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多模态MRI联合血清miR-125b对乳腺癌新辅助化疗疗效的预测价值

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放射学实践 2024年第3期39卷 371-376页

作者：邓勋伟黄波汪鹏陶洁武汉市中医医院放射科武汉430050

目的:探讨乳腺癌治疗前多模态MRI联合血清miR-125b水平预测新辅助化疗疗效的价值。方法:研究对象为于我院首次接受全程新辅助化疗并行手术切除治疗的90例女性乳腺癌患者。治疗前对患者进行乳腺MRI检查,记录病灶直径、边缘、形状、平扫T_... 详细信息

目的:探讨乳腺癌治疗前多模态MRI联合血清miR-125b水平预测新辅助化疗疗效的价值。方法:研究对象为于我院首次接受全程新辅助化疗并行手术切除治疗的90例女性乳腺癌患者。治疗前对患者进行乳腺MRI检查,记录病灶直径、边缘、形状、平扫T_(2)WI图像上病灶内是否高信号和时间信号强度曲线(TIC)类型、表观扩散系数(ADC)、单纯扩散系数(D)、伪扩散系数(D*)及灌注分数(f)。依据Miller-Payne分级标准对病理学反应进行评估,分为病理反应不佳(NR)组和病理反应良好(R)组。结果:乳腺癌患者新辅助化疗后R组52例(57.78%),NR组38例(42.22%),两组的年龄、临床分期、病理类型、雌激素受体(er)、孕激素受体(PR)和人表皮生长因子受体2(Her2)表达水平差异无统计学意义(P>0.05)。R组中Ki-67>14%的比例显著高于NR组(P0.05)。R组的TIC类型为Ⅲ型的比例显著高于NR组,ADC值显著低于NR组,f值显著高于NR组(P<0.05)。R组的血清miR-125b相对表达量显著低于NR组(t=-11.007,P<0.001)。二元Logistic回归分析结果显示,较高的ADC值、血清miR-125b水平和较低的f值是乳腺癌新辅助化疗后疗效为NR的独立危险因素(P<0.05)。ADC值、f值、血清miR-125b水平及三者联合预测乳腺癌新辅助化疗疗效的AUC分别为0.863(95%CI:0.799~0.927,P<0.001)、0.819(95%CI:0.744~0.893,P<0.001)、0.832(95%CI:0.755~0.908,P<0.001)和0.958(95%CI:0.929~0.988,P<0.001)。结论:治疗前多模态MRI联合血清miR-125b水平对乳腺癌患者新辅助化疗疗效具有一定的预测价值。

关键词：乳腺肿瘤磁共振成像血清miR-125b 新辅助化疗

基于地学信息图谱的科西河流域滑坡空间分异研究

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地理科学 2024年第6期44卷 1111-1122页

作者：张建强黄宇陈容孔博中国科学院、水利部成都山地灾害与环境研究所四川成都610041 东华理工大学测绘与空间信息工程学院江西南昌330013

以科西河流域滑坡为例,对滑坡信息图谱的概念和内容进行研究,归纳滑坡信息图谱由条件图谱、编目图谱、风险分布图谱和风险管理图谱组成,提出滑坡信息图谱按表达内容和功能的分类方法。基于滑坡条件图谱与编目图谱,采用空间统计的方法,... 详细信息

以科西河流域滑坡为例,对滑坡信息图谱的概念和内容进行研究,归纳滑坡信息图谱由条件图谱、编目图谱、风险分布图谱和风险管理图谱组成,提出滑坡信息图谱按表达内容和功能的分类方法。基于滑坡条件图谱与编目图谱,采用空间统计的方法,揭示了研究区滑坡垂直向和纬度向分布与演化的空间分异规律:滑坡在垂直向200~1 000 m的高程段内为数量高密度区,400~1 200 m和2 800~3 600 m高程段面积比例大,北纬26°42′00″N~26°48′00″N为数量高密度区,26°42′00″N~26°48′00″N和27°24′00″N~27°30′00″N滑坡面积比例较大;相比1992年滑坡,新增滑坡在垂直向200~1 000 m和2 800~3 600 m高程段数量密度高,在3 200~3 400 m高程段面积比例较大,北纬26°48′00″N~26°54′00″N和27°48′00″N~27°54′00″N为高数量密度区,27°24′00″N~27°42′00″N为高面积比例区。

关键词：地学信息图谱滑坡垂直地带性纬度地带性科西河流域

A STUDY OF DRAG COEFFICIENT RELATED WITH VEGETATION BASED ON THE FLUME EXPerIMENT

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Journal of Hydrodynamics 2010年第3期22卷 329-337页

作者： HUI er-qing HU Xing-e JIANG Chun-bo MA Fang-kai ZHU Zhen-duo China Three Gorges Corporation Yichang 443002 China State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China State Key Laboratory of Hydroscience and Engineering Tsinghua University Beijing 100084 China

This study is focused on the effects of ecological factors （diameter and flexibility） and vegetation community composition on the drag coefficient related with vegetation. The single leafy shrub and three mixed communities （including shrub-grass, shrub-reed and reed-grass community） were studied. The flow velocity and water level were measured and used to calculate the drag coefficient based on the Bernoulli＇s equation, Darcy drag formula and the expression for the drag coefficient related with Darcy drag factor. The trend of the drag coefficient in the vertical direction was analyzed against flow depth, diameter, diameter P（eynolds number, flow depth Reynolds number and relative roughness height in different discharges. The results show that beside the dense leafy shrubs community, the vertical trend of the drag coefficient among other cases against flow depth, diameter, diameter Reynolds number, flow depth Reynolds number and relative roughness height can be approximately expressed by power law functions under different flow discharges. Moreover, in a mixed community with two plants with distinctly different ecological factors, the one with the most distinct variations of ecological factors determines the vertical trend of the drag coefficient; the other one only affects the magnitude of the drag coefficient. Furthermore, if the ecological factors of the vegetation in the vertical direction are kept almost not changed, the drag coefficient can be approximately regarded as a constant.

关键词： vegetated channel drag coefficient flume experiment

Enhanced Giant Magnetoimpedance Effect in Rapid Heat-Treated Fe-Based Amorphous Ribbons

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Chinese Physics Letters 2013年第3期30卷 150-153页

作者： ZHANG Yi DONG Juan FENG er-Xi LUO Cai-Qin LIU Qing-Fang WANG Jian-bo Institute of Applied Magnetics Key Laboratory for Magnetism and Magnetic Materials of the Ministry of EducationLanzhou UniversityLanzhou 730000

An enhanced giant magnetoimpedance(GMI)effect of Fe-based amorphous ribbons is obtained by rapid heat *** structural investigations on the ribbon reveal the presence of two phases,i.e.a fine grained Fe3Si phase and a residual amorphous phase on rapid heat *** soft magnetic property is improved by rapid heat treatment;the crystal size and grain size of Fe_(3)Si *** maximum magnetoimpedance ratio obtained in the present study is 81%at 10 MHz,and the optimized heat-treated rate is 200℃/*** GMI curves are observed after the simultaneous rapid heat treatment and magnetic field *** suggests that tailoring of the nanocrystalline microstructures induced by optimum rapid heat treatment conditions can result in an excellent GMI effect.

关键词： grain treatment amorphous

面向大规模目标跟踪的相控阵雷达资源分配方法

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信号处理 2024年第9期40卷 1608-1620页

作者：卓娅玲李响左磊胡娟唐波西安电子科技大学雷达信号处理全国重点实验室陕西西安710071 清华大学电子工程系北京100084 国防科技大学电子对抗学院安徽合肥230037

相比于传统雷达,相控阵雷达能够同时生成多个波束并灵活改变波束指向,被广泛应用于多目标跟踪领域。在大规模集群目标协同探测场景中,为支持后续节点对敌方目标进行火力拦截与打击的任务需求,相控阵雷达需要在规定时间内将空域内优先级... 详细信息

相比于传统雷达,相控阵雷达能够同时生成多个波束并灵活改变波束指向,被广泛应用于多目标跟踪领域。在大规模集群目标协同探测场景中,为支持后续节点对敌方目标进行火力拦截与打击的任务需求,相控阵雷达需要在规定时间内将空域内优先级更高的目标更快地跟踪至火控精度,然而若空域内目标数量过多,雷达探测资源有限,难以完成指定跟踪任务。为了解决这一问题,本文提出了一种面向大规模目标跟踪的相控阵雷达目标分配与功率联合优化算法。首先,推导出包含目标分配和功率优化的预测条件克拉美罗下界,并将其作为目标跟踪性能的衡量指标;随后,本文同时考虑跟踪容量和跟踪精度,以最大化满足跟踪精度的目标数量和最小化多目标优先级加权平均跟踪误差为优化目标,结合相控阵雷达系统资源,建立了大规模目标跟踪下的目标分配和功率联合优化模型,对目标分配变量和发射功率变量进行自适应联合优化配置。针对上述优化问题,本文采用两步分解法,将其分解为目标分配子问题和功率优化子问题,并结合激活函数对非平滑非凸的目标函数进行平滑近似。然后,利用谱投影梯度法进行求解。仿真实验验证了所提算法相较于传统算法在多个场景下均能在指定时间内更快速地将更多目标跟踪至指定精度。

关键词：相控阵雷达大规模目标跟踪目标分配功率优化

10t/d双螺杆榨油机压榨油茶籽的工艺研究

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粮油食品科技 2024年第1期32卷 77-81页

作者：周万猛张新文石胜瑜陈波宇倪二毛金俊吴港城重庆酉州油茶科技有限公司重庆400010 江南大学食品学院江苏无锡214122

为提高油茶籽油的品质,减少传统油茶籽制油工艺对油茶籽油的营养成分损失,对日处理10t双螺杆榨油机压榨油茶籽的工艺进行了研究。结果表明,最佳工艺条件为:油茶籽经过分级处理后入榨油茶仁水分控制在9%、油茶仁中含壳控制在8%时,压榨饼... 详细信息

为提高油茶籽油的品质,减少传统油茶籽制油工艺对油茶籽油的营养成分损失,对日处理10t双螺杆榨油机压榨油茶籽的工艺进行了研究。结果表明,最佳工艺条件为:油茶籽经过分级处理后入榨油茶仁水分控制在9%、油茶仁中含壳控制在8%时,压榨饼中残油率为2.49%,且产品符合一级油的国家标准。与市场上销售的油茶籽油相比,通过本工艺获得的油茶籽油中α-生育酚的保留率更高,从而进一步提高油茶籽油的营养价值,可为我国油茶籽油的高值化加工提供了技术参考。

关键词：油茶籽双螺杆榨油机剥壳及壳仁分离产品质量

The enhancement of performance and imbibition effect of slickwater-based fracturing fluid by using MoS_(2)nanosheets

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Petroleum Science 2023年第4期20卷 2187-2201页

作者： Hang Xu Yuan Li Guo-Lin Yu Sa-Sa Yang bo-Jun Li Fu-Jian Zhou er-Dong Yao Hao Bai Zhi-Yu Liu Unconventional Petroleum Research Institute China University of Petroleum(Beijing)Beijing102249China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China

Slickwater-based fracturing fluid has recently garnered significant attention as the major fluid for volumetric fracturing;however,lots of challenges and limitations such as low viscosity,poor salt tolerance,and possible formation damage hinder the application of the conventional simple slickwater-based fracturing *** addition,nanomaterials have proven to be potential solutions or improvements to a number of challenges associated with the *** this paper,molybdenum disulfide(MoS_(2))nanosheets were chemically synthesized by hydrothermal method and applied to improve the performance of conventional slickwater-based fracturing ***,the microstructure characteristics and crystal type of the MoS_(2)nanosheets were analyzed by SEM,EDS,TEM,XPS,and Raman spectroscopy ***,a series of evaluation experiments were carried out to compare the performance of MoS_(2)nanosheet-modified slickwater with the conventional slickwater,including rheology,drag reduction,and sand ***,the enhanced imbibition capacity and potential mechanism of the nanosheet-modified slickwater were systematically *** results showed that the self-synthesized MoS_(2)nanosheets displayed a distinct ultrathin flake-like morphology and a lateral size in the range of tens of *** the nano-composites,each MoS_(2)nanosheet plays the role of cross-linking point,so as to make the spatial structure of the entire system more ***,nanosheet-modified slickwater demonstrates more excellent properties in rheology,drag reduction,and sand *** nanosheet-modified slickwater has a higher apparent viscosity after shearing 120 min under 90℃ and 170 s^(−1).The maximum drag reduction rate achieved 76.3%at 20℃,and the sand settling time of proppants with different mesh in the nano-composites was *** imbibition experiments showed that the gel-breaking fluid of nanosheet-modified slickwater exhibited excellent capability of

关键词： Slickwater-based fracturing fluid MoS_(2)nanosheet Performance evaluation spontaneous imbibition Climbing film

Ciona intestinalis as an emerging model organism: its regeneration under controlled conditions and methodology for egg dechorionation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第6期7卷 467-474页

作者： LIU Li-ptng XIANG Jian-hai DONG bo NATARAJAN Pavanasam YU Kui-jie CAI Nan-er Key Laboratory of Experimental Marine Biology Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China College of Aqua-Life Science and Technology Shanghai Fisheries University Shanghai 200090 China Department of Aquatic Biology and Fisheries University of Kerala Trivandrum 695034 India

The ascidian Ciona intestinalis is a model organism of developmental and evolutionary biology and may provide orucial clues concerning two fundamental matters, namely, how chordates originated from the putative deuterostome ancestor and how advanced chordates originated from the simplest chordates. In this paper, a whole-life-span culture of C. intestinalis was conducted. Fed with the diet combination of dry Spirulina, egg yolk, Dicrateria sp., edible yeast and weaning diet for shrimp, C. intestinalis grew up to average 59 mm and matured after 60 d cultivation. This culture process could be repeated using the artificially cultured mature ascidians as material. When the fertilized eggs were maintained under 10, 15, 20, 25 ℃, they hatched within 30 h, 22 h, 16 h and 12 h 50 min respectively experiencing cleavage, blastulation, gastrulation, neurulation, tailbud stage and tadpole stage, The tadpole larvae were characterized as typical but simplified chordates because of their dorsal nerve cord, notochord and primordial brain. After 8-24 h freely swimming, the tadpole larvae settled on the substrates and metamorphosized within 1-2 d into filter feeding sessile juvenile ascidians. In addition, unfertilized eggs were successfully dechorionated in filtered seawater containing 1% Tripsin, 0.25% EDTA at pH of 10.5 within 40 min. After fertilization, the dechorionated eggs developed well and hatched at normal hatching rate. In conclusion, this paper presented feasible methodology for rearing the tadpole larvae of C. intestinalis into sexual maturity under controlled conditions and detailed observations on the embryogenesis of the laboratory cultured ascidians, which will facilitate developmental and genetic research using this model system.

关键词： Cona intestinalls Model organism Laboratory culture Embryogenesis

Flight Pulmonary Artery to Left Atrial Fistula Confirmed by 320-slice Computerized Tomography

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Chinese Medical Journal 2015年第18期 2549-2550页

作者： Jian Zhu er-Ping Xi Ming Yan Shui-bo Zhu Department of Thoracic Cardiovascular Surgery Wuhan General Hospital of Guangzhou Command Wuhan Hubei 430070 China

To the Editor： Right pulmonary artery-left atrial fistula （RPALAF） is an extremely rare congenital cardiovascular malformation that may be difficult to diagnose by clinical symptoms. High resolution computed tomographic （CT） gives a clear view of cardiovascular and can provide an accurate diagnosis, and it has not been reported in the last literature date though 320-slice CT scan giving these clear views. On the base of a case of this disease, we describe an 18-year-old girl with RPALAF confirmed by 320-slice CT. This case demonstrates that the 320-slice CT scan is a sensitive and reliable technique for establishing the diagnosis of RPALAF when it cannot be visualized by clinical symptoms.

关键词：肺动脉钙调蛋白结合蛋白质类体层摄影术体层摄影术 X线计算机血气分析胰岛素铍瘘