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Malignant pleural mesothelioma:The disdained member of thoracic oncology!

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World Journal of Experimental Medicine 2024年第3期14卷 1-10页

作者： Divya Khosla Pawan kumar Singh Bharath A Chhabria Vaishali Kataria Navneet Singh Rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Pulmonary and Critical Care Medicine Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical SciencesRohtak 124001India Department of Pulmonary and Critical Care Medicine Ramaiah Memorial HospitalBengaluru 560054India Department of Pulmonary Medicine Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos *** ban on asbestos has helped to lower the incidence,but in developing countries like India,it is expected to *** has an extended latency period usually progressing over decades and presents with nonspecific *** has a median survival ranging between 10-22 *** diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography(CT),magnetic resonance imaging,or positron emission tomography-CT,with the last two predicting the resectability of the tumor better than CT alone.A pleural biopsy along with an array of immunohistochemical markers,such as p16,BRCA1 associated protein 1,and claudin-4,are required for a definitive *** genetic alterations have prognostic significance as *** current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being *** combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid ***,the latter continues to be a robust treatment option for patients with the epithelioid *** is recommended for resectable cases with radiotherapy being indicated in neoadjuvant,adjuvant,and palliative settings along with systemic *** review article provides an overview of epidemiology,etiology,clinical manifestations,diagnostic approaches(including immunohistochemical and genetic markers),staging,and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery,chemotherapy,immunotherapy,and *** also sheds light on some recent studies(EMPHACIS,CALGB30901,Checkmate-743,etc.)that have led to significant developments in recent years with clinically mean

关键词： Chemotherapy Diagnosis Immunotherapy Malignant pleural mesothelioma Radiotherapy

Effects of the type of forest alteration on gross nitrogen mineralization in soils of southern India

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Journal of Forestry Research 2021年第4期32卷 1689-1697页

作者： Niharika sharma Sanjeev kumar Geosciences Division Physical Research LaboratoryAhmedabadGujarat 380009India

Change in land-use practices can result in major shifts in the cycling of various elements,particularly nitrogen(N),which is prone to anthropogenic *** quantifying these shifts,accurate measurements of rates of biogeochemical transformations of N are *** used the(^(15)N) isotope dilution technique to understand the effects of the types of forest alteration on(N) transformation rates by comparing gross N mineralization and ammonium(NH_(4)^(+)) consumption rates in soils of a managed forest,an unmanaged forest,and a rubber plantation in Kerala,***,nitrate(NO_3~-) dominated soils of the managed and unmanaged forests,whereas soils in the rubber plantation showed relatively higher NH_(4)^(+) *** N(TN) and total organic carbon(TOC) concentrations were the highest under the rubber canopy(TN:1.49±0.02 mg N g^(-1);TOC:7.96±0.86 mg C g^(-1)).In soils of all three forest types,gross N mineralization rates were higher compared to NH_(4)^(+) consumption *** high TN and TOC concentrations,the rates of gross N mineralization and NH_(4)^(+) consumption were considerably lower in the rubber plantation(mineralization:1.08±0.08 mg N kg^(-1)d^(-1);consumption:0.85±0.09 mg N kg^(-1) d^(-)) compared to the managed(mineralization:3.71±0.35 mg N kg^(-1) d^(-1);consumption:2.20±1.41 mg N kg^(-1) d^(-1)) and unmanaged(mineralization:2.20±1.07 mg N kg^(-1) d^(-1);consumption:1.39±0.27 mg N kg^(-1) d^(-1)) *** lower NH_(4)^(+) consumption rates in the rubber plantation led to significantly higher(p<0.05) residence time of NH_(4)^(+)(~4 days) compared to the managed and unmanaged forests(<2 days),possibly contributing to acidification of rubber soils(pH~4.8).These results together suggest that replacement of naturally grown forests with a mono-cropped plantation such as rubber negatively impact rates of N transformation processes in tropical soils and imply that change in tree species composition of naturally grown forests can adve

关键词： Nitrogen Mineralization Forest soils Rubber plantation Land-use change

Punjabi DeConverter for generating Punjabi from Universal Networking Language

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第3期14卷 179-196页

作者： Parteek kumar Rajendra kumar sharma Department of Computer Science & Engineering Thapar University School of Mathematics & Computer Applications Thapar University

DeConverter is core software in a Universal Networking Language(UNL) system.A UNL system has EnConverter and DeConverter as its two major *** is used to convert a natural language sentence into an equivalent UNL expression,and DeConverter is used to generate a natural language sentence from an input UNL *** paper presents design and development of a Punjabi *** describes five phases of the proposed Punjabi DeConverter,i.e.,UNL parser,lexeme selection,morphology generation,function word insertion,and syntactic *** paper also illustrates all these phases of the Punjabi DeConverter with a special focus on syntactic linearization issues of the Punjabi *** linearization is the process of defining arrangements of words in generated *** algorithms and pseudocodes for implementation of syntactic linearization of a simple UNL graph,a UNL graph with scope nodes and a node having un-traversed parents or multiple parents in a UNL graph have been discussed in this *** cases of syntactic linearization with respect to Punjabi language for UNL relations like 'and','or','fmt','cnt',and 'seq' have also been presented in this *** paper also provides implementation results of the proposed Punjabi *** DeConverter has been tested on 1000 UNL expressions by considering a Spanish UNL language server and agricultural domain threads developed by Indian Institute of Technology(IIT),Bombay,India,as *** proposed system generates 89.0% grammatically correct sentences,92.0% faithful sentences to the original sentences,and has a fluency score of 3.61 and an adequacy score of 3.70 on a 4-point *** system is also able to achieve a bilingual evaluation understudy(BLEU) score of 0.72.

关键词： DeConverter EnConverter Machine translation Universal Networking Language(UNL) Syntactic linearization

Sacred groves of India:repositories of a rich heritage and tools for biodiversity conservation

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Journal of Forestry Research 2021年第3期32卷 899-916页

作者： Sakshi sharma Rajesh kumar Department of Botany DAV CollegeAmritsarPunjab 143001India DAV College AmritsarPunjab 143001India

Sacred groves preserve a rich religious and socio-cultural heritage of Indian biodiversity from primeval times,due to their *** act as a bridge between man and *** help to improve soil quality,replenish water resources and are pivotal for biodiversity conservation of plants and animals including rare,endemic,threatened,vulnerable species and ethnobotanical *** of India's sacred groves are associated with a deity or a spiritual being,who protects the grove and local *** cover of these groves has traditional ethnobotanical value,especially in the field of ethnomedicine,which accounts for the conservation of groves over the *** plant species from sacred groves are used according to tradition and culture to prevent or cure various health ***,modernisation,industrialisation,increased encroachment and misuse of forest resources increasingly threaten sacred *** treasures of nature must be conserved by formulating and applying new laws and policies while creating awareness among people about the value of sacred *** this aim,we review the distribution,ecological and socio-cultural significance of sacred groves of India and strategies to conserve them.

关键词： Biodiversity Conservation Endemic Ethnobotany Ethnomedicine

A Novel Variant of Moth Flame Optimizer for Higher Dimensional Optimization Problems

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Journal of Bionic Engineering 2023年第5期20卷 2389-2415页

作者： Saroj kumar Sahoo Sushmita sharma Apu kumar Saha Department of Mathematics National Institute of Technology AgartalaJiraniaTripura799046India

Moth Flame Optimization(MFO)is a nature-inspired optimization algorithm,based on the principle of navigation technique of moth toward *** to less parameter and easy implementation,MFO is used in various field to solve optimization ***,for the complex higher dimensional problems,MFO is unable to make a good trade-off between global and local *** overcome these drawbacks of MFO,in this work,an enhanced MFO,namely WF-MFO,is introduced to solve higher dimensional optimization *** a more optimal balance between global and local search,the original MFO’s exploration ability is improved by an exploration operator,namely,Weibull flight *** addition,the local optimal solutions have been avoided and the convergence speed has been increased using a Fibonacci search process-based technique that improves the quality of the solutions ***-nine benchmark functions of varying complexity with 1000 and 2000 dimensions have been utilized to verify the projected *** popular algorithms and MFO versions have been compared to the achieved *** addition,the robustness of the proposed WF-MFO method has been evaluated using the Friedman rank test,the Wilcoxon rank test,and convergence *** to other methods,the proposed WF-MFO algorithm provides higher quality solutions and converges more quickly,as shown by the ***,the proposed WF-MFO has been used to the solution of two engineering design issues,with striking *** improved performance of the proposed WF-MFO algorithm for addressing larger dimensional optimization problems is guaranteed by analyses of numerical data,statistical tests,and convergence performance.

关键词： Moth Flame Optimization(MFO)algorithm Bio-inspired algorithm Fibonacci search method Weibull distribution Higher dimensional functions

Proactive Connection Recovery Strategy with Recovery Time Constraint for Survivable Elastic Optical Networks

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China Communications 2021年第9期18卷 236-248页

作者： Dinesh kumar Rajiv kumar Neeru sharma Department of Electronics&Communication Engineering Jaypee University of Information Technology WaknaghatSolan(HP)India

This paper presents a halfway signaling exchange shared path protection(HSE-SPP)on the backup route for a fast connection recovery *** the proposed HSE-SPP,a pre-assigned intermediate node on the backup route is chosen for signaling *** connection fails,source and destination nodes simultaneously generate backup connection setup messages to the pre-assigned intermediate node on the reserved backup *** the intermediate node,signaling process occurs,and acknowledgment is generated for data transmission to the respective end ***,connection recovery time by applying HSE-SPP becomes very *** are performed for network parameters and results are verified with existing *** average recovery time(RT),bandwidth blocking probability(BBP),bandwidth provisioning ratio(BPR),and resource overbuild(RO)ratio of HSE-SPP for ARPANET is 13.54 ms,0.18,3.02,0.55,and for dedicated path protection(DPP)are 13.20 ms,0.56,6.30,3.75 and for shared path protection(SPP)22.19 ms,0.22,3.23,0.70 ***,average RT,BBP,BPR and RO of HSE-SPP for COST239 are8.33 ms,0.04,1.64,0.26,and for DPP 4.23,0.47,3.50,2.04,and for SPP 11.81,0.08,1.66,0.27 ***,results of the proposed strategy are better in terms of RT,BBP,BPR,and RO ratio.

关键词： routing and spectrum assignment halfway signaling exchange-shared path protection(HSE-SPP) dedicated path protection bandwidth blocking probability(BBP)

Analysis of the wave properties of a new two-lane continuum model with the coupling effect

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Chinese Physics B 2012年第1期21卷 295-309页

作者： Arvind kumar Gupta Sapna sharma Department of Mathematics Indian Institute of Technology Ropar Department of Mathematics Birla Institute of Technology & Science Pilani

A multilane extension of the single-lane anisotropic continuum model （GK model） developed by Gupta and Katiyar for traffic flow is discussed with the consideration of the coupling effect between the vehicles of different lanes in the instantaneous traffic situation and the lane-changing effect. The conditions for securing the linear stability of the new model are presented. The shock and the rarefaction waves, the local cluster effect and the phase transition are investigated through simulation experiments with the new model and are found to be consistent with the diverse nonlinear dynamical phenomena observed in a real traffic flow. The analysis also focuses on empirically observed two- lane phenomena, such as lane usage inversion and the density dependence of the number of lane changes. It is shown that single-lane dynamics can be extended to multilane cases without changing the basic properties of the single-lane model. The results show that the new multilane model is capable of explaining some particular traffic phenomena and is in accordance with real traffic flow.

关键词： two-lane traffic numerical simulation lane usage inversion

Nonlinear analysis of traffic jams in an anisotropic continuum model

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Chinese Physics B 2010年第11期19卷 156-164页

作者： Arvind kumar Gupta Sapna sharma Department of Mathematics IIT Ropar-140001India Mathematics Group Birla Institute of Technology and SciencePilani-333031India

This paper presents our study of the nonlinear stability of a new anisotropic continuum traffic flow model in which the dimensionless parameter or anisotropic factor controls the non-isotropic character and diffusive influence. In order to establish traff^c flow stability criterion or to know the critical parameters that lead, on one hand, to a stable response to perturbations or disturbances or, on the other hand, to an unstable response and therefore to a possible congestion, a nonlinear stability criterion is derived by using a wavefront expansion technique. The stability criterion is illustrated by numerical results using the finite difference method for two different values of anisotropic parameter. It is also been observed that the newly derived stability results are consistent with previously reported results obtained using approximate linearisation methods. Moreover, the stability criterion derived in this paper can provide more refined information from the perspective of the capability to reproduce nonlinear traffic flow behaviors observed in real traffic than previously established methodologies.

关键词： traffic flow non-linear stability wavefront method

MOLECULAR DYNAMICS SIMULATION OF POLYMER/CARBON NANOTUBE COMPOSITES

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Acta Mechanica Solida Sinica 2015年第4期28卷 409-419页

作者： Sumit sharma Rakesh Chandra Pramod kumar Navin kumar Department of Mechanical Engineering Dr.B.R.Ambedkar National Institute of Technology School of Mechanical Materials & Energy Engineering (SMMEE) Indian Institute of Technology

In this paper, we present classical molecular dynamics （MD） simulations of model polymer/CNT composites constructed by embedding a single wall （10,10） CNT into two different amorphous polymer matrices： poly（methyl methacrylate） and poly{（m-phenylene-vinylene）-co- [（2,5-dioctoxy-p-phenylene） vinylene]}, respectively, with different volume fractions. The simulation results support the idea that it is possible to use CNTs to mechanically reinforce an appropri- ate polymer matrix, especially in the longitudinal direction of the nanotube. The comparison of the simulation results with the macroscopic rule-of-mixtures for composite systems showed that for strong interfacial interactions, there can be large deviations of the results from the rule-of- mixtures. In order to verify this study, results obtained have been compared with those given by Elliott and Han （2007）.

关键词： nano-structures elasticity mechanical properties computational modeling