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Does the use of double hormone replacement therapy for trauma patient organ donors improve organ recovery for transplant

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World Journal of Transplantation 2024年第2期14卷 119-125页

作者： Eden M Gallegos Tanner Reed Paige Deville blake Platt Claudia Leonardi Lillian Bellfi Jessica Dufrene Saad Chaudhary John Hunt Lance Stuke Patrick Greiffenstein Jonathan Schoen Alan Marr Anil Paramesh Alison A smith Department of Physiology Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70124United States Department of Medicine Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Surgery Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Trauma Surgery Tacoma General HospitalTacoma 98405United States Department of Public Health Louisiana State University Health Sciences Center New OrleansNew OrleansLA 70112United States Department of Donation Services Louisiana Organ Procurement AgencyCovingtonLA 70433United States Department of Surgery Tulane Transplant InstituteTulane University School of MedicineNew OrleansLA 70112United States

BACKGROUND With an ongoing demand for transplantable organs,optimization of donor management protocols,specifically in trauma populations,is important for obta-ining a high yield of viable organs per *** management of brain-dead potential organ donors(BPODs)is controversial,leading to heterogeneous clinical management *** studies have shown that when levo-thyroxine was combined with other treatments,including steroids,vasopressin,and insulin,BPODs had better organ recovery and survival outcomes were increased for transplant *** To determine if levothyroxine use in combination with steroids in BPODs increased the number of organs donated in trauma *** A retrospective review of adult BPODs from a single level 1 trauma center over ten years was *** criteria included patients who were not solid organ donors,patients who were not declared brain dead(donation after circulatory death),and patients who did not receive steroids in their hospital *** and steroid administration,the number of organs donated,the types of organs donated,and demographic information were *** analyses were performed with P0.05).In the ST/LT group,68.1%(n=47)donated a high yield(3-5)of organ types per donor compared to 42.1%(n=8)in the ST group(P=0.038).There was no difference in the total number of organ types donated between the groups(P=0.068).CONCLUSION This study suggests that combining levothyroxine and steroid administration increases high-yield organ donation per donor in BPODs in the trauma patient *** to this study include

关键词： Organ donation Trauma Brain death Levothyroxine Hormone replacement therapy Steroids Organ donor Retrospective

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曼哈顿Big U规划

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城市环境设计 2019年第2期118卷 240-249页

作者： Kurt Nieminen Dammy Lee Yifu Sun Jack Lipson David Spittler blake smith David Dottelonde Ken Amoah Choonghyo Lee Wesley Chiang Daisy Zhong Hector Garcia Riccardo de Palma Yaziel Juarbe Taylor Hewett Jan Casimir Daniele Pronesti Tore Banke Yehezkiel Wiliardy 朱翰林

"设计重建计划"是飓风桑迪重建工作组和美国住房与城市发展部的一项倡议,该计划旨在解决飓风肆虐之后造成的地区性结构破坏和环境缺陷问题,并衍生出一种经济上可行的解决方案以保护居民免受未来气候问题的影响。而Big U规划是一个围绕... 详细信息

"设计重建计划"是飓风桑迪重建工作组和美国住房与城市发展部的一项倡议,该计划旨在解决飓风肆虐之后造成的地区性结构破坏和环境缺陷问题,并衍生出一种经济上可行的解决方案以保护居民免受未来气候问题的影响。而Big U规划是一个围绕着曼哈顿的保护系统,从西54街向南至巴特里,并一直延伸至东40街:1条绵延10英里(约16.1千米)的低洼带,其中包含着分布密集、充满活力但又脆弱不已的都市空间。

关键词：曼哈顿防洪系统 Big U

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Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad Melissa Palmer Minjun Chen Arie Regev Rajarshi Banerjee Rob Myers Robert Riccio Richard Torstenson Ramy Younes Puneet SArora Henrik Landgren Morten A.Karsdal Martin blake David A.Shapiro Hans-Juergen Gruss Muhammad Y.Sheikh Dina Attia Steven Bollipo Alastair D.smith Bradley Freilich Robert G.Gish Detlef Schuppan Department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver Consulting LLC New YorkNYUSA Division of Bioinformatics and Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and Company IndianapolisINUSA Perspectum Diagnostics Ltd OxfordUK Gilead Sciences Inc Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nordic Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and Hepatology Department Beni-Suef UniversityBeni SuefEgypt Department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medicine and Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA Division of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and Research Center for Immune Therapy University Medical CenterMainzGermany Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related *** no effective treatments exist,novel approaches to drug development are ***,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and *** international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be *** allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and *** share the sense of urgency for change and will act in new ways to achieve our *** there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build *** provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD *** hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health *** this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.

关键词： NAFLD MAFLD NASH Fatty liver disease Liver Fibrosis

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Immunoprotective antigens of Eimeria maxima:identification using genetics and the immune host

Immunoprotective antigens of Eimeria maxima:identification u...

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The 15th World Veterinary Poultry Congress

作者： Darner P blake Martin W Shirley Adrian L smith Institute for Animal Health ComptonBerkshireRG20 7NNUK Institute for Animal Health ComptonBerkshireRG20 7NNUK Institute for Animal Health ComptonBerkshireRG20 7NNUK

＜正＞Control of the Eimeria species,causative organisms of the disease coccidiosis,has largely been based up- on chemotherapy or vaccination with live wild-type or attenuated ***,the widespread oc- currence of drug r...

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Parasite Genetics, the Immune Host and DNA Fingerprinting in the Identification of Loci Encoding Protective Antigens of Eimeria Maxima

Parasite Genetics, the Immune Host and DNA Fingerprinting in...

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12th International Congress of Protozoology

作者： Damer P. blake Adrian L. smith Martin W. Shirley Institute for Animal Health Compton BerkshireRG20 7NNUK Institute for Animal Health Compton BerkshireRG20 7NNUK Institute for Animal Health Compton BerkshireRG20 7NNUK

＜正＞Many protozoan genomes are the subject of extensive sequencing projects but the identification of genes that encode antigens capable of stimulating a protective immune response remains a demanding task. The rational identification of genuinely immunoprotective gene products encoded by unsequenced genomes is even more daunting. The majority of screens for vaccine candidates protective against protozoan infection have been largely empirical, based upon the induction of an immune response rather than protection. However, consideration of the genetics of immune escape by different strains of Eimeria maxima has raised the possibility of the targeted identification of a gene （or genes） under immune

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先进封装技术提升系统散热性能

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电子产品世界 2006年第2X期13卷 98-100页

作者： Carl blake Carl smith International Rectifier

近年来,随着对功率的需求越来越高,PCB板的散热设计变得更为关键。本文以几个实例论述了MOSFET封装如何改善整个电路板的温度,使其在期望的范围之内。除了DC总线转换器(可达220W级别),本文还讨论了在控制和同步FET插座内带有不同MOSFET... 详细信息

近年来,随着对功率的需求越来越高,PCB板的散热设计变得更为关键。本文以几个实例论述了MOSFET封装如何改善整个电路板的温度,使其在期望的范围之内。除了DC总线转换器(可达220W级别),本文还讨论了在控制和同步FET插座内带有不同MOSFET的同步降压转换器。对不同设备的相关性能进行了比较。通过测试同步降压转换器和DC总线转换器,发现并联MOSFET并不像期望的那样会降低电路板的温度。优化DC总线转换器会得到比较好的效果,这说明每个插座中的单个设备只有具备良好的Rdson和散热性能,才能达到最佳的整体性能。

关键词：散热性能封装技术提升系统同步降压转换器 MOSFET 总线转换器散热设计 PCB板相关性能通过测试

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温哥华公寓

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城市环境设计 2019年第2期118卷 210-219页

作者： Carl McDonald Melissa Bauld Aaron Mark Alan Tansey Alex Wu Alexandra Gustafsson Alina Tamosiunaite Amina Blacksher Aran Coakley Arash Adel Ahmadian Armen Menendian Barbora Srpkova Ben Zunkeler Benjamin Caldwell Benjamin Novacinski Bennett Gale Birk Daugaard blake Theodore smith Brian Foster Brian Rome Carolien Schippers Christopher James Malcolm Jr. Christopher Junkin Christopher Tron David Brown David Dottelonde Deborah Campbell Doug Stechschulte Douglass Alligood Edward Yung Elena Bresciani Filip Milovanovic Francesca Portesine Gabriel Hernandez Solano Gabriel Jewell-Vitale Hector Garcia Ivy Hume Jan Leenknegt Janice Rim John Kim Josiah Poland Julian Liang Julianne Gola Julie Kaufman Karol Bogdan Borkowski Kurt Nieminen Lauren Turner Lorenz Krisai Lucio Santos Marcella Martinez Martin Voelkle Matthew Dlugosz Megan Ng Michael Robert Taylor Otilia Pupezeanu Paula Domka Phillip MacDougall Ryan Yang Sean Franklin Sebastian Grogaard Simon Scheller Spencer Hayden Taylor Fulton Terrence Chew Terry Lallak Thomas smith Tianqi Zhang Tobias Hjortdal Tran Le Valentina Mele Xinyu Wang Yaziel Juarbe Yoanna Shivarova Zach Walters Zhifei Xu Andrew Latreille Glotman Simpson Urban YVR 运小红

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城... 详细信息

温哥华公寓的建成预示着这个年轻的城市正在打开城市政策制定的新局面。它将成为从Granville大桥进入温哥华市中心的城市大门。塔楼和群房的设计是对新城市主义地域类型中的"温哥华主义"建筑的全新解读,配合一座纤细的塔楼,试图保留城市视觉通廊并激活步行通道。住宅塔楼借助高度和毗邻河流的地理位置,是唯一可以同时享受水景和山景的建筑,坐拥温哥华广袤的自然风光。

关键词：温哥华平面图 Dialog 立面图

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A test of two mechanisms proposed to optimize grassland aboveground primary productivity in response to grazing

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Journal of Plant Ecology 2012年第4期5卷 357-365页

作者： A.K.Knapp D.L.Hoover J.M.Blair G.Buis D.E.Burkepile A.Chamberlain S.L.Collins R.W.S.Fynn K.P.Kirkman M.D.smith D.blake N.Govender P.O'Neal T.Schreck A.Zinn Graduate Degree Program in Ecology and Department of Biology Colorado State UniversityFort CollinsCO 80526USA Division of Biology Kansas State UniversityManhattanKS 66506USA Department of Biological Sciences Florida International UniversityNorth MiamiFL 33181USA Department of Biology MSC03-2020University of New MexicoAlbuquerqueNM 87131USA Okavango Research Institute University of BotswanaPrivate Bag 285MaunBotswana School of Biological and Conservation Science University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa Department of Ecology and Evolutionary Biology Yale UniversityNew HavenCT 06520USA Scientific Services Kruger National ParkPrivate Bag X402Skukuza1350South Africa Department of Ecology and Evolutionary Biology University of CaliforniaIrvineCA 92697USA

Aims Mesic grasslands have a long evolutionary history of grazing by large herbivores and as a consequence,grassland species have numerous adaptations allowing them to respond favourably to *** empirical evidence has been equivocal,theory predicts that such adaptations combined with alterations in resources can lead to grazing-induced overcompensation in aboveground net primary production(ANPP;grazed ANPP>ungrazed ANPP)under certain *** tested two specific predictions from ***,overcompensation is more likely to occur in annually burned grasslands because limiting nutrients that would be lost with frequent fires are recycled through grazers and stimulate ***,overcompensation of biomass lost to grazers is more likely to occur in unburned sites where grazing has the greatest effect on increasing light availability through alterations in canopy *** We tested these nutrient versus light-based predictions in grazed grasslands that had been annually burned or protected from fire for>20 *** assessed responses in ANPP to grazing by large ungulates using both permanent and moveable grazing exclosures(252 exclosures from which biomass was harvested from 3192 quadrats)in a 2-year *** sites were located at the Konza Prairie Biological Station(KPBS)in North America and at Kruger National Park(KNP)in South *** KPBS,sites were grazed by North American bison whereas in KNP sites were grazed either by a diverse suite of herbivores(*** wildebeest,Burchell’s zebra,African buffalo)or by a single large ungulate(African buffalo).Important Findings We found no evidence for overcompensation in either burned or unburned sites,regardless of grazer ***,there was no support for either mechanism leading to ***,complete compensation of total biomass lost to grazers was the most common response characterizing grazing–ANPP relationships with,in some cases,undercompensation of grass ANPP being of

关键词： aboveground net primary production fire forbs herbivores savanna

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工业用中间合金细化晶粒的作用

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轻合金加工技术 1986年第8期 33-37+12页

作者： N.W.blake R.W.smith 金旭东杨小永

在半连续铸锭和铸件生产中,晶粒细化会带来很多好处。在半连续铸造中,采取细化晶粒的措施后,可以提高铸造速度,减少裂纹、冷隔和偏析,提高坚固性,对于改善合金的机械性能也有重要作用。工业生产中,经常通过在铸造前的某个时候向熔体添... 详细信息

在半连续铸锭和铸件生产中,晶粒细化会带来很多好处。在半连续铸造中,采取细化晶粒的措施后,可以提高铸造速度,减少裂纹、冷隔和偏析,提高坚固性,对于改善合金的机械性能也有重要作用。工业生产中,经常通过在铸造前的某个时候向熔体添加变质剂来细化晶粒,这些变质剂是含少量钛或含少量钛、硼的母合金,通常称为“中间合金”。目前,很多不同的中间合金在工业上得到了应用,采用何种形式和成分的中

关键词：中间合金 TIA TIB 母合金细化晶粒晶粒细化再结晶

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阿梅格尔巴克/哥本山

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城市环境设计 2019年第2期 172-183页

作者： Nanna Gyldholm M?ller Alberto Cumerlato Aleksander Wadas Alexander Codda Alexander Ejsing Alexandra Gustafsson Alina Tamosiunaite Armor Gutierrez Anders Hjortn?s Andreas Klok Pedersen Annette Jensen Ariel Wallner Ask Andersen Balaj IIulian blake smith Borko Nikolic Brygida Zawadzka Buster Christensen Chris Falla Chris Zhongtian Yuan Daniel Selensky Dennis Rasmussen Espen Vik Finn N?rkj?r Franck Fdida Gonzalo Castro Gül Ertekin George Abraham Helen Chen Henrick Poulsen Henrik R?mer Kania Horia Spirescu Jakob Ohm Laursen Jelena Vucic Jeppe Ecklon Ji-young Yoon Jing Xu Joanna Jakubowska Johanna Nenander Kamilla Heskje Katarzyna Siedlecka Krzysztof Marciszewski Laura W?tte Liang Wang Lise Jessen Long Zuo Maciej Zawadzki Mads Enggaard Stidsen Marcelina Kolasinska Marcos Bano Maren Allen Mathias Bank Matti N?rgaard Michael Andersen Narisara Ladawal Schr?der Niklas A. Rasch Nynne Madsen ?ssur Nols? Pero Vukovic Richard Howis Ryohei Koike Se Hyeon Kim Simon Masson Sunming Lee Toni Mateu Xing Xiong Zoltan David Kalaszi Rasmus Hjortshoj 陈子钰

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新... 详细信息

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新。我们提出了一种新型的垃圾焚烧发电厂,这种工厂能产生经济、环保和社会效益。我们不将阿梅格尔巴克/哥本山视为一个孤立的对象,而是调动起建筑的

关键词：巴克本山

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