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Comparative efficacy and safety of cognitive enhancers for treating vascular cognitive impairment: systematic review and Bayesian network meta-analysis

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Neural Regeneration Research 2019年第5期14卷 805-816页

作者： bo-Ru jin Hua-Yan Liu Department of Neurology First Affiliated Hospital China Medical University

Objective: To assess and compare the clinical efficacy and safety of cognitive enhancers(donepezil, galantamine, rivastigmine, and memantine) on cognition, behavior, function, and global status in patients with vascular cognitive *** sources: The initial literature search was performed with PubMed, EMBASE, the Cochrane Methodology Register, the Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing & Allied Health(CINAHL) from inception to January 2018 for studies regarding donepezil, galantamine, rivastigmine, and memantine for treatment of vascular cognitive *** selection: Randomized controlled trials on donepezil, galantamine, rivastigmine, and memantine as monotherapy in the treatment of vascular cognitive impairment were included. A Bayesian network meta-analysis was conducted. Outcome measures: Efficacy was assessed by changes in scores of the Alzheimer's Disease Assessment Scale, cognitive subscale, Mini-Mental State Examination, Neuropsychiatric Inventory scores and Clinician's Interview-Based Impression of Change Scale Plus Caregiver's Input, Activities of Daily Living, the Clinical Dementia Rating scale. Safety was evaluated by mortality, total adverse events(TAEs), serious adverse events(SAEs), nausea, vomiting. diarrhea, or cerebrovascular accidents(CVAs). Results: After screening 1717 citations, 12 randomized controlled trials were included. Donepezil and rivastigmine(mean difference(e) = –0.77, 95% confidence interval(CI): 0.25–1.32; MD = 1.05, 95% CI: 0.18–1.79) were significantly more effective than placebo in reducing Mini-Mental State Examination scores. Donepezil, galantamine, and memantine(MD = –1.30, 95% CI: –2.27 to –0.42; MD = –1.67, 95% CI: –3.36 to –0.06; MD = –2.27, 95% CI: –3.91 to –0.53) showed superior benefits on the Alzheimer's Disease Assessment Scale–cognitive scores compared with placebo. Memantine(MD = 2.71, 95% CI: 1.05–7.29) improved global status(Clinician's Interview-Based Impres

关键词： nerve regeneration vascular cognitive impairment vascular dementia pharmacotherapy cholinesterase inhibitors donepezil galantamine rivastigmine memantine systematic review Bayesian network meta-analysis neural regeneration

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A debris-flow impact pressure model combining material characteristics and flow dynamic parameters

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Journal of Mountain Science 2018年第12期15卷 2721-2729页

作者： TANG jin-bo HU Kai-heng Key Laboratory of Mountain Hazards and Surface Process Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China

Impact force is a crucial factor to be considered in debris-resisting structure design. The impact of debris flow against a structural barrier depends not only on the flow dynamics but also on the barrier material. Based on the structural vibration equation and energy conservation law, a simple model for calculating debris-flow impact pressure is proposed, which includes the mechanical impedance of the material, debris-flow velocity and Froude number. Twenty-five impact tests have been conducted using different kinds of materials: steel, black granite, white granite, marble and polyvinyl chloride(PVC) board, and the ratio of the maximum impact time to the vibration period of the structure is determined for the model. It is found that the ratio's square root shows a linear relationship with the material solid Froude number. This indicates that the impedance of the structures plays an important role in the flow-barrier interaction. Moreover, the debrisflow impact force is found to decrease with the travel time of the elastic stress wave though the structures.

关键词： Debris flows Impact pressure Dynamical responses Mechanical impedance

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Photo-assisted Cl doping of SnO_(2) electron transport layer for hysteresis-less perovskite solar cells with enhanced efficiency

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Rare Metals 2022年第2期41卷 361-367页

作者： jin-bo Wu Chao Zhen Gang Liu Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Developing efficient electron transport layers(ETLs)along with proper interface engineering is crucial to achieve high-performance perovskite solar cells(PSCs).Herein,a photo-assisted doping strategy was developed to modify SnO_(2)ETLs with Cl^(-)for efficient *** Cl^(-)modified SnO2(Cl^(-)SnO_(2))with passivated surface defects as ETL material favors the formation of high phase-purity perovskite films and promotes the electron collection across the SnO_(2)/perovskite ***,the efficiency of PSC is improved from 16.35%without Cl modification to 18.94%with the Cl modification,with little hysteresis and high stability.

关键词： stability perovskite transport

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Investigating the bacterial community and amoebae population in rural domestic wastewater reclamation for irrigation

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Journal of Environmental Sciences 2018年第8期30卷 97-105页

作者： Bingjian Cui jinxue Luo Decai jin bo jin Xuliang Zhuang Zhihui Bai Research Center for Eco-Environmental Sciences Chinese Academy of Sciences School of Chemical Engineering The University of Adelaide College of Resources and Environment University of Chinese Academy of Sciences

Reclamation of domestic wastewater for agricultural irrigation is viewed as a sustainable option to create an alternative water source and address water scarcity. Free-living amoebae（FLA）, which are amphizoic protozoa, are widely distributed in various environmental sources. The FLA could cause considerable environmental and health risks. However, little information is available on the risk of these protozoa. In this study, we evaluated the feasibility using rural domestic wastewater for agricultural irrigation, and analyzed dynamic changes of the microbial community structure and FLA populations in raw and treated wastewater, as well as the phyllosphere and rhizosphere of lettuce production sites that were irrigated with different water sources. The bacterial community dynamics were analyzed by terminal restriction fragment length polymorphism（T-RFLP）. The bacterial community structures in the influent were similar to that in the effluent, while in some cases relative abundances varied significantly. The populations of Acanthamoeba spp. and Hartmannella vermiformis in the anaerobically treated wastewater were significantly higher than in the raw wastewater. The vegetables could harbor diverse amoebae, and the abundances of Acanthamoeba spp. and H. vermiformis in the rhizosphere were significantly higher than in the phyllosphere. Accordingly, our studies show insight into the distribution and dissemination of amoebae in wastewater treatment and irrigation practices.

关键词： Rural domestic wastewater Amoebae Bacterial community Phyllosphere Rhizosphere

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Hierarchical Ti_(3)C_(2)T_(x)@ ZnO Hollow Spheres with Excellent Microwave Absorption Inspired by the Visual Phenomenon of Eyeless Urchins

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Nano-Micro Letters 2022年第5期14卷 62-76页

作者： Yan‑Qin Wang Hai‑bo Zhao jin‑bo Cheng bo‑Wen Liu Qiang Fu Yu‑Zhong Wang Collaborative Innovation Center for Eco‑Friendly and Fire‑Safety Polymeric Materials(MoE) State Key Laboratory of Polymer Materials EngineeringNational Engineering Laboratory for Eco‑Friendly Polymer Materials(Sichuan)College of ChemistrySichuan UniversityChengdu 610064People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Ingenious microstructure design and rational composition selection are effective approaches to realize high-performance microwave absorbers,and the advancement of biomimetic manufacturing provides a new *** nature,urchins are the animals without eyes but can“see”,because their special structure composed of regular spines and spherical photosensitive bodies“amplifies”the light-receiving ***,inspired by the above phenomenon,the biomimetic urchin-like Ti_(3)C_(2)T_(x)@ZnO hollow microspheres are rationally designed and fabricated,in which ZnO nanoarrays(length:~2.3μm,diameter:~100 nm)as the urchin spines are evenly grafted onto the surface of the Ti_(3)C_(2)T_(x) hollow spheres(diameter:~4.2μm)as the urchin spherical photosensitive *** construction of gradient impedance and hierarchical heterostructures enhance the attenuation of incident electromagnetic *** the EMW loss behavior is further revealed by limited integral simulation calculations,which fully highlights the advantages of the urchin-like *** a result,the Ti_(3)C_(2)T_(x)@ZnO hollow spheres deliver a strong reflection loss of−57.4 dB and broad effective absorption bandwidth of 6.56 GHz,superior to similar *** work provides a new biomimetic strategy for the design and manufacturing of advanced microwave absorbers.

关键词： Bioinspired Hierarchical heterostructures Ti_(3)C_(2)T_(x)MXene ZnO nanoarrays Microwave absorption

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A highly efficient La-modified ZnAl-LDO catalyst and its performance in the synthesis of dimethyl carbonate from methyl carbamate and methanol

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Chinese Journal of Chemical Engineering 2023年第9期61卷 9-23页

作者： Mingxue Yin bo Jia Kuiyi You bo jin Yangqiang Huang Xiao Luo Zhiwu Liang College of Chemistry and Chemical Engineering the Engineering Research Center of Advanced CatalysisMinistry of EducationHunan UniversityChangsha 410082China College of Chemical Engineering Xiangtan UniversityXiangtan 411105China

In this paper,the highly efficient ZnAlLa layered double oxide(ZnAlLa-LDO)catalyst was evaluated and used in methyl carbamate(MC)alcoholysis synthesis of dimethyl *** optimal conditions,the MC conversion was 33.5% and the dimethyl carbonate(DMC)selectivity was up to 92,4% at 443 K and in 9 *** prepared catalysts were well characterized to investigate the effect on the catalytic performance and reaction catalysis *** experimental results show that the addition of La adjusted the structure and chemical properties of ZnAl composite oxide and that the synergistic effect among Zn,Al and La play a key role in adjusting the acid-base properties and stability of the catalyst,which definitely improved the DMC selectivity and catalytic *** on the proposed reaction mechanism,two kinetic models of the catalytic reaction were established and modified:LangmuirHinshelwood and power-rate law kinetic *** good agreement between kinetic models and experimental data showed that the power-rate law kinetic model based on the elementary reactions is a suitable model for providing a theoretical *** pre-exponential factor and activation energy of the main reaction are 5.77×10^(7)and 77.60 kJ·mol^(-1),respectively.

关键词： Methanol Urea alcoholysis Dimethyl carbonate Kinetic model

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Bimetal nanoparticles hybridized with carbon nanotube boosting bifunctional oxygen electrocatalytic performance

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Rare Metals 2022年第8期41卷 2616-2623页

作者： Chen Sun Yong-Jie Zhao Xuan-Yi Yuan jing-bo Li Hai-bo jin Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Beijing Key Laboratory of Opto-Electronic Functional Materials&Micro-Nano Devices Department of PhysicsRenmin University of ChinaBeijing100872China

Developing bifunctional oxygen catalysts with high efficiency and low cost to replace platinum-group metal catalysts commonly utilized in metal-air batteries is critically *** this article,a convenient method to synthesis NiFe nanoparticles hybridized with N-doped carbon nanotube(NiFe@N-CNTs)is *** performance analysis indicates that Ni_(x)Fc_(1-x)@N-CNTs offers favorable oxygen reduction reaction(ORR)kinetics(onset potential(E_(onset))is 0.87 V and half-wave potential(E_(1/2))is0.84 V),together with excellent oxygen evolution reaction(OER)performance(an overpotential of 270 mV to drive10 mA·cm^(-2)).Contributed by the synergetic effect between NiFe alloy and N-CNTs,when being utilized as air cathode,rechargeable Zn-air batteries present superior cycling stability for over 150 *** research provides a universal strategy to synthesize the hybrids of intertwined carbon nanotube matrix loaded with alloy nanoparticles.

关键词： NiFe alloy Oxygen evolution reaction(OER) Oxygen reduction reaction(ORR) Zn-air batteries

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Current understanding on the roles of gut microbiota in fish disease and immunity

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Zoological Research 2019年第2期40卷 70-76页

作者： jin-bo Xiong Li Nie Jiong Chen Laboratory of Biochemistry and Molecular Biology School of Marine Sciences Ningbo University Key Laboratory of Applied Marine Biotechnology of Ministry of Education Ningbo University

Intensive aquaculture has increased the severity and frequency of fish *** the functional importance of gut microbiota in various facets of host physiology,modulation of this microbiota is a feasible strategy to mitigate emerging diseases in *** achieve this,a fundamental understanding of the interplay among fish health,microbiota, and invading pathogens is *** commentary focuses on current knowledge regarding the associations between fish diseases,dysbiosis of gut microbiota,and immune responses. Furthermore,updated research on fish disease from an ecological perspective is discussed,including colonization resistance imposed by commensals and strategies used by pathogens to overcome *** also propose several directions for future research,such as exploration of the causal links between fish diseases and specific taxa,and identification of universal gut microbial biomarkers for rapid disease diagnosis.

关键词： microbiota fish disease immunity

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Updated roles of the gut microbiota in exploring shrimp etiology, polymicrobial pathogens, and disease incidence

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Zoological Research 2024年第4期45卷 910-923页

作者： jin-bo Xiong Hao-Nan Sha Jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Key Laboratory of Aquacultural Biotechnology Ministry of EducationSchool of Marine SciencesNingbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingboZhejiang 315211China

Litopenaeus vannamei is the most extensively cultured shrimp species globally,recognized for its scale,production,and economic ***,its aquaculture is plagued by frequent disease outbreaks,resulting in rapid and massive *** research often lags behind the emergence of new diseases,leaving the causal agents of some shrimp diseases unidentified and leading to nomenclature based on symptomatic presentations,especially in cases involving co-and polymicrobial *** data on shrimp disease statuses remain *** this review,we summarize current knowledge on shrimp diseases and their effects on the gut ***,we also propose a workflow integrating primary colonizers,“driver”taxa in gut networks from healthy to diseased states,disease-discriminatory taxa,and virulence genes to identify potential polymicrobial *** examine both abiotic and biotic factors(e.g.,external and internal sources and specific-disease effects)that influence shrimp gut microbiota,with an emphasis on the“holobiome”concept and common features of gut microbiota response to diverse *** excluding the effects of confounding factors,we provide a diagnosis model for quantitatively predicting shrimp disease incidence using disease common-discriminatory taxa,irrespective of the causal *** to the conservation of functional genes used in designing specific primers,we propose a practical strategy applying qPCR-assayed abundances of disease common-discriminatory functional *** review updates the roles of the gut microbiota in exploring shrimp etiology,polymicrobial pathogens,and disease incidence,offering a refined perspective for advancing shrimp aquaculture health management.

关键词： Shrimp disease Gut microbiota Polymicrobial pathogens Diagnosis model Disease common-discriminatory taxa Disease prediction

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Characterisation of dissolved organic matter in stormwater using high-performance size exclusion chromatography

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Journal of Environmental Sciences 2016年第4期28卷 236-245页

作者： Huiping Huang Christopher W.K.Chow bo jin School of Chemical Engineering The University of Adelaide School of Earth and Environmental Sciences The University of Adelaide Australian Water Quality Centre SA Water Corporation

Understanding the complexity of dissolved organic matter（DOM）in stormwater has drawn a lot of interest,since DOM from stormwater causes not only environmental impacts,but also worsens downstream aquatic quality associated with water supply and *** study introduced and employed high-performance size exclusion chromatography（HPSEC）coupled with an ultraviolet–visible（UV–vis）diode array detector to assess changes in stormwater-associated DOM *** DOM was also analysed in relation to storm event characteristics,water quality and spectroscopic *** tools were used to determine the correlations within DOM and water quality *** showed that dissolved organic carbon（DOC）and UV absorbance at 254 nm（UV（254））as conventional DOM parameters were found to be correlated well to the changes in stormwater quality during each of the three storm events *** detector wavelengths（210and 254 nm）and their ratio（A（210）/A（254））were found to provide additional information on the physiochemical properties of stormwater-associated *** study indicated that A（210）/A（254） is an important parameter which could be used to estimate the DOM proportions of functional groups and conjugated carbon *** study provided also an understanding of stormwater quality constituents through assessing variability and sensitivity for various parameters,and the additional information of rainfall characteristics on runoff quality data for a better understanding of parameter correlations and influences.

关键词： Stormwater Dissolved organic matter HPSEC

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