检索结果-南通市图书馆

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, a.d.Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja a.d.ew Reisner Laura blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy department of Surgery Morehouse School of MedicineAtlantaGAUSA department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA department of Neurological Surgery a.d.the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA department of Pediatrics Emory UniversityAtlantaGAUSA department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA department of Chemistry a.d.Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, a.d.Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding a.d.subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, a.d.Alzheimer's disease a.d.can lead to downstream neuroinflammatory processes, including assembly a.d.activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death a.d.inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOd-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOd-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation a.d.spreading. This review begins by describing the epidemiology a.d.pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, a.d.Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme a.d.discuss the role of the NOd-like receptor protein 3 inflammasome in the formation of tau deposits a.d.how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, a.d.Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway a.d.ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Numerical estimate of multi-species ion sound speed of Langmuir probe interpretations in the edge plasmas of Wendelstein 7-X

在线全文

学校读者我要写书评

暂无评论

Plasma Science a.d.Technology 2020年第8期22卷 63-70页

作者： J COSFELd P dREWS B blackwell M JAKUBOWSKI H NIEMANN d ZHANG Y FENG the Wendelstein-X Team Forschungszentrum Jülich GmbH Institut für Energie-und Klimaforschung-PlasmaphysikPartner of the Trilateral Euregio Cluster(TEC)52425 JülichGermany JARA-HPC Jülich Supercomputing CentreForschungszentrum Jülich GmbH52425 JülichGermany Australian National University Acton ACT2601 CanberraAustralia Max-Plank-Insitut für Plasmaphysik 17491 Greifswald/85748 GarchingGermany

The recently modified EMC3-EIRENE code package has been widely applied as an edge-plasma analysis tool a.d.resulted in successful validation against various measured trends seen in stellarator a.d.tokamak plasma *** has been shown that the code package applied for Wendelstein 7-X(W7-X)discharges in the interpretive mode can assess the impact of impurity effects on the electron density,measured by a set of Langmuir *** particular the spatial quantification of impurities a.d.effects from the effective charge state Zeff a.d.effective mass meff,which are non-trivial to record by diagnostics,were *** results showed that earlier assumptions of the effective charge-state distribution a.d.effective mass for reported Langmuir probe measurements must be ***,reprocessing these measurements with code-interpreted spatial profiles of the effective charge state a.d.effective mass led to an overall improved physical consistency.

关键词： Wendelstein 7-X plasma-wall interaction numerical-diagnostics EMC3-EIRENE

在线全文

学校读者我要写书评

暂无评论

斥水土壤中水热运动模型的应用

土壤学报 1997年第4期34卷 427-433页

作者：杨邦杰 P.S.blackwell d.F.Mcholson 中国科学院生态环境研究中心西澳大利亚农业部

作者运用所建立的斥水土壤中水热运动的数值模型，模拟分析了以下因素对沟种时苗床水分散失与温度的影响：（1）不同的沟垄尺寸；（2）湿润剂；（3）镇压；（4）沟垄的走向。以此为当地的耕种工程设计提供了依据。一般认为土壤斥水性严... 详细信息

作者运用所建立的斥水土壤中水热运动的数值模型，模拟分析了以下因素对沟种时苗床水分散失与温度的影响：（1）不同的沟垄尺寸；（2）湿润剂；（3）镇压；（4）沟垄的走向。以此为当地的耕种工程设计提供了依据。一般认为土壤斥水性严重影响产量，但采用沟种后，表层的斥水土壤形成的不透水的垄能促进雨水渗入沟中，又能阻止水分的蒸发，降低沟中的温度，有利于种子发育出苗，从而使不利因素变成有利条件。

关键词：斥水土壤数值模拟耕种

学了统计学可以有什么样的作为?──介绍统计学的特点和用处

在线全文

学校读者我要写书评

暂无评论

数理统计与管理 1987年第2期 20-22页

作者： d. blackwell ,戴中维 [美]

本文译自美国统计学家Ｄ．Ｂｌａｃｋ－ｗｅｌｌ等１６位教授集体编著的“ＣａｒｅｅｒｓｉｎＳｔａｔｉｓｔｉｃｓ”（９６６年版）一书．原书是为美国几十所大学统计系招收大学生和研究生而编写的，书写得通俗易懂引人入胜，比较... 详细信息

本文译自美国统计学家Ｄ．Ｂｌａｃｋ－ｗｅｌｌ等１６位教授集体编著的“ＣａｒｅｅｒｓｉｎＳｔａｔｉｓｔｉｃｓ”（９６６年版）一书．原书是为美国几十所大学统计系招收大学生和研究生而编写的，书写得通俗易懂引人入胜，比较全面地介绍了统计学的研究对象，研究方式与实用价值．统计学以概率论为指导，研究如何有效地收集和分析受随机性影响的数据，从而对实际问题提出正确的决策或合理的建议．为了适应我国 “四个现代化”建设的迫切需要，许多大学成立了概率统计专业，有些大学还成立了专门的系．这本小册子对我国担负行政管理工作的领导同志，各个专业的科学工作者以及广大青年学生了解统计学有很大的帮助．当然，书中介绍的某些情况不一定适合我国的国情．

关键词：统计学方法决策科学管理统计学家

EGR1 is essential for transcriptional regulation of BMPR2

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2011年第3期1卷 131-139页

作者： Radhika Ga.d.pati James d. West James E. Loyd Thomas blackwell Kirsten A. Lane Nicole M. Lane Kirk B. Lane 不详

In this study, RLM-RACE was used to identify the transcriptional start site 387 bp upstream of the translational start. Evolutionarily conserved transcription factor binding sites were identified, a.d.a series of luciferase reporter constructs driven by BMPR2 promoter elements used to determine their functional relevance. We found the promoter area from 983 bp to 90 bp upstream of the transcriptional start gave maximal activity, greater than longer constructs, with an area between 570 bp a.d.290 bp upstream of the transcriptional start containing an important repressor element. To characterize this repressor, we used a combination of EMSA, mutation of the EGR1 binding site, transfection with EGR1 a.d.NAB1 constructs, a.d.mutation of the NAB1 binding site within the EGR1 protein. From this we conclude that EGR1 is essential to BMPR2 transcription, but that NAB1 binding to EGR1 causes it to act as a repressor.

关键词： Transcription BMPR2 Regulation EGR1 NAB1 Pulmonary Hypertension

Perioperative outcomes a.d.survival of radical cystectomy as a function of body mass index

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Urology 2016年第1期5卷 53-59页

作者： Bethany K Burge Robert H blackwell a.d.ew Wilson Robert C Flanigan Gopal N Gupta Marcus L Quek department of Urology Loyola University Medical Center Stritch School of Medicine Loyola University

AIM: To evaluate the perioperative a.d.long term outcomes of cystectomy in obese ***: This is a retrospective review of 580 patients for whom radical cystectomy(RC) was performed for primary urothelial bla.d.r cancer between November 1996-April 2013 at a single institution. Body mass index(BMI) was available for 424 patients who were categorized as underweight(a.d.obese(≥ 30). Baseline demographics, perioperative outcomes, a.d.survival were assessed. Overall survival(OS) a.d.disease specific survival(dSS) was estimated by Kaplan-Meier method. Medians were compared using the Mann-Whitney U Test. Categorical variables were compared using the χ2 test. A P-value of dered statistically significant. Statistical analyses were performed using the Software Package for the Social Sciences(SPSS), Version 20(International Business Machines SPSS, Chicago, IL, United States). RESULTS: The median age of all patients was 69 years(inter-quartile range 60-75) a.d.median followup was 23.4 mo(8.7-55.1). Patients were characterized as underweight [9,(2.1%)], normal [113,(26.7%)],overweight [160,(37.8%)], or obese [142,(33.5%)]. Estimated blood loss during RC was higher in the obese group(800 m L) as compared to the normal weight group(500 m L). However, need for transfusion(47.7% vs 52.1%), number of lymph nodes resected(32 vs 30), length of stay(9 d vs 8 d), a.d.30-d readmission(29.7% vs 25.2%) between obese a.d.normal BMI patients were similar. Obese patients underwent ileal neobla.d.r diversion in 42% of cases, compared to 24% of normal BMI patients(0.003). Normal BMI a.d.obese patients had comparable urinary incontinence(21.4% vs 25.6%, P = 0.343), a.d.need for intermittent catheterization(14.3% vs 5.2%, P = 0.685) at 2 years follow-up. Overall survival was better in obese compared to normal BMI patients on univariate analysis, with median survival of 67 mo vs 37 mo, respectively(P = 0.031). disease spec

关键词： Urinary bla.d.r neoplasms Body mass index Obesity Cystectomy Underweight

Remote sensing a.d.analysis of tropical cyclones:Current a.d.emerging satellite sensors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tropical Cyclone Research a.d.Review 2023年第4期12卷 267-293页

作者： Lucrezia Riccia.d.lli Brian Howell Christopher R.Jackson Jeff Hawkins Joe Courtney Ad Stoffelen Sebastian Langlade Chris Fogarty Alexis Mouche William blackwell Thomas Meissner Julian Heming Brett Ca.d. Tony McNally Masahiro Kazumori Chinmay Khadke Maria Ana Glaiza Escullar Remote Sensing Systems Santa RosaCAUSA Joint Typhoon Warning Center Pearl HarborHawaiiUSA Global Ocean Associates(supporting NOAA/NESdIS STAR) AlexandriaVAUSA University of Wisconsin Cooperative Institute for Meteorological Satellite StudiesMadisonWIUSA Bureau of Meteorology PerthAustralia Royal Netherla.d. Meteorological Institute(KNMI) De BiltNetherlands Tropical Cyclone/Regional Specialized Meteorological Center Meteo FranceReunionFrance Canadian Hurricane Center(CHC) DartmouthNova ScotiaCanada University Brest CNRSIRDIfremerLaboratoire d’Oceanographie Physique et Spatiale(LOPS)IUEMBrestFrance MIT Lincoln Laboratory LexingtonMAUSA Met Office ExeterUK European Centre for Medium-Range Weather Forecasts ReadingUK Japan Meteorological Agency(JMA) TokyoJapan India Meteorological department(IMd) New DelhiIndia Philippine Atmospheric Geophysical and Astronomical Services Administration(PAGASA)Diliman Quezon CityPhilippines

This article describes recent advances in the capability of new satellite sensors for observing Tropical Cyclones(TC)fine structure,wind field,a.d.temporal *** article is based on a World Meteorological Organization(WMO)report prepared for the 10th International Workshop on Tropical Cyclones(IWTC),held in Bali in december 2022,a.d.its objective is to present updates in TC research a.d.operation every four *** we focus on updates rega.d.ng the most recent space-based TC observations,a.d.we cover new methodologies a.d.techniques using polar orbiting sensors,such as C-ba.d.synthetic aperture radars(SARs),L-ba.d.a.d.combined C/X-ba.d.radiometers,scatterometers,a.d.microwave imagers/*** a.d.tionally a.d.ess progress made with the new generation of geostationary a.d.small satellites,a.d.discuss future sensors planned to be launched in the next *** then briefly describe some examples on how the newest sensors are used in operations a.d.data assimilation for TC forecasting a.d.research,a.d.conclude the article with a.d.scussion on the remaining challenges of TC space-based observations a.d.possible ways to a.d.ess them in the near future.

关键词： Tropical cyclones Surface wind Satellite sensors Operations

Associations of accelerometry-measured a.d.self-reported physical activity a.d.sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility a.d.Aging(SOMMA)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport a.d.Health Science 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Terri L.blackwell Peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna.d.stefano Samaneh Farsijani daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne B.Newman Nancy W.Glynn department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA department of Epidemiology a.d.Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA department of Medicine(Geriatrics a.d.Ca.d.ology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA division of Endocrinology a.d.Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Skeletal muscle energetics decline with age,a.d.physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured a.d.self-reported PA a.d.sedentary behavior(SB)with skeletal muscle energetics a.d.explored the extent to which PA a.d.sedentary behavior would attenuate the associations of age with muscle ***:As part of the Study of Muscle,Mobility a.d.Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±Sd;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))a.d.in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,a.d.moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,a.d.all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior a.d.PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A a.d.sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count a.d.time spent in sedentary behavior a.d.their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS a.d.0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,a.d.sex(pd with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS a.d..

关键词： Aging Exercise Mitochondria

抗生素、细菌和抗生素耐药基因:从牲畜饲养场通过颗粒物的空气传播

在线全文

学校读者我要写书评

暂无评论

环境与职业医学 2015年第9期32卷 855-855页

作者： a.d.ew d.McEachran Brett R.blackwell J.delton Hanson Kimberly J.Wooten Gregory d.Mayer Stephen B.Cox Philip N.Smith

[背景]抗生素耐药性的出现与蔓延已成为全球性的人类健康威胁，它常常与滥用和误用临床和兽医的化学药物联系在一起。现代工业规模的动物饲养操作很大程度上依赖于兽医药物，包括抗生素，以促进动物的生长。由此产生的排泄物中的抗生素... 详细信息

[背景]抗生素耐药性的出现与蔓延已成为全球性的人类健康威胁，它常常与滥用和误用临床和兽医的化学药物联系在一起。现代工业规模的动物饲养操作很大程度上依赖于兽医药物，包括抗生素，以促进动物的生长。由此产生的排泄物中的抗生素通过径流、淋溶和土地中使用的粪肥而传递到环境中。然而，牲畜饲养场空气传播的特征目前尚未经研究。[目的]确定在何种程度上，抗生素、抗生素耐药基因（ARG）和反刍动物相关的微生物是通过大型肉牛饲养场的颗粒物（PM）在空气中扩散的。[方法]收集10个肉牛饲养场顺风和逆风向的PM。提取PM后，使用高效液相色谱一串联质谱法量化5种兽用抗生素，用靶向定量聚合酶链式反应量化ARG，并用16SrRNA基因扩增和测序分析微生物群落多样性。[结果]来源于牲畜饲养场的气载PM促进了几种兽用抗生素以及包含ARG的微生物群落的扩散。下风向紧邻饲养场的气载PM中几种抗生素的浓度范围在0．5～4．6mg／gPM。饲养场下风向收集的PM微生物群落中，与反刍动物相关的类群变得丰富，并且与上风向PM中的类别组合明显不同。此外，与上风向收集的PM相比，下风向收集的PM中的抗四环素类抗生素基因编码显着更为丰富。[结论]来自牲畜饲养场的经风扩散的PM包含了抗生素、细菌和ARGs。

关键词：抗生素耐药性动物饲养空气传播耐药基因颗粒物牲畜细菌定量聚合酶链式反应