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三元前驱体废水脱氨节能工艺

当代化工研究 2024年第3期 157-159页

作者：朱碧云丁乾昆山三一环保科技有限公司江苏215334

为解决三元前驱体废水处理中难度大、成本高、效果差等问题,以三元前驱体废水脱氨工艺为研究对象,比较常规再沸器式脱氨工艺、直接压缩塔顶富氨蒸汽工艺、再沸器壳程闪蒸气压缩工艺、塔釜管程含氨蒸汽闪蒸气压缩工艺4种工艺,以系统的投... 详细信息

为解决三元前驱体废水处理中难度大、成本高、效果差等问题,以三元前驱体废水脱氨工艺为研究对象,比较常规再沸器式脱氨工艺、直接压缩塔顶富氨蒸汽工艺、再沸器壳程闪蒸气压缩工艺、塔釜管程含氨蒸汽闪蒸气压缩工艺4种工艺,以系统的投资成本和运行成本最低为目标函数,得到最优工艺方案。结果表明:当采用直接压缩塔顶富氨蒸汽工艺时,投资成本为15.49万元/吨水,运行成本为10.78元/吨水,总费用最低,相比于常规脱氨塔工艺投资成本增加39%,运行成本降低64.6%,总成本降低1034万元/年。有望解决三元前驱体废水处理中脱氨高成本的难点和痛点,保障整个系统连续稳定地实施生产。

关键词：三元前驱体废水脱氨节能压缩机

Diagnosis of pancreatic carcinoma based on combined measurement of multiple serum tumor markers using artificial neural network analysis

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Chinese Medical Journal 2014年第10期127卷 1891-1896页

作者： Yang Yingchi Chen Hui Wang Dong Luo Wei zhu biyun Zhang Zhongtao Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China Institute of Biomedical Engineering Capital Medical UniversityBeijing 100069 China

Background Artificial neural network （ANN） has demonstrated the ability to assimilate information from multiple sources to enable the detection of subtle and complex *** this reseamh,we evaluated an ANN model in the diagnosis of pancreatic cancer using multiple serum *** In this retrospective analysis,913 serum specimens collected at the Department of General Surgery of Beijing Friendship Hospital were analyzed for carbohydrate antigen 19-9 （CA19-9）,carbohydrate antigen 125 （CA125）,and caminoembryonic antigen （CEA）.The three tumor marker values were used as inputs into an ANN and randomized into a training set of 658 （70.31％ were malignant） and a test set of the remaining 255 samples （70.69％ were malignant）.The samples were also evaluated using a Logistic regression （LR） *** The ANN-derived composite index was superior to each of the serum tumor markers alone and the Logistic regression *** areas under receiver operating characteristic curves （AUROC） was 0.905 （95％ confidence Interval （CI） 0.868-0.942） for ANN,0.812 （95％ CI 0.762-0.863） for the Logistic regression model,0.845 （95％ CI 0.798-0.893）for CA19-9,0.795 （95％ CI 0.738-0.851） for CA125,and 0.800 （95％ Cl 0.746-0.854） for *** analysis of multiple markers yielded a high level of diagnostic accuracy （83.53％） compared to LR （74.90％）.Conclusion The performance of ANN model in the diagnosis of pancreatic cancer is better than the single tumor marker and LR model.

关键词： artificial neural network tumor markers pancreatic cancer Logistic regression

基于干预映射理论的护理方案对视神经脊髓炎谱系病患者心理状态、疾病认知及残疾程度的影响

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河南医学研究 2024年第12期33卷 2280-2285页

作者：伍三霞潘婷婷朱碧云李爱丽郑州大学第一附属医院神经内科五病区河南郑州450000

目的探讨基于干预映射(IM)理论的护理方案在视神经脊髓炎谱系病(NMOSD)患者中的应用效果。方法选取郑州大学第一附属医院2021年3月至2022年12月收治的80例NMOSD患者,采用随机抽签法分为对照组(40例,接受常规护理方案干预)、干预组(40... 详细信息

目的探讨基于干预映射(IM)理论的护理方案在视神经脊髓炎谱系病(NMOSD)患者中的应用效果。方法选取郑州大学第一附属医院2021年3月至2022年12月收治的80例NMOSD患者,采用随机抽签法分为对照组(40例,接受常规护理方案干预)、干预组(40例,接受基于IM理论的护理方案干预)。比较两组心理应激反应(医院应激量表)、疾病认知、自我管理行为、残疾程度[扩展残疾状态量表(EDSS)]及日常生活能力(Barthel指数)。结果干预后,干预组医院应激量表总评分及家庭社会因素、环境陌生、不舒服、疾病威胁、缺乏信息维度评分低于对照组(P<0.05),疾病认知总评分及饮食知识、疾病与治疗相关知识、用药安全、运动健康维度评分高于对照组(P<0.05),NMOSD自我管理行为量表总评分及运动精确性、自我管理态度、饮食依从性维度评分高于对照组(P<0.05),EDSS评分低于对照组(P<0.05),BI评分高于对照组(P<0.05)。结论基于IM理论的护理方案能有效改善NMOSD患者的心理应激反应和疾病认知,降低残疾程度,提高自我管理行为和日常生活能力。

关键词：视神经脊髓炎谱系病干预映射理论护理残疾程度心理状态

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基于未确知测度理论的管道内涂层失效风险评价研究

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石油工程建设 2024年第4期50卷 52-57页

作者：张宏陈阳子贾贞贞朱碧云孙春亮梁昌晶中国石油华北油田公司第一采油厂河北任丘062552 中国石油华北油田公司安全监督检测中心河北任丘062552 中国石油华北油田公司第四采油厂河北廊坊065000

为提高管道内涂层质量的管控水平,从涂层性能、服役环境、涂层老化和施工缺陷等方面建立了三级指标、五级风险的评价指标体系,通过构造单指标测度、计算复合权重和构造多指标测度等步骤,实现了评价指标间差异性和不确定性的消除,并引入... 详细信息

为提高管道内涂层质量的管控水平,从涂层性能、服役环境、涂层老化和施工缺陷等方面建立了三级指标、五级风险的评价指标体系,通过构造单指标测度、计算复合权重和构造多指标测度等步骤,实现了评价指标间差异性和不确定性的消除,并引入有效度对未确知测度理论的识别准则进行改进,实现了风险等级的评价,并进行了工程应用。结果表明,通过复合权重可降低改进层次分析法和变异系数法两类权重结果带来的弊端,一级指标中涂层性能的影响权重最大,二级指标中电化学阻抗值、清管频次、服役时间、施工水平的影响权重较大;评价结果与现场实际情况相符,证明了本文模型的科学性和有效性,为内涂层失效的风险性评价提供了一种新方法。

关键词：未确知测度管道内涂层复合权重置信度有效度

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超选择栓塞治疗急性肾出血及CT血管成像在显示责任血管中的作用

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中华介入放射学电子杂志 2024年第2期12卷 155-160页

作者：郭亚潘孙敬孙鹏程张鑫朱碧云李智倪才方苏州市相城人民医院介入科江苏苏州215131 苏州市相城人民医院手术室江苏苏州215131 苏州大学附属第一医院介入科江苏苏州215000

目的研究超选择肾动脉栓塞(renal artery embolization,RAE)治疗急性肾出血的成功率,以及栓塞前CT血管成像(computed tomography an giography,CTA)在显示责任血管中的作用。方法选择2016年1月至2021年12月苏州大学附属第一医院介入科... 详细信息

目的研究超选择肾动脉栓塞(renal artery embolization,RAE)治疗急性肾出血的成功率,以及栓塞前CT血管成像(computed tomography an giography,CTA)在显示责任血管中的作用。方法选择2016年1月至2021年12月苏州大学附属第一医院介入科和苏州市相城人民医院介入科完成的RAE病例。以发现并栓塞责任血管、出血停止、血压恢复为技术成功,以康复出院为临床成功,以RAE前后肌酐、尿素氮、肾小球滤过率的变化,以及栓塞相关并发症评价安全性。进一步筛选,病因为创伤或医源性损、有确切出血征象、有术前增强CT的病例。将增强CT数据回传工作站,行最大密度投影(maximal intensity projection,MIP)、曲面重建(curved planar reformation,CPR)、容积再现(volume rendering,VR)重建。以RAE术中造影为金标准,研究CTA的灵敏度和特异度。结果共纳入52例,首次技术成功率90.4%,补救技术成功率96.2%,临床成功率92.3%。临床成功的48例患者中,RAE前后血清肌酐、尿素氮、肾小球滤过率差异无统计学意义,均在正常值范围内。随访期间无RAE相关并发症。共16例完成CTA重建。MIP、VR、CPR的灵敏度分别为68.8%、62.5%、68.8%。综合3种重建方法,CTA总的灵敏度为75.0%,特异度均为100%。结论我中心超选择RAE治疗急性肾出血的技术成功率为96.2%。对于创伤或医源性损伤所致的急性肾出血,栓塞前CTA可显示出血责任血管,联合多种重建方法效果更好。

关键词：急性肾出血肾动脉栓塞责任血管 CT血管成像

Arabidopsis ENOR3 regulates RNAi-mediated antiviral defense

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Journal of Genetics and Genomics 2018年第1期45卷 33-40页

作者： Hua Gao Mai Yang Haitao Yang Yue Qin biyun zhu Gang Xu Chengyuan Xie Dewei Wu Xiaolin Zhang Wanxiang Li Jianbin Yan Susheng Song Tiancong Qi Shou-Wei Ding Daoxin Xie Tsinghua-Peking Joint Center for Life Sciences and MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 China Department of Microbiology and Plant Pathology University of California Riverside CA 92521 USA Beijing Key Laboratory of Plant Gene Resources and Biotechnology for Carbon Reduction and Environmental Improvement College of Life Sciences Capital Normal University Beijing 100048 China

Viruses can infect host plants to cause severe diseases and substantial agricultural loss, while plants have evolved RNA interference （RNAi） strategy to defend against viral infection. Despite enormous efforts, only a few host proteins in RNAi pathway were shown to mediate antiviral defense, including RNA-dependent RNA polymerase I （RDRI）, RDR6, DICER-LIKE 2 （DCL2） and DCL4. In this study, we carried out a genetic screen for antiviral factors of RNAi pathway in Arabidopsis rdr6 background via inoculation with a 2b- deficient Cucumber Mosaic Virus （CMV-△2b）. We identified a mutant susceptible to CMV-△2h, referred to as enhancer o ojrdr6 （enor） 3-1 rdr6, and found that ENOR3 encodes a functionally unknown protein with high homology to the mammalian Non Imprinted in Prader-Willi/Angelman （NIPA） magnesium transporters. ENOR3 inhibits accumulation of CMV-△2b and acts additively with RDR1, RDR6, DCL2 and DCL4 in antivira/ defense. These results uncover that ENOR3 is a key component in antiviral RNAi Dathwav, and provide new insights into antiviral immunity.

关键词： Antiviral defense CMV-△2b DCL2/4 ENOR3 RDRI/6 RNAi

Multi-Effect Evaporation Coupled with MVR Heat Pump Thermal Integration Distillation for Separating Salt Containing Methanol Wastewater

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Energy and Power Engineering 2017年第12期9卷 772-785页

作者： Deming Yang Yifan Yin Zhengguang Wang biyun zhu Qiang Gu College of Petrochemical Engineering Changzhou University Changzhou China

Due to the high energy consumption for separation of salt containing methanol wastewater, in this work, the multi-effect evaporation coupled with mechanical vapor recompression (MVR) heat pump and thermal integration technologies were raised for the first time. The ELECNRTL thermodynamic model is used to simulate and optimize the evaporation rectification process. Energy consumption and total annual cost (TAC) are taken as objective functions. The results show that multi-effect evaporation coupled with conventional distillation process can save energy consumption and TAC by 44.12% and 39.14%. The multi-effect evaporation coupled with distillation process based on MVR heat pump technology can save energy consumption and TAC by 55.27% and 47.49%, which is super to three-effect evaporation coupled with conventional distillation process. The three-effect evaporation coupled with MVR heat integration process can save energy consumption and TAC by 81.32% and 58.55%, which is more economical than other processes. It can be clearly seen that three-effect evaporation coupled with MVR heat integration process is more competitive to deal with the salt containing methanol wastewater.

关键词： Salt Containing Methanol Wastewater MVR Heat Pump Heat Integration Energy Saving

Intelligent In-Vehicle Safety System Based on Yolov5

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Journal of Computer and Communications 2024年第3期12卷 207-218页

作者： biyun Chen Wei Cai Jinwen zhu College of Computer Information and Engineering Yancheng Teachers University Yancheng China

In order to reduce the occurrence of traffic accidents and assist drivers to avoid dangerous driving. This paper presents a smart in-vehicle safety system that utilises the Yolov5 algorithm. Yolov5 algorithm is used to anticipate driver fatigue and distraction behaviours, and remind drivers to pay attention to safe driving in time. The system continuously splits the frames and analyses the frame content through the video feedback from the front camera, compared to the traditional machine learning, Yolov5’s mosaic data is enhanced, resulting in a batch size enhancement of 92.3%, and it also uses the Drop Block mechanism to prevent overfitting. The hardware of this system uses STM32 microcontroller and uses system DMA interrupt control and buzzer alarm device to warn about dangerous driving behaviour.

关键词： Behaviour Detection STM32 Pyside2 Yolov5 Dlib Open Source Library Perclos Model

Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants

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Protein & Cell 2018年第9期9卷 814-819页

作者： Lei Yang Xiaohui Zhang Liren Wang Shuming Yin biyun zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li East China Normal University and Shanghai Fengxian DistrictCentral Hospital Joint Center for Translational Medicine ShanghaiKey Laboratory of Regulatory Biology School of Life SciencesEast China Normal University Shanghai 200241 China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201499 China Xinhua Hospital Shanghai Jiao Tong University School ofMedicine Shanghai 200092 China School of Life Sciences Hunan Normal University Changsha 410081 China Bioray Laboratories Inc. Shanghai 200241 China Department of Molecular and Cellular Medicine The Institute of Biosciences and Technology Texas AM University Health Science Center Houston TX 77030 USA

Dear Editor, The clustered regularly interspaced short palindromic repeat （CRISPR） system has been widely adapted to genome editing to either introduce or correct genetic mutations （Wang et al., 2016）. However, due to competition with the dominant non-homologous end-joining （NHEJ） pathway, precise genome modifications through Cas9-stimulated homologous recombination （HR） is inefficient. Through fusion of cytidine deaminases, APOBEC1 （apolipoprotein B editing complex 1） or AID （activation-induced deaminase）, with Cas9 variants, several groups have developed the cytidine base editor （BE） systems （Komor et al., 2016; Li et al., 2018; Nishida et al., 2016）. The BE system achieves programmable conversion of C-G base pairs to T.A without double-stranded DNA cleavage （Zhou et al., 2017）. More recently, adenine base editors （ABEs）, which efficiently convert A-T base pairs to G-C in genomic DNA, have been developed via fusion of an engineered tRNA adenosine deaminase （ecTadA from Escherichia coh） with nCas9 （Gaudelli et al., 2017）. The ABE system has quickly been adapted to generate disease models and correction of genetic disease in mice （Ryu et al., 2017; Liu et al, 2018）. However, whether the editing efficiency and the targeting scope of ABE could be improved is largely unexplored. In this study, we describe the efficient generation of base-edi- ted mice and rats modeling human diseases through ABEs with highest efficiency up to 100%. We also demonstrate an increase of ABE activity through injection of chemically modified tracrRNA and crRNA in mouse zygotes, and the expansion of editing scope by fusion of an ecTadA mutant to SaCas9n-KKH and Casgn-VQR variants in both cells and embryos. Our study suggests that the ABE system is a powerful and convenient tool to introduce precise base conversions in rodents.

关键词： GENOMIC DNA CRISPR-CAS9