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Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure

World Journal of Gastroenterology 2005年第45期11卷 7183-7187页

作者： Selim Aydemir binnaz handan ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu Department of Gastroenterology Department of Pathology

AIM： To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure （CRF）. METHODS： Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori （H pylori） and CRF status. Groups were labeled as follows： la： normal renal function, H pylori negative （n = 12）, lb： normal renal function, H pylori positive （n = 11）, 2a： CRF, H pylori negative （n = 10）, 2b： CRF, H pylori positive （n = 11）. Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation, antral biopsy specimens were taken from each patient. In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen （PCNA） labeling indexes （LI） were assessed with immunohistochemical staining method. RESULTS： For groups la, lb, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5, 60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22, respectively. When the one-way ANOVA test was applied, statistically significant differences were detected between the groups for both Bax LI （P = 0.004 〈0.01） and PCNA LI （P = 0.009 〈0.01）. When groups were compared further in terms of Bax LI and PCNA LI with Tukey＇s HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups la and 2b （P = 0.006 〈0.01）.CONCLUSION： In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells.

关键词： Helicobacter pylori Chronic renal failure Bax Proliferating cell nuclear antigen

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Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene:A case report

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世界临床病例杂志 2023年第26期11卷 6176-6182页

作者： Ugur Musabak Tuba Erdoğan Serdar Ceylaner EmreÖzbek Nuretdin Suna binnaz handanÖzdemir Department of Immunology and Allergy Baskent University School of MedicineAnkara 06490AnkaraTurkey Department of Medical Genetics Lokman Hekim UniversityAnkara 06000Turkey Department of Medical Genetics Intergen Genetic and Rare Disease Diagnosis and Reseach CenterAnkara 06000Turkey Department of Immunology-Allergy Etlik City HospitalAnkara 06490AnkaraTurkey Division of Gastroenterology Baskent University School of MedicineAnkara 06000Turkey Department of Pathology Baskent UniversityAnkara 06000Turkey

BACKGROUND Cytotoxic T Lymphocyte Antigen-4(CTLA4)deficiency is a genetic defect that causes a common variable immunodeficiency(CVID)clinical *** studies have reported an association between CTLA mutations or variants and various autoimmune *** therapy models,which have become increasingly popular in recent years,have been successful in treating CTLA4 *** this article,we discuss the clinical outcomes of abatacept treatment in a patient with CTLA4 and lipopolysaccharide-responsive beige-like anchor(LRBA)variants that was previously diagnosed with *** SUMMARY A 25-year-old female patient,who was visibly cachectic,visited our clinic over the course of five years,complaining of *** patient was diagnosed with ulcerative colitis in the centers she had visited previously,and various treatments were administered;however,clinical improvement could not be *** hypokalemia was detected during an *** serum immunoglobulin levels,CD19+B-cell percentage,and CD4/CD8 ratio were *** endoscopic examination revealed erosive gastritis,nodular duodenitis,and *** findings supported the presence of immune mediated *** the patient was examined carefully,she was diagnosed with CVID,and intravenous immunoglobulin treatment was *** and rectal therapeutic drugs including steroid therapy episodes were administered to treat the immune mediated *** follow-ups and treatment were performed due to the *** conducting genetic analyses,the CTLA4 and LRBA variants were identified and abatacept treatment was *** targeted therapy,the patient’s clinical and laboratory findings rapidly regressed,and there was an increase in *** The heterozygous CTLA4 variant identified in the patient has been previously shown to be associated with various autoimmune *** successful clinical outcome of abatacept treatment in this patien

关键词： Common variable immunodeficiency Abatacept CTLA4 antigen Case report

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Mixed Epithelial and Stromal Tumor of the Kidney: A Case Report

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Surgical Science 2011年第2期2卷 66-68页

作者： Ebru Demiralay Cem Comunoglu handan ozdemir Ramazan Yavuz Akman Department of Pathology Faculty of MedicineBaskent UniversityAnkaraTurkey Department of Urology Faculty of MedicineBaskent UniverstyAnkaraTurkey

Mixed epithelial and stromal tumor of the kidney (MESTK) is a recently described rare neoplasm. Malignant transformation, recurrence and metastasis are rare, therefore histopathological distinction from other renal neoplasms, especially from renal cell carcinoma is important. Histologically the tumor is composed of biphasic components including cysts and tubules embedded in the spindle cell stroma. We report a case of a MESTK in 60-year-old postmenopousal woman who presented with an incidental solid renal mass but no urinary complaint.

关键词： Kidney Mixed Epithelial and Stromal Tumor

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The Frequency of K-ras Mutation in Colorectal Adenocarcinomas with Absence of Distant Metastasis at Diagnosis

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Surgical Science 2012年第3期3卷 111-115页

作者： Ebru Demiralay Yaman Saglam Gulum Altaca Banu Bilezikci handan ozdemir Department of General Surgery School of Medicine Baskent University Istanbul Turkey Department of Pathology School of Medicine Baskent University Istanbul Turkey Medical Genetics Laboratory Goztepe Park Medical Hospital Istanbul Turkey

Purpose: K-ras mutations were reported to be in 40% - 60% of patients with sporadic colorectal cancers (CRCs). HER-2/neu oncogene that is important in breast carcinoma was reported in CRCs in several studies. The aims of our study are to determine;the frequency of K-ras mutation in CRC and positivity of HER-2/neu, the relation between K-ras mutation and HER-2/neu positivity, and also the relation between clinicopathological findings with K-ras mutation and HER-2/neu expression. Methods: Total of 35 colon resection specimen from patients without distant metastasis who were operated due to colorectal adenocarcinoma were included in the study. The sections were examined with light microscopy. Vascular and perineural invasions and pericolonic tumor deposits (PCTD) were investigated. HER-2/neu was applied immunohistochemically. DNA sample obtained from tumor paraffin block was screened for presence of 20 mutations in K-ras gene-codon 12, 13, 61 by AutoGenomics and Infinity Analyzer. Results: K-ras gene mutation was detected in 14 of 35 patients (40%). HER-2/neu positivity was detected in 7 cases (28.57%). There was not any significant correlation between HER-2/neu positivity, K-ras gene mutation and clinicopathological findings. There was direct correlation between PCTD and vascular invasion. Conclusions: There was not correlation between K-ras mutation and clinicopathological findings similar to several other studies. The relation between HER-2/neu expression and clinicopathological findings was not found.

关键词： Colon Adenocarcinoma K-ras HER-2/Neu

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Striae gravidarum as a predictor of spontaneous preterm delivery: A case control study

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Open Journal of Obstetrics and Gynecology 2012年第4期2卷 394-397页

作者： Sefa Kelekci Servet Gencdal Orcun ozdemir Emre Destegul Kiymet handan Kelekci Dermatology Clinic Ataturk Education and Research Hospital Ministry of Health Izmir Turkey Obstetrics and Gynecology Clinic Adana Numune Education and Research Hospital Ministry of Health Adana Turkey Obstetrics and Gynecology Clinic Aegean Education and Research Hospital Ministry of Health Izmir Turkey

Background/Aims: The association between striae gravidarum (SG) and preterm delivery may be postulated because of sharing similar poor organization of extracellular matrix in both skin and cervix. Our goal was to compare the frequency of striae gravidarum in women who gave preterm birth and women who gave term birth. Methods: A case-control study was conducted in women who gave preterm birth (n = 66) and age matched women who gave term birth (n = 68). Cases and controls were recruited from puerperal women consequently seen at delivery wards of perinatology unit. All women underwent dermatologic examination in terms of SG blindly to theirs gestational weeks of delivery. The frequency of SG was compared in all groups. Results: The frequency of SG was 63.6% in women with preterm birth and 54.4% in women with term birth (p = 0.278). SG is five times more common in late preterm group than in women with term group, but this difference was not statistically significant [(p = 0.227, OR: 5.02, CI 95% (0.5 - 44.0)]. The rate of preventive cream usage was not statistically different in women with SG and without SG (p = 0.245). Conclusions: It seems that there was no statistically significant association between the risk of preterm labor and the presence of striae gravidarum. Larger prospective observational studies are needed to state expressly the probable clinical association between the presence of SG and preterm delivery.

关键词： Preterm Delivery Predictive Screening Striae Distensae Striae Gravidarum Term Delivery

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