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3种光剂量δ-氨基-γ-酮戊酸光动力疗法治疗光线性角化病的疗效:一项随机、观察者盲法、患者自评的比较研究

世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 10-11页

作者： Radakovic-Fijan S. blecha-thalhammeru. Kittler H. A. Tanew 冯义国 Division of Special and EnvironmentalDermatology Department of DermatologyMedical University of ViennaWaehringer Guertel 18- 20 A- 1090Vienna AustriaDr.

Background: Topical 5- aminolevulinic acid- based photodynamic therapy (ALA- PDT) has been established in recent years as an effective treatment for disseminated actinic keratosis (AK). As yet, however, data are lacking to define the optimal light dose for activation of ALA- induced protoporphyrin IX in AK. Objective: In the present study our purpose was to compare the efficacy and tolerability of 3 different doses of red light for ALA- PDT of AK. Methods: Twenty- seven patients with at least 3 clearly definable, mild or moderate AKs on the scalp or face entered the study. After occlusion for 4 hours with 20% ALA, one AK each was irradiated at random with a single dose of 70, 100, or 140 J/cm2. PDT- induced pain was assessed by the patients by means of a visual analog scale that graded pain intensity between 0 and 10. Follow- up examinations were performed 1 and 3 months after PDT. Results: One month after PDT, the rate of complete remission (CR)was 89% for 70 J/cm2, 92% for 100 J/cm2, and 81% for 140 J/cm2. The CR rates at 3 months were 81% for 70 J/cm2, 77% for 100 J/cm2, and 69% for 140 J/cm2. No significant difference in therapeutic efficacy was found among the 3 light doses at either 1month (P = .36) or 3 months (P=.96) after PDT. The degree of PDT- induced pain during irradiation was substantial and not statistically different (P=.06) for all 3 light doses. Limitations: The conclusions from this study are limited by the small sample size and only apply to topical ALA- PDT. Conclusion: Our results indicate that a red light dose of 70 J/cm2 may be sufficient for effective topical ALA- PDT of disseminated, mild to moderate AK on the face and scalp.

关键词：光线性角化病光动力疗法患者自评光剂量盲法原卟啉封包疼痛强度播散性完全缓解率

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Cardiac beta-defensins upregulate with a high fat diet and influence monocyte migration

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Open Journal of Internal Medicine 2013年第2期3卷 81-94页

作者： Annika Linde Christopher Ross Frank blecha Gerald H. Lushington Tonatiuh Melgarejo Center for Veterinary Health Sciences Oklahoma State University Stillwater USA Department of Anatomy & Physiology Kansas State University Manhattan USA Department of Medicinal Chemistry University of Kansas Lawrence USA

Inflammation plays a central role in development of cardiovascular pathology, and enhanced understanding of the innate immune response will help direct novel therapeutic strategies to address heart disease. Host defense peptides (HDPs)—hereunder defensins—exhibit antimicrobial, chemotactic, tissue healing and other key biological properties. Beta-defensin expression in whole-heart-homogenate has been reported in different species, and plasma alpha-defensins have been associated with cardiovascular morbidity and mortality. Still, the role of defensins in cardiac pathophysiology remains widely undetermined. Here, we show that a subset of rat-beta-defensins (rBDs) is constitutively expressed in the myocardium, and that their gene-expression level is influenced by systemic exposure to inflammatory mediators (highfat-diet and lipopolysaccharide). Using synthetic analogues of select rBD peptides, we evaluated the antimicrobial activity of these HDPs against clinically relevant pathogens and their ability as immunoregulatory compounds. We found that an innate myocardial response that involves rBDs is activated by highfat-diet feeding in rats, and that these HDPs influence monocyte migration-findings that suggest the peptides responding to exogenous danger-signals, and act within the context of a myocardial “first-line-of-defense”.

关键词： Antimicrobial Peptides Myocardial Endotoxin Dietary Lipid Cell Migration

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增强食用动物免疫力的新途径

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国外兽医学（畜禽传染病） 1991年第3期11卷 21-23页

作者： blecha,F 唐雨德

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1例10岁男孩阑尾黏液囊腺瘤继发慢性腹痛

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世界核心医学期刊文摘（儿科学分册） 2006年第4期2卷 51-52页

作者： blecha M.J. Gupta A. Hoover J.D. Madonna M.B. 王经纬 Department of Pediatric Surgery Children's Memorial Hospital Chicago IL 60657 United States

Mucocele of the appendix is a thin-walled dilated appendix filled with mucus. It occurs secondary to chronic obstruction of the appendiceal lumen because of a range of pathologies. Cystadenomas in children are exceedingly rare and most frequently of ovarian origin. A mucous cystadenoma of the appendix in a 10- year-old boy with chronic abdominal pain is presented.

关键词：黏液囊腺瘤慢性腹痛阑尾黏液囊肿阑尾腔慢性梗阻

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