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Study on the preservation effects of the amputated forelimb by machine perfusion at physiological temperature

Chinese Journal of Traumatology 2024年第2期27卷 114-120页

作者： Sheng-Feng Chen bo-Yao Yang Tie-Yuan Zhang Xiang-Yu Song Zhi-bo jia Lei-jia Chen Meng-Yi Cui Wen-Jing Xu jiang Peng Guizhou Medical University Guiyang550025China Medical School of PLA Beijing100048 China Beijing Key Lab of Regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLADepartment of OrthopedicsThe Fourth Medical CenterChinese PLA General HospitalBeijing100048China Hebei North Universiy Zhangjiakou075000Hebei ProvinceChina

Purpose:Ischemia and hypoxia are the main factors limiting limb replantation and *** cold storage(SCS),a common preservation method for tissues and organs,can only prolong limb ischemia time to 4-6 *** normothermic machine perfusion(NMP)is a promising method for the preservation of tissues and organs,which can extend the preservation time in vitro by providing continuous oxygen and *** study aimed to evaluate the difference in the efficacy of the 2 limb preservation ***:The 6 forelimbs from beagle dogs were divided into 2 *** the SCS group(n=3),the limbs were preserved in a sterile refrigerator at 4°C for 24 h,and in the NMP group(n=3),the perfusate prepared with autologous blood was used for the oxygenated machine perfusion at physiological temperature for 24 h,and the solution was changed every 6 *** effects of limb storage were evaluated by weight gain,perfusate biochemical analysis,enzyme-linked immunosorbent assay,and histological *** statistical analyses and graphs were performed using GraphPad Prism 9.0 one-way or two-way analysis of *** p value of less than 0.05 was considered to indicate statistical ***:In the NMP group,the weight gained percentage was 11.72%±4.06%;the hypoxia-inducible factor-1αcontents showed no significant changes;the shape of muscle fibers was normal;the gap between muscle fibers slightly increased,showing the intercellular distance of(30.19±2.83)μm;and the vascularα-smooth muscle actin(α-SMA)contents were lower than those in the normal blood *** creatine kinase level in the perfusate of the NMP group increased from the beginning of perfusion,decreased after each perfusate change,and remained stable at the end of perfusion showing a peak level of 4097.6 U/*** lactate dehydrogenase level of the NMP group increased near the end of perfusion and reached the peak level of 374.4 U/*** the SCS group,the percentage of weight gain was 0.18%±0.10%,a

关键词： Traumatic amputation Machine perfusion Static cold storage Limb replantation

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Higher palaeoelevation in the Baoshan Basin:Implications for landscape evolution at the southeastern margin of the Tibetan Plateau

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Journal of Palaeogeography 2024年第3期13卷 563-580页

作者： Yong-jiang Huang Hao-Ran Zong Shi-Tao Zhang Arata Momohara Jin-Jin Hu Lin-bo jia Yun-Heng Ji Zhe-Kun Zhou Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences College of Forestry Shandong Agricultural University Faculty of Land Resource Engineering Kunming University of Science and Technology Graduate School of Horticulture Chiba University Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences

Surface uplift at the southeastern margin of the Tibetan Plateau has been widely studied, but more palaeoaltimetry data are required to better understand the elevation history of this geologically complex region. In this study, fossil leaves of Abies(Pinaceae), a cool-temperate element, recovered from the latest Miocene-Pliocene Yangyi Formation of the southern Baoshan Basin, were used as a proxy to estimate the local palaeoelevation. Based on the regional modern altitude range(2100-4280 m) of the genus as well as regional temperature discrepancy(1.5°C) between the past and present, the palaeoelevation of the study area was calculated to be > 2360 m above sea level as compared to 1670 m at present. Our result suggests that the southern Baoshan Basin experienced pronounced uplift prior to the time of fossil deposition, probably as a result of crustal shortening and thickening of the northern Baoshan Terrane during the Eocene-Oligocene. We infer that surface growth in areas south of the Dali Basin may have been greater than previously interpreted,and that a widespread plateau or plateau patches higher than 2000 m probably extended southwards into at least the Baoshan Basin by the latest Miocene-Pliocene. We also infer that the elevation of the southern Baoshan Basin has decreased by at least 690 m since then, in contrast to most other scenarios in which the elevation of the southeastern margin of the Tibetan Plateau has increased or remained close to modern levels since the late Miocene. The major cause of the inferred altitude decline is likely tectonic deformation. As a transtensional graben basin, the Baoshan Basin has experienced pull-apart and base-fall movement since the late Miocene, which would reduce the altitude of its southern part located on the hanging wall. Surface erosion associated with the increased summer rainfall might also have played a role especially in reducing the local relief, although its contribution can be limited. Our study provides one of

关键词： Abies Lapse rate Palaeoaltimetry Surface uplift Tectonic movement Tibetan plateau

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Bibliometrics analysis based on the Web of Science:Current trends and perspective of gastric organoid during 2010-2023

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World Journal of Gastroenterology 2024年第8期30卷 969-983页

作者： Kai-Lin jiang Yue-bo jia Xue-jiao Liu Qing-Ling jia Li-Kun Guo Xiang-Xiang Wang Ke-Ming Yang Chen-Heng Wu Bei-Bei Liang jiang-Hong Ling Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200021China Laboratory of Cancer Biology University of OxfordOxford OX37DQUnited Kingdom School of Traditional Chinese Medicine Shanghai University of Chinese MedicineShanghai 200021China Shanghai Key Laboratory of Molecular Imaging Shanghai University of Medicine and Health SciencesShanghai 201318China

BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy *** use of gastric organoid models holds significant promise for advancing personalized medicine ***,a comprehensive bibliometric review of this burgeoning field has not yet been *** To analyze and understand the development,impact,and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection(WoSCC)*** This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023,as indexed in the *** and VOSviewer were used to depict network maps illustrating collaborations among authors,institutions and keywords related to gastric ***,co-citation,and burst analysis methodologies were applied to assess the impact and progress of *** A total of 656 relevant studies were *** majority of research was published in gastroenterology-focused ***,Yana Zavros,Hans Clevers,James M Wells,Sina Bartfeld,and Chen Zheng were the 5 most productive authors,while Hans Clevers,Huch Meritxell,Johan H van Es,Marc Van de Wetering,and Sato Toshiro were the foremost influential scientists in this *** from the University Medical Center Utrecht,Netherlands Institute for Developmental Biology(Utrecht),and University of Cincinnati(Cincinnati,OH,United States)made the most significant ***,gastric organoids are used mainly in studies investigating gastric cancer(GC),Helicobacter pylori-infective gastritis,with a focus on the mechanisms of GC,and drug screening *** Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening *** contributions from renowned academic institutions highlight this field’s dynamic growth.

关键词： Gastric organoid Gastric disease Bibliometrics analysis Gastric cancer Gastritis

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No Incidence of Liver Cancer Was Observed in A Retrospective Studyof Patients with Aristolochic Acid Nephropathy

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Chinese Journal of Integrative Medicine 2024年第2期30卷 99-106页

作者： SU Tao FANG Zhi-e GUO Yu-ming WANG Chun-yu WANG jia-bo JI Dong BAI Zhao-fang YANG Li XiAO Xiao-he Renal Division Department of MedicinePeking University First HospitalBeijing(100034)China Department of Pharmacy Chongqing Hospital of Traditional Chinese MedicineChongqing(400021)China Department of Hepatology Fifth Medical Center of Chinese PLA General HospitalBeijing(100039)China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing(100039)China Phase I Clinical Trials Unit Department of Medicine for Infectious DiseasesFifth Medical Center of Chinese PLA General HospitalBeijing(100039)China Department of Pharmacy Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan(250000)China National Key Laboratory of Kidney Diseases Beijing(100039)China

Objective:To assess the risk of aristolochic acid(AA)-associated cancer in patients with AA nephropathy(AAN).Methods:A retrospective study was conducted on patients diagnosed with AAN at Peking University First Hospital from January 1997 to December ***-term surveillance and follow-up data were analyzed to investigate the influence of different factors on the prevalence of *** primary endpoint was the incidence of liver cancer,and the secondary endpoint was the incidence of urinary cancer during 1 year after taking AA-containing medication to ***:A total of 337 patients diagnosed with AAN were included in this *** the initiation of taking AA to the termination of follow-up,39 patients were diagnosed with *** cases of liver cancer were observed throughout the entire follow-up period,with urinary cancer being the predominant type(34/39,87.17%).Logistic regression analysis showed that age,follow-up period,and diabetes were potential risk factors,however,the dosage of the drug was not significantly associated with urinary ***:No cases of liver cancer were observed at the end of ***,a high prevalence of urinary cancer was observed in AAN *** a direct causality between AA and HCC is challenging.

关键词： aristolochic acid hepatocellular carcinoma urinary cancer drug safety retrospective study

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Design of pH-responsive antimicrobial peptide melittin analog-camptothecin conjugates for tumor therapy

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 135-146页

作者： Sujie Huang Yuxuan Gao Ling Ma bo jia Wenhao Zhao Yufan Yao Wenyuan Li Tongyi Lin Rui Wang Jingjing Song Wei Zhang Institute of Pharmacology School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical SciencesLanzhou UniversityLanzhou 730000China State Key Laboratory of Veterinary Etiological Biology College of Veterinary MedicineLanzhou UniversityLanzhou 730000China Lanzhou University Second Hospital Lanzhou UniversityLanzhou 730000China

Melittin,a classical antimicrobial peptide,is a highly potent antitumor ***,its significant toxicity seriously hampers its application in tumor *** this study,we developed novel melittin analogs with pH-responsive,cell-penetrating and membranelytic activities by replacing arginine and lysine with *** conjugation with camptothecin(CPT),CPT-AAM-1 and CPT-AAM-2 were capable of killing tumor cells by releasing CPT at low concentrations and disrupting cell membranes at high concentrations under acidic ***,we found that the C-terminus of the melittin analogs was more suitable for drug conjugation than the ***-AAM-1 significantly suppressed melanoma growth in vivo with relatively low ***,the present study demonstrates that the development of antitumor drugs based on pH-responsive antimicrobial peptide-drug conjugates is a promising strategy.

关键词： Antimicrobial peptide Peptide-drug conjugate Cell-penetrating activity Membrane disruption Antitumor activity

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Dietary cooking oils and cardiometabolic measurements in an elderly Chinese population

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Journal of Geriatric Cardiology 2024年第6期21卷 642-650页

作者： Xin-Yu WANG Chao-Ying MIAO Xiao-Fei YE Wen-Yuan-Yue WANG jia-bo ZHU Yi ZHOU Yan LI Ji-Guang WANG School of Public Health Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Cardiovascular Medicine Centre for Epidemiological Studies and Clinical TrialsThe Shanghai Institute of HypertensionRuijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

OBJECTIVE To investigate three features of dietary cooking oil intake,namely,the consumption,cooking style,and composition of fatty acids in relation to several cardiometabolic measurements in an elderly Chinese *** The elderly(≥65 years)participants for this study were recruited from two community health centers in the urban area of Shanghai.A questionnaire was administered to collect information on dietary oil consumption(low,medium and high)and cooking styles(fry or stir-fry ***)and the composition of fatty acids(poly-unsaturated ***-unsaturated).The cardiometabolic measurements included anthropometry,blood pressure,fasting plasma glucose and serum *** The 1186 study participants had a mean age of 70.9±5.4 *** mean dietary oil consumption was 35.0 g/d,being low(bove and additional adjustment for dietary oil consumption,the fry or stir-fry cooking style was significantly(P≤0.048)and positively associated with body mass index,but inversely with systolic and diastolic blood pressure and serum low-density lipoprotein cholesterol,and the dietary intake of oils rich in mono-unsaturated fat acids was significantly(P≤0.02)and positively associated with diastolic blood pressure,serum triglycerides,total cholesterol and low-density lipoprotein cholesterol,and the prevalence of hypertriglyceridemia and *** This study showed that both the consumption and composition of fatty acids of the dietary oils mattered with regard to sev

关键词： cooking elderly unsaturated

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Catalytic Asymmetric Diastereodivergent Synthesis of 2-Alkenylindoles Bearing both Axial and Central Chirality

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Precision Chemistry 2024年第5期2卷 208-220页

作者： Shuang Yang jia-bo Huang Da-Hua Wang Ning-Yi Wang Yu-Yu Chen Xin-Yan Ke Hao Chen Shao-Fei Ni Yu-Chen Zhang Feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials ScienceJiangsu Normal UniversityXuzhou 221116China Department of Chemistry Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China Department of Otolaryngology Xuzhou First People’s HospitalAffiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221002China School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China

The catalytic asymmetric diastereodivergent synthesis of axially chiral 2-alkenylindoles was established via chiral phosphoric acid-catalyzed addition reactions of C3-unsubstituted 2-alkenylindoles with o-hydroxybenzyl alcohols under different reaction *** this strategy,two series of 2-alkenylindoles bearing both axial and central chirality were synthesized in a diastereodivergent fashion with moderate to high yields and good stereoselectivities(up to 99%yield,95:5 er,>95:5 dr).Moreover,theoretical calculations were performed on the key transition states leading to different stereoisomers,which provided an in-depth understanding of the origin of the observed stereoselectivity and diastereodivergence of the products under different reaction *** importantly,these 2-alkenylindoles were utilized in asymmetric catalysis as chiral organocatalysts and in medicinal chemistry for evaluation of their cytotoxicity,which demonstrated their potential *** study has not only established the catalytic atroposelective synthesis of axially chiral 2-alkenylindoles,but also provided an efficient strategy for catalytic asymmetric diastereodivergent construction of indole-based scaffolds bearing both axial and central chirality.

关键词： 2-Alkenylindole Axial chirality Central chirality Diastereodivergent synthesis Chiral phosphoric acid

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基于高分一号卫星影像的水体信息提取方法初探

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经纬天地 2024年第3期 6-10页

作者：贾波山西省测绘地理信息院山西太原030001

本文以山西汾河水库为研究区域,利用高分一号卫星影像,分别选择阈值分割法、归一化差异水体指数法和面向对象法对研究区水体信息进行提取,并对3种方法提取结果进行精度检查。通过试验得出如下结论:阈值分割法对水体先验知识要求低,简单... 详细信息

本文以山西汾河水库为研究区域,利用高分一号卫星影像,分别选择阈值分割法、归一化差异水体指数法和面向对象法对研究区水体信息进行提取,并对3种方法提取结果进行精度检查。通过试验得出如下结论:阈值分割法对水体先验知识要求低,简单易用;归一化差异水体指数法由于未能消除阴影与水体的混淆问题,使得提取水体信息精度较低;面向对象法提取水体信息结果精度较高,但易丢失人工水塘与沟渠信息。该研究结果对利用高分一号卫星影像进行其他土地利用信息的提取具有一定借鉴意义。

关键词：水资源信息提取高分一号卫星阈值分割法归一化差异水体指数法面向对象法

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圆柱空腔橡胶层局域共振声子晶体双层板减振特性分析

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噪声与振动控制 2024年第1期44卷 15-21,28页

作者：宋春生杨琪贾博杜刚武汉理工大学机电工程学院武汉430070 湖北省磁悬浮工程技术研究中心武汉430070

针对机械设备中的低频减振问题,提出一种圆柱空腔橡胶层局域共振声子晶体双层板结构,即在双层板间周期性排列具有圆柱空腔的橡胶层和实心散射体振子。首先结合弹性波理论和BLOCH定理,采用有限元方法计算带隙范围并分析弯曲波带隙形成的... 详细信息

针对机械设备中的低频减振问题,提出一种圆柱空腔橡胶层局域共振声子晶体双层板结构,即在双层板间周期性排列具有圆柱空腔的橡胶层和实心散射体振子。首先结合弹性波理论和BLOCH定理,采用有限元方法计算带隙范围并分析弯曲波带隙形成的原理,其次通过单变量和组合变量的方式分析单元参数对带隙的影响规律并依此对单元参数进行调整,使其弯曲波带隙范围为48.52~206.21 Hz,最后通过振动传输特性仿真验证其对弯曲波振动的减振效果。研究表明,圆柱空腔橡胶层双层板式声子晶体可以产生200 Hz以下的弯曲波带隙,且可以通过调整单元参数来使其匹配目标减振频段。声子晶体板的振动传输特性分析和振动位移图验证了其对带隙范围内弯曲波传输的抑制作用,可为基于声子晶体减振的工程应用提供一定的参考。

关键词：振动与波声子晶体局域共振带隙特性圆柱空腔

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后续养护方式缓解蒸汽养护混凝土性能缺陷的试验研究

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水电能源科学 2024年第8期42卷 79-82页

作者：贾彦丽杨德志贾博文河南交通职业技术学院河南郑州450006 郑州大学土木工程学院河南郑州450001

为研究后续养护缓解蒸汽养护造成的永久损伤,以蒸汽养护混凝土为例,设计了4种后续养护方式,测试不同后续养护方法对混凝土抗压强度、吸附系数、氯离子扩散系数和透气性等性能参数的影响。结果表明,后续养护方式对混凝土试件28 d强度增... 详细信息

为研究后续养护缓解蒸汽养护造成的永久损伤,以蒸汽养护混凝土为例,设计了4种后续养护方式,测试不同后续养护方法对混凝土抗压强度、吸附系数、氯离子扩散系数和透气性等性能参数的影响。结果表明,后续养护方式对混凝土试件28 d强度增长贡献率由大到小为标准养护、饱和石灰水养护、水养护和空气养护;混凝土毛细吸附性、氯离子扩散性和透气性曲线均呈近似“L”形,即随养护时间增加而降低,且前期(龄期3 d前)下降显著,后期趋于平缓;蒸汽养护混凝土预制构件均应及时进行适当加湿养护,但不建议长时间浸泡于水环境中养护。

关键词：混凝土蒸汽养护毛细吸水率氯离子扩散抗压强度耐久性

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