检索结果-南通市图书馆

Is There Any Impact of VDR Gene Polymorphism in Bataks Ethnic to Have Tuberculosis？

Journal of Health Science 2017年第1期5卷 1-8页

作者： yahwardiah Siregar bintang y.m. sinaga Department of Biochemistry Faculty of Medicine Universitas Sumatera Utara Medan Indonesia Department of Pulmonology and Respiratory Faculty of Medicine Universitas Sumatera Utara--Adam Malik Hospital MedanIndonesia

The active metabolite of vitamin D activates macrophages and results in the restriction of growth of Tuberculosis （TB） pathogen m. tuberculosis. The effect of vitamin D is achieved through binding to the Vitamin D Receptor （VDR）, which ultimately produces the antimicrobial peptide Cathelicidin. matched case-control study with 76 pulmonary tuberculosis Indonesian Batak ethnic patients and 76 healthy normal control were completed. Genetic polymorphisms of VDR gene were analysed using PCR and RFLP. The genotype frequencies of ApaI were AA 10.6%, Aa 44.7%, aa 44.7% for the control group and AA 10.6%, Aa 43.4%, aa 46% for the PTB patients. For the Fokl genotype the frequencies were FF 39.5%, Ff 44.7%, ff 15.8% for the control group and FF 35.5%, Ff 55.3%, ff9.2% for the PTB patients. In these two genotypes there were no significant differences found between the control group and the PTB patients （P 〉 0.05）. Besides, there genotypic frequencies were in agreemem with the Hardy-Weinberg Equilibrum （P 〉 0.05）. However, for the BsmI genotype frequencies, BB 2.6%, Bb 23.7% and bb 73.7% for the control group and BB 0%, Bb 68.4%, bb 31.6% for the PTB patients, there was a significant association found with PTB; the bb genotype is correlated with a decreased risk for PTB （OR 0.22, 95% CI： 0.11-0.45）. ApaI and Fokl polymorphisms ofVDR gene do not appear to be responsible for host susceptibility to pulmonary tuberculosis in the Indonesian Batak ethnic population but BsmI polymorphism had association with host resistant to PTB.

关键词： Pulmonary tuberculosis VDR polymorphism Batak Indonesia.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：