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Jure Piskur (1960—2014)

Journal of Genetics and Genomics 2015年第5期42卷 275-277页

作者： birgitte munch-petersen Zoran Gojkovic Wolfgang Knecht Department of Science Systems and Models Roskilde University The Department of Applied Yeast Research Carlsberg Laboratory Department of Biology Molecular Cell Biology & Lund Protein Production Platform Lund University

Following a short struggle against an aggressive cancer, Prof. Jure Piskur （Fig. 1 ）, a professor of molecular genetics at Lund University （LU）, Sweden, and the University of Nova Gorica （UNG）, Slovenia, died in his home in Lund on 18 May 2014. He leaves behind his lifelong partner and wife, Judita Gartner, and their sons, Jan and Jure.

关键词： Jure Piskur ICAP

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Non-Viral Deoxyribonucleoside Kinases——Diversity and Practical Use

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Journal of Genetics and Genomics 2015年第5期42卷 235-248页

作者： Louise Slot Christiansen birgitte munch-petersen Wolfgang Knecht Department of Biology Lund University Department of Science Systems and ModelsRoskilde University Lund Protein Production Platform Lund University

Deoxyribonucleoside kinases （dNKs） phosphorylate deoxyribonucleosides to their corresponding monophosphate compounds, dNks also phosphorylate deoxyribonucleoside analogues that are used in the treatment of cancer or viral infections. The study of the mammalian dNKs has therefore always been of great medical interest. However, during the last 20 years, research on dNKs has gone into non- mammalian organisms. In this review, we focus on non-viral dNKs, in particular their diversity and their practical applications. The diversity of this enzyme family in different organisms has proven to be valuable in studying the evolution of enzymes. Some of these newly discovered enzymes have been useful in numerous practical applications in medicine and biotechnology, and have contributed to our understanding of the structural basis of nucleoside and nucleoside analogue activation.

关键词： Nucleosides Nucleotides Nucleoside salvage pathway Evolution Suicide gene therapy Deoxynucleosides Deoxynucleotides Deoxy-nucleoside kinases

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