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THE CASE FOR UNDERFLOOR AIR CONDITIONING:THE ENVIRONMENTAL AND COST BENEFITS EXAMINED

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THE CASE FOR UNDERFLOOR AIR CONDITIONING:THE ENVIRONMENTAL A...

Temporo-spatial dynamics and behavioural patterns of 2012 cholera epidemic in the African mega-city of Conakry,Guinea

International Symposium of Air Conditioning in High Rise Buildings’2000

作者： G.blake THOMAS Advanced Ergonomic Technologies Ltd 78a High StreetBletchingleySurreyRH1 4PAUK

＜正＞ In the last two years a dramatic increase in the use of underfloor air conditioning has occurred in Europe and the Far East. This is partly due to greater awareness of the suitability of the system in commercial office use, but also because of changes in business *** paper will use examples of projects, which currently use the underfloor system to highlight the customer and developer benefits that are available. It is primarily concerned with the concepts and major design issues that surround the system. These include the impact on construction cost, in addition to program and life costing （analysis）. It will draw on research undertaken on the normal performance of concrete slabs, and how these can be used as thermal stores along with computer simulated temperature pick up in floor *** supply and return systems （Constant volume supply/variable volume introduction） and floor supply and room or ceiling return systems （Variable volume supply/variable volume introduction） are discussed and compared with conventional ceiling based systems. Issues such as air quality, energy consumption, environmental impacts and demand on world resources, staff comfort and other topical matters related to current construction techniques will be raised throughout.

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Infectious Diseases of Poverty 2018年第1期7卷 145-154页

作者： Alexandre blake Veronique Sarr Keita Delphine Sauvageot Mamadou Saliou Berthe Marie Njanpop Fode Sory Bertrand Sudre Koivogui Lamine Martin Mengel Bradford DGessner Keita Sakoba Agence de Medecine Préventive ParisFrance Division Prevention et Lutte contre la Maladie(DPLM) Ministere de la santéPublique et de l’Hygiene Publique ConakryConakryGuinea Institut National de Sante Publique(INSP) ConakryGuinea Franche-Comtéuniversity(UMR 6249 chrono-environnement) BesançonFrance.

Background:Cholera is endemic in Guinea,having suffered consecutive outbreaks from 2004 to 2008 followed by a lull until the 2012 *** we describe the temporal-spatial and behavioural characteristics of cholera cases in Conakry during a three-year period,including the large-scale 2012 ***:We used the national and African Cholera Surveillance Network(Africhol)surveillance data collected from every cholera treatment centre in Conakry city from August 2011 to December *** prevalence of suspect and confirmed cholera cases,the case fatality ratio(CFR),and the factors associated with suspected cholera were described according to three periods:pre-epidemic(A),epidemic 2012(B)and post epidemic(C).Weekly attack rates and temporal-spatial clustering were calculated at municipality level for period *** was confirmed by culture at the cholera national reference ***:A total of 4559 suspect cases were reported:66,4437,and 66 suspect cases in periods A,B and C,*** the 204 suspect cases with culture results available,6%,60%,and 70%were confirmed in periods A,B,and C,*** 0.3%,the CFR was significantly lower in period B than in periods A(7.6%)and C(7.1%).The overall attack rate was 0.28%in period B,ranging from 0.17%to 0.31%across ***,a cluster of cases was identified in two districts in the northern part of *** 14%,rice water stools were less frequent in period A than in period B and C(78%and 84%).Dehydration(31%vs 94%and 89%)and coma(0.4%vs 3.1%and 2.9%)were lower during period B than in periods A and *** treatment of drinking water was less frequent in period A,while there were more reports of recent travel in period ***:The epidemic dynamic and the sociological description of suspect cases before,during,and after the large-scale epidemic revealed that the Vibrio cholerae was already present before the ***,it appeared that infected individuals react

关键词： Cholera Space-time clustering Guinea

维多株单抗在炎症性肠病手术患者中的应用:临床试验和上市后评估

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Gastroenterology Report 2019年第5期7卷 322-330,I0001页

作者： Bo Shen Aimee blake Karen Lasch Michael Smyth Fatima Bhayat Center for Inflammatory Bowel Disease Digestive Disease and Surgery InstituteCleveland ClinicClevelandOHUSA Global Patient Safety Evaluation Takeda Pharmaceuticals International Co.CambridgeMAUSA US Medical Office Takeda Pharmaceuticals USA Inc.DeerfieldILUSA Global Medical Affairs Takeda Development Centre Europe LtdLondonUK Kyowa Kirin International plc ChertseyUK

背景:炎症性肠病(IBD)患者常需手术治疗,但其长期接受免疫治疗会增加术后并发症的风险。本研究从临床试验和上市后应用两个层面,调查接受维多株单抗(一种已被批准用于中重度IBD的肠道选择性抗体)治疗的炎症性肠病患者术后并发症的发生... 详细信息

背景:炎症性肠病(IBD)患者常需手术治疗,但其长期接受免疫治疗会增加术后并发症的风险。本研究从临床试验和上市后应用两个层面,调查接受维多株单抗(一种已被批准用于中重度IBD的肠道选择性抗体)治疗的炎症性肠病患者术后并发症的发生频率。方法:本研究基于GEMINI 1、GEMINI 2两项临床试验的安全性数据以及长期安全性研究数据进行析因分析,上述研究对象为接受结肠切除术或小肠切除术的IBD患者。同时,本研究也对维多株单抗全球安全性数据库进行上市后分析(截止日期:2016年5月19日)。使用Medical Dictionary for Regulatory Activities推荐术语对术后并发症相关的不良事件进行定义。结果:GEMINI 1和GEMINI 2研究共计纳入58例手术病例,维多株单抗治疗者和安慰剂对照者术后并发症发生率分别为5.9%(3/51)和14.3%(1/7)。在长期安全性研究中,2,243例病例中有157例(7%)接受了结肠或小肠切除手术,其中11例(7%)出现术后并发症。维多株单抗末次服药与手术的中位间隔时间,在GEMINI 1试验中为23天,在GEMINI 2试验中为20天,在长期安全性研究中为39-40天。上市后,基于46,978例维多株单抗服用者的分析显示,仅19例病例报道了术后并发症。结论:在临床试验中,结肠或小肠切除术后并发症并不常见,其在维多株单抗与安慰剂对照之间的差异甚微。在上市后分析中,术后并发症发生频率似乎非常低。

关键词：安慰剂对照肠切除手术临床试验炎症性肠病结肠切除术病例报道单抗治疗术后并发症

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蛋白Ⅲ的结构、功能和遗传

国外医学（微生物学分册） 1989年第6期12卷 257-258页

作者： blake MS 钱利生

本文用纯化和基因克隆产生的淋球菌蛋白Ⅲ(PⅢ),研究PⅢ的结构、功能和遗传,并发现PⅢ与肠道菌OmpA蛋白、绿脓杆菌有同源序列。利用OmpA蛋白模型,从同源起始点推测PⅢ分子结构,发现23～70之间的残基暴露于淋球菌表面,其余则位于原生质... 详细信息

本文用纯化和基因克隆产生的淋球菌蛋白Ⅲ(PⅢ),研究PⅢ的结构、功能和遗传,并发现PⅢ与肠道菌OmpA蛋白、绿脓杆菌有同源序列。利用OmpA蛋白模型,从同源起始点推测PⅢ分子结构,发现23～70之间的残基暴露于淋球菌表面,其余则位于原生质周。兔抗PⅢ血清亦证实PⅢ位于该菌表面,约70%的抗血清可被完整细菌吸收。有关PⅢ分子在细菌致病或生理学中的作用尚不清楚。

关键词：淋球菌蛋白Ⅲ 结构功能遗传

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QX-314抑制细菌穿孔毒素和神经元TRPV1介导的金黄色葡萄球菌引发的疼痛

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中国疼痛医学杂志 2019年第3期25卷 163-166页

作者： blake KJ Baral P Voisin T 贾欣同济大学医学院附属第一康复医院

许多细菌感染的特征是疼痛,但活性病原菌入侵机体时产生疼痛的潜在机制目前还不清楚。本研究阐明了耐甲氧西林金黄色葡萄球菌(MRSA)感染过程中产生疼痛的关键分子机制。研究发现自发性疼痛依赖于细菌毒性决定因子agr和细菌穿孔毒素PFTs... 详细信息

许多细菌感染的特征是疼痛,但活性病原菌入侵机体时产生疼痛的潜在机制目前还不清楚。本研究阐明了耐甲氧西林金黄色葡萄球菌(MRSA)感染过程中产生疼痛的关键分子机制。研究发现自发性疼痛依赖于细菌毒性决定因子agr和细菌穿孔毒素PFTs。MRSA的三种PFTs:alpha-溶血素(Hla)、酚溶性调质(PSMs)和双组份白介素(HlgAB),可直接引发神经元放电并产生自发性疼痛。背根神经节神经元的阳离子通道TRPV1特异性介导MRSA所致的热痛敏。在MRSA作用下神经元形成的穿孔允许QX-314进入伤害性感受器,从而在感染期间缓解疼痛。QX-314在MRSA感染时可以即刻并且长时程阻断疼痛,其镇痛效果明显优于临床广泛应用的利多卡因和布洛芬两种镇痛药。

关键词：细菌感染分子机制热痛敏机械痛敏感染过程神经元 QX-314 TRPV1 自发痛金黄色葡萄球菌伤害性感受器穿孔毒素

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Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer

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Genes & Diseases 2022年第2期9卷 347-357页

作者： Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022PR China Department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhanHubei 430071PR China Hubei Cancer Clinical Study Center Zhongnan HospitalWuhan UniversityWuhanHubei 430071PR China Department of Orthopaedic Surgery Johns Hopkins UniversityBaltimoreMD 21205USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine Department of Clinical BiochemistrySchool of Laboratory MedicineChongqing Medical UniversityChongqing 400016PR China Departments of Nephrology and Obstetrics and GynecologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016PR China Department of Spine Surgery Second Xiangya HospitalCentral South UniversityChangshaHunan 410011PR China Department of Surgery The University of Chicago Medical CenterChicagoIL 60637USA

The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and *** drugs act by interfering with tumor growth and inducing the death of cancer ***-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy ***,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer *** is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer *** is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox *** review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment.

关键词： Cancer Cancer therapy Clinical application Ferroptosis Lipid peroxidation Pathogenesis

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英国铁路的机车车辆维修及制造的新战略

国外机车车辆工艺 1990年第5期 1-7+58页

作者： D.C. blake 王滨盐

两年多以前,英国铁路管理局机械及电气工程处主任在英国铁路内部介绍了全面调研机车车辆维修政策的结果。这一新维修政策的成功,在于降低了维修成本,提高了利用率,具有十分重要的意义。本文介绍了这一政策及其成就。

关键词：机车车辆维修制造政策

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香蕉穿孔线虫及其防治

植物检疫 1989年第5期3卷 371-376页

作者： C.D.blake 高殷平

Cobb 在1915年首次报道,他观察到香蕉穿孔线虫 Radopholus similis 是斐济自1890年以来引起大蕉 Musa sapientum 根广泛坏死的原因。不久之后。

关键词：香蕉香蕉穿孔线虫线虫防治

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Ethambutol Induced Optic Neuritis Associated with Tenofovir Nephrotoxicity

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World Journal of AIDS 2012年第2期2卷 43-47页

作者： Sonia Vibhakar Diana Yu Romina Kee blake Max Children’s Mercy Hospitals and Clinics Kansas City USA Collaborative Research Unit (CRU) Department of Medicine Cook County Health and Hospitals Sys- tem Chicago USA The Ruth M. Rothstein CORE Center Cook County Health and Hospitals System Chicago USA The Ruth M. Rothstein CORE Center Cook County Health and Hospitals System Chicago USA University of Illinois at Chicago College of Pharmacy Chicago USA

Morbidity and mortality associated with human immunodeficiency virus (HIV) has decreased with highly active anti-retroviral therapy (HAART). Tenofovir is a nucleotide reverse transcriptase inhibitor (NRTI) that is preferred by the Department of Health and Human Services (DHHS) HIV treatment guidelines and is widely used for the initial treatment of HIV. Although tenofovir is generally well-tolerated, it has been associated with rare cases of acute nephrotoxicity. HIV-infected patients frequently have co-morbidities that require treatment, thus adding another level of complexity due to drug interactions and medication adverse effects with antiretrovirals. We present a patient who suffered an acute deterioration in renal function from tenofovir, leading to an accumulation of co-administered ethambutol, thus resulting in optic neuritis.

关键词： Tenofovir Nephrotoxicity Ethambutol Optic Neuritis Human Immunodeficiency Virus (HIV)