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Target Oriented Synthesis and Mass Spectral Characterization of Curcumin-Phenformin Adduct： Potential Insights into the Role of this Conjugate as Anti-Diabetic and Anti-Cancer Agent

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Journal of Environmental Science and Engineering(A) 2016年第6期5卷 286-293页

作者： bishambar dayal Apexa Mehta Sagar Patel Dhaval Shah Priyanka Chitkul Michael Anthony Lea 2 Department of Medicine Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA Department of Microbiology Biochemistry and Molecular Genetics Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA

Recently microwave-induced chemical synthesis of curcumin-metformin adduct to enhance the efficacy of metformin in preventing the formation of Advanced Glycation End Products （AGEs） has been reported from authors＇ laboratory. The present studies describe microwave-induced chemical synthesis and mass spectral characterization of curcumin-phenformin adducts using LC-MS/MS. The mechanism of formation and its analytical data via Thin-Layer Chromatography （TLC） combined with MS/MS fragmentation revealed a major six membered ring adduct and a minor eight membered ring isomer. A facile chemical synthesis and identification of major and minor isomers presented in this study may offer novel therapeutic strategies for inhibiting AGEs as well as anti-cancer treatments.

关键词： Diabetes mellitus advanced glycation end- products glycated human serum albumin curcumin phenformin metformin anti-cancer agents.

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Facile Synthetic Design and Characterization of Curcumin-Metformin Adduct： Potential Insights into the Role of This Conjugate in Diseases of Aging

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Journal of Environmental Science and Engineering(B) 2016年第3期5卷 123-130页

作者： bishambar dayal Apexa Mehta Abhimanyu Teja Yarramaneni Biren Patel Sagar Patel James Patrick O'Connor Michael Anthony Lea Jesse Chou Department of Medicine Rutgers University-New Jersey Medical School Newark New Jersey 07103 USA Department of Microbiology Biochemistry and Molecular Genetics Rutgers University-New Jersey Medical School Newark NewJersey 07103 USA Department of Chemistry Princeton University Princeton New Jersey 08544 USA

Recently, the anti-glycation and anticancer properties of curcumin longa and okra seed extract were studied alone and also in combination with the well-established drug metformin. The combined effect of curcumin with metformin and metformin with okra seed extract was found to be highly efficacious in inhibiting Advanced Glycation End-products （AGEs）. In order to understand the mechanistic implications of curcumin combined with metformin and its enhanced anti-glycation activity, a Curcumin-Metformin Adduct was chemically synthesized. This adduct was fully characterized by thin-layer chromatography, Nano Drop spectrophotometry and electrospray-ionization mass spectrometry. The adduct may be helpful not only in elucidating the mechanism of anti-glycation and anti-cancer activities but also in studying the role of curcumin in binding of AI3-oligomers and disaggregating fibrillar formation in Alzheimer＇s disease.

关键词： Curcumin metformin diabetes anticarcinogenic.

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