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World Journal of clinical cases 2016年第10期4卷 351-355页

作者： Vivek B Kute Himanshu V Patel Pankaj R Shah Pranjal R Modi Veena R Shah Sayyed J Rizvi bipin c pal Manisha P Modi Priya S Shah Umesh T Varyani Pavan S Wakhare Saiprasad G Shinde Viajay A Ghodela Minaxi H Patel Varsha B Trivedi Hargovind L Trivedi Department of Nephrology and clinical Transplantation Institute of Kidney Diseases and Research CenterDr.HL Trivedi Institute of Transplantation Sciences(IKDRC-ITS) Department of Urology and Transplantation IKDRC-ITS Department of Anesthesia IKDRC-ITS Department of Pathology Laboratory MedicineTransfusion Services and ImmunohematologyIKDRC-ITS

The combination of kidney paired donation(KPD) with desensitization represents a promising method of increasing the rate of living donor kidney transplantation(LDKT) in immunologically challenging patients. Patients who are difficult to match and desensitize due to strong donor specific antibody are may be transplanted by a combination of desensitization and KPD protocol with more immunologically favorable donor. We present our experience of combination of desensitization protocol with three-way KPD which contributed to successful LDKT in highly sensitized end stage renal disease patient. All recipients were discharged with normal and stable allograft function at 24 mo follow up. We believe that this is first report from India where three-way KPD exchange was performed with the combination of KPD and desensitization. The combination of desensitization protocol with KPD improves access and outcomes of LDKT.

关键词： Kidney failure chronic Desensitization Immunologic Kidney transplantation Blood group incompatibility Living donors Tissue and organ procurement

Six end-stage renal disease patients benefited from first non-simultaneous single center 6-way kidney exchange transplantation in India

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World Journal of Nephrology 2016年第6期5卷 531-537页

作者： Vivek B Kute Himanshu V Patel Umesh T Varyani Pankaj R Shah Pranjal R Modi Veena R Shah Sayyed J Rizvi bipin c pal Priya S Shah Pavan S Wakhare Vijay A Ghodela Saiprasad G Shinde Varsha B Trivedi Minaxi H Patel Hargovind L Trivedi Department of Nephrology and clinical Transplantation Institute of Kidney Diseases and Research Center Dr HL Trivedi Institute of Trans-plantation Sciences Department of Urology and Transplantation Dr HL Trivedi Institute of Trans-plantation Sciences Department of Anesthesia Dr HL Trivedi Institute of Transplantation Sciences Department of Pathology and laboratory medicine Dr HL Trivedi Institute of Transplantation Sciences

AIM To avoid desensitization protocols and ABO incompatible kidney transplantation(KT) due to high costs and increased risk of infections from intense *** We present institutional ethical review board- approved study of single center 6-way kidney exchange transplantation. The participants comprised ABO incompatibility(n = 1); positive cross-match and/or presence of donor specific antibody(n = 5). The average time required from registration in kidney paired donation(KPD) registry to find suitable donors was 45 d and time required to perform transplants after legal permission was 2 mo. RESULTS Graft and patient survival were 100%, and 100%, respectively. One patient had biopsy-proven acute borderline T cell rejection(Banff update 2013, type 3). Mean serum creatinine was 0.8 mg/dL at 9 mo followup. The waiting time in KPD was short as compared to deceased donor KT. cONcLUSION We report first non-simultaneous, single center, 6-way kidney exchange transplantation from India. Our experience will encourage other centers in India to undertake this practice.

关键词： Kidney transplantation/methods Kidney paired donation Living donors/supply and distribution Donor selection/methods

International kidney paired donation transplantations to increase kidney transplant of O group and highly sensitized patient: First report from India

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World Journal of Transplantation 2017年第1期7卷 64-69页

作者： Vivek B Kute Himanshu V Patel Pankaj R Shah Pranjal R Modi Veena R Shah Sayyed J Rizvi bipin c pal Priya S Shah Pavan S Wakhare Saiprasad G Shinde Vijay A Ghodela Umesh T Varyani Minaxi H Patel Varsha B Trivedi Hargovind L Trivedi Department of Nephrology and clinical Transplantation Institute of Kidney Diseases and Research Center Dr HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS) Department of Urology and transplantation IKDRC-ITS Department of Anesthesia IKDRC-ITS Department of Pathology Laboratory Medicine Transfusion Services and Immunohematology IKDRC-ITS

AIM To report the first international living related two way kidney paired donation(KPD) transplantation from India which occurred on 17 th February 2015 after legal per-mission from authorization committee. METHODS Donor recipient pairs were from Portugal and India who were highly sensitized and ABO incompatible with their spouse respectively. The two donor recipient pairs had negative lymphocyte cross-matching, flow cross-matchand donor specific antibody in two way kidney exchange with the intended KPD donor. Local KPD options were fully explored for Indian patient prior to embarking on international KPD. RESULTS Both pairs underwent simultaneous uneventful kidney transplant surgeries and creatinine was 1 mg/d L on tacrolimus based immunosuppression at 11 mo follow up. The uniqueness of these transplantations was that they are first international KPD transplantations in our *** International KPD will increases quality and quantity of living donor kidney transplantation. This could be an important step to solving the kidney shortage with additional benefit of reduced costs, improved quality and increased access for difficult to match incompatible pairs like O blood group patient with non-O donor and sensitized patient. To the best of our knowledge this is first international KPD transplantation from India.

关键词： Kidney paired donation International kidney paired donation Living donor kidney transplantation

Past, present and future of kidney paired donation transplantation in India

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World Journal of Transplantation 2017年第2期7卷 134-143页

作者： Vivek B Kute Himanshu V Patel Pankaj R Shah Pranjal R Modi Veena R Shah Sayyed J Rizvi bipin c pal Manisha P Modi Priya S Shah Umesh T Varyani Pavan S Wakhare Saiprasad G Shinde Vijay A Ghodela Minaxi H Patel Varsha B Trivedi Hargovind L Trivedi Department of Nephrology and clinical Transplantation Institute of Kidney Diseases and Research CentreDr HL Trivedi Institute of Transplantation Sciences(IKDRC-ITS) Department of Urology and transplantation Department of Anaesthesia IKDRC-ITS Department of Pathology Laboratory MedicineTransfusion Services and Immunohematology

One third of healthy willing living kidney donors are rejected due to ABO blood group incompatibility and donor specific antibody. This increases pre-transplant dialysis duration leading to increased morbidity and mortality on the kidney transplantation waiting list. Over the last decade kidney paired donation is most rapidly increased source of living kidney donors. In a kidney transplantation program dominated by living donor kidney transplantation, kidney paired donation is a legal and valid alternative strategy to increase living donor kidney transplantation. This is more useful in countries with limited resources where ABO incompatible kidney transplantation or desensitization protocol is not feasible because of costs/infectious complications and deceased donor kidney transplantation is in initial stages. The matching allocation, ABO blood type imbalance, reciprocity, simultaneity, geography were the limitation for the expansion of kidney paired donation. Here we describe different successful ways to increase living donor kidney transplantation through kidney paired donation. compatible pairs, domino chain, combination of kidney paired donation with desensitization or ABO incompatible transplantation, international kidney paired donation, nonsimultaneous, extended, altruistic donor chain and list exchange are different ways to expand the donor *** absence of national kidney paired donation program,a dedicated kidney paired donation team will increase access to living donor kidney transplantation in individual centres with team work. Use of social networking sites to expand donor pool, HLA based national kidney paired donation program will increase quality and quantity of kidney paired donation transplantation. Transplant centres should remove the barriers to a broader implementation of multicentre, national kidney paired donation program to further optimize potential of kidney paired donation to increase transplantation of O group and sensitized patients. T

关键词： Living donor kidney transplantation Kidney paired donation Renal replacement therapy Developing country

A Linearized Branch Flow Model considering Line Shunts for Radial Distribution Systems and Its Application in Volt/VAr control

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Journal of Modern Power Systems and clean Energy 2023年第4期11卷 1191-1200页

作者： Hanyang Lin Firdous Ul Nazir Bikash c.pal Ye Guo Tsinghua-Berkeley Shenzhen Institute Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518071China Department of Electrical and Electronic Engineering Glasgow Caledonian UniversityGlasgow Caledonian UniversityGlasgowG4 OBAU.K. Department of Electrical and Electronic Engineering Imperial College LondonLondonSW72AZU.K.

When urban distribution systems are gradually modernized,the overhead lines are replaced by underground cables,whose shunt admittances can not be *** power flow(PF)model withπequivalent circuit shows non-convexity and long computing time,and most recently proposed linear PF models assume zero shunt *** of them are not suitable for fast calculation and optimization problems of modern distribution systems with non-negligible line ***,this paper proposes a linearized branch flow model considering line shunt(LBFS).The strength of LBFS lies in maintaining the linear structure and the convex nature after appropriately modeling theπequivalent circuit for network equipment like *** results show that the calculation accuracy in nodal voltage and branch current magnitudes is improved by considering shunt *** show the application scope of LBFS by controlling the network voltages through a two-stage stochastic Volt/VAr control(VVc)problem with the uncertain active power output from renewable energy sources(RESs).Since LBFS results in a linear VVc program,the global solution is *** study exhibits that VVc framework can optimally dispatch the discrete control devices,*** transformers and shunt capacitors,and also optimize the decision rules for real-time reactive power control of ***,the computing efficiency is significantly improved compared with that of traditional VVc methods.

关键词： Line shunt linear power flow model stochastic optimization Volt/VAr control(VVc)

Searching systematics for nonfactorizable contributions to B^(-)and B^(0) hadronic decays

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chinese Physics c 2022年第7期46卷 47-55页

作者： Maninder Kaur Supreet pal Singh R.c.Verma Department of Physics Punjabi UniversityPatiala-147002India

The two-body weak decays B→πD/B→ρD and B→πD are examined using isospin analysis to study nonfactorizable *** determining strong interaction phases and obtaining factorizable contributions from spectator-quark diagrams for Nc=3,we determine nonfactorizable isospin amplitudes from the experimental data for these *** results support the universality of the ratio of nonfactorizable isospin reduced amplitudes for these decays within experimental *** demonstrate that these systematics are not coincidental,we also plot our results *** ratio.

关键词： nonfactorization weak hadronic decays HEP-PHE

An analytical study on the Rayleigh wave generation in a stratified structure

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Applied Mathematics and Mechanics(English Edition) 2020年第7期41卷 1039-1054页

作者： A.MANDI S.KUNDU P.PATI P.c.pal Department of Mathematics and computing Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India

In this paper,an analytical method is used to investigate the Rayleigh wave generation in a stratified structure and the wave generation in a dry sandy layer constrained between the couple stress and inhomogeneous orthotropic *** study is devoted to analyzing the impact of various effective parameters associated with the media on the phase velocities of the *** displacement components for each medium are derived by implementing the separable variable *** frequency equa-tion is secured by using the displacement components in the boundary conditions,imposed at the interfaces between the layer and ***,the secured equation is the relation between the phase velocity and the wave *** computations are performed,and graphical representations are demonstrated between the phase velocity and the wave number for both phase velocities with different values of the *** comparison between the phase velocities is observed for the same value of each pa-rameter.

关键词： Rayleigh wave dry sandy layer couple stress orthotropic phase velocity wave number

Insulin resistance and adipose tissue interactions as the cornerstone of metabolic(dysfunction)-associated fatty liver disease pathogenesis

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World Journal of Gastroenterology 2023年第25期29卷 3999-4008页

作者： Shreya c pal Nahum Méndez-Sánchez Faculty of Medicine National Autonomous University of MexicoMexico City 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationMexico City 04510Mexico

The relationship between metabolic derangements and fatty liver development are undeniable,since more than 75% of patients with type 2 diabetes mellitus present with fatty *** is also significant epidemiological association between insulin resistance(IR)and metabolic(dysfunction)-associated fatty liver disease(MAFLD).For little more than 2 years,the nomenclature of fatty liver of non-alcoholic origin has been intended to change to MAFLD by multiple *** a myriad of reasons for which MAFLD is thought to be of metabolic origin could be exposed,the bottom line relies on the role of IR as an initiator and perpetuator of this *** is a reciprocal role in MAFLD development and IR as well as serum glucose concentrations,where increased circulating glucose and insulin result in increased de novo lipogenesis by sterol regulatory elementbinding protein-1c induced lipogenic enzyme stimulation;therefore,increased endogenous production of *** same effect is achieved through impaired suppression of adipose tissue(AT)lipolysis in insulin-resistant states,increasing fatty acid influx into the *** complementary reciprocal situation occurs when liver steatosis alters hepatokine secretion,modifying fatty acid metabolism as well as IR in a variety of tissues,including skeletal muscle,AT,and the *** aim of this review is to discuss the importance of IR and AT interactions in metabolic altered states as perhaps the most important factor in MAFLD pathogenesis.

关键词： Metabolic(dysfunction)-associated fatty liver disease Insulin resistance Adipose tissue Fatty liver Metabolic syndrome Adipokine

Observation of complex Organic Molecules containing Peptide-like Bonds Toward Hot core G358.93-0.03 MM1

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Research in Astronomy and Astrophysics 2024年第7期24卷 181-189页

作者： Arijit Manna Sabyasachi pal Department of Physics and Astronomy Midnapore City CollegePaschim MedinipurWest Bengal721129India

In star formation regions,the complex organic molecules(cOMs)that contain peptide bonds(-NH-c(=O)-)play a major role in the metabolic process because-NH-c(=O)-is connected to amino acids(R-cHNH_2-cOOH).Over the past few decades,many cOMs containing peptide-like bonds have been detected in hot molecular cores(HMcs),hot corinos,and cold molecular clouds,however,their prebiotic chemistry is poorly *** present the first detection of the rotational emission lines of formamide(NH_2cHO)and isocyanic acid(HNcO),which contain peptide-like bonds toward the chemically rich HMc G358.93-0.03 MM1,using high-resolution and high-sensitivity Atacama Large Millimeter/submillimeter Array bands 6 and *** estimate that the column densities of NH_2cHO and HNcO toward G358.93-0.03 MM1 are(2.80±0.29)×10~(15)cm~(-2)and(1.80±0.42)×10~(16)cm~(-2)with excitation temperatures of 165±21 K and 170±32 K,*** fractional abundances of NH_2cHO and HNcO toward G358.93-0.03 MM1 are(9.03±1.44)×10~(-10)and(5.80±2.09)×10^(-9).We compare the estimated abundances of NH_2cHO and HNcO with the existing threephase warm-up chemical model abundance values and notice that the observed and modeled abundances are very *** conclude that NH_2cHO is produced by the reaction of NH_2and H_2cO in the gas phase toward G358.93-0.03 ***,HNcO is produced on the surface of grains by the reaction of NH and cO toward G358.93-0.03 *** also find that NH_2cHO and HNcO are chemically linked toward G358.93-0.03 MM1.

关键词： ISM individual objects(G358.93-0.03)-ISM abundances-ISM kinematics and dynamics-stars formation-astrochemistry

Soil Respiration, Microbial Biomass c and N Availability in a Sandy Soil Amended with clay and Residue Mixtures

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Pedosphere 2016年第5期26卷 643-651页

作者： Sharmistha pal Petra MARScHNER IcAR-Indian Institute of Soil and Water conservation Research Centre School of Agriculture Food and Wine The University of Adelaide

crop yields in sandy soils can be increased by addition of clay-rich soil, but little is known about the effect of clay addition on nutrient availability after addition of plant residues with different c/N ratios. A loamy sandy soil （7% clay） was amended with a clay-rich subsoil （73% clay） at low to high rates to achieve soil mixtures of 12%, 22%, and 30% clay, as compared to a control （sandy soil alone） with no clay addition. The sandy-clay soil mixtures were amended with finely ground plant residues at 10 g kg-l： mature wheat （Triticum aestivum L.） straw with a c/N ratio of 68, mature faba bean （Vicia faba L.） straw with a c/N ratio of 39, or their mixtures with different proportions （0% 100%, weight percentage） of each straw. Soil respiration was measured over days 0-45 and microbial biomass c （MBc）, available N, and pH on days 0, 15, 30, and 45. cumulative respiration was not clearly related to the c/N ratio of the residues or their mixtures, but c use efficiency （cumulative respiration per unit of MBc on day 15） was greater with faba bean than with wheat and the differences among the residue mixtures were smaller at the highest clay addition rate. The MBc concentration was lowest in sole wheat and higher in residue mixtures with 50% of wheat and faba bean in the mixture or more faba bean. Soil N availability and soil pH were lower for the soil mixtures of 22% and 30% clay compared to the sandy soil alone. It could be concluded that soil cumulative respiration and MBc concentration were mainly influenced by residue addition, whereas available N and pH were influenced by clay addition to the sandy soil studied.

关键词： available N c use efficiency c/N ratio cumulative respiration nutrient availability pH plant residues