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猫抓病的视神经炎表现

世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 7-7页

作者： biousse v. 杨秀梅 Neuro-Ophthalmology Unit Emory Eye Center 1365-B C lifton Road NE Atlanta GA 30322 United States

Ocular and neuro-ophthalmic manifestations of cat scratch disease are not unc ommon. The association of anterior optic neuritis with retinal lesions suggests neuroretinitis, which is highly suggestiv. of cat scratch d... 详细信息

关键词：视神经炎猫抓病视神经视网膜炎高度提示新病例

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垂体卒中

世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 8-8页

作者： biousse v. Makki A. 邢咏新 Neuro-Ophthalm- ology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 United States

Pituitary apoplexy is a life threatening condition caused by sudden hemorrhage or infarction of the pituitary gland. Most patients present with headaches and neuro-ophthalm- ologic symptoms and signs, often associated... 详细信息

关键词：神经眼科

滴用二硫化铁溴莫尼定对对侧眼Leber遗传性视神经病的预防:一项公开标签的非随机多中心研究

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 6-6页

作者： Newman N.J.. biousse v. Dav.d R 杨秀梅 Neuro-Ophthalmology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 United States Dr

PURPOSE: To test a topical agent with purported antiapoptotic properties as prophylactic treatment after first eye inv.lv.ment in Leber hereditary optic neuropathy (LHON), a maternally-inherited disorder characterized by bilateral, often sequential, v.sual loss. DESIGN: Open labeled, nonrandomized prospectiv. pilot ***: Nine primary mutation molecularly confirmed LHON patients with one eye v.sion loss for less than 6 months and normal v.sual function in the fellow eye were treated with brimonidine purite 0.15% (Alphagan P) 4 times daily in the unaffected eye for up to 2 years. v.sual acuity was the primary efficacy outcome. Secondary measures included changes on automated perimetry and quantification of the relativ. afferent pupillary defect. RESULTS: There were 8 men and 1 woman enrolled, aged 13 to 54 years (mean 32 years), eight with the 11778 mitochondrial DNA (mtDNA) mutation, and one with the 3460 mutation. Despite normal v.sual acuity at baseline in all patients, 7 patients had some minimal changes in the central v.sual field of the study eye. All patients had deterioration of v.sion in their second eye. In 1 of the 2 patients who had treatment initiated within 16 days after first eye inv.lv.ment, good v.sual acuity was maintained in the study eye at 15 month followup, despite a mildly abnormal study eye baseline v.sual field. CONCLUSIONS: LHON may be a bilateral condition at onset more frequently than appreciated, with asymmetric sev.rity at presentation. Topical brimonidine purite in this dosage was unsuccessful in prev.nting second eye inv.lv.ment in recently monocularly-symptomatic LHON.

关键词：对侧眼患者视力 LH Leber 遗传性视神经病标签

进展性外部视网膜坏死表现为孤立的视神经病变

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 47-47页

作者： Nakamoto B.K. Dorotheo E.U. biousse v. N.J. Newman 张玉龙 Neuro-Ophth almology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 Un ited States Dr.

Progressiv. outer retinal necrosis is a necrotizing herpetic retinopathy usua lly seen in immunocompromised patients. The authors describe two patients with t his disease who initially had findings suggestiv. of an optic neuropathy. v.sion declined after treatment with methylprednisolone, after which fundus examinatio n became consistent with progressiv. outer retinal necrosis. These cases undersc ore the importance of careful examination of the retinal periphery before manage ment of any presumed optic neuropathy with steroids.

关键词：视网膜坏死视神经病变视网膜病眼底检查疱疹性

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外伤性同侧偏盲

世界核心医学期刊文摘（眼科学分册） 2006年第12期2卷 1-2页

作者： Bruce B.B. Kedar S. v. biousse 张磊 Neuro-ophthalmology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 United StatesDr.

Objectiv.: To describe the characteristics of patients with homonymous hemianopia from traumatic brain injury (TBI) seen in our unit between 1989 and 2004. Methods: Only patients with a history of TBI, who had detailed clinical information and results of neuroimaging, were included in our study. Demographic characteristics, clinical features, types of v.sual field defects, location of lesion and ev.lution of v.sual field defects were recorded. Results: Of the 880 patients with homonymous hemianopia seen in our unit, 103 patients (112 with homonymous hemianopia) had TBI (74 men and 29 women, mean age 30.7 (SD 15.3) years). Median time from injury to initial v.sual field testing was 5 (range 0.5-360) months. In all, 64 (57.1%) patients sustained injuries that were motor v.hicle-related; 19 (17%) v.olence-related; 17 (15.2%) due to falls; and 12 (10.7%) because of other blunt head trauma. v.sual field defects included complete homonymous hemianopia in 44 (39.3%) patients and incomplete homonymous hemianopia in 68 (60.7%) patients. The lesion was occipital in 14 (12.5%) patients, associated with optic radiation in 26 (23.2%) and the optic tract in 12 (10.7%), and multiple in 60 (53.6%). Conclusion: Most cases of homonymous hemianopia from TBI were motor v.hicle-related. Patients were younger, more often male, and had multiple brain lesions more often than patients with homonymous hemianopia from causes other than TBI. A median delay of 5 months was observ.d before the documentation of the homonymous hemianopia, which may hav. a major effect on the success of rehabilitation and driv.ng training in these young patients.

关键词：外伤性同侧偏盲视野缺损颅脑外伤检查结果神经影像临床资料

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同侧偏盲:904例患者的临床-解剖关系

世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 12-13页

作者： Kedar S. Lynn M.J. v. biousse 谢琰臣 Neuroophthalmology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 United States Dr.

Objectiv.: To describe the clinical characteristics and clinical-anatomic correlations of homonymous hemianopia (HH). Background: Homonymous hemianopia impairs v.sual function and frequently precludes driv.ng. Most knowledge of HH is based on relativ.ly few cases with clinical-anatomic correlations. Methods: The authors rev.ewed medical records of all patients with HH seen in their serv.ce between 1989 and 2004. Demographic characteristics, characteristics of v.sual field defects, causes of v.sual field defects, neuroradiologic definition of lesion location, and associated neurologic deficits were recorded. Results: A total of 904 HH were found in 852 patients. A total of 340 HH (37.6%) were complete and 564 HH (62.4%) were incomplete. Homonymous quadrantanopia (264 HH, 29%) was the most common type of incomplete HH, followed by homonymous scotomatous defects (116 HH, 13.5%), partial HH (114 HH, 13%), and HH with macular sparing (66 HH, 7%). A total of 407 HH (45.0%) were isolated. Causes of HH included stroke (629 HH, 69.6%), trauma (123, 13.6%), tumor (102, 11.3%), brain surgery (22, 2.4%), demyelination (13, 1.4%), other rare causes (13, 1.4%), and unknown etiology (2, 0.2%). The lesions were most commonly located in the occipital lobes (45%) and the optic radiations (32.2%). Ev.ry type of HH, except for unilateral loss of temporal crescent and homonymous sectoranopia, was found in all lesion locations along the retrochiasmal v.sual pathways. Conclusion: Homonymous hemianopia is usually secondary to stroke, head trauma, and tumors. Although the characteristics of v.sual field defects can be helpful in lesion location, specific v.sual field defects do not always indicate specific brain locations.

关键词：临床特征解剖关系同侧偏盲神经功能缺陷视觉传导通路视野缺损人口统计学

ND5基因在LHON中的作用:一种新型异质体LHON基因突变的特征

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世界核心医学期刊文摘（眼科学分册） 2006年第3期2卷 6-7页

作者： Mayorov.v.biousse v.Newman N.J Brown M.D. 张磊 Mercer Univ.rsity School of Medicine Macon GA 31207 United StatesDr.

Leber’s hereditary optic neuropathy (LHON) causes central v.sion loss from bilateral optic neuropathy. Although 13 mitochondrial DNA (mtDNA)mutations are strongly associated with LHON, only three account for roughly 90%of cases and thus are found inmultiple independent LHON families. The remaining LHON mutations are rare. Here, we describe the clinical and genetic characterization of a new LHON mtDNA mutation. The 12848T mutation alters a highly conserv.d amino acid in the ND5 complex I gene, is not found in controls, and is heteroplasmic. Despite ND5 being the largest of the mtDNA complex I genes, ND5 mutations are quite rare in LHON.

关键词：基因突变 LHON Leber遗传性视神经病异质体视神经病变视力丧失线粒体

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同侧偏盲的自然病程

世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 5-6页

作者： Kedar S. Lynn M.J. v.biousse 桑延智 Neuro-ophthalmology Unit Emory Eye Center1365-B Clifton RoadNEAtlantaGA 30322United States Dr.

Objectiv.:To describe the characteristics of spontaneous recov.ry of homonymous hemianopia(HH).Methods:The authors rev.ewed medical records of all patients with HH confirmed by formal v.sual field testing and seen in follow-up in their serv.ce between 1989 and *** characteristics,causes,neuroradiologic definition of lesion location,final outcome,and ev.lution of the v.sual field defects were *** associations among final v.sual field defect outcome,time from injury,and clinical features were ***:A total of 254 patients with 263 HH were included in this *** v.sual field defect recov.ry was observ.d in 101 HH(38.4%).The likelihood of spontaneous recov.ry decreased with increasing time from injury to initial v.sual field testing(p=0.0003).The probability of improv.ment was related to the time since injury(p=0.0003)with a 50 to 60% chance of improv.ment for cases tested within 1 month after injury that decreased to about 20% for cases tested at 6 months after *** other factor was found to correlate with the final outcome of the v.sual field *** after 6 months from injury was mild and usually related to improv.ment of the underlying ***:Spontaneous improv.ment of homonymous hemianopia is seen in at least 50% of patients first seen within 1 month of *** most cases,the improv.ment occurs within the first 3 months from *** improv.ment after 6 months postinjury should be interpreted with caution as it is most likely related to improv.ment of the underlying disease or to improv.ment in the patient’ s ability to perform v.sual field testing reliably.

关键词：同侧自然病程偏盲损害情况视野检查自然恢复视野缺损时间延长

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同侧偏盲的自然病史

世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 12-12页

作者： Kedar S. Lynn M.J. v. biousse 谢琰臣 Neuroophthalmology Unit Emory Eye Center 1365-B Clifton Road NE Atlanta GA 30322 United States Dr.

Objectiv.: To describe the characteristics of spontaneous recov.ry of homonymous hemianopia (HH). Methods: The authors rev.ewed medical records of all patients with HH confirmed by formal v.sual field testing and seen in follow-up in their serv.ce between 1989 and 2004. Clinical characteristics, causes, neuroradiologic definition of lesion location, final outcome, and ev.lution of the v.sual field defects were recorded. The associations among final v.sual field defect outcome, time from injury, and clinical features were analyzed. Results: A total of 254 patients with 263 HH were included in this study. Spontaneous v.sual field defect recov.ry was observ.d in 101 HH (38.4%). The likelihood of spontaneous recov.ry decreased with increasing time from injury to initial v.sual field testing (p = 0.0003). The probability of improv.ment was related to the time since injury (p = 0.0003) with a 50 to 60%chance of improv.ment for cases tested within 1 month after injury that decreased to about 20%for cases tested at 6 months after surgery. No other factor was found to correlate with the final outcome of the v.sual field defects. Improv.ment after 6 months from injury was mild and usually related to improv.ment of the underlying disease. Conclusion: Spontaneous improv.ment of homonymous hemianopia is seen in at least 50%of patients first seen within 1 month of injury. In most cases, the improv.ment occurs within the first 3 months from injury. Spontaneous improv.ment after 6 months postinjury should be interpreted with caution as it is most likely related to improv.ment of the underlying disease or to improv.ment in the patient’s ability to perform v.sual field testing reliably.

关键词：自然病史偏盲同侧视野缺损检查时间预后相关自发缓解临床特征