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Spleen-kidney supplementing formula alleviates insulin resistance via regulating AKT/glycogen synthase kinase 3β pathway in rats with type 2 diabetic induced by high-fat diet

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Journal of Traditional Chinese Medicine 2019年第2期39卷 199-206页

作者： Tian Chunyu Wang Ya La Xiaojin Li Ji'an zhang biwei Department of Traditional Chinese Medicine North China University of Science and Technology

OBJECTIVE: To explore the molecular mechanism underpinning the action by investigating its effect on glycogen content and AKT(also known as protein kinase B)/glycogen synthase kinase 3β(GSK-3β) pathway in the liver of rats with type 2 diabetic induced by high-fat ***: The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injection. Diabetic rats were divided into five groups: the model control group, the Metformin group, spleen-kidney supplementing formula groups of low, medium and high doses. Fasting blood glucose(FBG) levels were measured before treatment and every two weeks during *** the treatment, oral glucose tolerance test was performed, and hemoglobin A1c (HbA1c) and C-peptide were measured to assess the formula's effect on glucose metabolism and insulin resistance. The protein expression levels of AKT, GSK-3βand their phosphorylated forms in the liver were also measured to study the formula's role in insulin signaling ***: Spleen-kidney supplementing formula significantly relieved the symptoms of polydipsia,polyuria and weight loss in type 2 diabetic rats, reduced FBG and HbA1c levels, increased glycogen content, and improved insulin sensitivity. The anti-diabetic effects of spleen-kidney supplementing formula are dose dependent. It also increased the total AKT protein level and the GSK-3β phosphorylation in the liver of type 2 diabetic ***: Spleen-kidney supplementing formula has hypoglycemic effect and relieves insulin resistance by enhancing AKT/GSK-3β signaling pathway in the liver of type 2 diabetic rats.

关键词： Spleen-kidney supplementing formula Insulin resistance Proto-oncogene proteins c-akt Glycogen Phosphorylation

Multidither coherent optical adaptive technique for deep tissue two-photon microscopy

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Journal of Innovative Optical Health Sciences 2019年第4期12卷 83-93页

作者： biwei zhang Wei Gong Chenxue Wu Lejia Hu Xinpei Zhu Ke Si State Key Laboratory of Modern Optical Instrumentation Department of Neurobiology of the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310027 P.R.China College of Optical Science and Engineering Zhejiang University Hangzhou 310027P.R.China NHC and CAMS Key Laboratory of Medical Neurobiology Department of Neurobiology Center for Neuroscience Zhejiang University School of Medicine Hangzhou 310058P.R.China

Two-photon microscopy normally suffers from the scattering of the tissue in biological *** coberent optical adaptive technique(COAT)can correct the scattered wavefront in ***,the determination of the corrective phases may not be completely accurate using conventional method,which undermines the performance of this *** this paper,we theoretically demonstrate a method that can obtain more accurate corrective phases by determining the phase values from the square root of the fuorescence signal.A numnerical simulation model is established to study the performance of adaptive optics in two-photon micros-copy by combining scalar diffraction theory with vector diffraction *** results show that the distortion of the wavefront can be corrected more thoroughly with our method in two-photon *** our simulation,with the scattering from a 450-mn-thick mouse brain tissue,excitation focal spots with higher peak-to background ratio(PBR)and images with higher contrast can be ***,further enhancement of the multidither COAT correction performance in two-photon imaging can be expected.

关键词： Coherent optical adaptive technique two-photon microscopy adaptive optics deep tissue

键槽接缝PC墙板抗震性能试验研究及有限元分析

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华中科技大学学报（自然科学版） 2023年第8期51卷 32-40页

作者：罗小勇张璧玮程俊峰申智勇中南大学土木工程学院湖南长沙410075 湖南省装配式建筑工程技术研究中心湖南长沙410075

为满足低烈度区多层装配式混凝土(PC)墙板结构的抗震性能需求并实现快速装配,提出一种水平键槽式接缝连接形式,通过对6片采用该连接的PC墙板试件开展低周反复荷载试验,探究接缝处有、无竖向灌浆套筒连接、轴压比及墙厚等因素对墙板抗震... 详细信息

为满足低烈度区多层装配式混凝土(PC)墙板结构的抗震性能需求并实现快速装配,提出一种水平键槽式接缝连接形式,通过对6片采用该连接的PC墙板试件开展低周反复荷载试验,探究接缝处有、无竖向灌浆套筒连接、轴压比及墙厚等因素对墙板抗震性能的影响.试验结果表明:施加轴压力或增添灌浆套筒连接对试件的耗能、承载能力及延性均有明显提高,但轴压比的继续增大使得耗能能力和延性有所降低;减小墙厚对试件耗能及承载能力影响显著.采用ABAQUS对低周反复荷载下的墙板试件开展了有限元分析,在验证了模型的准确性后,对比探讨了套筒位置及套筒连接钢筋直径对墙板承载能力的影响,并给出了水平键槽接缝连接的PC墙板的承载力简化计算方法,计算结果与试验结果误差在15%以内.

关键词：装配式混凝土(PC)墙板水平键槽接缝灌浆套筒连接低周反复荷载试验有限元分析

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外界振动对住宅的影响分析及减振措施

山西建筑 2023年第24期49卷 31-33页

作者：张弼伟山西省建筑科学研究院集团有限公司山西太原030001

针对某6层砌体结构住宅楼因受其南侧学校操场学生跑操影响,导致楼内居民振感明显的问题,综合对住宅的振动观察,现场使用拾振器对住宅楼进行了振动检测,根据测试结果,对比分析了学校的学生课间操跑步对该楼的振动影响特征,并针对性地采... 详细信息

针对某6层砌体结构住宅楼因受其南侧学校操场学生跑操影响,导致楼内居民振感明显的问题,综合对住宅的振动观察,现场使用拾振器对住宅楼进行了振动检测,根据测试结果,对比分析了学校的学生课间操跑步对该楼的振动影响特征,并针对性地采取了合理有效的工程措施,达到了较好的实际效果,对类似工程问题的解决有一定的参考意义。

关键词：结构振动振动控制振动频率振动速度

山西地区抗剪法检测混凝土抗压强度的技术研究

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混凝土 2016年第12期 142-145页

作者：张弼伟郭庆许家文山西省建筑科学研究院山西太原030001

阐述了抗剪法测试混凝土抗压强度的基本原理。通过相关试验,初步建立了适用于山西地区的抗剪法测强拟合曲线和测强公式。试验结果表明:抗剪法相对于传统的混凝土抗压强度检测方法,具有精度高、操作简便、适用范围广、对结构损伤小等特点... 详细信息

阐述了抗剪法测试混凝土抗压强度的基本原理。通过相关试验,初步建立了适用于山西地区的抗剪法测强拟合曲线和测强公式。试验结果表明:抗剪法相对于传统的混凝土抗压强度检测方法,具有精度高、操作简便、适用范围广、对结构损伤小等特点,具有极高的使用价值和较好的发展前景。

关键词：抗剪法混凝土抗压强度早期强度

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He Jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang Yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong Ren Xiaoping Ouyang Jianhong Liu biwei Xiao Jiangtao Hu Qianling zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

钻芯-超声对测法判定混凝土构件烧伤深度的实践应用

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山西建筑 2024年第12期50卷 39-41,65页

作者：张弼伟山西省建筑科学研究院集团有限公司山西太原030001

准确判定混凝土构件的烧伤深度,是火作用后混凝土结构加固修复的前提。围绕某混凝土框架地下车库的火灾案例,阐述了火作用后混凝土构件的损伤特点,根据超声波测试混凝土构件表层损伤厚度的原理,提出了钻芯-超声对测法对混凝土构件烧伤... 详细信息

准确判定混凝土构件的烧伤深度,是火作用后混凝土结构加固修复的前提。围绕某混凝土框架地下车库的火灾案例,阐述了火作用后混凝土构件的损伤特点,根据超声波测试混凝土构件表层损伤厚度的原理,提出了钻芯-超声对测法对混凝土构件烧伤深度进行测试,可为其他火灾后混凝土检测鉴定中的构件烧伤深度的测定提供借鉴。

关键词：火灾混凝土超声波烧伤深度

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顶升纠偏技术在既有砌体住宅楼中的实践应用

山西建筑 2024年第10期50卷 50-52,93页

作者：张弼伟山西省建筑科学研究院集团有限公司山西太原030001

围绕某砌体结构住宅楼的纠偏工程案例,对此建筑物倾斜原因进行深入分析,该住宅楼由于地基土层受到多次侵蚀,导致小区道路地面沉陷明显。结合现场实际情况,采用PLC同步液压顶升法对住宅楼进行了纠偏,最终很好地完成了纠偏任务,将住宅楼... 详细信息

围绕某砌体结构住宅楼的纠偏工程案例,对此建筑物倾斜原因进行深入分析,该住宅楼由于地基土层受到多次侵蚀,导致小区道路地面沉陷明显。结合现场实际情况,采用PLC同步液压顶升法对住宅楼进行了纠偏,最终很好地完成了纠偏任务,将住宅楼成功纠正。

关键词：既有建筑砌体结构 PLC同步液压纠偏顶升法

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新疆蒙古族射箭习俗文化及其生存现状考察

武术研究 2017年第7期2卷 110-112页

作者：张碧威新疆师范大学体育学院新疆乌鲁木齐830054

文章主要采用文献资料法,研究了蒙古族射箭运动悠久的历史,射箭文化是蒙古族传统体育文化中的一个重要组成部分和特色文化项目,射箭是蒙古族"男儿三技"之一,技艺高超的射手极受尊崇,射箭在技艺、狩猎、制造、文化等方面有着深刻的影响... 详细信息

文章主要采用文献资料法,研究了蒙古族射箭运动悠久的历史,射箭文化是蒙古族传统体育文化中的一个重要组成部分和特色文化项目,射箭是蒙古族"男儿三技"之一,技艺高超的射手极受尊崇,射箭在技艺、狩猎、制造、文化等方面有着深刻的影响。射箭习俗文化渗入了蒙古族文化的方方面面,并且对蒙古族的历史进程产生了重大影响。文章结合蒙古传统射箭运动的特点,就如何构建保护和传承该文化提出了建议。

关键词：蒙古族射箭运动文化传承