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Advances in Enzyme Research 2022年第4期10卷 83-100页

作者： Silvia Alejandra meza-Ireta blanca Colin-Lozano Penélope Merino-Montiel José Luis Vega-Báez Sara Montiel-Smith Facultad de Ciencias Químicas Ciudad Universitaria Benemérita Universidad Autónoma de Puebla Puebla México

Hormone Receptor positive (HR+) breast cancer is the most common malignancy in women. New strategies in the treatments have targeted the estrogen biosynthesis pathways including the inhibition of the aromatase and 17β-HSD1 enzymes. The present work, describes the study of a new family of 9 hybrid compounds derived from estrone attached to a coumarin fragment, linked through different lengths of hydrocarbon chains. The activity of these compounds was evaluated by molecular docking with two relevant enzymes in breast cancer (HR+). It has been proposed nine compounds as 17β-HSD1 inhibitors and six as aromatase inhibitors. We found important interactions with key amino acids at the orthosteric site of each enzyme and their score values compared to the crystallographic ligand. The in silico analysis showed good score values in the proposed compounds, where the steroidal portion presented important interactions with Met374 and Tyr155 in aromatase and in 17β-HSD1 respectively. Highlighting Compounds 2, 5 and 8 with an aromatic ring at the C4 position of the coumarin moiety, which favored arene-H type interactions essential for protein-ligand recognition. In addition, the results related to the 17β-HSD1 enzyme demonstrated how the length of the linker influences the interaction;the best score was found for derivative 8 with a chain of 8 methylenes.

关键词： Estrone Coumarins Aromatase Inhibitors 17β-HSD1 Inhibitors Molecular Docking

Qualification of nursing potential in maternal mortality in Mexico

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International Journal of Nursing Sciences 2020年第3期7卷 344-348页

作者： Rey Arturo Salcedo-Alvarez blanca Consuelo gonzález-Caamano Sara Huerta-gonzález Andrea Del Prado-Vázquez Universidad Nacional Autónoma de México Escuela Nacional de Enfermería y ObstetriciaCamino viejo a Xochimilco S/N y Viaducro TlalpanColonia San Lorenzo Huipulco14370Mexico CityMexico Universidad Veracruzana Región Poza Rica-Tuxpan.Boulevard Lázaro Cárdenas#801Colonia Morelos93240Poza RicaVeracruzMexico

Objectives:To develop a method that measures nursing potential through the factor analysis of relevant nursing data and social context by taking maternal mortality as the study ***:A Cross-sectional and analytical study,a multivariate analysis was *** Nursing Coverage Index,the Human Development Index,population density and the proportion of nurses with a bachelor's degree or upper degree,are studied by federative entity,only data from government sources are *** Index of Nursing Qualification in Mexico(INQM)was constructed through principal component ***:The highest correlation was between the INQM and the Nursing Coverage Prioritization Index(NCPI),which was 0.849(Pg positive linear *** Population Density Prioritization Index(PDPI)shows a strong positive correlation with the INQM(0.716,Pgenerated with the three main components in a *** is very low correlation between INQM and maternal mortality rate(MMR)and no statistical significance was ***:This study shows that nursing qualification must include economic,geographic and social *** INQM is an indicator that summarises the potential of each federative *** these results,a contribution is provided for the application of these indices,which can help determine nursing potential in a specific geographical region.

关键词： Maternal mortality Mexico Nursing care Population density

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高雪维尔的白色诱惑

现代装饰（家居） 2014年第4期 28-35页

作者： blanca Sanchez Polly Baldwin Roxanne Holland 肖俊英国Halo Design Interiors

英国室内设计事务所HaloDesignInteriors最近完成了依偎在高雪维尔滑雪场附近的滑雪小屋的改造设计。面对年久失修的建筑结构，业主希望借用温馨的木材和天然材料打造一个永恒的室内空间，

关键词：改造设计室内设计建筑结构室内空间天然材料滑雪场事务所业主

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Low serum levels of ghrelin are associated with gallstone disease

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World Journal of gastroenterology 2006年第19期12卷 3096-3100页

作者： Nahum Méndez-Sánchez guadalupe Ponciano-Rodríguez Luisa Bermejo-Martínez Antonio R Villa Norberto C Chávez-Tapia Daniel Zamora-Valdés Raúl Pichardo-Bahena blanca Barredo-Prieto Martha H Uribe-Ramos Martha H Ramos Héctor A Baptista-gonzález Misael Uribe Liver Unit Biomedical Research Department Medica Sur Clinic and FoundationMexico CityMexico Faculty of Medicine National Autonomous University of Mexico (UNAM) Mexico CityMexico Clinical Research Department National Institute of Perinatology Mexico CityMexico Clinical Epidemiology Unit National Institute of Medical Sciences and Nutrition Mexico CityMexico

AIM： To explore the role of ghrelin in gallstone disease. METHODS： We carried out a cross-sectional study in 150 subjects, 38 with gallstones （cases） and 112 controls. We also did a real-time PCR-RT study in twenty gallbladder samples each. Body mass index （BNI）, serum insulin, ghrelin, and serum lipids were measured. Logistic regression analyses （univariate and multivariate） were conducted to estimate the probability of gallstone disease associated with serum ghrelin concentrations. RESULTS： Cases were statistically different from controls in gender distribution （P = 0.01）, age （53 vs 44 yr, P = 0.002）, BNI （28 vs 25; P = 0.004）, and glucose （5.26 vs 4.98 mmol/L; P = 0.05）. The prevalence of ghrelin serum levels above the third tercile was lower in subjects without metabolic syndrome （P 〈 0.05）. In a multivariate model, we found a protective effect, when ghrelin values were higher than the median value （OR = 0.27, 95%CI 0.09-0.82, P = 0.02）. Twenty （20%） gallbladder specimens expressed ghrelin mRNA. CONCLUSION： Serum ghrelin concentrations are associated with a protective effect of gD.

关键词： gallstones Obesity ghrelin gallbladder gastrointestinal hormones

Review of the biological and engineering aspects of algae to fuels approach

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International Journal of Agricultural and Biological Engineering 2009年第4期2卷 1-30页

作者： Paul Chen Min Min Yifeng Chen Liang Wang Yecong Li Qin Chen Chenguang Wang Yiqin Wan Xiaoquan Wang Yanling Cheng Shaobo Deng Kevin Hennessy Xiangyang Lin Yuhuan Liu Yingkuan Wang blanca Martinez Roger Ruan Center for Biorefining Department of Bioproducts and Biosystems EngineeringUniversity of Minnesota1390 Eckles Ave.St.PaulMN 55108USA State Key Laboratory of Food Science and Technology Engineering Research Center for Biomass ConversionMinistry of EducationNanchang UniversityNanchang 330047China Biochemical Engineering College Beijing Union UniversityBeijingChina College of Biological Science and Technology Fuzhou UniversityFuzhou 350108China Chinese Academy of Agricultural Engineering Beijing 100125China

Current biofuel production relies on limited arable lands on the earth,and is impossible to meet the biofuel *** producing algae are alternative biofuel feedstock with potential to meet the world’s ambitious goal to replace fossil *** review provides an overview of the biological and engineering aspects in the production and processing technologies and recent advances in research and development in the algae to fuels *** article covers biology,selection and genetic modification of algae species and strains,production systems design,culture media and light management,harvest and dewatering,downstream processing,and environment and economic *** the many advances made over several decades,commercialization of algal fuels remains challenging chiefly because of the techno-economic *** breakthroughs in all major aspects must take place before commercial production of algal fuels becomes economically viable.

关键词： algae microalgae open pond enclosed photobioreactor light harvest dewatearing extraction hydrothermal liquefaction gasification pyrolysis fermentation

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ESP及其他:寻求相关性

外语教学理论与实践 1992年第2期 23-26页

作者： blanca A.de Escorcia 刘运同华侨大学

引言尽管这篇文章主要涉及南美洲的ESP情况,但我并不打算把它写成一个现有水平的报告;相反地,我想提出几个近期ESP领城中的关键性问题,然后细致地考察南美洲国家是如何对待这些问题的。在南美洲已经形成了三个非常独特的发展模式,这可... 详细信息

引言尽管这篇文章主要涉及南美洲的ESP情况,但我并不打算把它写成一个现有水平的报告;相反地,我想提出几个近期ESP领城中的关键性问题,然后细致地考察南美洲国家是如何对待这些问题的。在南美洲已经形成了三个非常独特的发展模式,这可以举智利、巴西和哥伦比亚的ESP情况作为例子。尽管总的来说存在着一个明显的倾向,即追随该领域全球范围内的一般发展趋势,但每个国家处理问题的方式自然不同。我将把哥伦比亚的情况作为一个起点,试着把它放在其他国家更广的范围来考察。

关键词：南美洲国家语言教师学习策略语言教学 ESP 阅读策略学习技巧教材编写语言学习外语交际

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Evaluation of antimycobacterium activity of the essential oils of cumin (Cuminum cyminum), clove (Eugenia caryophyllata), cinnamon (Cinnamomum verum), laurel (Laurus nobilis) and anis (Pimpinella anisum) against Mycobacterium tuberculosis

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Advances in Biological Chemistry 2013年第5期3卷 480-484页

作者： Andrade-Ochoa Sergio Chacón-Vargas Fabiola Nevarez-Moorillon guadalupe Rivera-Chavira blanca Hernández-Ochoa León Facultad de Ciencias Químicas Universidad Autónoma de Chihuahua Campus Universitario #2 Chihuahua México

In this study Essential oils were used with cumin, cloves, cinnamon, laurel and anis to determine Minimum Inhibitory Concentration (MIC) against Mycobacterium tuberculosis strains. The MICs were determined on M. tuberculosis H37Rv sensitive to all five firstline antituberculosis drugs (streptomycin, isoniazid, rifampicin, ethambutol and pirazinamide), two H37-Rv (CH-8 and CH-15) isoniazid-resistant, two H37Rv (CH-07 and CH-09) rifampicin-resistant, two H37Rv (CH-03 and CH-06) streptomycin-resistant, and two H37Rv (CH-09 and CH-10) ethambutol-resistant using the microplate alamar blue assay. The results obtained showed that the cumin and cinnamon essential oils showed a MIC of 12.5 μg/ml against reference strain H37Rv. The five essential oils used in this study were effective against the isoniazid-resistant variant of H37RV with MIC values in the range 12.5-100 μg/ml, the most potent being the cumin and cin-namon (MIC = 12.5). Similar results were obtained against rifampicin-resistant variant of H37RV with MIC values in the range 12.5-100 μg/ml;the most active ones?in this case were the essential oils of cumin and cloves. The essential oils of anis and laurel were active with MIC value to 100 μg/ml. Clove, cumin, and cinnamon essential oils were active against all strains utilized in this study, with MIC values in the range 6.25 μg/ml to 25 μg/ml.

关键词： Antimycobacterial Activity Essential Oils Monoterpenoids Mycobacterium tuberculosis

Correspondence amongst the PENO Test Battery Cognitive Results and Hippocampal Lesions in Alzheimer’s Disease

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Advances in Aging Research 2014年第3期3卷 239-251页

作者： Rojas Karla Diaz Alfonso Espinosa blanca Montano Luis Felipe Dilhuydy Hugo geraux Francine Joanette Yves Robitaille Yves guevara Jorge Laboratorio Experimental de Enfermedades Neurodegenerativas Instituto Nacional de Neurologia y Neurocirugia“M.V.S.”Mexico DFMexico Departamento de Farmacia Facultad de Ciencias QuimicasBUAPPueblaMexico Departamento Bioquimica INERMexico DFMexico Departamento de Biologia Celular y Tisular Facultad de MedicinaUNAMMexico DFMexico Centre de Recherche Institut Universitaire de Geriatrie de MontrealMontrealCanada Departament de Pathologie Hopital Ste-JustineMontrealCanada Departamento de Bioquimica Facultad de MedicinaUNAMMexico DFMexico

Alzheimer’s disease (AD) is characterized by a decline of cognitive functions. Distinctive histopathological hallmarks are neuritic plaques, neurofibrillary tangles, and synaptic alterations. Abnormally enlarged synaptic structures called “Meganeurite clusters” have been linked to plasticity changes. The aims of this study were to determine if cognitive impairment was related to specific neuritic and synaptic degeneration processes in patients with AD, and if the results of a cognitive test could be correlated with the histopathological damage. The neuropsychological evaluation obtained by the Protocole d’evaluation neuropsychologique optimal (PENO) test battery was used in live AD and control individuals. The histopathological evaluation of their brain after their death was carried out with specific polyclonal and monoclonal antibodies to Aβ, pTau protein, synaptophysin, and gAP-43. Images were obtained by confocal microscopy. The results showed a significant difference between healthy controls and Alzheimer’s patients in neuropsychological evaluation and histopathological hallmarks expression. The most significant positive correlation in AD patients was between memory and language results with the PENO test and the presence of Aβ +pTau+ plaques in the hippocampus. An interesting negative correlation was between cognitive impairment and the presence of Meganeuritic clusters, considered as “plasticity” markers. These results strongly supported the use of the PENO battery test to evaluate the progression of cognitive impairment in AD prone individuals and patients due to the strong correlation of the test results with histopathological brain lesions characteristic of Alzheimer’s disease.

关键词： Cognitive Decline Neuropsychological Evaluation Synapsis Plasticity Alzheimer’s Disease

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湖畔浅居

现代装饰（家居） 2015年第12期 32-41页

作者： blanca Sanchez Richard gooding 范嘉苑英国Halo Design Interiors

这座度假别墅位于英格兰的科茨沃尔德,毗邻湖畔,被一片美丽的郊野景色所包围。业主是一对年轻的夫妇及其四个孩子,平常居住在萨里,为了释放工作和生活压力,他们选择在离萨里不远的地方购买了一套别墅,周末的时候可以一家人过来放松娱乐... 详细信息

这座度假别墅位于英格兰的科茨沃尔德,毗邻湖畔,被一片美丽的郊野景色所包围。业主是一对年轻的夫妇及其四个孩子,平常居住在萨里,为了释放工作和生活压力,他们选择在离萨里不远的地方购买了一套别墅,周末的时候可以一家人过来放松娱乐一下。首层是主要的起居空间,一排玻璃落地滑门在起居室一侧一字排开,优美的湖光景色自然而然地映入室内空间之中。

关键词：落地玻璃人过来萨里科茨暗色调儿童房往前走沃尔德地滑《星球大战》

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Analysis of the Meteorological Variables for Puebla City 2011-2012 Applying the Modeling Ion-Wavelets in a Hypothetical Manner

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Atmospheric and Climate Sciences 2013年第4期3卷 450-458页

作者： Rogelio Ramos-Aguilar Patricia Máximo-Romero blanca Susana Soto-Cruz Salvador Alcántara-Iniesta José guillermo Pérez-Luna Engineering School Benemérita Universidad Autónoma de Puebla Puebla México Research Center of Semiconductor Devices Benemérita Universidad Autónoma de Puebla Puebla México

This work presents the results of the analysis of meteorological variables applying the modeling Ion-Wavelets in a hypothetical manner. In this case the Morlet wavelet transform is used, which is the result of a huge number of researches made in the80’s and applied to various physical phenomena derived from natural chaotic processes;the data were processed using the phenomenon “El Nino” and CO2 (Carbon dioxide) due to the fact that these are the meteorological phenomena which best adapt to our object of study correlating with distribution of gauss and Morlet during the study period in the Puebla Valley.

关键词： Wavelets gauss Morlet Variables Model