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Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

Science China Earth Sciences 2025年第1期68卷 11-26页

作者： Man-Hei NG Xiaoping ZHANG Jianwu CHEN Yongqiang SHI fuchang ZUO Wenxi PENG Weichun fu Liansheng LI Pengwei LUO Chi-Long TANG Guozheng ZHANG Zhiwu MEI Li WANG Cunhui LI Jiaming OU Yanyan XU State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology China National Space Administration (CNSA) Macau Center for Space Exploration and Science Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control Engineering Institute of High Energy Physics Chinese Academy of Sciences Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of Physics

The Solar X-ray Detector(SXD) on-board the Macao Science Satellite-1B(MSS-1B) was successfully launched via the Chinese Long March-2C rocket on 21 May 2023, and commenced operations in early June of the same year. The MSS-1B/Soft X-ray Detection Units(SXDUs) employ two silicon drift detectors(SDDs), providing a wide range of energy spectra spanning from 0.7 to 24 keV. Notably, the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 second. Here, we perform thorough calibrations of the MSS-1B/SXDUs, employing a combination of ground experiments and simulations. In addition, quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES), provides compelling evidence of their consistency. furthermore, the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs, unlocking their potential for facilitating the study of dynamic evolution of solar flares. Moreover, the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays, thereby making valuable contributions to the advancements in solar research.

关键词： Macao Science Satellite-1B (MSS-1B) Calibration Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

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双因子显式二阶积分法

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工程力学 2025年第1期42卷 20-31页

作者：刘慧鹏刘付钧周福霖傅向荣广州大学工程抗震中心广州510006 广州容联建筑科技有限公司广州510180 中国农业大学土木工程系北京100083

研究了一类超收敛的显式二阶积分方法。该方法从哈密顿体系动力相场出发，利用二阶泰勒展开式，构造了动力时程分析迭代算法的基本格式。采用高斯积分处理在迭代步内荷载项的积分，并引入超收敛因子\begin{document}$ \alpha $\end{docu... 详细信息

研究了一类超收敛的显式二阶积分方法。该方法从哈密顿体系动力相场出发，利用二阶泰勒展开式，构造了动力时程分析迭代算法的基本格式。采用高斯积分处理在迭代步内荷载项的积分，并引入超收敛因子\begin{document}$ \alpha $\end{document}和\begin{document}$ \beta $\end{document}来提高算法的收敛步长和计算稳定性。该方法避免了整体刚度矩阵的求逆和相乘，因此不需要进行整体刚度矩阵的组集，是一种快速的新型动力显式积分法。引入超收敛因子后，该算法可大幅提高收敛步长，可在理论时间步长下稳定收敛。数值算例表明：双因子超收敛显式二阶积分法比传统精细积分法具有更高算法稳定性和精度;在合适分析步长下可与常用积分算法保持一致的精度和稳定性，且随着分析步长的增大具有更好的精度稳定性。

关键词：精细积分显式积分超收敛动力时程分析哈密顿体系

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Underground laboratories · Deep underground observation ·Scientific questions—Insights from observations of multi-physic fields in deep underground labs

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Science China Earth Sciences 2025年

作者： Huiqi REN Yun WANG Chang CHEN Guangyu fu Longqing QIU Lianghui GUO Chengliang XIE Yongsheng HE Heping SUN Jiwen TENG Institute of Defense Engineering Academy of Military Sciences State Kay Laboratory of Geological Processes and Mineral Resources Key Laboratory of Intraplate Volcanoes and Earthquakes Ministry of Education China University of Geosciences (Beijing) Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences

This paper presents a comprehensive review on recent development and research conducted in domestic and international underground laboratories. We first introduce the differences in three environments—surface, mountain tunnel cavities and underground coal mine tunnels—by examining cosmic ray background, ambient noises related to gravity and seismic measurement, and electromagnetic noises in magnetic and magnetotelluric measurements. We highlight potential misuse of the term Underground Lab or Deep Underground Lab when describing observations in different physical fields. We introduce unique features of underground coal mine tunnels in China, such as large spaces, ultra-quiet conditions, and ultra-clean environments. When comparing with mountain tunnel cavities and borehole observations, coal mine tunnel observations have superior long-term stability and high precision. Through observations and comparisons of multi-physic fields at surface and the deep underground, we find that the higher SNR seismic observations conducted in deep underground tunnels in coal mines are beneficial to improve velocity tomography of the solid earth. The gravity observation with a Superconducting Quantum Interference Device(SQUID) makes it possibly to capture slow earthquake, which has not been observed previously in the Chinese mainland. SQUID magnetic observations can detect fluctuations as weak as femto-Tesla(fT), enabling us to explore the attenuation of Schumann Resonance down to the solid Earth. This opens opportunities to investigate the connections between the Earth's magnetic field and the interactions within the human brain and heart. To improve the precision of quantum measurement,we should consider the possible effects of weak magnetic disturbances in deep underground environments. Finally, we discuss the importance of deep underground laboratories, observing facilities and techniques deployed in these laboratories, and their possible connection with respect to “deep space” an

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尿NGAL在2型糖尿病肾病肾小管间质损伤评价中的价值

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中华肾病研究电子杂志 2016年第4期5卷 163-167页

作者：陈佳肖菲付碧琼林利容陈客宏张建国李开龙郑卢权何娅妮第三军医大学大坪医院野战外科研究所肾内科重庆400042

目的探讨尿中性粒细胞明胶酶相关载脂蛋白(NGAL)对评价2型糖尿病肾病(DN)患者肾小管间质损伤的价值。方法研究对象为2012年1月至2015年12月第三军医大学大坪医院2型糖尿病患者167例(2型糖尿病组);将2型糖尿病组再分为正常白蛋白尿组(n=... 详细信息

目的探讨尿中性粒细胞明胶酶相关载脂蛋白(NGAL)对评价2型糖尿病肾病(DN)患者肾小管间质损伤的价值。方法研究对象为2012年1月至2015年12月第三军医大学大坪医院2型糖尿病患者167例(2型糖尿病组);将2型糖尿病组再分为正常白蛋白尿组(n=56)、微量白蛋白尿组(n=58)、大量白蛋白尿组(n=53),其中51例患者进行了肾活检。50例非糖尿病患者作为正常对照组。采用酶联免疫吸附测定方法检测尿液中NGAL水平,分光光度法测定尿N-乙酰-β-D-葡萄糖苷酶(NAG)。分析尿NGAL水平与肾功能相关指标[尿NAG、尿白蛋白/肌酐比值(ACR)、e GFR]及肾组织损伤病理评分之间的相关性,以及NGAL对DN肾小管间质损伤严重程度的评价效能,采用SPSS软件进行统计学分析,相关性分析采用Pearson或Spearman方法。结果糖尿病患者尿NGAL水平较非糖尿病正常对照组明显增加;尿NGAL水平与尿NAG、ACR呈正相关(r=0.528,0.578,P<0.001),与e GFR呈负相关(r=-0.637,P<0.001);尿NGAL水平与DN肾小管萎缩与间质纤维化(IFTA)的严重程度呈显著正相关(r=0.652,P<0.001);尿NGAL曲线下面积最大(AUC=0.868),特异度94.7%,敏感度71.9%。结论尿NGAL是评价DN肾小管间质损伤理想的生物标志物之一。

关键词：中性粒细胞明胶酶相关载脂蛋白糖尿病肾病肾小管间质损伤生物标志物

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG fu CHENG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

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Positive effect of Mo on mechanical properties of a Ni-42W-10Co-x Mo medium heavy alloy

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China Foundry 2025年

作者： Guo-xin Cao Jian-xin Dong Yong-sheng He He Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan fu School of Materials Science and Engineering University of Science and Technology Beijing Xi'an Superalloy Technology Co. Ltd. School of Materials Science and Engineering Beijing Institute of Technology Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou University

In this study,a novel Ni-W-Co-Mo medium heavy alloy (MHA) was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-xM o alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypoeutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-xM o alloys is Mo-induced solid solution strengthening and precipitation strengthening.

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长江文化的历史内涵与现代价值——兼论长江国家文化公园的建构逻辑

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武汉大学学报（哲学社会科学版） 2025年第1期78卷 54-66页

作者：傅才武李高峰武汉大学国家文化发展研究院湖北武汉430072 武汉大学中国传统文化研究中心

长江流域是世界稻作文明的起源地。水稻以其特有的物种属性和经济属性,为中华民族的人口繁衍与文化传承提供了丰厚的物质基础和有利的社会条件。借助于大运河、荆襄古道、金牛道的南北互济以及茶马古道的东西融通,中华文化构建了一套北... 详细信息

长江流域是世界稻作文明的起源地。水稻以其特有的物种属性和经济属性,为中华民族的人口繁衍与文化传承提供了丰厚的物质基础和有利的社会条件。借助于大运河、荆襄古道、金牛道的南北互济以及茶马古道的东西融通,中华文化构建了一套北方与南方、中心与边缘的双循环体系,形成了内源性动力机制。陆上和海上丝绸之路为中华文化汲取外部文明打开了窗口,促进了中西文明的交流互鉴。长江流域作为驱动双循环的核心区域,居功至伟,成为中华民族“历史的地理枢纽”。在新时期建设中华民族现代文明的过程中,长江“历史的地理枢纽”需要转化为“当代地理枢纽”:通过“长江大保护”来恢复生态长江并推动经济长江的高质量发展;以长江国家文化公园的建设,推动长江文明与世界大河文明对话,深化中外文明的交流互鉴。

关键词：长江双循环历史的地理枢纽国家文化公园长江文明

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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面向高速流场成像的聚焦纹影研究进展

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 238-249页

作者：田立丰付双旭中山大学航空航天学院广东深圳518107 深圳市智能微小卫星星座技术与应用重点实验室广东深圳518107

相较于传统的光学流动可视化技术,聚焦纹影技术能对非聚焦区域的流场信息进行模糊化处理,从而反映窄景深内的流场信息,具有高空间分辨率、抗干扰能力强、无需播撒示踪粒子、低成本等特点,这些特点使得聚焦纹影十分适用于高速流场的流动... 详细信息

相较于传统的光学流动可视化技术,聚焦纹影技术能对非聚焦区域的流场信息进行模糊化处理,从而反映窄景深内的流场信息,具有高空间分辨率、抗干扰能力强、无需播撒示踪粒子、低成本等特点,这些特点使得聚焦纹影十分适用于高速流场的流动显示和流场测量。本文在对聚焦纹影系统成像的基本原理进行介绍的基础上,以传统聚焦纹影在格栅对准和非定常流动多平面测量方面面临的挑战为出发点,总结了聚焦纹影的国内外相关研究,并进一步展望了聚焦纹影的未来发展。

关键词：聚焦纹影流动显示流场成像

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轮毂电动机驱动车辆并联式复合制动策略

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江苏大学学报（自然科学版） 2025年第1期46卷 9-17页

作者：付翔肖帅徐超武汉理工大学汽车工程学院湖北武汉430070

基于并联式轮毂电动机驱动实车构型,分析影响制动能量回收效率的主要因素,采用联邦卡尔曼滤波纵向车速估计算法,提出了三层式复合制动控制策略.该策略中的制动决策层根据踏板输入信号和行驶状态来识别制动工况,并进入相应的制动模式.制... 详细信息

基于并联式轮毂电动机驱动实车构型,分析影响制动能量回收效率的主要因素,采用联邦卡尔曼滤波纵向车速估计算法,提出了三层式复合制动控制策略.该策略中的制动决策层根据踏板输入信号和行驶状态来识别制动工况,并进入相应的制动模式.制动控制层根据制动决策层的指令,在常规制动工况下通过粒子群优化(PSO)算法优化前、后轮电制动力矩分配,实现电池有效回收效率最大化;紧急制动工况下,通过模糊自整定PID算法实现车辆在不同附着路面上各轮滑移率的安全有效控制,优化了制动防抱死控制的鲁棒性,提高制动安全性.制动执行层响应制动控制层的指令,设计了电制动补偿机制,以迅速补偿调节各轮轮缸的压力误差,提高车辆制动稳定性.最后实车验证了该复合控制策略的有效性.

关键词：轮毂电动机驱动车辆并联式复合制动粒子群优化制动能量回收模糊自整定PID

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