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The Role of Dihydroresveratrol in Enhancing the Synergistic Effect of Ligilactobacillus salivarius Liol and Resveratrol in Ameliorating Colitis in Mice

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Research 2022年第4期2022卷 223-238页

作者： Yiqiu Fei Shuobo Zhang Shengyi Han Bo Qiu Yanmeng Lu Weixing Huang Fang Li Deying Chen bjorn berglund Hang Xiao Lanjuan Li Mingfei Yao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Afiliated HospitalZhejiang University School of MedicineHangzhou 310003China jinan Microecological Biomedicine Shandong Laboratory Jinan 250021China Zhejiang Tongchuang Yuecheng Health Science and Technology Co. Ltd.ShaoxingChina Cardiometabolic Genomics Program Division of CardiologyDepartment of MedicineColumbia University Irving Medical Center630W168thStPeS10-401NewYorkNY10032USA Department of Food Science University of MassachusettsAmherstMassachusetts 01003USA Department of Biomedical and Clinical Sciences Linkoping UniversityLinkopingSweden Zhejiang University Department of Food Science and NutritionZhejiang Key Laboratory for Agro-Food ProcessingFuli Institute of Food ScienceZhejiang R e D Center for Food Technology and EquipmentHangzhou 310058China

Currently approved therapeutical strategies for inflammatory bowel diseases(IBD)suffer from variable efficacy and association with risk of serious side effects.Therefore,efforts have been made in searching for alternative therapeutics strategies utilizing gut microbiota manipulation.In this study,we show that the probiotic strain Ligilactobacillus salivarius Li01(Li01)and the phytochemical prebiotic resveratrol(RSV)have synergistic effect in ameliorating colitis in mice.Oral coadministration of Li01(109 CFU/d)and RSV(1.5 g/kg/d)promoted restoration of various inflammatory injuries and gut microbiota composition,exhibiting a favorable anti-inflammatory effect in DSS-induced colitis mice.The combination treatment was associated with reductions in the levels of proinflammatory cytokines IL-1βand IL-6 and increases in the levels of the anti-inflammatory cytokine IL-17A in mouse serum.Moreover,the combination treatment was found to alter the composition and metabolism of the gut microbiota,especially influencing the production of short chain fatty acids and anti-inflammatory related molecules.The mechanism underlying the improved anti-inflammatory effect from the RSV and Li01 combination treatment was found to be associated with the environmental sensor mammalian aryl hydrocarbon receptor(AHR)and tryptophan metabolism pathway.Administration of RSV in combination with Li01 in different mouse model led to enhanced conversion of RSV into metabolites,including dihydroresveratrol(DHR),resveratrol-sulfate,and resveratrol-glucuronide.DHR was found to be the dominant metabolite of RSV in conventional and colitis mice.An increased DHR/RSV ratio was confirmed to activate AHR and contribute to an enhanced anti-inflammatory effect.DHR is considered as a potential AHR ligand.The DHR/RSV ratio also affected the serotonin pathway by controlling the expression of Tph1,SERT,and 5-HT7R leading to amelioration of colitis in mice.Our data suggest that treatment with a combination of Li01 and RSV has potential as a therapeutic strategy fo

关键词： metabolism injuries resveratrol

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降压治疗过程中血糖水平升高是心肌梗死的预测因素:以人群为基础的队列研究

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英国医学杂志中文版 2003年第4期6卷 254-254页

作者： Kristina Dunder Lars Lind bjorn Zethelius Lars berglund Hans Lithell 杜昕

研究目的:研究血糖水平升高对发生心肌梗死危险的影响,尤其是对服用降压药物的患者。设计:以人群为基础的前瞻性队列研究研究地点:瑞典乌普萨拉参与者:1860名男性,在1970～1973年间参加了一项旨在确定心血管疾病危险因素的健康调查。

关键词：降压治疗血糖心肌梗死心血管疾病

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