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A non-antibiotic organic coating on ZA6-1 surface releasing different concentrations of sodium dodecyl sulphate/levulinic acid for orthopaedic application

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BIOSURFACE AND BIOTRIBOLOGY 2024年第2期10卷 42-51页

作者： Zou, Feng Zhao, Deren Liu, Yangkai Lu, Qiqi Liu, Hulin Chen, Zilin Fang, Yaxing Tan, Xiaodong Xiang, Yunjie Feng, Xue Zhang, Yongping rao, Xi Southwest Univ Sch Mat & Energy Chongqing Peoples R China Southwest Univ Chongqing Key Lab Soft Matter Mat Chem & Funct Mfg Chongqing Peoples R China Chongqing Med Univ Univ Town Hosp Dept Clin Lab Chongqing Peoples R China

Bone implantation surgery is often accompanied by bacterial infection, resulting in infectious bone non-union, pathological fracture and other serious consequences, which will aggravate the pain of patients. A non-antibiotic coating consisting of sodium dodecyl sulphate (SDS) and levulinic acid (LA) with different concentrations was prepared by the authors on the zinc-aluminium alloy (ZA6-1) using a wet chemistry treatment for orthopaedic application. The influence of SDS/LA concentrations on the surface morphology, composition and performance of the developed coating was investigated. The results showed that as-prepared coating on a zinc alloy surface could improve the substrate's corrosion resistance and increase the degradation rate from 0.82 to 19.70 mu m/year upon raising the SDS/LA concentration. Furthermore, higher hydrophilicity (100%) and morphology, as well as good cell adhesion and differentiation (ALP >95% for 7 days) were observed on coated zinc alloys. The increased SDS/LA concentration slightly weakens the biocompatibility and enhances the antibacterial performance of coated zinc alloys due to the synergistic effect of SDS/LA. Overall, the coating comprising 6 wt.% SDS and 9 wt.% LA showed excellent antibacterial action with a high level of biocompatibility, confirming its potential application for orthopaedic implants.

关键词： antibacterial biocompatibility biomaterials material property IN-VITRO ALLOY ANTIBACTERIAL ZINC BEHAVIOR CELLS BIODEGRADATION SANITIZER NANOTUBES MECHANISM

倾斜椭球凹陷阵列湍流强化传热实验与数值分析

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推进技术 2024年第4期45卷 144-152页

作者：许超张鹏饶宇上海交通大学机械与动力工程学院上海200240

为了提高涡轮叶片内部通道对流传热性能,本文基于瞬态液晶热像技术分别针对矩形通道表面排布的球形凹陷和斜椭球凹陷阵列的传热和压力损失特性进行了实验研究。在雷诺数为1×10^(4)~6×10^(4)内,与基准球形凹陷相比,平行排布和V形排布... 详细信息

为了提高涡轮叶片内部通道对流传热性能,本文基于瞬态液晶热像技术分别针对矩形通道表面排布的球形凹陷和斜椭球凹陷阵列的传热和压力损失特性进行了实验研究。在雷诺数为1×10^(4)~6×10^(4)内,与基准球形凹陷相比,平行排布和V形排布的斜椭球凹陷总体传热分别增强了23.8%~33.8%和104%~121%,V形排布的斜椭球凹陷综合传热性能显著提高了25%~68.3%。通过数值模拟发现,平行排布的斜椭球凹陷虽然可以诱发更强烈的二次流,但是平行的排布方式使下游凹陷受到来自上游凹陷升温后的流体冲刷,因此限制了传热的进一步增强。V形排布的斜椭球凹陷通过诱发大尺度的纵向涡对将来自主流的冷流体输运至壁面,冷流体直接冲击壁面并与近壁流体剪切,极大地增强了对流传热。

关键词：涡轮叶片冷却斜椭球凹陷传热瞬态液晶热像实验流动结构

Research on Heterogeneous Information Network Link Prediction Based on Representation Learning

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Journal of Electronic Research and Application 2024年第5期8卷 32-37页

作者： Yan Zhao Weifeng rao Zihui Hu Qi Zheng School of Information Engineering Jingdezhen Ceramic UniversityJingdezhen 333403China School of Mechanical and Electronic Engineering Jingdezhen Ceramic UniversityJingdezhen 333403China

A heterogeneous information network,which is composed of various types of nodes and edges,has a complex structure and rich information content,and is widely used in social networks,academic networks,e-commerce,and other *** prediction,as a key task to reveal the unobserved relationships in the network,is of great significance in heterogeneous information *** paper reviews the application of presentation-based learning methods in link prediction of heterogeneous information *** paper introduces the basic concepts of heterogeneous information networks,and the theoretical basis of representation learning,and discusses the specific application of the deep learning model in node embedding learning and link prediction in *** effectiveness and superiority of these methods on multiple real data sets are demonstrated by experimental verification.

关键词： Heterogeneous information network Link prediction Presentation learning Deep learning Node embedding

A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： Ping Yu Tanwei Gu Yueyang rao Weimin Liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou Guangdong Provincial Key Laboratory of New Drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMPA Key Laboratory for Research and Evaluation of Drug Metabolism School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Lewwin Pharmaceutical Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S14,targeting peroxiredoxin 1(PRDX1).By binding to Cys83 of PRDX1 and augmenting its peroxidase activity,S14 alleviates kidney injury efficiently in Prdx1-overexpression(Prdx1-OE)***,S14 also increases PRDX1 nuclear translocation and directly activates the Nrf2/HO-1/NQO1 pathway to inhibit ROS *** to the limited druggability of S14 with low bioavailability(2.6%)and poor renal distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticle system is constructed to load S14 for precise treatment of AKI.L-Serine conjugation to chitosan imparts specificity to kidney injury molecule-1(Kim-1)-overexpressed *** developed S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsulation with micelles,the AUC_(0-t),half-life time,and renal distribution of S14 increase 2.5-,1.8-,and 3.1-fold,*** main factors contributing to the improved druggability of S14 nanodrugs include the lower metabolic elimination rate and UDPglycosyltransferase(UGT)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent while enhancing its ADME properties and druggability through nanotechnology,thereby driving advancements in marine drug development for AKI.

关键词： Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability

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明清诗歌叙事传统之因变及研治策略

苏州大学学报（哲学社会科学版） 2024年第4期45卷 132-141页

作者：饶龙隼四川大学中国俗文化研究所四川成都610207

明清诗歌叙事传统之确立,绝非独立突兀地自成一体;而是经历长期的蓄势发展,并以元代诗歌叙事为前导。正是在因承早前的基础上,才有所拓展并现若干新变。其拓展与新变固然重要,但并非诗歌叙事之主导;主导明清时期诗歌叙事的,还是诗歌叙... 详细信息

明清诗歌叙事传统之确立,绝非独立突兀地自成一体;而是经历长期的蓄势发展,并以元代诗歌叙事为前导。正是在因承早前的基础上,才有所拓展并现若干新变。其拓展与新变固然重要,但并非诗歌叙事之主导;主导明清时期诗歌叙事的,还是诗歌叙事传统之因承。在因承的基础上拓充,在新变的驱动下互渗,拓充与互渗,才是其主线。故明清诗歌叙事传统之因承新变,主要表征为体制拓充与功能互渗。尽管学界期待对之作定量分析,但在目前条件下暂时难以落实;针对明清诗歌叙事传统因承新变的研治策略,还应落实为定性分析、特征描述和变量追踪。

关键词：诗歌叙事叙事传统因承新变研治策略

Phytochemicals of Aloe barbadensis miller as Potential Inhibitors of Uropathogenic Escherichia coli for Urinary Tract Infection Therapy: An in Silico Approach

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Open Journal of Biophysics 2024年第2期14卷 99-120页

作者： Mikidadi Salehe Gurisha Pulapa Venkata Kanaka rao Laxmikanth Cherupally Department of Physics College of Natural and Mathematical Sciences University of Dodoma Dodoma Tanzania

Urinary tract infections (UTIs) are common infections caused by normal skin or rectum bacteria that get into the urethra and infect the urinary tract. Although the infection can affect various parts of the tract, bladder infections are the most prevalent kind. Uropathogenic Escherichia Coli (UPEC) is the most common pathogen associated with UTI development. Therefore, inhibiting the UPEC protein target (PDB ID: 8BVD) appears to be a promising therapeutic strategy. Therefore, in this study, molecular docking and dynamics were conducted to examine the antibacterial activity of Aloe barbadensis miller against UPEC bacteria. The Aloe barbadensis miller natural compounds licochalcone A, palmidin B and palmidin C were downloaded from PubChem with amoxicillin, which was used as a control drug and studied against the target molecule. The potential parameters examined were the docking scores, absorption, distribution, metabolism, excretion, toxicity (ADMET), bioavailability, root mean square deviation (RMSD), root mean square fluctuation (RMSF), hydrogen bonding, radius of gyration, and potential energy of the system. Docking scores showed that all ligands demonstrated an admirable candidature as an inhibitor to 8BVD molecule, and the score hierarchy is licochalcone A (-6.4 kcal/mol), palmidin C (-6.1 kcal/mol), palmidin B (-6.0 kcal/mol), and amoxicillin (-5.9 kcal/mol). All ligands appeared to have good drug-like properties and oral bioavailability. Molecular dynamic studies showed that all ligands exhibited an excellent nominee as inhibitors in their vicinity at 20 ns. However, there is a relatively high fluctuation of palmidin B compared with other compounds, which seems to be more stable. This work suggests that the selected phytoconstituents could be used as inhibitors of the 8BVD protein in the fight against UTIs. However, further investigation on the clinical and experimental validation of UTI treatment’s specific mechanisms and effects is still welcomed.

关键词： Uropathogenic Escherichia Coli Phytochemicals Molecular Docking Ligand Hydrogen Bond

Hierarchical V_(3)S_(4)/C nanofibers with fast kinetics for superior alkali metal batteries

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Rare Metals 2024年第4期43卷 1836-1844页

作者： Li Chen Zhi-Xin rao Zhi Chen Zhao-Hui Wu Shuai Yang Zhi-Jun Feng Hui-Yong Yang Fan-Yan Zeng Xi-Bao Li Jin-Yang Hu Jun-Tong Huang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang330063China

Owing to the numerous benefits,including low cost and great theoretical capacity,V3S4 has been a research hotspot for Li^(+)/Na^(+)/K^(+) ***,the V_(3)S_(4) electrode with long cycling stability and high specific capacities continues to pose significant *** this work,vacuum vulcanization is combined with electrospinning to synthesize V_(3)S_(4)/C composite nanofibers(V_(3)S_(4)@CNF).

关键词： composite fibers kinetics

Cretaceous integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1229-1289页

作者： Dangpeng XI Guobiao LI Shijun JIANG Xin rao Tian JIANG Tianyang WANG Zuohuan QIN Yasu WANG Jianzhong JIA Muhammad KAMRAN Zhongye SHI Yuyang WU Panxi WANG Lixin SUN Qinggao ZENG Xiaoqiao WAN State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China College of Oceanography Hohai UniversityNanjing 213200China Key Laboratory of Palaeobiology and Petroleum Stratigraphy Nanjing Institute of Geology and PaleontologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Tibetan Plateau Earth System Environmentand Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China China National Offshore Oil Corporation Limited Beijing 100028China Shanghai Science and Technology Museum Shanghai 200120China Xizang Bureau of Geological and Mineral Exploration and Development Lhasa 850000China Tianjin Geological Survey Center of China Geological Survey Tianjin 300170China

The Cretaceous Period is a vital time interval in deciphering the evolutionary history of the Neo-Tethys Ocean and the convergence of different plates and blocks across the Qinghai-Tibetan Plateau.A detailed stratigraphic framework and paleogeographic patterns are the basis for understanding the evolution of the Neo-Tethys Ocean and the formation of the QinghaiTibetan ***,the Cretaceous stratigraphy,biota,paleogeography,and major geological events in the Qinghai-Tibetan Plateau are analyzed to establish an integrative stratigraphic framework,reconstruct the paleogeography during the Cretaceous Period,and decode the history of the major geological *** Cretaceous rocks of the Qinghai-Tibetan Plateau and its surrounding area are predominantly marine deposits,with a small amount of interbedded marine-terrestrial and terrestrial *** Indus-Yarlung Tsangpo Suture Zone was responsible for the deposition of deep marine sediments dominated by ophiolite suites and radiolarian *** the south,the Tethys Himalayas and Indus Basin received marine sediments of varying depths and lithology;to the north,the Xigaze and Ladakh forearc basins are also filled with marine *** Lhasa Block,Karakorum Block,western Tarim Basin,and West Burma block consist of shallow marine,interbedded marine-terrestrial,and terrestrial *** Qiangtang Basin and other areas are dominated by terrestrial *** Cretaceous strata of the Qinghai-Tibetan Plateau and its surrounding areas are widely distributed and diversified,with abundant foraminifera,calcareous nannofossils,radiolarians,ammonites,bivalves,and *** the basis of integrated lithostratigraphic,biostratigraphic,geochronologic,and chemostratigraphic analyses,we proposed herein a comprehensive stratigraphic framework for the Cretaceous Period of the eastern *** analyzing the Cretaceous biota of different biogeographic zones from eastern Neo-Tethys and its surrounding a

关键词： Qinghai-Tibetan Plateau Tethys Cretaceous Stratigraphy Biota Paleogeography

Progress in the diagnosis and treatment of graft fibrosis after liver transplantation

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Portal Hypertension & Cirrhosis 2024年第1期3卷 22-30页

作者： Youwei Zhao Lijun Wang Man Xie Wei rao Department of Gastroenterology Medical College of Qingdao UniversityQingdaoShandongChina Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Division of Hepatology Liver Disease CenterThe Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Department of Organ Transplantation Center The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina

Liver transplantation(LT)is considered one of the best treatments for patients with end-stage liver ***,some patients with no significant clinical manifestations or abnormal laboratory tests still experience graft fibrosis during postoperative follow-up,which is often recognized by graft *** fibrosis can lead to graft dysfunction,thereby reducing the survival time of the recipient and even requiring ***,noninvasive methods are widely applied in the assessment of hepatic and allograft *** both noninvasive diagnostic models based on laboratory examination indicators and elastography technology that can quantify liver stiffness have some value in the evaluation of fibrosis,the diagnostic accuracy and characteristics of these various methods vary and cannot replace liver biopsy *** recent years,some liver-protective drugs and proprietary Chinese traditional medicines have been proven to delay or reverse chronic liver ***,their efficacy and safety for LT recipients need to be further *** article reviews the diagnosis and treatment of graft fibrosis after LT to provide a reference for improving the overall survival rate of LT recipients.

关键词： diagnosis fibrosis liver transplantation therapeutics