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相对于男性,女性进行冠状动脉造影产生的额外的心血管病风险与严重受损的冠状动脉血流储备,而非阻塞性疾病相关

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中华高血压杂志 2016年第11期24卷 1041-1041页

作者：刘莉叶鹏 Taqueti Vr Shaw LJ Cook Nr Murthy VL Shah Nr Foster Cr Hainer J blankstein r Dorbala S Di Carli MF

与男性相比,女性的心血管病死亡率更高,但是阻塞性冠状动脉疾病（coronary artery disease,CAD）在女性中不太普遍。冠状动脉血流储备（coronary flow reserve,CFr）是大、小血管CAD和心肌缺血的综合测量指标,可识别出具有心血管病死亡... 详细信息

与男性相比,女性的心血管病死亡率更高,但是阻塞性冠状动脉疾病（coronary artery disease,CAD）在女性中不太普遍。冠状动脉血流储备（coronary flow reserve,CFr）是大、小血管CAD和心肌缺血的综合测量指标,可识别出具有心血管病死亡风险的患者,但其在临床实践中不是常规测量的指标。该研究试图调查性别、CFr和血管造影CAD严重程度对不良心血管事件的影响。

关键词：冠状动脉血流心血管病冠状动脉造影阻塞性疾病心肌灌注血管造影综合测量复合终点非致死性临床实践

肥胖患者的冠状动脉微血管功能障碍和心血管病风险

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中华高血压杂志 2018年第9期26卷 809-809页

作者： Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S blankstein r Bhatt DL Di Carli MF Taqueti Vr 刘青叶鹏

全世界有〉5亿的肥胖人群，其心血管病风险增加的病理生理机制是复杂的，并且可能涉及脂肪细胞相关因子的过量分泌，导致血管氧化应激增加，神经激素活性上调，以及低度全身炎症，可能导致交感神经系统激活增加，血管张力改变，冠状动... 详细信息

全世界有〉5亿的肥胖人群，其心血管病风险增加的病理生理机制是复杂的，并且可能涉及脂肪细胞相关因子的过量分泌，导致血管氧化应激增加，神经激素活性上调，以及低度全身炎症，可能导致交感神经系统激活增加，血管张力改变，冠状动脉微血管功能障碍（coronary microvascular dysfunction, CMD）。

关键词：微血管功能障碍心血管病冠状动脉肥胖患者风险病理生理机制神经激素活性交感神经系统

青年心肌梗死患者的家族性高胆固醇血症刘青(译),叶鹏(摘、审校)

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中华高血压杂志 2019年第7期27卷 621-621页

作者：刘青(译) 叶鹏(摘/审校) Singh A Gupta A Collins BL Qamar A Monda KL Biery D Lopez JAG de Ferranti SD Plutzky J Cannon CP Januzzi JL Jr Di Carli MF Nasir K Bhatt DL blankstein r 不详

关于在年轻时经历心肌梗死的美国成年人中家族性高胆固醇血症(familial hypercholesterolemia,FH)的患病率和治疗的数据有限。该研究旨在评估临床确定的FH的患病率,并检查他汀类药物使用率和心肌梗死1年后低密度脂蛋白胆固醇(low densit... 详细信息

关于在年轻时经历心肌梗死的美国成年人中家族性高胆固醇血症(familial hypercholesterolemia,FH)的患病率和治疗的数据有限。该研究旨在评估临床确定的FH的患病率,并检查他汀类药物使用率和心肌梗死1年后低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的水平。

关键词：家族性高胆固醇血症心肌梗死患者低密度脂蛋白胆固醇他汀类药物患病率成年人使用率

Ultrasound in the diagnosis of clinical orthopedics:The orthopedic stethoscope

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World Journal of Orthopedics 2011年第2期2卷 13-24页

作者： Alexander blankstein Department of Orthopedics Sheba Medical CenterUniversity of Tel Aviv School of Medicine16 Kehilat Bavel St.Ramat Hasharon 47322Israel

Ultrasonography has advantages over other imaging modalities in terms of availability and comfort,safety,and diagnostic potential.Operating costs are low compared with both computed tomography(CT)and magnetic resonance imaging(MrI).The portable equipment is accessible at locations distant from medical centers.Importantly,ultrasonography is performed while patients lie in a comfortable position,without pain or claustrophobia.Ultrasonography is a totally safe noninvasive imaging technique.In contrast to CT and X-rays,it does not emit ionizing radiation.Unlike MrI,it is safe for all patients,including those with cardiac pacemakers and metal implants,without any contraindications.Of the many indications for musculoskeletal ultrasonography,the evaluation of soft tissue pathology is particularly common.In addition,ultrasonography is useful for the detection of fluid collection,and for visualization of cartilage and bone surfaces.Color or power Doppler provides important physiological information,including that relating to the vascular system.The capability of ultrasonography in delineating structures according to their echotextures results in excellent pictorial representation.This imaging principle is based on physical changes in composition,as compared to imaging with MrI,which is based on changes in chemical composition.This article reviews the contribution of sonography to the evaluation of the musculoskeletal system.

关键词： Ultrasound Orthopedic surgery Safety No radiation Soft tissue

reliability of a simple fluoroscopic image to assess leg length discrepancy during direct anterior approach total hip arthroplasty

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World Journal of Orthopedics 2021年第11期12卷 850-858页

作者： Sandi Caus Hailee reist Christopher Bernard Michael blankstein Nathaniel J Nelms The robert Larner College of Medicine University of VermontBurlingtonVT 05405United States Department of Orthopaedics and rehabilitation Unviversity of VermontBurlingtonVT 05405United States

BACKGrOUND Direct anterior approach(DAA)total hip arthroplasty(THA)in a supine position provides a unique opportunity to assess leg length discrepancy(LLD)intraoperatively with fluoroscopy.reported fluoroscopic techniques are useful but are generally complicated or costly.Despite the use of multiple techniques for leg length assessment,LLD continues to be a major post-operative source of patient dissatisfaction further emphasizing the importance of near-anatomic restoration.The utility of an alternative direct measurement of LLD on an intra-operative fluoroscopic pelvic image during DAA THA has not been reported.AIM To determine the reliability of a novel simple intra-operative measurement of LLD using a parallel line technique on a single fluoroscopic digital image of the pelvis.METHODS One hundred and seventy-one patients who underwent DAA THA were included for analysis.Intra-operative fluoroscopic and post-operative anterior-posterior radiographs were imported to TraumaCad and calibrated for LLD measurement.LLD was measured on each image using the right-left hip differences in lesser trochanter to pelvic reference line distances.Pelvic reference points included the teardrops and ischia.Fluoroscopic LLD was compared to the gold-standard measurement of LLD measured on a post-operative radiograph.rESULTS Mean absolute difference in teardrop referenced LLD between fluoroscopic and post-operative radiographs was 2.17 mm and based on the ischia mean absolute difference was 2.63 mm.Linear regression of fluoroscopic and post-operative radiograph LLD based on teardrop and ischia LLD found r2 values of 0.57 and 0.84,respectively.Mean absolute difference between fluoroscopic and postoperative x-ray LLD was within 5 mm in 95%of cases regardless of pelvic reference.CONCLUSION This study demonstrates that a single fluoroscopic view obtained during DAA THA for leg length assessment is clinically useful.

关键词： Leg-length discrepancy Total hip arthroplasty Intra-operative fluoroscopy Direct anterior approach Limb asymmetry

双源CT上腺苷诱导应激心肌灌注成像对冠状动脉血管成像的补充作用

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国际医学放射学杂志 2010年第2期 180-180页

作者： J.A.rocha-Filho r.blankstein L.D.Shturman H.G.Bezerra D.r.Okada I.S.rogers 李琼 Cardiovascular MrI and CT Program Baptist Cardiac and Vascular Institute8900 N Kendall DrMiamiFL 33176USA

目的首先评价在同一个检查中,应激诱导CT灌注联合冠状动脉CT血管成像方案的可行性。然后评价在双源CT冠状动脉血管成像基础上结合灌注成像对增加高危人群中阻塞性

关键词：心肌灌注成像冠状动脉血管成像双源腺苷 CT 应激

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降低核素心肌灌注显像辐射剂量的方法

中华核医学与分子影像杂志 2017年第8期37卷 514-521页

作者：潘青青罗亚平李方 Sharmila Dorbala ron Blakstein Hicham Skali Mi-Ae Park Jolene Fantony Charles Mauceri James Semer Stephen C. Moore Marcelo F. Di Carli 中国医学科学院、北京协和医学院北京协和医院核医学科 100730 Division of Nuclear Medicine and Molecular Imaging Department of Radiology the Noninvasive Cardiovascular Imaging Program Departments of Medicine (Cardiology) and Radiology Brigham and Women's Hospital Boston Massachusetts

核素心肌灌注显像（MPI）在冠状动脉疾病患者的评估和管理中起着举足轻重的作用.从21世纪初叶中期开始,随着MPI应用的急剧增加,其不合理运用以及显像相关辐射暴露的问题逐渐得到重视.各专业学会相继制定了MPI合理运用的标准,与此同时,... 详细信息

核素心肌灌注显像（MPI）在冠状动脉疾病患者的评估和管理中起着举足轻重的作用.从21世纪初叶中期开始,随着MPI应用的急剧增加,其不合理运用以及显像相关辐射暴露的问题逐渐得到重视.各专业学会相继制定了MPI合理运用的标准,与此同时,新显像技术、传统显像仪器图像重建软件的革新以及心脏显像专用仪器的出现推动了低和（或）极低显像剂剂量MPI的诞生.该文阐述了用传统技术和新技术实现低剂量MPI的实践方法.

关键词： SPECT 低剂量 PET 辐射剂量心肌灌注显像质量保证