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Science China(Life Sciences) 2022年第2期65卷 448-450页

作者： Xiaolong Wang björn petersen Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712110China Institute of Farm Animal Genetics Friedrich-Loeffler-Institute(FLI)Mariensee 31535Germany

In recent years,various gene-edited crops and livestock have been developed to find rapid and unconventional solutions to boost agriculture,animal breeding,environmental sustain-ability,and animal *** the animal production field,significant gene-edited livestock with economic beneficial traits,like the MSTN-edited double muscles,can be com-mercialized on a large scale to benefit more people with real *** demand for animal proteins increases an-nually with improvement of living conditions in modern societies and developing ***,the number of people with special needs for healthier meat(with high-protein and low-fat)is growing(e.g.,elderly patients with cardio/cerebrovascular diseases).With steady global en-vironmental deterioration,increasing human population,growing food demand,continuous disease outbreaks,and concerns regarding animal welfare。

关键词： abundant crops breeding

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Time averaged consensus in a direct coupled coherent quantum observer network

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Control Theory and Technology 2017年第3期15卷 163-176页

作者： Ian R. petersen Research School of Engineering The Australian National University Canberra ACT 2601 Australia

This paper considers the problem of constructing a direct coupling quantum observer for a closed linear quantum system. The proposed distributed observer consists of a network of quantum harmonic oscillators and it is shown that the observer network converges to a consensus in a time averaged sense in which each element of the observer estimates the specified output of the quantum plant. An example and simulations are included to illustrate the properties of the observer network.

关键词： Quantum systems quantum observers quantum networks

FerryBox: Using Automated Water Measurement Systems to Monitor Water Quality: Perspectives for the Yangtze River and Three Gorges Dam

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Journal of Earth Science 2010年第6期21卷 861-869页

作者： Carsten Frank Friedhelm Schroeder Wilhelm petersen Helmholtz-Zentrum Geesthacht GmbH Institute for Coastal Research

The building of the Three Gorges Dam （Hubei （湖北） Province, China） has transformed a region with an economy based on sustainable agriculture for millennia into an entirely different environment within an exceptionally short time. This disrupts the natural biogeochemieal cycles of carbon, nutrients, and metals and possibly will affect the whole catchment including downstream ecosystems, such as wetlands, estuaries, deltas, and adjacent sea areas. Starting from changes that have already been documented, this article concentrates on the possible use of a ＂FerryBox＂, which is an automated water quality measurement system on board a ship or on shore, to monitor the short and long term development of the quality of the river water in the backwater area and downstream of the dam. While there are already research programmes running to monitor the water quality of the river and the backwater area, these programs are limited to ship campaigns with sampling and laboratory analysis. The spatial and temporal resolution of such measurements is not sufficient for an overall assessment of the water quality and for prognoses in the context of anthropogenic and climate change. Therefore, a concept of applying regular automated observations by a FerryBox is presented. It is shown that such systems are very well suited to give feedback for the assessment of measures to improve the water quality.

关键词： Three Gorges Dam Yangtze River eutrophication FerryBox.

Utilizing melt crystallization fundamentals in the development of a new tabletting technology

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Frontiers of Chemical Science and Engineering 2014年第3期8卷 346-352页

作者： Ahmed ABOUZEID Sandra petersen Joachim ULRICH Martin Luther University Halle-Wittenberg Center for Engineering Science Thermal Process Engineering D-06099 Halle Germany

Increasing production effeciency and lowering costs are some of the many advantages melt crystallization technology offers over the conventional methodology of tabletting. A normal tablet consists of a pure shell or a coat and a separate core constituting the pharmaceutical active ingredient. Great emphasis is put on the purity of the shell since its purpose is to solely protect and deliver the active ingredient to its target. Melt crystallization is a purification （separation） process. It is discussed here for its ability to produce coated tablets, by separating the ＂coating＂ material from the ＂to be coated＂ material coming from one molten mixture. Molten drops of lutrol-ibuprofen mixture are produced using the drop forming technique. The subsequent analysis involves proving and quantifying the phase separation （coat purity）. The mechanism of a crystallizing drop is shown as direct evidence of the ongoing process. Moreover, solidified tablet batches are analyzed for the purity of their coating by measuring the ibuprofen concentration. This optimization process is carried out through multiple stages of development and condition enhancements in order to produce the most pure tablet coating. As a result, a trial showing an almost purely coated tablet is presented here.

关键词： phase separation melt crystallization tablets,process optimization

Importance of emulsions in crystallization --applications for fat crystallization

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 43-48页

作者： Sandra petersen K. CHALEEPA Joachim ULRICH Center for Engineering Science Thermal Process Engineering Martin Luther University Halle-Wittenberg D-06099 Halle (Saale) Germany

Emulsions and crystallization are two independent research topics which normally do not overlap although a combination of the two could be applicable to many areas. Here, the importance of emulsions in the field of fat crystallization is described. Three applications with industrial relevance were chosen for investigation： fat fractionation, the solidification of phase change materials and solid lipid nanoparticles. For fat fractionation and phase change materials, emulsification can be applied as a tool to improve the fat crystallization process, and thus the product quality of the crystallized fat. Furthermore, the use of emulsification creates new solid lipid nanoparticles in the application fields such as area of fat crystallization.

关键词： emulsion fat crystallization phase change material emulsion ffactionation emulsion solidification

Generation of diverse neural cell types through direct conversion

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World Journal of Stem Cells 2016年第2期8卷 32-46页

作者： Gayle F petersen Padraig M Strappe School of Biomedical Sciences Charles Sturt University

A characteristic of neurological disorders is the loss of critical populations of cells that the body is unable to replace,thus there has been much interest in identifying methods of generating clinically relevant numbers of cells to replace those that have been damaged or *** process of neural direct conversion,in which cells of one lineage are converted into cells of a neural lineage without first inducing pluripotency,shows great potential,with evidence of the generation of a range of functional neural cell types both in vitro and in vivo,through viral and non-viral delivery of exogenous factors,as well as chemical induction *** neural cells have been proposed as an attractive alternative to neural cells derived from embryonic or induced pluripotent stem cells,with prospective roles in the investigation of neurological disorders,including neurodegenerative disease modelling,drug screening,and cellular replacement for regenerative medicine applications,however further investigations into improving the efficacy and safety of these methods need to be performed before neural direct conversion becomes a clinically viable *** this review,we describe the generation of diverse neural cell types via direct conversion of somatic cells,with comparison against stem cell-based approaches,as well as discussion of their potential research and clinical applications.

关键词： Adult stem cells Embryonic stem cells Generation of neural cells Induced pluripotent stem cells In vitro differentiation In vivo differentiation Clinical applications Direct conversion Induced neural cells

Jure Piskur (1960—2014)

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Journal of Genetics and Genomics 2015年第5期42卷 275-277页

作者： Birgitte Munch-petersen Zoran Gojkovic Wolfgang Knecht Department of Science Systems and Models Roskilde University The Department of Applied Yeast Research Carlsberg Laboratory Department of Biology Molecular Cell Biology & Lund Protein Production Platform Lund University

Following a short struggle against an aggressive cancer, Prof. Jure Piskur （Fig. 1 ）, a professor of molecular genetics at Lund University （LU）, Sweden, and the University of Nova Gorica （UNG）, Slovenia, died in his home in Lund on 18 May 2014. He leaves behind his lifelong partner and wife, Judita Gartner, and their sons, Jan and Jure.

关键词： Jure Piskur ICAP

Role of simple biomarkers in predicting fibrosis progression in HCV infection

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World Journal of Gastroenterology 2010年第45期16卷 5710-5715页

作者： Rajasekhara R Mummadi John R petersen Ned Snyder Division of Gastroenterology and Hepatology Department of Internal MedicineUniversity of Texas Medical BranchHoustonTX 77025United States Department of Pathology University of Texas Medical BranchHoustonTX 77025United States Department of Gastroenterology and Hepatology Kelsey Seybold Clinic2727 W. HolcombeHoustonTX 77025United States

AIM: To examine the accuracy of the aspartate aminotransferase (AST)/Platelet Ratio Index (APRI) and FIB-4, in predicting longitudinal changes in liver histology in hepatitis C virus (HCV) ***: Patients that underwent repeat liver biopsies at least 1 year apart from 1999 to 2007 were identified. Liver fibrosis was staged on needle core biopsies evaluated by a single expert liver pathologist. Only laboratory values within 3 mo of the liver biopsies were ***: Thirty-six patients met the inclusion criteria with 50% stage 1 on initial biopsy, 25% stage 2, and 22% stage 3. Nineteen of 36 (53%) had progression of fibrosis on repeat biopsies, while 16 (44%) showed no change in stage, and one (3%) showed improvement. Patients that showed progression of fibrosis had significantly higher alanine aminotransferase and aspartate aminotransferase levels than the group that did not show progression. A significant correlation was seen between change in stage of fibrosis and change in APRI (r2 = 0.39, P = 0.00001) and a change in FIB-4 (r2 = 0.31, P = 0.00004). A change in APRI (ΔAPRI) of 0.18 had 80% positive predictive value (PPV) and 67% nega- tive predictive value (NPV) for progression of fibrosis. A change in FIB-4 (ΔFIB-4) of 0.39 had 75% PPV and 75% NPV for predicting progression of fibrosis. CONCLUSION: ΔAPRI and ΔFIB-4 parallel changes in fibrosis progression, and could be useful tools for clinicians in following patients with active chronic HCV infection.

关键词： Hepatitis C Liver fibrosis Liver biopsy Biomarkers

Biotechnological approaches in glucosinolate production

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Journal of Integrative Plant Biology 2018年第12期60卷 1231-1248页

作者： Annette petersen Cuiwei Wang Christoph Crocoll Barbara Ann Halkier DynaMo Center Copenhagen Plant Science Centre Department of Plant and Environmental Sciences University of Copenhagen

Glucosinolates(GLSs) are sulfur-rich, amino acid-derived defense compounds characteristic of the Brassicales order. In the past, GLSs were mostly known as anti-nutritional factors in fodder, biopesticides in agriculture, and flavors in condiments such as mustard. However, in recent times, GLSs have received increased attention as promoters of human *** has spurred intensive research towards generating rich sources of health-promoting GLSs. We provide a comprehensive overview of the biotechnologica approaches applied to reach this goal. This includes optimization of GLS production and composition in native, GLS-producing plants, including hairy root and cell cultures thereof, as well as synthetic biology approaches in heterologous hosts, such as tobacco and the microbial organisms Escherichia coli and Saccharomyces cerevisiae. The progress using these different approaches is discussed.

关键词： GLS Biotechnological approaches in glucosinolate production

Evaluation of a new qPCR test to identify the organisms causing high total bacterial count in bulk tank milk

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Journal of Integrative Agriculture 2018年第6期17卷 1241-1245页

作者： Jorgen Katholm Lene Trier Olesen Anders petersen Snorri Sigurdsson DNA Diagnostic A/S Risskov 8240Denmark ARLA Foods amba Viby 8260Denmark SEGES Aarhus N 8200Denmark

Milk quality in bulk tank milk （BTM） is measured by flow cytometry technology as total bacterial count （TBC） and somatic cell count （SCC）. To investigate SCC problems, culture or PCR can be used to identify mastitis causing bacteria, e.g., Mastit 4, a commercially available qPCR test. TBC in BTM can be investigated further using culture-based methods such as standard plate count, laboratory pasteurization count, coliform count, and spore counts. To our knowledge, no qPCR addressing the bacteria involved in TBC has been commercially introduced. The aim of this study is to evaluate a recently introduced 3-h qPCR test, TBC 4. The TBC 4 qPCR detects four target groups, Pseudomonas, Streptococci, Enterobacteriacea/ Enterococcus, and Bacillus/Clostridia. These target groups relate to problems on the farm such as cooling, mastitis, environment, and silage. We will continue with new research to compare the TBC 4 qPCR test with traditional culture. For this study, BTM samples from different TBC intervals were selected based on BactoCount results found at routine payment investigation at Eurofins laboratory （Vejen, Denmark）. These samples were analyzed using TBC 4 qPCR assay within 24 h. In total, 346 BTM samples were divided into six different intervals of colony forming units （CFU）. For all four targets in each of the different intervals of CFU, the percent of positive samples, the average Ct-value, the percent of positive samples with Ct〈30 and Ct〈25 were calculated. For Pseudomonas, Streptococci, and Enterobacteriacea/Enterococcus, the number of positive samples with lower Ct-values （high bacteria content） correlated with the CFU mL-1. We found Enterobacteriacea/ Enterococcus, Pseudomonas, and Streptococci in high number of bacteria （Ct〈25） in 25, 19 and 56％ of samples with CFU mL-1 between 50001-100000 and 53, 44, and 39％ in samples with CFU mL-1〉100000. The TBC 4 qPCR test showed to be a strong and fast tool for farmers, advisors and service technicians to address probl

关键词： TBC bulk tank milk qPCR milk quality