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Autophagy and its role in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第36期30卷 4014-4020页

作者： bo-Zong shao Wen-Gang Zhang Zhen-Yu Liu En-Qiang Linghu Department of Gastroenterology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system,such as the esophagus,stomach,colon,rectum,pancreas,liver,small intestine,and bile *** role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant *** paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research ***,we delve into inflammation-related gastrointestinal conditions,including ulcerative colitis,Crohn’s disease,and pancreatitis,as well as gastrointestinal cancers such as esophageal,gastric,and colorectal ***,we provide commentary on a recent publication by Chang et al in the World Journal of *** objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal *** review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant *** discussed,the role of autophagy in gastrointestinal diseases is complex and,at times,*** harness the full therapeutic potential of autophagy in treating these conditions,more in-depth research is imperative.

关键词： Autophagy Inflammation Cancer Inflammatory bowel disease Pancreatitis

Joint Effects of Multipollutant Mixtures on Mortality in Chengdu,China

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Biomedical and Environmental Sciences 2024年第1期37卷 112-116页

作者： ZHANG Ying TIAN Qi Qi HU Wen Dong ZHANG shao bo WANG Shi Gong ZHENG Can Jun Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225SichuanChina Yunnan R&D Institute of Natural Disaster on Chengdu University of Information Technology Kunming 650034YunnanChina Chengdu Plain Urban Meteorology and Environment Sichuan Provincial Field Scientific Observation and Research Station Chengdu 610225SichuanChina Chinese Center for Disease Control and Prevention National Institute for Communicable Disease Control and PreventionBeijing 102206China

Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant ***,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.

关键词： mixtures monoxide consequences

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论中华文化走向世界的困境以及可能性

内蒙古社会科学 2024年第1期45卷 191-197页

作者：史少博西安电子科技大学马克思主义学院陕西西安710126

文化是人类实践的产物,是人类精神以及物质的载体。人类为了生存创造了文化,文化又引导人类更好地生存。新时代,中华文化更好更快地走向世界还面临一定的困境,如国家主流意识形态之间的排斥、文化民族性的排斥、文化传播方式的局限等。2... 详细信息

文化是人类实践的产物,是人类精神以及物质的载体。人类为了生存创造了文化,文化又引导人类更好地生存。新时代,中华文化更好更快地走向世界还面临一定的困境,如国家主流意识形态之间的排斥、文化民族性的排斥、文化传播方式的局限等。20世纪以来西方思想文化运动的“东方转向”为中华文化更好更快地走向世界提供了契机,国家实力的不断增强为新时代中华文化更好更快地走向世界提供了物质保障,人类的跨文化存在为推动新时代中华文化走向世界提供了空间的可能性。

关键词：中华文化困境可能性

Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： shao-bo Ma Li-Na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong Zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-Tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

Depositional model of the Member Deng-2 marginal microbial mound-bank complex of the Dengying Formation in the southwestern Sichuan Basin, SW China: Implications for the Ediacaran microbial mound construction and hydrocarbon exploration

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Petroleum Science 2024年第2期21卷 806-822页

作者： Jin-Min Song Xin Jin Zhong Luo Shu-Gen Liu shao-bo Liu Xing-Zhi Ma Zhi-Wu Li Xue-Song Lu Ling-Li Zhao Ke-Ran Li Jia-Xin Ren Li-Zhou Tian Hao-Shuang Deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina PetroChina Research Institute of Petroleum Exploration and Development Beijing100083China Xihua University Chengdu610039SichuanChina

Recent advances in hydrocarbon exploration have been made in the Member Deng-2 marginal microbial mound-bank complex reservoirs of the Dengying Formation in the western Sichuan Basin, SW China,where the depositional process is regarded confusing. The microfacies, construction types, and depositional model of the Member Deng-2 marginal microbial mound-bank complex have been investigated using unmanned aerial vehicle photography, outcrop section investigation, thin section identification,and seismic reflections in the southwestern Sichuan Basin. The microbialite lithologic textures in this region include thrombolite, dendrolite, stromatolite, fenestral stromatolite, spongiostromata stone,oncolite, aggregated grainstone, and botryoidal grapestone. Based on the comprehensive analysis of“depositional fabrics-lithology-microfacies”, an association between a fore mound, mound framework,and back mound subfacies has been proposed based on water depth, current direction, energy level and lithologic assemblages. The microfacies of the mound base, mound core, mound flank, mound cap, and mound flat could be recognized among the mound framework subfacies. Two construction types of marginal microbial mound-bank complex have been determined based on deposition location, mound scale, migration direction, and sedimentary facies association. Type Jinkouhe microbial mound constructions(TJMMCs) develop along the windward margin owing to their proximity to the seaward subfacies fore mound, with a northeastwardly migrated microbial mound on top of the mud mound,exhibiting the characteristics of large-sized mounds and small-sized banks in the surrounding area. Type E'bian microbial mound constructions(TEMMCs) primarily occur on the leeward margin, resulting from the presence of onshore back mound subfacies, with the smaller southwestward migrated microbial mounds existing on a thicker microbial flat. The platform margin microbial mound depositional model can be correlated with certain late

关键词： Sichuan Basin The Member Deng-2 Marginal microbial mound-bank complex Depositional model Exploration implications

大语言模型环境下高校未来学习中心的探索与实践

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图书馆学研究 2024年第7期 70-76,109页

作者：刘莉邵波南京大学信息管理学院南京大学图书馆

文章采用文献调研法以及网络调查法,对国内外未来学习中心的建设与研究进行回顾,并对大语言模型在未来学习中心的研究现状进行重点调研。在此基础上,提出大语言模型环境下未来学习中心的建设目标以及实施路径,并以南京大学建设未来学习... 详细信息

文章采用文献调研法以及网络调查法,对国内外未来学习中心的建设与研究进行回顾,并对大语言模型在未来学习中心的研究现状进行重点调研。在此基础上,提出大语言模型环境下未来学习中心的建设目标以及实施路径,并以南京大学建设未来学习中心的实践为例,探讨大语言模型赋能未来学习中心的成效,以期为大语言模型在高校未来学习中心的应用提供参考。结果表明:嵌入大语言模型的未来学习中心,通过搭建智慧平台,满足了未来学习中心空间再造的要求;聚合学科资源,实现了资源专题定制与智能推荐;更提供AI智能学习助手,辅助了高校的教学与科研。

关键词：未来学习中心大语言模型空间再造辅助教学科研

共享图书馆服务平台:国外图书馆联盟重构的实践路径与启示

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图书情报工作 2024年第3期68卷 40-48页

作者：王怡邵波南京大学信息管理学院南京210046 南京大学图书馆南京210046

[目的/意义]梳理国外图书馆联盟共享平台项目的趋势和案例,为国内图书馆联盟提供更清晰的发展思路。[方法/过程]采集Library Technology Guides数据库中联盟相关数据,分析联盟共享平台的增长趋势、迁移趋势、平台类型等;通过文献调研和... 详细信息

[目的/意义]梳理国外图书馆联盟共享平台项目的趋势和案例,为国内图书馆联盟提供更清晰的发展思路。[方法/过程]采集Library Technology Guides数据库中联盟相关数据,分析联盟共享平台的增长趋势、迁移趋势、平台类型等;通过文献调研和网络调研方法,从案例角度总结国外图书馆联盟的实施方案、组织方式、项目成效等内容。[结果/结论 ]研究结果表明,国外图书馆联盟已经分3个时期进行了平台迁移,联盟共享平台呈现出集中化、趋同化的情况。根据国外联盟经验,合适的平台产品、严密的项目规划、技术化的联盟结构是联盟重构能够成功的主要因素。

关键词：共享图书馆系统共享图书馆服务平台图书馆联盟联盟重构

学术自由理念的反思与重建——基于康德自由学说的思考

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大学教育科学 2024年第1期 41-49页

作者：霍少波许少玲湖南大学教育科学研究院长沙410082 北京师范大学教育学部北京100091

当前人们关于学术自由历史、含义、案例等方面的论述,基本上把学术自由视作一个由他者给予的行动空间:它是外界给予的,是在与他者斗争中争取出来的,过分强调对外部干预的排斥或对外部资源的依赖而忽视对自身的要求;学术自由被描述为一... 详细信息

当前人们关于学术自由历史、含义、案例等方面的论述,基本上把学术自由视作一个由他者给予的行动空间:它是外界给予的,是在与他者斗争中争取出来的,过分强调对外部干预的排斥或对外部资源的依赖而忽视对自身的要求;学术自由被描述为一个相对独立的行动空间,无关道德,所有学术行为都将得到学术自由的辩护,从而可能滑向对学术自由的滥用。这些都要求走出“薄的自由理论”,以更厚重的自由学说为学术自由奠基。康德哲学以人的自由为核心关切,分析康德自由学说能够让我们看到一个别样的自由图景:一种出于自身理性的庄严承诺。自由具有先验性、法则性和义务性,基于康德自由学说,学术自由从根本上意味着一个道德原则,它预设着正直、胜任与谦虚,表现为学术勇气、学术担当和学术宽容。

关键词：学术自由康德自由学说学术勇气学术担当学术宽容

元宇宙视域下高校图书馆跨学科知识交互空间建设研究

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图书馆杂志 2024年第3期43卷 33-40,60页

作者：傅爱雯邵波南京大学信息管理学院南京大学图书馆

在多学科和数字技术的交叉发展下,新型知识内容不断延伸,图书馆作为大学重要的知识集成库,应当把握机会,构建知识交互新模式。本文从元宇宙角度出发,研究归纳元宇宙图书馆知识交互空间发展的可行性,以知识交互演化需求为基础,从人、资... 详细信息

在多学科和数字技术的交叉发展下,新型知识内容不断延伸,图书馆作为大学重要的知识集成库,应当把握机会,构建知识交互新模式。本文从元宇宙角度出发,研究归纳元宇宙图书馆知识交互空间发展的可行性,以知识交互演化需求为基础,从人、资源、环境三方面进行构建元宇宙高校图书馆跨学科知识交互空间,以期为用户知识交互生态发展、元宇宙图书馆知识系统建设提供参考。

关键词：元宇宙图书馆跨学科知识交互空间建设