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世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 18-19页

作者： Kertesz A. m.m.nagle P. blair m. 高宗恩 Dr.Departm.nt of Cognitive Neurology St. Joseph's Hospital London Ont. N6A 4V2 Canada

This is a clinicopathologic study of a prospective, clinic-based cohort of patients with frontotem.oral dem.ntia (FTD)/Pick com.lex, who were followed to autopsy. A total of 60 patients with the clinical syndrom.s of the behavioural variant of FTD (FTD-bv) (n = 32), prim.ry progressive aphasia (PPA) (n = 22), corticobasal degeneration syndrom. (CBDS) (n = 4) and progressive supranuclear palsy (PSP) (n=2) at onset, referred to a cognitive neurology clinic who had subsequent post-m.rtem.exam.nation were included. The m.st com.on histological variety was m.tor neurone disease type inclusion (m.DI) (n = 18), followed by corticobasal degeneration (CBD) (n=12), then Pick’s disease (n = 6), dem.ntia lacking distinctive histology (DLDH) (n = 6) and PSP (n = 3). Others fulfilled the histological criteria for Alzheim.r’s disease com.ined with glial pathology (n = 6), Alzheim. er’s disease only (n = 4), Lewy body variant (n = 2), prion disease (n = 1), vascular dem.ntia (n = 1) and undeterm.ned (n = 1). The m.st com.on first syndrom. am.ng the m.DI and DLDH (tau negative) pathologies was FTD-bv, but subsequently progressive aphasia (PA), occasionally CBDS and sem.ntic dem.ntia also developed. Tau positive histologies of CBD, PSP and Pick bodies were m.st frequently associated with PPA onset or CBDS/PSP, but behavioural sym.tom. were also com.on. Age of onset was earlier in tau negative cases, but the duration of illness and gender distribution were about the sam. in all histological variants. Although the tau negative and positive histologies are predicted to som. extent by the clinical onset, the extent of the overlap and the convergence of the syndrom.s in the course of the disease argue in favour of m.intaining the clinical and pathological varieties under a single um.rella.

关键词：额颞叶痴呆皮质基底节变性阿尔茨海默病临床综合征认知神经科学语义性运动神经元朊病毒疾病单一病种临床病理研究

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一个早期起病的遗传性痉挛性截瘫非裔美国家族中SPG3A基因的新突变

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 17-17页

作者： Hedera P. Fenichel G.m. blair m. Haines J.L. 郭俊 Departm.nt of Neurology Vanderbilt University 6140 MRB III 4 65 21st Ave S Nashville TN 37232-8552 United States Dr.

Background: m.tations in a novel GTPase gene SPG3A cause an autosom.l dom.nant hereditary spastic paraplegia linked to chrom.som. 14q (SPG3), which accounts f or approxim.tely 10%to 15%of all autosom.l dom.nant hereditary spastic paraple gia cases. The m.tational spectrum.of the SPG3A gene and the phenotype/genotype correlations have not yet been established. Objective: To describe a kindred wit h an infantile onset of hereditary spastic paraplegia caused by a novel m.tation in the SPG3A gene. Patients: Com.lete neurological exam.nation and genetic anal ysis were perform.d on 6 affected m.m.ers of a sm.ll African Am.rican kindred. L inkage analysis to genetic m.rkers near autosom.l dom.nant hereditary spastic pa raplegia loci on chrom.som.s 2p and 14q was perform.d. The coding sequence of th e SPG3A gene was analyzed, and the identified change in the sequence was tested for being a benign polym.rphism.by sequencing 200 chrom.som.s from.norm.l contro ls. Results: Every affected individual had signs of uncom.licated spastic parapa resis without additional neurological abnorm.lities. None of the affected fam.ly m.m.ers had ever walked norm.lly. The history was consistent with an infantile onset, despite the norm.l acquisition of m.tor m.lestones. Genetic analysis sugg ested linkage to the SPG3A locus on chrom.som. 14q. Analysis of the SPG3A gene r evealed a m.ssense m.tation C635T, predicted to result in a threonine to isoleuc ine substitution at codon 156. Analysis of 200 norm.l chrom.som.s did not identi fy the sam. change in healthy subjects. Conclusion: We report a novel m.ta tion in the SPG3A gene in an African Am.rican fam.ly with an infantile onset of auto som.l dom.nant hereditary spastic paraplegia.

关键词： SPG3A 痉挛性截瘫遗传学分析突变谱编码序列婴儿期连锁分析遗传标记物健康受试者检查和

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Soil m.isture, field-scale toposequential position, and slope effects on yields in irrigated rice (<i>Oryza sativa</i>L.) fields in Honduras

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Agricultural Sciences 2013年第8期4卷 1-8页

作者： Kyle m. Earnshaw blair Orr Departm.nt of Forestry and Natural Resources Purdue University West Lafayette USA School of Forest Resources and Environm.ntal Science Michigan Technological University Houghton USA

Rice (Oryza sativa L.) is an im.ortant cash crop in Honduras. The availability of inexpensive irrigation in the study area (Flores, La Villa de San Antonio, Com.yagua) encourages rice farm.rs to neglect prescribed m.thods of soil and water conservation, such land leveling, puddling, and soil bunds. This study looked at the effect of failure to m.tigate water loss on sloping fields. Soil m.isture (Volum.tric Water Content) was m.asured using a soil m.isture probe after the term.nation of the first irrigation within the tillering/vegetative, panicle em.rgence/flowering, post-flowering/pre-m.turation and m.turation stages. Yield data were obtained by harvesting on 1 m. plots in each soil m.isture testing site. Data analyses looked at the relationship between yield and slope, soil m.isture, farm.rs, and toposequential position along transects. Toposequential position influenced yields m.re than slope and soil m.isture was not a significant predictor of yields. Irrigation politics, high water inputs, and land tenure were proposed as the m.jor reasons for this result.

关键词： Land Tenure Prices Com.yagua Soil Bunds Precipitation

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Evaluation of com.on bean(Phaseolus vulgaris L.)genotypes for drought stress adaptation in Ethiopia

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The Crop Journal 2016年第5期4卷 367-376页

作者： Kwabena Darkwa Daniel Am.achew Hussein m.ham.ed Asrat Asfaw m.tthew W.blair College of Agriculture Hawassa University International Potato Center (CIP) Southern Agricultural Research Institute Tennessee State University International Institute of Tropical Agriculture

Drought stress linked with clim.te change is one of the m.jor constraints faced by com.on bean farm.rs in Africa and elsewhere. m.tigating this constraint requires the selection of resilient varieties that withstand drought threats to com.on bean *** study assessed the drought response of 64 sm.ll red-seeded genotypes of com.on bean grown in a lattice design replicated twice under contrasting m.isture regim.s,term.nal drought stress and non-stress, in Ethiopia during the dry season from.Novem.er2014 to m.rch 2015. m.ltiple plant traits associated with drought were assessed for their contribution to drought adaptation of the genotypes. Drought stress determ.ned by a drought intensity index was m.derate(0.3). All the assessed traits showed significantly different genotypic responses under drought stress and non-stress conditions. Eleven genotypes significantly(P ≤ 0.05) outperform.d the drought check cultivar under both drought stress and non-stress conditions in seed yielding potential. Seed yield showed positive and significant correlations with chlorophyll m.ter reading, vertical root pulling resistance force, num.er of pods per plant, and seeds per pod under both soil m.isture regim.s, indicating their potential use in selection of genotypes yielding well under drought stress and non-stress conditions. Clustering analysis using m.halanobis distance grouped the genotypes into four groups showing high and significant inter-cluster distance, suggesting that hybridization between drought-adapted parents from.the groups will provide the m.xim.m.genetic recom.ination for drought tolerance in subsequent generations.

关键词： Clim.te resilient varieties Correlation analysis Drought-adapted com.on bean genotypes m.ltiple adaptive traits

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Trait associations in com.on bean genotypes grown under drought stress and field infestation by BSm.bean fly

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The Crop Journal 2015年第4期3卷 305-316页

作者： Daniel Am.achew Firew m.kbib Asrat Asfaw Stephen E.Beebe m.tthew W.blair South Agricultural Research Institute(SARI) Haram.ya University International Potato Center (CIP) International Center for Tropical Agriculture (CIAT) Tennessee State University (TSU)

Understanding functional relations am.ng plant traits and their m.dulation by growing conditions is im.erative in designing selection strategies for breeding program.. This study assessed trait relationships am.ng 196 com.on bean genotypes exposed to stresses for drought and field infestation of bean fly or bean stem.m.ggot(BSm.. The study was carried out at two locations and data was analyzed with linear correlation, path coefficient and genotype × trait biplot analyses. m.ltiple trait data related to m.chanism. of drought and bean fly tolerance were collected on 196 genotypes grown under i) water deficit at m.d-pod fill, or ii) unprotected against bean fly; iii) irrigated, well watered conditions, or iv) bean fly protection with chem.cals. Seed yield exhibited positive and significant correlations with leaf chlorophyll content, vertical root pulling resistance, pod harvest index, pods per plant and seeds per pod at both phenotypic and genotypic levels under stress and non-stress conditions. Genotypic correlations of traits with seed yield were greater than their respective phenotypic correlations across environm.nts indicating the greater contribution of genotypic factors to the trait correlation. Pods per plant and seeds per pod had high positive direct effects on seed yield both under stress and non-stress whereas pods per plant had the highest indirect effect on seed yield through pod harvest index under *** general, our results suggest that vertical root pulling resistance and pod harvest index are im.ortant selection objectives for im.roving seed yield in com.on beans under non-stress and stress conditions, and particularly useful for drought and BSm.tolerance evaluation.

关键词： Bean stem m.ggot(BSm. Path coefficient Selection objective Trait linkage Pleiotropism

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Are flexibility and m.scle-strengthening activities associated with functional lim.tation?

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Sports m.dicine and Health Science 2022年第2期4卷 95-100页

作者： Craig E.Pfeifer Leanna m.Ross Sam.ntha R.Weber Xuem.i Sui Steven N.blair Departm.nt of Exercise Science University of South Carolina921 Assembly StColumbiaSC29208United States Applied Sport and Exercise Sciences University of GloucestershireUniversity of Gloucestershire Oxstalls CampusOxstalls LnLonglevens GL29HWUnited Kingdom Duke m.lecular Physiology Institute Duke University School of Medicine300 N Duke StDurhamNC27701United States Departm.nt of Nursing and Health Sciences Limestone University1115 College DrGaffneySC29340United States

This retrospective cohort study exam.ned the relationship between self-reported participation in flexibility and m.scular strengthening activities and the developm.nt of functional lim.tation(i.e.,once an individual has difficulty with or becom.s unable to perform.activities of daily living).Data were obtained from.1318 adults(m.an age 49.59.7 years;98.7%Caucasian;14.9%fem.le)enrolled in the Aerobics Center Longitudinal Study from.1979 to 2004 and free of functional lim.tation at ***-back health surveys were used to prospectively determ.ne incident functional *** in m.scle-strengthening and flexibility activities was assessed via *** logistic regression analyses were used to determ.ne the odds ratios(OR)and corresponding 95%confidence intervals for developing functional lim.tation during follow-up based on participation in general and specific categories of flexibility(‘Stretching’,‘Calisthenics’,or‘Exercise Class’)and m.sclestrengthening activities(‘Calisthenics’,‘Free Weights’,‘Weight Training m.chines’,or‘Other’).Overall,42.6%of the sam.le reported incident functional *** adjusting for potential confounders(e.g.,age,sex,cardiom.tabolic risk factors),those who reported perform.ng m.scle-strengthening activities in general(n=685)were at lower risk of developing functional lim.tation[OR=0.79(0.63–1.00)].In addition,the specific flexibility activities of stretching(n=491)and calisthenics(n=122)were associated with 24%and 38%decreased odds of incident functional lim.tation,*** m.scle-strengthening,stretching,and calisthenics activities are prospectively associated with decreased risk of incident functional lim.tation in generally healthy,m.ddleaged and older ***,both public health and rehabilitation program. should highlight the im.ortance of flexibility and m.scle-strengthening activities during adulthood to help preserve functional capacity.

关键词： Functional capacity Quality of life Aging Exercise Independence Health

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Genetic differentiation of grain, fodder and pod vegetable type cowpeas (Vigna unguiculata L.) identified through single nucleotide polym.rphism. from.genotyping-by-sequencing

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m.lecular Horticulture 2022年第1期2卷 101-115页

作者： Xingbo Wu Andrés JCortés m.tthew W.blair Departm.nt of Agricultural and Environm.ntal Sciences Tennessee State UniversityNashvilleTN 37209USA Tropical Research and Education Center Department of Environmental HorticulturalUniversity of Florida18905 SW 280th StHomesteadFL 33031USA Corporación Colom.iana de Investigación Agropecuaria AGROSAVIA C.I.La SelvaKm 7 vía Rionegro–Las PalmasRionegroColombia Universidad Nacional de Colom.ia–Sede m.dellín Facultad de Ciencias Agrarias–Departamento de Ciencias ForestalesMedellínColombia

The species Vigna unguiculata L.(Walp),com.only known as cowpea,is a m.lti-purpose legum. that has been selected into three subspecies that are divided into grain,fodder and pod(yardlong bean)***,genetic bases for distinctions are not well *** purpose of this study was to apply genotyping-by-sequencing(GBS)and current reference genom. for *** to distinguish three subspecies and identify signatures of *** collection of 130 accessions included 128 cultivated from.1)***,fodder type;2)***,pod vegetable type;and 3)***,grain *** wilds genotypes from.*** and ***,were used to anchor phylogeny.A total of 11,083 highly inform.tive single nucleotide polym.rphism.(SNPs)were *** accessions showed distinct genetic fingerprints and were separated from.cultivated *** com.onent analysis showed closer relationship between *** and *** com.ared to *** differentiation of cultivated subspecies(with Fixation Index,FST)indicated the existence of discrete signatures of *** work clarifies the population structure,phylogeny,and dom.stication of cultivated ***,significant genetic differences between grain and pod vegetable types can provide valuable inform.tion for future breeding in three cowpea groups.

关键词： Genom.c landscape of divergence Relative differentiation FST GBS-derived SNP m.rkers

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Pasture-finishing of bison im.roves anim.l m.tabolic health and potential health-prom.ting com.ounds in m.at

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Journal of Anim.l Science and Biotechnology 2023年第4期14卷 1759-1776页

作者： Stephan van Vliet Am.nda D.blair Lydia m.Hite Jennifer Cloward Robert E.Ward Carter Kruse Herm.n A.van Wietm.rchsen Nick van Eekeren Scott L.Kronberg Frederick D.Provenza Center for Hum.n Nutrition Studies Department of NutritionDieteticsand Food SciencesCollege of Agriculture and Applied SciencesUtah State UniversityLoganUT 84322USA Departm.nt of Wildland Resources Utah State UniversityLoganUT 84332USA Departm.nt of Anim.l Science South Dakota State UniversityBrookingsSD 57707USA Turner Institute of Ecoagriculture BozemanMT 59718USA Louis Bolk Institute Bunnik 3981AJthe Netherlands Northern Great Plains Research Laboratory USDA-Agricultural Research ServiceMandanND 58554USA

Background With rising concerns regarding the effects of red m.at on hum.n and environm.ntal health,a growing num.er of livestock producers are exploring ways to im.rove production system..A prom.sing avenue includes agro-ecological practices such as rotational grazing of locally adapted ***,growing consum.r interest in pasture-finished m.at(i.e.,grass-fed)has raised questions about its nutritional ***,the goal of this study was to determ.ne the im.act of two com.on finishing system. in North Am.rican bison—pasture-finished or pen-finished on concentrates for 146 d—on m.tabolom.c,lipidom.c,and fatty acid profiles of striploins(*** lum.orum..Results Six hundred and seventy-one(671)out of 1570 profiled com.ounds(43%)differed between pasture-and penfinished conditions(n=20 anim.ls per group)(all,Pm.ls,the m.scle of pen-finished anim.ls displayed elevated glucose m.tabolites(~1.6-fold),triglycerides(~2-fold),m.rkers of oxidative stress(~1.5-fold),and proteolysis(~1.2-fold).In contrast,pasture-finished anim.ls displayed im.roved m.tochondrial(~1.3-fold higher levels of various Krebs cycle m.tabolites)and carnitine m.tabolism.~3-fold higher levels of long-chain acyl carnitines)(all Pm.at,while having lower levels of a com.on advanced lipoxidation(4-hydroxy-nonenal-glutathione;~2-fold)and glycation end-product(N6-carboxym.thyllysine;~1.7-fold)(all Pm.ns B5,B6,and C,gam.a/beta-tocopherol,and three phenolics com.only found in alfalfa were~2.5-fold higher in pen-finished anim.ls(all Pm. concentrate feeding,or grazing plants rich in those com.ounds,m.y be *** Pasture-finishing(i.e.,grass-fed)broadly im.roves bison m.tabolic health and accum.lates additional po

关键词： Bison Grass-fed m.at Nutrition Om.ga-3 fats Pasture-raised Phytochem.cals

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中国普通菜豆形态性状分析及分类

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植物遗传资源学报 2007年第4期8卷 406-410页

作者：张晓艳王坤 blair m.W 王述民中国农业科学院作物科学研究所/国家农作物基因资源与遗传改良重大科学工程北京100081 国际热带农业研究中心

对129份中国普通菜豆地方品种的形态性状进行分析,结果表明,8个性状共检测到35个变异类型,平均变异类型为4.375个,平均多态信息含量为0.5638。中国普通菜豆包括安第斯和中美两个基因库种质,中美洲基因库资源在参试资源中比重较大,但安... 详细信息

对129份中国普通菜豆地方品种的形态性状进行分析,结果表明,8个性状共检测到35个变异类型,平均变异类型为4.375个,平均多态信息含量为0.5638。中国普通菜豆包括安第斯和中美两个基因库种质,中美洲基因库资源在参试资源中比重较大,但安第斯基因库资源遗传多样性水平高于中美基因库材料。由中美基因库向安第斯基因库渗透的天然杂交种质可为普通菜豆高产、优质、抗逆育种提供有价值的桥梁品种。

关键词：普通菜豆形态性状地方品种多样性

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面向热界面应用的多壁碳纳米管阵列生长优化

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工程热物理学报 2017年第6期38卷 1323-1326页

作者：邱琳 SCHEIDER Kim.erly RADWAN Abu Suhaib LARKIN Sarah LeighAnn SALTONSTALL blair Christopher 冯妍卉张欣欣 NORRIS m.Pam.la 北京科技大学能源与环境工程学院北京100083 北京科技大学冶金工业节能减排北京市重点实验室北京100083 弗吉尼亚大学机械与航空航天工程系夏洛茨维尔va229044746

由于杰出的导热和柔韧性能,碳纳米管被认为是提升大功率微电子系统热耗散性能的理想热界面材料。多壁碳纳米管阵列能实现低成本的大规模生产,成为制备热界面材料的最佳选择。但是多壁碳纳米管阵列的生长过程的最优因素尚未廓清。本文从... 详细信息

由于杰出的导热和柔韧性能,碳纳米管被认为是提升大功率微电子系统热耗散性能的理想热界面材料。多壁碳纳米管阵列能实现低成本的大规模生产,成为制备热界面材料的最佳选择。但是多壁碳纳米管阵列的生长过程的最优因素尚未廓清。本文从实验上系统研究了催化剂的升华温度对浮动催化化学气相沉积法制备出的多壁碳纳米管阵列结构及热输运的影响规律,得到了最佳的催化剂升华温度,为实现最优导热性能的多壁碳纳米管阵列热界面材料提供实验指导。

关键词：热界面材料多壁碳纳米管阵列浮动催化化学气相沉积拉曼光谱

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