variation is proposed, and the unified expression is further established. In addition, the small-signal stability of the proposed control strategy is validated. Finally, the effectiveness of this control strategy is confirmed through MATLAB/Simulink and HIL(Hardware-in-the-Loop) experiments.

关键词： regional integrated electric-thermal energy systems real-time power balance virtual asynchronous machine adaptive inertia small-signal stability

Organoid co-culture models of the tumor microenvironment promote precision medicine

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Cancer Innovation 2024年第1期3卷 79-103页

作者： Zhaoru Gu Quanyou Wu Bingqing Shang Kaitai zhang Wen zhang State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Immunology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

In recent years,the three-dimensional(3D)culture system has emerged as a promising preclinical model for tumor research owing to its ability to replicate the tissue structure and molecular characteristics of solid tumors in *** system offers several advantages,including high throughput,efficiency,and retention of tumor *** Matrigel-submerged organoid cultures primarily support the long-term proliferation of epithelial *** solution for the exploration of the tumor microenvironment is a reconstitution approach involving the introduction of exogenous cell types,either in dual,triple or even multiple *** solution is a holistic approach including patient-derived tumor fragments,air-liquid interface,suspension 3D culture,and microfluidic tumor-on-chip *** co-culture models have also gained popularity for studying the tumor microenvironment,evaluating tumor immunotherapy,identifying predictive biomarkers,screening for effective drugs,and modeling *** leveraging these 3D culture systems,it is hoped to advance the clinical application of therapeutic approaches and improve patient outcomes.

关键词： air-liquid interface immunotherapy organoid tumor microenvironment tumor-on-chip

***2 regulates plant height by affecting the main inflorescence length and first effective branch height in Brassica napus L.

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The Crop Journal 2024年第4期12卷 1102-1111页

作者： Chengke Pang Jun Yu Liang zhang Min Tang Hongfang Liu Ying Cai Feng Chen Jiefu zhang Wei Hua Xiaodong Wang Ming Zheng Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences Key Laboratory of Biology and Genetic Improvement of Oil CropsMinistry of Agriculture and Rural AffairsWuhan 430062HubeiChina Key Laboratory of Cotton and Rapeseed Ministry of Agriculture and Rural AffairsKey Laboratory of Jiangsu Province for AgrobiologyInstitute of Industrial CropsJiangsu Academy of Agricultural SciencesNanjing 210014JiangsuChina National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina

Rapeseed(Brassica napus L.)is one of the main oil crops in the world,and increasing its yield is of great significance for ensuring the safety of edible ***,improving rapeseed plant architecture is an effective way to increase rapeseed yield with higher planting ***,the regulatory mechanism of rapeseed plant architecture is poorly *** this study,a dwarf rapeseed mutant dwarf08(df08)is obtained by ethyl methane sulfonate(EMS)-*** decrease in plant height of df08 is mainly caused by the reduction in main inflorescence length and first effective branch height and controlled by a single semi-dominant *** hybrid plants(F1)show a semi-dwarf *** map-based cloning and transgenic assay,we confirm that the nonsynonymous single nucleotide variant(SNV)(C to T)in ***2,which is homologous with Arabidopsis(Arabidopsis thaliana)BIN2,is responsible for the dwarfism of ***2 interacts with BnaBZR1/BES1 and involves in brassinosteroids(BRs)signal *** to Leucine substitution in 284(P284L)enhances the protein stability of ***2-D,disrupts BRs signal transduction and affects the expression of genes regulating cell division,leading to dwarfism of *** study provides a new insight for the mechanism of rapeseed plant height regulation and creates an elite germplasm that can be used for genetic improvement of rapeseed architecture.

关键词： Brassica napus Plant height Brassinosteroids BIN2

Magnetic Interactions with Strain Gradient in Ultrathin Pr_(0.67)Sr_(0.33)MnO_(3) Films

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Engineering 2024年第9期40卷 158-165页

作者： Bangmin zhang Ping Yang Jun Ding Jingsheng Chen Gan Moog Chow Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices School of PhysicsSun Yat-sen UniversityGuangzhou 510275China Singapore Synchrotron Light Source National University of SingaporeSingapore 117603Singapore Department of Materials Science and Engineering National University of SingaporeSingapore 117575Singapore

Strain gradient is a normal phenomenon around a heterostructural interface in ultrathin film,and it is important to determine its effect on magnetic interactions to understand interfacial *** this work,ultrathin Pr_(0.67)Sr_(0.33)MnO_(3)(PSMO)films on different substrates are *** PSMO film under different in-plane strain conditions,the saturated magnetization and Curie temperature can be qualitatively explained by double-exchange interaction and the Jahn-Teller ***,the difference in the saturated magnetization with zero field cooling and 5 T field cooling is proportional to the strain ***-gradient-induced structural disorder is proposed to enhance phonon-electron antiferromagnetic interactions and the corresponding antiferromagnetic-to-ferromagnetic phase transition via a strong magnetic field during the field cooling process.A non-monotonous structural transition of the MnO_(6) octahedral rotation can enlarge the strain gradient in PSMO film on a SrTiO_(3) *** work demonstrates the existence of the flexomagnetic effect in ultrathin manganite film,which should be applicable to other complex oxide systems.

关键词： Strain gradient Manganite film Octahedral rotation Flexomagnetic Magnetic interactions Phase transition

Quantitative understanding of phase segregation behaviors by precisely building discrete oligo-ester-b-oligo-olefin block copolymers

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Science China Chemistry 2024年第3期67卷 1008-1016页

作者： Yuxin Liu Rui Tan Haibing Wu Xue-Hui Dong Zhengbiao zhang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Block copolymers(BCPs) with high Flory-Huggins parameter(χ) and balanced surface energy have aroused tremendous interest for ultra-small nanopatterns ***,high χ and balanced surface energy are generally *** fine tune of chain structure might be a useful way to achieve high χ and balanced surface *** realize this,the block copolymer with exactly uniform chain structure,i.e.,defined molecular structure,is highly desirable for accurately evaluating the phase ***,two kinds of discrete oligo ester-b-oligo olefin block copolymers with different chemical structures(oligo lactic acid-boligo olefin BCP,oLA_(n)-b-C_(m);oligo phenyl lactic acid-b-oligo olefin BCP,oPL_(n)-b-C_(m)) were modularly synthesized through iterative growth *** effect of chain structure on segregation strength and surface properties was quantitatively investigated using the discrete BCPs as precise *** the one hand,introducing rigid and nonpolar phenyl groups into oligo ester block has a negligible effect on the chemical incompatibility,as confirmed by the identical high χ values of oLA_(n)-b-C_(m) and oPL_(n)-b-C_(m)(χ_(oLA/C)=0.21 and χ_(oPL/C)=0.19).On the other hand,the incorporation of nonpolar phenyl groups creates balanced surface energy,that is,the high χ and balanced surface energy were simultaneously achieved by oPL_(n)-b-C_(m).Therefore,sub-10 nm perpendicular nanopatterns can be easily produced upon brief thermal treatment,demonstrating its potential application in semiconductor manufacturing with ultra-small feature *** discrete BCP can serve as a quantitative and exquisite model to study the critical contribution of chain structures on phase separation behavior,providing insightful understanding to facilitate the potential application in the chip process.

关键词： discrete polymer iterative growth self-assembly highχ balanced surface

Extending homogeneous fluidization flow regime of Geldart-A particles by exerting axial uniform and steady magnetic field

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Chinese Journal of Chemical Engineering 2024年第1期65卷 169-177页

作者： Qiang zhang Wankun Liu Hengjun Gai Quanhong Zhu College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China School of Chemical&Environmental Engineering China University of Mining&Technology-BeijingBeijing 100083China

The homogeneous/particulate fluidization flow regime is particularly suitable for handling the various gas–solid contact processes encountered in the chemical and energy *** work aimed to extend such a regime of Geldart-A particles by exerting the axial uniform and steady magnetic *** the action of the magnetic field,the overall homogeneous fluidization regime of Geldart-A magnetizable particles became composed of two parts:inherent homogeneous fluidization and newly-created magnetic *** the former remained almost unchanged whereas the latter became broader as the magnetic field intensity increased,the overall homogeneous fluidization regime could be extended *** for Geldart-A nonmagnetizable particles,certain amount of magnetizable particles had to be premixed to transmit the magnetic *** others,the mere addition of magnetizable particles could broaden the homogeneous fluidization *** added content of magnetizable particles had an optimal value with smaller/lighter ones working *** added magnetizable particles might raise the ratio between the interparticle force and the particle *** the magnetic field was exerted,the homogeneous fluidization regime was further expanded due to the formation of magnetic stabilization flow *** more the added magnetizable particles,the better the magnetic performance and the broader the overall homogeneous fluidization ***/lighter magnetizable particles were preferred to maximize the magnetic performance and extend the overall homogeneous fluidization *** phenomenon could be ascribed to that the added magnetizable particles themselves became more Geldart-A than-B type as their density or size decreased.

关键词： Fluidized-bed Fluidization Geldart-A particles Flow regimes Extend Magnetic stabilization

Atom-referenced and stabilized soliton microcomb

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 2-8页

作者： Rui Niu Shuai Wan Tian-Peng Hua Wei-Qiang Wang Zheng-Yu Wang Jin Li Zhu-bo Wang Ming Li Zhen Shen Yu Robert Sun Shui-Ming Hu Brent ELittle Sai Tak Chu Wei Zhao Guang-Can Guo Chang-Ling Zou Yun-Feng Xiao Wen-Fu zhang Chun-Hua Dong State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Materials Science City University of Hong KongHong Kong 999077China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

For the applications of the frequency comb in microresonators,it is essential to obtain a fully frequency-stabilized microcomb laser *** this study,we present a system for generating a fully atom-referenced stabilized soliton *** pump light around 1560.48 nm is locked to an ultra-low-expansion(ULE)*** pump light is then frequency-doubled and referenced to the atomic transition *** repetition rate of the soliton microcomb is injection-locked to an atomic-clockstabilized radio frequency(RF)source,leading to mHz stabilization at 1 *** a result,all comb lines have been frequencystabilized based on the atomic reference and the ULE cavity,achieving a very high precision of approximately 18 Hz at 1 s,corresponding to the frequency stability of 9.5×10^(-14).Our approach provides a fully stabilized microcomb experiment scheme with no requirement of f-2f technique,which could be easily implemented and generalized to various photonic platforms,thus paving the way towards the ultraprecise optical sources for high precision spectroscopy.

关键词： microcavity frequency comb dissipative Kerr solitons fully stabilized microcomb

Study of the ability of SWOT to detect sea surface height changes caused by internal solitary waves

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Acta Oceanologica Sinica 2024年第5期43卷 54-64页

作者： Hao zhang Chenqing Fan Lina Sun Junmin Meng First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China College of Oceanography and Space Informatics China University of Petroleum(Huadong)Qingdao 266580China

Surface Water and Ocean Topography(SWOT)is a next-generation radar altimeter that offers high resolution,wide swath,imaging *** has provided free public data worldwide since December *** paper aims to preliminarily analyze the detection capabilities of the Ka-band radar interferometer(KaRIn)and Nadir altimeter(NALT),which are carried out by SWOT for internal solitary waves(ISWs),and to gather other remote sensing images to validate SWOT *** effectively detects ISW surface features and generates surface height variation maps reflecting the modulations induced by ***,its swath width does not completely cover the entire wave packet,and the resolution of L2/L3 level products(about 2 km)cannot be used to identify ISWs with smaller ***,significant wave height(SWH)images exhibit blocky structures that are not suitable for ISW studies;sea surface height anomaly(SSHA)images display systematic leftright *** optimize this imbalance using detrending methods;however,more precise treatment should commence with L1-level *** analysis based on L3-level SSHA data indicates that the average SSHA variation induced by ISWs ranges from 10 cm to 20 *** disturbed by ISWs record unusually elevated SWH and SSHA values,rendering the data unsuitable for analysis and necessitating targeted corrections in future retracking *** the normalized radar cross section,Ku-band and four-parameter maximum likelihood estimation retracking demonstrated greater sensitivity to minor changes in the sea surface,making them more suitable for ISW *** conclusion,SWOT demonstrates outstanding capabilities in ISW detection,significantly advancing research on the modulation of the sea surface by ISWs and remote sensing imaging mechanisms.

关键词： internal solitary waves Surface Water and Ocean Topography(SWOT) Ka-band radar interferometer(KaRIn) Nadir altimeter(NALT) sea surface height anomaly(SSHA) normalized radar cross section(NRCS)

Insights into the enhancement of food flavor perception:strategies,mechanism and emulsion applications

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Food Science and Human Wellness 2024年第5期13卷 2410-2424页

作者： Luyao Huang Yujie Dai Fan zhang Longtao zhang Baodong Zheng Yi zhang Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition Ministry of EducationFuzhou 350002China College of Food Science Fujian Agriculture and Forestry UniversityFuzhou 350002China

The core drivers of the modern food industry are meeting consumer demand for tasty and healthy *** application of food flavor perception enhancement can help to achieve the goals of salt-and sugar-reduction,without compromising the sensory quality of the original food,and this has attracted increasing research *** analysis of bibliometric results from 2002 to 2022 reveals that present flavor perception enhancement strategies(changing ingredient formulations,adding salt/sugar substitutes,emulsion delivery systems)are mainly carry out based on sweetness,saltiness and *** systems is becoming a novel research foci and development trends of international food flavor perception-enhancement *** structured design of food emulsions,by using interface engineering technology,can effectively control,or enhance the release of flavor ***,this review systematically summarizes strategies,the application of emulsion systems and the mechanisms of action of food flavor perception-enhancement technologies,based on odor-taste cross-modal interaction(OTCMI),to provide insights into the further structural design and application of emulsion systems in this field.

关键词： Food flavor perception Emulsion Mechanism Bibliometric