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Oxcarbazepine oral suspension in young pediatric patients with partial seizures and/or generalized tonic-clonic seizures in routine clinical practice in China: a prospective observational study

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World Journal of Pediatrics 2018年第3期14卷 280-289页

作者： Jiong Qin Yi Wang Xin-Fang Huang Yu-Qin Zhang Fang Fang yin-bo Chen Zhong-Dong Lin Yan-Chun Deng Fei yin Li Jiang Ye Wu Xiang-Shu Hu Department of Pediatrics Peking University People’s HospitalNo.11 Xi Zhi Men Nan Da JieXicheng DistrictBeijing 100044China Department ofP ediatrics Peking University First HospitalBeijingChina Department ofN eurology Children’s HospitalFudan UniversityShanghaiChina Department ofP ediatrics Quanzhou Women’s andChildren’s HospitalQuanzhouChina Department of N eurology Tianjin Children’s HospitalTianjinChina Department of N eurology Beijing Children’s HospitalBeijingChina Department of Pediatric Neurology The First Bethune HospitalJilin UniversityChangchunChina Department of Pediatric Neurology The 2nd Affi liated HospitalWenzhou Medical UniversityWenzhouChina Department of N eurology Xijing HospitalXi’anChina Department of P ediatrics Xiangya HospitalCentral South UniversityChangshaChina Department of N eurology Children’s HospitalChongqing Medical UniversityChongqingChina The third Department ofN eurology Guangdong 999 Brain HospitalGuangzhouChina

Background This study aimed to assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-5 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. Methods This 26-week, prospective, single-arm, multicenter, observational study recruited pediatric patients aged 2-5 years with PS or GTCS suitable for OXC oral suspension treatment based on physicians' judgments from 11 medical centers in China. Enrolled subjects started OXC oral suspension treatment as monotherapy or in combination with other antiepileptic drugs. Primary efficacy outcome was the percentage of pediatric subjects achieving ≥ 50% seizure frequency reduction at the end of the 26-week treatment. Secondary efficacy-related parameters and safety parameters such as adverse events (AEs) and serious AEs (SAEs) were also monitored during the 26-week treatment period. Results Six hundred and six pediatric patients were enrolled and 531 (87.6%) completed the study. After 26 weeks of treat-ment, 93.3% subjects achieved ≥ 50% seizure frequency reduction, and 81.8% achieved 100% seizure frequency reduction compared to baseline. Among diff erent seizure types, OXC was eff ective in all subjects with simple PS and in > 90% of subject with other type of seizure present in the study. AEs were observed in 49 (8.1%) subjects. Only three subjects expe-rienced SAE. Rash (n = 18, 2.97%) was the most common AE. Only 17 subjects discontinued due to AEs. Conclusion This study, reporting the real-world data, further confi rms the efficacy and good safety profi le of OXC oral suspension in Chinese pediatric patients aged 2-5 years with PS and/or GTCS.

关键词： Antiepileptic drugs Generalized tonic-clonic seizures Oxcarbazepine oral suspension Partial seizures Pediatric patients

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Stromal lenticule addition keratoplasty with corneal crosslinking for corneal ectasia secondary to FS-LASIK:a case series

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 596-602页

作者： Li-Xiang Wang ying-Ping Deng Meng-Zhen Xie Ke Ma Hong-bo yin Qiong Wang Rui Gong Jing Tang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

●AIM:To explore the clinical efficacy and safety of stromal lenticule addition keratoplasty(SLAK)with corneal crosslinking(CXL)on patients with corneal ectasia secondary to femtosecond laser-assisted in situ keratomileusis(FS-LASIK).●METHODS:A series of 5 patients undertaking SLAK with CXL for the treatment of corneal ectasia secondary to FS-LASIK were followed for *** lenticules were collected from patients undertaking small incision lenticule extraction(SMILE)for the correction of *** a stromal lenticule was aimed at improving the corneal thickness for the safe application of crosslinking and compensating for the thin cornea to improve its mechanical strength.●RESULTS:All surgeries were conducted successfully with no significant *** best corrected visual acuity(BCVA)ranged from 0.05 to 0.8-2 before *** pre-operational total corneal thickness ranged from 345-404μm and maximum keratometry(Kmax)ranged from 50.8 to *** the combination surgery,both the corneal keratometry(range 55.9 to 92.8)and total corneal thickness(range 413-482μm)significantly *** out of 5 patients had improvement of corneal biomechanical parameters(reflected by stiffness parameter A1 in Corvis ST).However,3 patients showed decreased BCVA after surgery due to the development of irregular astigmatism and transient *** the onset of corneal edema right after SLAK,the corneal topography and thickness generally stabilized after 3mo.●CONCLUSION:SLAK with CXL is a potentially beneficial and safe therapy for advanced corneal *** work needs to address the poor predictability of corneal refractometry and compare the outcomes of different surgical modes.

关键词： corneal ectasia femtosecond laserassisted in situ keratomileusis stromal lenticule addition keratoplasty corneal crosslinking corneal thickness corneal biomechanics

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Numerical study of inhibition mechanism of high-pressure hydrogen leakage self-ignition with the addition of ammonia

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Petroleum Science 2023年第5期20卷 3184-3193页

作者： Lin Teng Xi-Gui Li Zhi-Wei Shan Wei-Dong Li Xin Huang Peng-bo yin Yong-Zhen Liu Jiang Bian Yu Luo Li-Long Jiang National Engineering Research Center of Chemical Fertilizer Catalyst(NERC-CFC) College of Chemical EngineeringFuzhou UniversityFuzhou350000FujianChina Qingyuan Innovation Laboratory(QYIL Fujian Innovation Laboratory of Chemical Engineering)Quanzhou362000FujianChina cEngineering China University of Petroleum(East China)Qingdao266580ShandongChina State Key Laboratory of Automobile Safety and Energy School of Vehicle and MobilityTsinghua UniversityBeijing100084China

Hydrogen and ammonia have attracted increasing attention as carbon-free *** is considered to be an effective energy storage and hydrogen storage ***,a small amount of unremoved NH3 is still present in the product during the decomposition of ammonia to produce ***,it is very essential to investigate the self-ignition of hydrogen-ammonia mixtures in order to accommodate the various scenarios of hydrogen energy *** this paper,the effect of NH3 addition on the self-ignition of high-pressure hydrogen release is numerically *** RNG k-εturbulence model,EDC combustion model,and 213-step detailed NH_(3)/H_(2) combustion mechanism are ***-Pro programs for zero-dimensional homogeneous and constant volume adiabatic reactor models are used for sensitivity analysis and ignition delay time of the chemical reaction *** results showed that the minimum burst pressure required for self-ignition increased significantly after the addition of *** maximum temperature and shock wave intensity inside the tube decreases with increasing ammonia *** ignition delay time and H,HO2,and OH radicals reduce with increasing ammonia concentration.H and HO2 radicals are suggested as indicators for tracking the second and third flame branches,respectively.

关键词： Ammonia-hydrogen energy Self-ignition Shock waves Diffusion ignition Computational fluid dynamics

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Reverse Circulation DTH Hammer Drilling Technique

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Global Geology 2011年第4期14卷 259-264页

作者： bo Kun yin Kun PENG Jianming College of Construction Engineering Jilin University Changchun 130026 China

The technical characteristics and operational principal of the reverse circulation DTH hammer drilling technology is integrated introduced in this paper. Using simulation technology to assist the drilling tool design, the optimum designed DTH hammer gets stable performance, and the bit has reverse circulation ability, and further more, it has already developed serial products. The reverse circulation DTH hammer drilling technique has been fully applied in field such as the geological core exploration in complex strata, water well drilling, and large diameter rock embedding piles drilling in hard rock, and obviously, it is achieved favorable economic and social benefits.

关键词： Hollow-through DTH hammer reverse circulation reverse circulation bit simulation

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PC/EVA共混体系在加工过程中的反应

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高分子材料科学与工程 2005年第6期21卷 201-204,208页

作者：赵印廖永霞尹波杨鸣波四川大学高分子科学与工程学院高分子材料工程国家重点实验室四川成都610065

通过转矩流变分析、差示扫描量热(DSC)和核磁共振氢谱(1H-NM R)等手段研究了不同聚碳酸酯(PC)/乙烯-醋酸乙烯酯共聚物(EVA)共混体系在加工过程中的大分子反应,考察了有机金属催化剂(氧化二丁基锡DBTO)含量和反应时间对共混体系的影响。... 详细信息

通过转矩流变分析、差示扫描量热(DSC)和核磁共振氢谱(1H-NM R)等手段研究了不同聚碳酸酯(PC)/乙烯-醋酸乙烯酯共聚物(EVA)共混体系在加工过程中的大分子反应,考察了有机金属催化剂(氧化二丁基锡DBTO)含量和反应时间对共混体系的影响。结果表明,PC和EVA可以在熔融共混过程中发生大分子反应,在界面原位形成接枝或交联的PC-EVA共聚物,催化剂用量增大、反应时间延长易生成共交联的PC-EVA共聚物,但混合时间过长,体系的断链加剧,所生成产物不稳定。

关键词：聚碳酸酯/乙烯-醋酸乙烯酯共聚物共混体系酯交换反应原位增容

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Bioinspired hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers

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National Science Review 2020年第1期7卷 73-83页

作者： Huai-Ling Gao Ran Zhao Chen Cui yin-bo Zhu Si-Ming Chen Zhao Pan Yu-Feng Meng Shao-Meng Wen Chuang Liu Heng-An Wu Shu-Hong Yu Division of Nanomaterials & Chemistry Hefei National Laboratory for Physical Sciences at the Microscale CAS Center for Excellence in Nanoscience Hefei Science Center of CAS Department of Chemistry University of Science and Technology of China CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China

Bio-sourced nanocellulosic materials are promising candidates for spinning high-performance sustainable macrofibers for advanced applications. Various strategies have been pursued to gain nanocellulose-based macrofibers with improved strength. However, nearly all of them have been achieved at the expense of their elongation and toughness. Inspired by the widely existed hierarchical helical and nanocomposite structural features in biosynthesized fibers exhibiting exceptional combinations of strength and toughness, we report a design strategy to make nanocellulose-based macrofibers with similar characteristics. By combining a facile wet-spinning process with a subsequent multiple wet-twisting procedure, we successfully obtain biomimetic hierarchical helical nanocomposite macrofibers based on bacterial cellulose nanofibers, realizing impressive improvement in their tensile strength, elongation and toughness simultaneously. The achievement certifies the validity of the bioinspired hierarchical helical and nanocomposite structural design proposed here. This bioinspired design strategy provides a potential platform for further optimizing or creating many more strong and tough nanocomposite fiber materials for diverse applications.

关键词： bioinspired nanocomposite hierarchical helical macrofibers strength and toughness bacterial cellulose

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Preparation and Magnetic Properties of Submicron CrO2 Thin Film on Poly-crystal TiO2 Film

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Chemical Research in Chinese Universities 2013年第3期29卷 600-602页

作者： YUAN Ju-jun WEN Ge-hui ZHAO Qiang FAN yin-bo ZHANG Cai-ping ZHANG Xian-ke YU Hua-jun XIE ying-mao College of Physics and Electronics Gannan Normal University Ganzhou 341000 P. R. China State Key Laboratory of Superhard Materials Jilin University Changchun 130012 P. R. China Institute of Optoelectronic Materials and Technology Gannan Normal University Ganzhou 341000 P. R. China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Chengdu 610054 P. R. China

The submicron chromium dioxide（CrO2） thin film was fabricated on a poly-crystal titania（TiO2） film using Si wafers as substrates by atmospheric pressure chemical vapor deposition（CVD） method. X-Ray diffraction patterns show that the CrO2 films were pure rutile structure. Scanning electron microscopy（SEM） images indicate that the CrO2 films consisted of submicron grains with a grain size of 250--750 rim. The magnetic researches reveal that the magnetic easy axis is parallel to the films, and at room temperature, the CrO2 films show linear magnetoresistance.

关键词： CrO2 film TiO2 film Chemical vapor deposition(CVD) Magnetic property Half-metal ferromagnet

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网络传销犯罪的司法认定逻辑及其修正

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比较法研究 2022年第1期36卷 116-129页

作者：印波北京师范大学法学院暨刑事法律科学研究院英国阿伯丁大学

基于传销犯罪的诈骗本质以及网络传销所衍生的诸多形式,原有的组织、领导传销活动罪的界定已经无法适应惩治网络传销犯罪的需要,应当基于体系与实践的双重考量,对网络传销犯罪的立法和司法作出相应的调适。组织、领导传销活动罪与集资... 详细信息

基于传销犯罪的诈骗本质以及网络传销所衍生的诸多形式,原有的组织、领导传销活动罪的界定已经无法适应惩治网络传销犯罪的需要,应当基于体系与实践的双重考量,对网络传销犯罪的立法和司法作出相应的调适。组织、领导传销活动罪与集资诈骗罪系交叉竞合关系,两者在量刑上应保持平衡。网络传销犯罪在法益侵害程度方面未必高于传统传销犯罪。司法解释性文件对于网络传销犯罪的认定不应囿于组织内部参与传销活动人员30人三级的标准。网络团队计酬不应当构成犯罪。对于混合型传销,则应当结合"骗取财物"的要件予以全面判断。对为网络传销犯罪提供网络服务的行为,应区分情况适用共同犯罪、非法利用信息网络罪与帮助信息网络犯罪活动罪。对网络传销犯罪作证据综合认定时,应优先客观性证据,确立互联网电子数据的中枢证明作用,修正逐一收集参与传销活动人员的言词证据规则。

关键词：网络传销犯罪组织、领导传销活动罪团队计酬混合型传销证据综合认定

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走向自治的刑事诉讼法

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华南师范大学学报（社会科学版） 2020年第2期 130-139,191,192页

作者：印波北京师范大学刑事法律科学研究院

刑事诉讼法本身的法律属性尚处于欠缺状态,其原因是刑事诉讼法缺乏整体结构的自洽性认知。义务性刑事诉讼规则在结构上可以视为由刑事诉讼行为模式和违反的程序性后果两个相互联结的部分组成,刑事诉讼中的程序性违法行为是不符合刑事诉... 详细信息

刑事诉讼法本身的法律属性尚处于欠缺状态,其原因是刑事诉讼法缺乏整体结构的自洽性认知。义务性刑事诉讼规则在结构上可以视为由刑事诉讼行为模式和违反的程序性后果两个相互联结的部分组成,刑事诉讼中的程序性违法行为是不符合刑事诉讼行为模式的行为。刑事诉讼法具有实体真实、程序法定和法律和谐三项目的,它们是具体选择程序性后果应对程序性违法应当考虑的方向。刑事诉讼行为可以分成三组:实体形成行为、程序形成行为和裁判行为;职权行为和非职权行为;绝对无效行为和相对无效行为。参考以上三项目的和三组行为分类,分析义务性刑事诉讼规则、程序性违法行为和程序性后果的逻辑关系,构建框架图,还原刑事诉讼法应有的自治面貌。

关键词：刑事诉讼行为义务性刑事诉讼规则程序性违法行为程序性法律后果

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传销犯罪的司法限缩与立法完善

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中国法学 2020年第5期 243-262页

作者：印波北京师范大学刑事法律科学研究院中国企业家犯罪预防研究中心

《刑法修正案(七)》增设了组织、领导传销活动罪,并通过列明行为方式以及"骗取财物"的要件设定,将本罪的适用情形限定于诈骗型传销。传销之团队计酬具有复杂性、多样性的特点,可根据人员层级关系和奖金计酬方式划分类型。根据司法解释... 详细信息

《刑法修正案(七)》增设了组织、领导传销活动罪,并通过列明行为方式以及"骗取财物"的要件设定,将本罪的适用情形限定于诈骗型传销。传销之团队计酬具有复杂性、多样性的特点,可根据人员层级关系和奖金计酬方式划分类型。根据司法解释性文件,应将以销售商品为目的的真正的团队计酬完全除罪。团队计酬既不宜定组织、领导传销活动罪,也不宜定非法经营罪。团队计酬所产生的风险具有行政可控性,禁止团队计酬行为是一种权宜的立法行为。可以通过在解释中实现团队计酬非罪化完成传销犯罪的适度司法限缩,并根据其诈骗本质完善组织、领导传销活动罪的构成要件。

关键词：传销犯罪组织、领导传销活动罪诈骗团队计酬非罪化

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