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阴道无张力尿道悬吊术(tVt)成功与否的决定因素:来自荷兰tVt数据库的前瞻性多中心队列研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 5-6页

作者： Schraffordt Koops S.E. bisseling t.m. Van Brummen H.J. 李奎 Department of Obstetrics and Gynecology Meander Medical Center Ringweg Randenbroek 1103816CPAmersfoortNetherlands Dr.

Objective: the objective of this study was to report which preoperative and intraoperative factors influence the success of the tension-free vaginal tape procedure for stress urinary incontinence. Study design: this was a prospective cohort study of 809 patients. In 28 teaching hospitals and 13 local hospitals, 54 gynecologists and urologists performed the tension-free vaginal tape procedure. Results: Before treatment and 2 years postoperatively, the following question from the Urogenital Distress Inventory for stress urinary incontinence was selected to define success or failure: “Do you experience urinary leakage during physical activity, coughing, or sneezing?”Secondary outcome measurement was the outcome of the doctor’s question,“Do you leak during physical activity, coughing, or sneezing?”asked at the 2-year follow-up. Response rate was 78.7%. the success rate was significant higher in all analyses when the surgeons had performed more than 20 tension-free vaginal tape procedures (P = .003; beta = 1.918 [95%confidence interval 1.24-2.97]). General anesthesia had a negative effect on the success of the tension-free vaginal tape (P = .032; beta = 2.21 [95%confidence interval 1.07-4.55]). Conclusions:Inexperience of the surgeon with the tension-free vaginal tape procedure and general anesthesia had a negative effect on the result. We believe that the tension-free vaginal tape should be performed only by experienced surgeons.

关键词： tVt 队列研究张力性尿失禁漏尿妇科专家泌尿生殖系统泌尿科教学医院研究设计地方医院

既往有泌尿妇科手术史妇女无张力阴道吊带(tVt)的效果与生活质量:荷兰tVt数据库的分析

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 5-6页

作者： Koops S.E.S. bisseling t.m. Heintz A.P.m. Vervest H.A.m. 翁梨驹 Department of Gynecology and Obstetrics Meander Medical CenterAmersfoortNetherlands Dr.

Objective:Long-term outcome of tension-free vaginal tape (tVt) in women with a history of surgery for urinary incontinence and/or prolapse. Study design:Prospective cohort study of 809 women. twenty-eight teaching and 13 local hospitals,54 gynecologists and urologists performed the tVts. the Incontinence Impact Questionnaire (IIQ-7) and Urogenital Distress Inventory (UDI-6) were used to measure the results of the tVt procedure (preoperative at 2,6,12,24,and 36 months postoperative). According the recommendation of the International Continence Society,the question “Do you experience urinary leakage during physical activity,coughing or sneezing?”was selected from the UDI to assess stress urinary incontinence. Results:the decrease in IIQ/UDI mean scores was statistically significant. the UDI scores of women with a history of previous prolapse and/or incontinence surgery were not statistically different to the scores for primary cases after 3 years follow-up (P = .193). Conclusion:tVt is effective for women with recurrent stress urinary incontinence and/or previous prolapse surgery.

关键词： tVt 生活质量妇科医师泌尿生殖系统统计学显著性教学医院泌尿科前瞻性队列研究体力活动

荷兰地区经阴道无张力尿道悬吊术并发症的前瞻性研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第11期1卷 3-3页

作者： Schraffordt Koops S.E. bisseling t.m. Heintz A.P.m. Vervest H.A.m. 朱国栋 Department of Obstetrics and Gynecology Meander Medical Center Ringweg Randenbroek 110 3816 CP Amersfoort Netherlands Dr.

Objective: the intra-and postoperative anat.m.c complications, frequency, and influence of risk factors of the tension-free vaginal tape are described. Study design: this was a prospective cohort study of 809 patients. Results: the total intraoperative complication rate was 6.2% . Previous prolapse surgery was a risk factor for complications (odds ratio, 2.86; 95% CI, 1.15-7.11). We found more intraoperative complications in patients with general anesthesia than with local analgesia with sedation (odds ratio, 4.14; 95% CI, 2.01-8.53). In teaching hospitals the postoperative complication frequency was higher than in non-teaching hospitals (odds ratio, 0.55; 95% CI, 0.35-0.85). the learning curve is short, and more postoperative complications were found in the second 10 patients who underwent operation by 1 surgeon (odds ratio, 1.94; 95% CI, 1.14-3.29). Spinal analgesia gives fewer postoperative complications than local analgesia with sedation (odds ratio, 0.35; 95% CI, 0.13-0.92). Conclusion: tension-free vaginal tape is a relative safe procedure; concomitant pelvic surgery can be performed safely. Several risk factors for complications were identified: menopausal state, previous prolapse surgery, mode of anesthesia, teaching hospital, and the second ten procedures of each surgeon.

关键词：阴道脱垂盆腔手术教学医院全身麻醉患者外科医生手术危险局部麻醉前瞻性队列研究脊髓麻醉学习曲线

Rhizobium Lipo-chitooligosaccharide Signaling triggers Accumulation of Cytokinins in medicago truncatula Roots

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molecular Plant 2015年第8期8卷 1213-1226页

作者： Arjan van Zeijl Rik H.m. Op den Camp Eva E. Deinum tatsiana Charnikhova Henk Franssen Huub J.m. Op den Camp Harro Bouwmeester Wouter Kohlen ton bisseling Rene Geurts Department of Plant Sciences Laboratory of Molecular Biology Wageningen University Droevendaalsesteeg 16708 PB Wageningen The Netherlands Department of Syst.m. Biophysics FOM institute AMOLF Science Park 104 1098 XG Amsterdam The Netherlands Department of Plant Sciences Laboratory of Plant Physiology Wageningen University Droevendaalsesteeg 1 6708 PB Wageningen The Netherlands Department of microbiology IWWR Radboud University Nijmegen Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands College of Science King Saud University Post Office Box 2455 Riyadh 11451 Saudi Arabia

Legume rhizobium symbiosis is initiated upon perception of bacterial secreted lipo-chitooligosaccharides （LCOs）. Perception of these signals by the plant initiates a signaling cascade that leads to nodule formation. Several studies have implicated a function for cytokinin in this process. However, whether cytokinin accu- mulation and subsequent signaling are an integral part of rhizobium LCO signaling remains elusive. Here, we show that cytokinin signaling is required for the majority of transcriptional changes induced by rhizo- bium LCOs. In addition, we demonstrate that several cytokinins accumulate in the root susceptible zone 3 h after rhizobium LCO application, including the biologically most active cytokinins, trans-zeatin and iso- pentenyl adenine. these responses are dependent on calcium- and calmodulin-dependent protein kinase （CCamK）, a key protein in rhizobial LCO-induced signaling. Analysis of the ethylene-insensitive mtein21 mtsickle mutant showed that LCO-induced cytokinin accumulation is negatively regulated by ethylene. together with transcriptional induction of ethylene biosynthesis genes, it suggests a feedback loop negatively regulating LCO signaling and subsequent cytokinin accumulation. We argue that cytokinin accumulation is a key step in the pathway leading to nodule organogenesis and that this is tightly controlled by feedback loops.

关键词： medicago truncatula cytokinin ethylene rhizobium lipo-chitooligosaccharides CRE1