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工业安全与环保 2024年第4期50卷 64-67页

作者：包其富张超艳牟杰贾波崔鹏程浙江省应急管理科学研究院浙江杭州310012 岱山县应急管理局浙江舟山316200

主要基于目前岱山县安全生产和应急管理监管履责现状,探讨利用数字化技术和手段对监管履责过程的各类要素和流程进行重塑,构建既考核结果又考核过程的机制,形成责任落实到位、过程细节清楚和总体评价科学的履责考核机制。

关键词：监管能力履职履责数字化技术过程重塑

Genetic Analysis of the Resistance to Aspergillus flavus Infection in Maize (Zea mays L.)

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Agricultural Sciences in China 2009年第6期8卷 761-765页

作者： DENG De-xiang jiaNG Si-xia WANG Yi-jun BIAN Yun-long CHEN jian-jian jia bo jiangsu Province Key Laboratory of Crop Genetics and Physiology~Key Laboratory of Plant Functional Genomics Ministry of Education Yangzhou University Yangzhou 225009 P.R. China Yangzhou Environment and Resources Technical College Yangzhou 225009 P.R. China

Maize （Zea mays L.）, one of main crops in the world, is easily susceptible to Aspergillusflavus （Link： fr） infection, resulting huge loses worldwide. Breeding for A. flavus resistance has been proved an efficient way to solve the problem of aflatoxin contamination. Genetic analysis of the sources of resistance to *** in maize is necessary for this purpose. The complete diallel crosses of 6 inbred lines with different resistance to *** infection were implemented. Inoculation categorical data of each cross were analyzed with the additive-dominant and additive-dominant-epitasis genetic models. Results indicated some crosses fitted the 2 major genes with additive-dominant-epitasis genetic model. Others fitted the major gene and polygene mixed model. Moreover, the additive, dominant, and epitasis effects varied in crosses. The *** resistance was controlled by both major gene and polygene.

关键词： maize Aspergillus flavus resistance genetic model

Phosphatidic Acid （PA） PP2A Activity and PIN1 Binds PP2AA1 to Regulate Polar Localization

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Molecular Plant 2013年第5期6卷 1692-1702页

作者： Hong-bo Gao Yu-jia Chu Hong-Wei Xue National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chineseacademy of Sciences 200032 Shanghai People's Republic of China

Phospholipase D （PLD） exerts broad biological functions in eukaryotes through regulating downstream effectors by its product, phosphatidic acid （PA）. Protein kinases and phosphatases, such as mammalian target of rapa- mycin （mTOR）, Protein Phosphatase 1 （PP1） and Protein Phosphatase 2C （PP2C）, are PA-binding proteins that execute crucial regulatory functions in both animals and plants. PA participates in many signaling pathways by modulating the enzymatic activity and/or subcellular localization of bound proteins. In this study, we demonstrated that PLD-derived PA interacts with the scaffolding A1 subunit of Protein Phosphatase 2A （PP2A） and regulates PP2A-mediated PIN1 dephos- phorylation in Arabidopsis. Genetic and pharmacological studies showed that both PA and PP2A participate in the regu- lation of auxin distribution. In addition, both the phosphorylation status and polar localization of PIN1 protein were affected by PLD inhibitors, Exogenous PA triggered the membrane accumulation of PP2AA1 and enhanced the PP2A activity at membrane, while PLD inhibition resulted in the reduced endosomal localization and perinuclear aggregation of PP2AA1. These results demonstrate the important role of PLD-derived PA in normal PP2A-mediated PIN dephosphoryl- ation and reveal a novel mechanism, in which PA recruits PP2AA1 to the membrane system and regulates PP2A function on membrane-targeted proteins. As PA and PP2A are conserved among eukaryotes, other organisms might use similar mechanisms to mediate multiple biological processes.

关键词： phosphatidic acid (PA) PP2A PIN1 phosphorylation polar localization.

New strategies for asymmetric photocatalysis: asymmetric organocatalytic/photoredox relay catalysis for efficient synthesis of polycyclic compounds containing vicinal amino alcohols

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Science China Chemistry 2024年第3期67卷 945-952页

作者： jia-Lu Zhang Wen-bo He Xiu-Qin Hu Peng-Fei Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China State Key Laboratory of Veterinary Etiological Biology College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China MOE Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China

An asymmetric catalytic strategy in photocatalysis utilizing a chirality-induced approach through an organocatalytic/photoredox relay catalysis strategy is successfully achieved for the rapid construction of polycyclic compounds containing vicinal amino alcohols in a one-pot protocol. This methodology facilitates the efficient synthesis of diverse substituted polycyclic tetrahydroquinoline and benzofuran-derived vicinal amino alcohols, each containing five consecutive chiral centers, with high yields,excellent diastereoselectivities and enantioselectivities(up to 95% yield, >20:1 dr and 98% ee), under mild reaction conditions driven by sequential bifunctional squaramide organocatalyst-catalyzed [4+2] annulation and photocatalyst-catalyzed ketyl radical addition cyclization reaction process. Furthermore, investigations into the stereoselectivity mechanism and high-resolution mass spectrometry(HRMS) experiments on free radical trapping have provided evidence for elucidating the detailed mechanism of chirality-induced processes and chiral intermediate conversions in this procedure.

关键词： enantioselective photocatalysis asymmetric organocatalytic/photocatalysis relay catalysis five consecutive chiral centers chirality-induced strategy chirality vicinal amino alcohols

Single-cell RNA sequencing to understand host-virus interactions

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Virologica Sinica 2024年第1期39卷 1-8页

作者： jia-Tong Chang Li-bo Liu Pei-Gang Wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Single-cell RNA sequencing(scRNA-seq)has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell *** review summarizes the existing scRNA-seq technologies together with their strengths and *** applications of scRNA-seq in various virological studies are discussed in depth,which broaden the understanding of the immune atlas,host-virus interactions,and immune ***-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

关键词： Single-cell RNA sequencing(scRNA-seq) Host-virus interaction COVID-19 Flavivirus

High-precision,gelatin-based,hybrid,bilayer scaffolds using melt electro-writing to repair cartilage injury

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Bioactive Materials 2021年第7期6卷 2173-2186页

作者： Yu Han bo jia Meifei Lian Binbin Sun Qiang Wu Benlin Sun Zhiguang Qiao Kerong Dai Department of Orthopedic Surgery Shanghai Key Laboratory of Orthopedic ImplantsShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of Prosthodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011China Department of Orthopedic Surgery Renji HospitalSouth CampusShanghai Jiao Tong University School of MedicineShanghai201112China

Articular cartilage injury is a common disease in the field of *** cartilage has poor self-repairing ability,medical intervention is *** melt electro-writing(MEW)technology,tissue engineering scaffolds with high porosity and high precision can be ***,ordinary materials,especially natural polymer materials,are difficult to *** this study,gelatin was mixed with poly(lactic-co-glycolic acid)to prepare high-concentration and high-viscosity printer ink,which had good printability and formability.A composite scaffold with full-layer TGF-β1 loading mixed with hydroxyapatite was prepared,and the scaffold was implanted at the cartilage injury site;microfracture surgery was conducted to induce the mesenchyme in the bone *** stem cells thereby promoted the repair of damaged *** summary,this study developed a novel printing method,explored the molding conditions based on MEW printing ink,and constructed a bioactive cartilage repair *** scaffold can use autologous bone marrow mesenchymal stem cells and induce their differentiation to promote cartilage repair.

关键词： Gelatin-based hybrid bilayer scaffolds Melt electro-writing Cartilage injury bone marrow mesenchymal stem cells

Special Unipotent Representations of Simple Linear Lie Groups of Type A

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Acta Mathematica Sinica,English Series 2024年第3期40卷 707-716页

作者： Dan BARBASCH jia Jun MA Bin Yong SUN Chen bo ZHU Department of Mathematics Cornell UniversityIthacaNY 14853USA School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China Department of Mathematics Xiamen University Malaysia CampusSepangSelangor Darul Ehsan43900Malaysia Institute for Advanced Study in Mathematics&New Cornerstone Science Laboratory Zhejiang UniversityHangzhou 310058P.R.China Department of Mathematics National University of Singapore10 Lower Kent Ridge RoadSingapore 119076

Let G be a special linear group over the real,the complex or the quaternion,or a special unitary *** this note,we determine all special unipotent representations of G in the sense of Arthur and Barbasch-Vogan,and show... 详细信息

关键词： Special unipotent representations unitary representations coherent continuation Weyl group representations

Compressed sensing-based structured joint channel estimation in a multi-user massive MIMO system

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Frontiers of Information Technology & Electronic Engineering 2017年第12期18卷 2082-2100页

作者： Ruo-yu ZHANG Hong-lin ZHAO Shao-bo jia Communication Research Center Harbin Institute of Technology Harbin 150080 China

Acquisition of accurate channel state information （CSI） at transmitters results in a huge pilot overhead in massive multiple input multiple output （MIMO） systems due to the large number of antennas in the base station （BS）. To reduce the overwhelming pilot overhead in such systems, a structured joint channel estimation scheme employing compressed sensing （CS） theory is proposed. Specifically, the channel sparsity in the angular domain due to the practical scattering environment is analyzed, where common sparsity and individual sparsity structures among geographically neighboring users exist in multi-user massive MIMO systems. Then, by equipping each user with multiple antennas, the pilot overhead can be alleviated in the framework of CS and the channel estimation quality can be improved. Moreover, a structured joint matching pursuit （SJMP） algorithm at the BS is proposed to jointly estimate the channel of users with reduced pilot overhead. Furthermore, the probability upper bound of common support recovery and the upper bound of channel estimation quality using the proposed SJMP algorithm are derived. Simulation results demonstrate that the proposed SJMP algorithm can achieve a higher system performance than those of existing algorithms in terms of pilot overhead and achievable rate.

关键词： Compressed sensing Multi-user massive multiple input multiple output (MIMO) Frequency-division duplexing Structured joint channel estimation Pilot overhead reduction

Genotypic Difference in the Responses of Seedling Growth and Cd Toxicity in Rice(Oryza sativa L.)

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Agricultural Sciences in China 2006年第1期5卷 68-76页

作者： WU Fei-bo DONG Jing jia Guo-xia ZHENG Shan-jiu ZHANG Guo-ping Department of Agronomy Huajiachi Campus Zhejiang University Hangzhou 310029 P.R.China

The experiment was carried out to study the genotypic difference in the responses of seed germination, growth and physiological characters of rice seedlings to Cd toxicity. The result showed that the germination was slightly stimulated under low Cd concentration （0.01-1.5 mM Cd）, while severely depressed under higher Cd concentration （2.0 mM）. Rice seedlings exposed to 0.01 mM Cd showed slight increases in plant height, root volume, biomass and chlorophyll concentration. These parameters were significantly reduced when Cd level in the medium was increased to 0.5 mM, and meanwhile corresponding increase in superoxide dismutase （SOD） and peroxidase （POD） activities, and MDA （malondialdehyde） content was observed. However, SOD and POD activities declined when plants were exposed to 1 mM Cd when compared with those under 0.5 mM Cd. Cadmium addition lowered Fe, Cu and Mn concentrations in roots and shoots. There was significant genotypic difference in the response of these parameters to Cd stress. Under Cd stress, Xiushui 110 had the least inhibition of growth and increase in MDA content, higher shoot Cd concentration, and greatest increase in POD and SOD activities, indicating its higher tolerance to Cd toxicity, while Bing 9914 had the greatest reduction of growth, and Zn, Cu, Fe, and Mn contents, but greatest increase in MDA content, and least increase in activities of antioxidative enzymes, indicating its sensitivity to Cd toxicity.

关键词： anti-oxidative enzyme cadmium chlorophyll germination nutrition rice (Oryza sativa L.)

Fossil fruits of Firmiana and Tilia from the middle Miocene of South Korea and the efficacy of the Bering land bridge for the migration of mesothermal plants

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Plant Diversity 2021年第6期43卷 480-491页

作者： Lin-bo jia Gi-Soo Nam Tao Su Gregory W.Stull Shu-Feng Li Yong-jiang Huang Zhe-Kun Zhou CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650204China Gongju National University of Education 27Ungjin-roGongju-siChungcheongnam-do 32553South Korea CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China University of the Chinese Academy of Sciences Beijing 100049China Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Department of botany Smithsonian InstitutionWashingtonDC 20013USA

Determining whether the high-latitude Bering land bridge(BLB)was ecologically suitable for the migration of mesothermal plants is significant for Holarctic phytogeographic *** studies provide a critical source of data on the latitudinal positions of different plant lineages at different times,permitting assessment of the efficacy of the BLB for *** we report exceptionally preserved fossils of Firmiana and Tilia endochrysea from the middle Miocene of South *** represents a new reliable record of Firmiana and the first discovery of the *** lineage in the fossil record of *** occurrence of these fossils in South Korea indicates that the two lineages had a distribution that extended much farther north during the middle Miocene,but they were still geographically remote from the *** light of the broader fossil record of Asia,our study shows that,in the middle Miocene,some mesothermal plants apparently inhabited the territory adjacent to the BLB and thus they were possibly capable of utilizing the BLB as a migratory *** other mesothermal plants,such as Firmiana and the *** lineages,however,are restricted to more southern regions relative to the BLB based on current fossil *** lineages may have been ecologically unable to traverse the BLB,which raises questions about the efficacy of the BLB as a universal exchange route for mesothermal plants between Asia and North America during the middle Miocene.

关键词： Asia Bering land bridge Biogeography Middle Miocene Malvaceae