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Natural polyphenols effects on protein aggregates in Alzheimer＇s and Parkinson＇s prion-like diseases

Atmospheric and Climate Sciences（大气和气候科学） 2024年第2期 277页

作者： Wend Dolean Arsène Ilboudo Kassoum Yamba Windé Nongué Daniel Koumbem Issaka Ouédraogo

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neural Regeneration Research 2018年第6期13卷 955-961页

作者： aline freyssin guylène page bernard fauconneau agnès rioux bilan University of Poitiers EA380-8 NEUVACOD (Neurovascular Unit and Cognitive Disorders) Pole Biologie Sante Poitiers France

Alzheimer＇s and Parkinson＇s diseases are the most common neurodegenerative diseases. They are characterized by protein aggregates and so can be considered as prion-like disease. The major components of these deposits are amyloid peptide and tau for Alzheimer＇s disease, α-synuclein and synphilin-1 for Parkinson＇s disease. Drugs currently proposed to treat these pathologies do not prevent neurodegenerative processes and are mainly symptomatic therapies. Molecules inducing inhibition of aggregation or disaggregation of these proteins could have beneficial effects, especially if they have other beneficial effects for these diseases. Thus, several natural polyphenols, which have antioxidative, anti-inflammatory and neuroprotective properties, have been largely studied, for their effects on protein aggregates found in these diseases, notably in vitro. In this article, we propose to review the significant papers concerning the role of polyphenols on aggregation and disaggregation of amyloid peptide, tau, α-synuclein, synphilin-1, suggesting that these compounds could be useful in the treatments in Alzheimer＇s and Parkinson＇s diseases.

关键词： natural polyphenols protein aggregates Alzheimer's disease amyloid peptide amyloid plaques hyperphosphorylated tau Parkinson's disease a-synuclein synphilin-I

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Federico Uribe

Federico Uribe

Frontal Sinus Fractures: Management at the Yalgado Ouedraogo University Hospital Centre (Burkina Faso)

作者： Bartholomew F. bland edited by.

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Follicle-stimulating hormone(FSH)levels prior to prostatectomy are not related to long-term oncologic or cardiovascular outcomes for men with prostate cancer

Open Journal of Stomatology（口腔学期刊） 2024年第1期

作者： Arsène Coulibaly Patrik Gane-Bang Joseph Wend-Toin Biogo IbraïmaTraoré Tarcissus Konsem

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Asian Journal of Andrology 2022年第1期24卷 21-25页

作者： Kassim Kourbanhoussen France-Hélène Joncas Christopher JD Wallis Hélène Hovington Francois Dagenais Yves Fradet Chantal Guillemette Louis Lacombe Paul Toren Department of Surgery Faculty of MedicineUniversitéLavalCHU de Québec Research CenterOncology DivisionQuebec City G1R3S1Canada Department of Urology Vanderbilt University Medical CenterNashvilleTN 37232USA Institut Universitaire Cardiologie et Pneumologie de Québec Quebec City G1V 4G5Canada Faculty of Pharmacy UniversitéLavalCHU de Québec Research CenterQuebec City G1V 4G2Canada

Prior research suggests a link between circulating levels of follicle-stimulating hormone(FSH)and prostate cancer *** levels may also explain some of the observed differences in cardiovascular events among men treated with gonadotropin-releasing hormone(GnRH)antagonists compared to GnRH *** study evaluates the association between preoperative FSH and long-term cardiovascular and oncologic outcomes in a cohort of men with long follow-up after radical *** performed a cohort study utilizing an institutional biobank with annotated clinical *** levels were measured from cryopreserved plasma and compared with sex steroids previously measured from the same *** in oncologic outcomes between tertiles of FSH levels were compared using adjusted cox regression *** adverse cardiovascular events(MACE)were similarly assessed using hospital admission diagnostic codes.A total of 492 patients were included,with a median follow-up of 13.1(interquartile range:8.9–15.9)*** sulfate(DHEA-S)levels,but not other androgens,negatively correlated with FSH levels on linear regression analysis(P=0.03).There was no association between FSH tertile and outcomes of biochemical recurrence,time to castrate-resistant prostate cancer,or time to *** were identified in 50 patients(10.2%),with a mean time to first event of 8.8 *** association with FSH tertile and occurrence of MACE was *** results do not suggest that preoperative FSH levels are significantly associated with oncologic outcomes among prostate cancer patients treated with radical prostatectomy,nor do these levels appear to be predictors of long-term cardiovascular risk.

关键词： cardiovascular events follicle-stimulating hormone prostate cancer recurrence

Strong dependency of the tribological behavior of CuZr-based bulk metallic glasses on relative humidity in ambient air

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Friction 2023年第5期11卷 785-800页

作者： Solène BARLEMONT Paul LAFFONT Rémi DAUDIN Alexis LENAIN Guillaume COLAS Pierre-Henri CORNUAULT Femto-ST Institute Department of Applied MechanicsUniversity of Bourgogne Franche-ComtéCNRS/UFC/ENSMM/UTBMBesançon 25030France University of Grenoble Alpes CNRSSIMaPGrenoble 38000France Vulkam Inc.Amorphous metal micro casting Gières 38610France

Thanks to their outstanding mechanical properties,Bulk Metallic Glasses(BMGs)are new alternatives to traditional crystalline metals for mechanical and micromechanical applications including power ***,the tribological properties of BMGs are still poorly understood,mostly because their amorphous nature induces counter intuitive responses to friction and *** the present study,four different BMGs(Cu_(47)Zr_(46)Al_(7),Zr_(46)Cu_(45)Al_(7)Nb_(2),Zr_(60)Cu_(28)Al_(12),and Zr_(61)Cu_(25)Al_(12)Ti_(2))underwent ball-on-disc friction tests against 100Cr6 steel balls(American Iron and Steel Institute(AISI)52100)at different relative humidities(RHs)ranging from 20%to 80%.Controlling humidity enabled to observe a high repeatability of the friction and wear responses of the ***,the friction coefficient decreased by a factor of 2 when the humidity was increased,and the wear rate of BMGs was particularly low thanks to a 3rd-body tribolayer that forms on the BMG surface,composed of oxidized wear particles originating from the *** morphology of this tribolayer is highly correlated to *** study also identifies how the tribolayer is built up from the initial contact until the steady state is achieved.

关键词： Bulk Metallic Glasses(BMGs) tribology oxide transfer layer relative humidity(RH)

Estimating the Input Power of a Power Plant Using the Efficiency of the Inverter

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Mosquito Buzz Actually a Love Song

Smart Grid and Renewable Energy（智能电网与可再生能源） 2024年第3期 99页

作者： Toussaint Tilado Guingane Sosthène Tassembedo Eric Korsaga Dominique Bonkoungou Zacharie Koalaga François Zougmore

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科技英语学习 2009年第2期 8-10页

作者： Eric bland 廖丽

四大害虫之一的蚊子在炎热的夏季常常在我们耳边不停地发出令人讨厌的嗡嗡鸣声，它们叮人吸血，扰人睡眠，而且传播登革热、乙型脑炎、疟疾、丝虫病等传染病；对人类健康构成很大的威胁。但是，蚊子扰人的嗡嗡声却是它们发动求爱攻势的... 详细信息

四大害虫之一的蚊子在炎热的夏季常常在我们耳边不停地发出令人讨厌的嗡嗡鸣声，它们叮人吸血，扰人睡眠，而且传播登革热、乙型脑炎、疟疾、丝虫病等传染病；对人类健康构成很大的威胁。但是，蚊子扰人的嗡嗡声却是它们发动求爱攻势的一个讯号!科学家利用这一发现可以大大控制蚊子的数量。

关键词：害虫翻译方法英语教材

Evolution of X-pinch loads for pulsed power generators with current from 50 to 5000 kA

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Matter and Radiation at Extremes 2018年第6期3卷 267-277页

作者： T.A.Shelkovenko S.A.Pikuz I.N.Tilikin M.D.Mitchell S.N.bland D.A.Hammer Cornell University IthacaNY14850USA P.N.Lebedev Institute Moscow119991Russia Blackett Laboratory Imperial College LondonLondonSW72AZUK University of Evansville EvansvilleINUSA

A review of X-pinches of various configurations and of different materials as an X-ray source for various applications is presented. Theadvantages and disadvantages of different designs of X-pinches as a load for generators with a wide range of output parameters and as a sourceof X-ray radiation for X-ray point-projection imaging were analyzed.

关键词： X-pinch X-ray source X-ray point-projection imaging

Dispersal syndrome and landscape fragmentation in the salt-marsh specialist spider Erigone longipalpis

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Current Zoology 2023年第1期69卷 21-31页

作者： Maxime Dahirel Marie Wullschleger Tristan Berry Solène Croci Julien Pétillon Univ Rennes UR1CNRSEcosystèmesBiodiversitéÉvolution(ECOBIO)UMR 6553F-35000 RennesFrance Department of Biology Ghent UniversityB-9000 GhentBelgium Syndicat Mixte de Gestion des Milieux Naturels Réserve Naturelle Nationale de l’Étang NoirF-40510 SeignosseFrance CNRS Universitéde Rennes 2EPHE-PSLUniversitéd’AngersUniversitéde Bretagne OccidentaleUniversitéde Caen NormandieUniversitéde NantesUMR LETGF-35043 RennesFrance Institute for Coastal and Marine Research Nelson Mandela UniversityPort Elizabeth 6031South Africa

Dispersal and its evolution play a key role for population persistence in fragmented landscapes where habitat loss and fragmentation increase the cost of between-habitat *** such contexts,it is important to know how variation in dispersal and other traits is structured,and whether responses to landscape fragmentation are aligned with underlying dispersal-trait correlations,or dispersal ***,therefore,studied trait variation in Erigone longipalpis,a European spider species specialist of(often patchy)salt *** collected spiders in two salt-marsh landscapes differing in habitat *** then reared lab-born spiders for two generations in controlled conditions,and measured dispersal and its association with various key *** longipalpis population densities were lower in the more fragmented *** this,we found no evidence of differences in dispersal,or any other trait we studied,between the two *** a dispersal syndrome was present at the among-individual level(dispersers were more fecund and faster growing,among others),there was no indication it was genetically driven:among-family differences in dispersal were not correlated with differences in other ***,we showed that the observed phenotypic covariations were mostly due to within-family *** hypothesize that the dispersal syndrome is the result of asymmetric food access among siblings,leading to variation in development rates and carrying over to adult *** results show we need to better understand the sources of dispersal variation and syndromes,especially when dispersal may evolve rapidly in response to environmental change.

关键词： context-dependent dispersal habitat loss Linyphiidae phenotypic correlations population density