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Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene:A case report

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世界临床病例杂志 2023年第26期11卷 6176-6182页

作者： Ugur Musabak Tuba Erdoğan Serdar Ceylaner EmreÖzbek Nuretdin Suna binnaz handanözdemir Department of Immunology and Allergy Baskent University School of MedicineAnkara 06490AnkaraTurkey Department of Medical Genetics Lokman Hekim UniversityAnkara 06000Turkey Department of Medical Genetics Intergen Genetic and Rare Disease Diagnosis and Reseach CenterAnkara 06000Turkey Department of Immunology-Allergy Etlik City HospitalAnkara 06490AnkaraTurkey Division of Gastroenterology Baskent University School of MedicineAnkara 06000Turkey Department of Pathology Baskent UniversityAnkara 06000Turkey

BACKGROUND Cytotoxic T Lymphocyte Antigen-4(CTLA4)deficiency is a genetic defect that causes a common variable immunodeficiency(CVID)clinical *** studies have reported an association between CTLA mutations or variants and various autoimmune *** therapy models,which have become increasingly popular in recent years,have been successful in treating CTLA4 *** this article,we discuss the clinical outcomes of abatacept treatment in a patient with CTLA4 and lipopolysaccharide-responsive beige-like anchor(LRBA)variants that was previously diagnosed with *** SUMMARY A 25-year-old female patient,who was visibly cachectic,visited our clinic over the course of five years,complaining of *** patient was diagnosed with ulcerative colitis in the centers she had visited previously,and various treatments were administered;however,clinical improvement could not be *** hypokalemia was detected during an *** serum immunoglobulin levels,CD19+B-cell percentage,and CD4/CD8 ratio were *** endoscopic examination revealed erosive gastritis,nodular duodenitis,and *** findings supported the presence of immune mediated *** the patient was examined carefully,she was diagnosed with CVID,and intravenous immunoglobulin treatment was *** and rectal therapeutic drugs including steroid therapy episodes were administered to treat the immune mediated *** follow-ups and treatment were performed due to the *** conducting genetic analyses,the CTLA4 and LRBA variants were identified and abatacept treatment was *** targeted therapy,the patient’s clinical and laboratory findings rapidly regressed,and there was an increase in *** The heterozygous CTLA4 variant identified in the patient has been previously shown to be associated with various autoimmune *** successful clinical outcome of abatacept treatment in this patien

关键词： Common variable immunodeficiency Abatacept CTLA4 antigen Case report

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Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure

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World Journal of Gastroenterology 2005年第45期11卷 7183-7187页

作者： Selim Aydemir binnaz handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu Department of Gastroenterology Department of Pathology

AIM: To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure (CRF).METHODS: Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori (H pylori) and CRF status. Groups were labeled as follows: 1a: normal renal function, H pylori negative (n = 12), 1b: normal renal function,H pylori positive (n = 11), 2a: CRF, H pylori negative (n = 10), 2b: CRF, H pylori positive (n = 11). Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation,antral biopsy specimens were taken from each *** order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen (PCNA) labeling indexes (LI) were assessed with immunohistochemical staining ***: For groups 1a, 1b, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5,60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22,respectively. When the one-way ANOVA test was applied,statistically significant differences were detected between the groups for both Bax LI (P = 0.004 ＜0.01) and PCNA LI (P = 0.009 ＜0.01). When groups were compared further in terms of Bax LI and PCNA LI with Tukey's HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups 1a and 2b (P = 0.006 ＜0.01).CONCLUSION: In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells.

关键词：胃上皮细胞幽门螺杆菌细菌感染肾脏疾病胃疾病

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