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Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori

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Gastroenterology Report 2019年第1期7卷 42-49,I0002页

作者： Eng-Guan Chua Aleksandra W.Debowski KMary Webberley Fanny Peters binit lamichhane Mun-Fai Loke Jamuna Vadivelu Chin-Yen Tay Barry J.Marshall Michael J.Wise The Marshall Centre for Infectious Diseases Research and Training University of Western AustraliaPerthWestern AustraliaAustralia School of Biomedical Sciences Faculty of Health and Medical SciencesUniversity of Western AustraliaPerthWestern AustraliaAustralia Department of Medical Microbiology University of MalayaKuala LumpurWilayah PersekutuanMalaysia Shenzhen Dapeng New District Kuichong People Hospital ShenzhenGuangdongChina UM Marshall Centre University of MalayaKuala LumpurWilayah PersekutuanMalaysia School of Computer Science and Software Engineering University of Western AustraliaPerthWestern AustraliaAustralia

Background:Metronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate Helicobacter pylori ***,the global emergence of metronidazole resistance in Hp poses a major challenge to health *** of RdxA is known to be a major mechanism of conferring metronidazole resistance in ***,metronidazole resistance can also arise in *** strains expressing functional RdxA protein,suggesting that there are other mechanisms that may confer resistance to this ***:We performed whole-genome sequencing on 121 *** clinical strains,among which 73 were ***-alignment analysis of core protein clusters derived from clinical strains containing full-length RdxA was *** sites in each alignment were statistically compared between the resistant and susceptible groups to determine candidate genes along with their respective amino-acid changes that may account for the development of metronidazole resistance in ***:Resistance due to RdxA truncation was identified in 34%of metronidazole-resistant *** of core protein clusters derived from the remaining 48 metronidazole-resistant strains and 48 metronidazole-susceptible identified four variable sites significantly associated with metronidazole *** sites included R16H/C in RdxA,D85N in the inner-membrane protein RclC(HP0565),V265I in a biotin carboxylase protein(HP0370)and A51V/T in a putative threonylcarbamoyl–AMP synthase(HP0918).Conclusions:Our approach identified new potential mechanisms for metronidazole resistance in *** that merit further investigation.

关键词： Helicobacter pylori metronidazole antibiotic resistance whole-genome sequencing core protein clusters sequence alignment

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Outcomes and efficacy of magnetic resonance imaging-compatible sacral nerve stimulator for management of fecal incontinence: A multi-institutional study

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World Journal of Radiology 2024年第2期16卷 32-39页

作者： binit Katuwal Amy Thorsen Kunal Kochar Ryba Bhullar Ray King Ernesto Raul Drelichman Vijay K Mittal Jasneet Singh Bhullar Department of Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of Colon and Rectal surgery Alina Health Abbott Northwestern HospitalMinneapolisMN 55407United States Colon and Rectal Surgery Advocate Illinois MasonicPark RidgeIL 60068United States Volunteer Student Department of ResearchAscension Providence HospitalSouthfieldMI 48075United States Colon and Rectal Surgery University of WisconsinMadisonWI 53715United States General and Colorectal Surgery Ascension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States Department of Surgery Department of Medical EducationAscension Providence HospitalMichigan State University College of Human MedicineSouthfieldMI 48075United States

BACKGROUND Fecal incontinence(FI)is an involuntary passage of fecal matter which can have a significant impact on a patient’s quality of *** modalities of treatment exist for *** nerve stimulation is a well-established treatment for *** the increased need of magnetic resonance imaging(MRI)for diagnostics,the In-terStim which was previously used in sacral nerve stimulation was limited by MRI *** MRI-compatible InterStim was approved by the United States Food and Drug Administration in August 2020 and has been widely *** To evaluate the efficacy,outcomes and complications of the MRI-compatible *** Data of patients who underwent MRI-compatible Medtronic InterStim placement at UPMC Williamsport,University of Minnesota,Advocate Lutheran General Hospital,and University of Wisconsin-Madison was pooled and *** demographics,clinical features,surgical techniques,complications,and outcomes were *** the Reporting of Observational studies in Epidemiology(STROBE)cross-sectional reporting guidelines were *** Seventy-three patients had the InterStim *** mean age was 63.29±12.2 ***-seven(78.1%)patients were females and forty-two(57.5%)patients had *** addition to incontinence,overlapping symptoms included diarrhea(23.3%),fecal urgency(58.9%),and urinary incontinence(28.8%).Fifteen(20.5%)patients underwent Peripheral Nerve Evaluation before proceeding to definite implant ***-two(43.8%)patients underwent rechargeable InterStim ***(4.1%)patients needed removal of the *** of the external lead connection was observed in 7(9.6%)patients after the stage I *** explanation for one patient was due to ***(9.6%)patients had other complications like nerve pain,hematoma,infection,lead fracture,and *** mean follow-up was 6.62±3.5 ***-eight(93.2%)patients reported significant improvement of symptoms on

关键词： Fecal incontinence Sacral nerve stimulation InterStim Magnetic resonance imaging Sacral neuromodulation

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Reaction mechanism of hydrogen activation by frustrated Lewis pairs

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Green Energy & Environment 2019年第1期4卷 20-28页

作者： Lei Liu binit Lukose Pablo Jaque Bernd Ensing Department of Physics & Earth Sciences Jacobs University Max Planck Institute for Polymer Research School of Electrical and Computer Engineering Boston University Department of Organic and Physical Chemistry Faculty of Chemical and Pharmaceutical Sciences University of Chile Van't Hoff Institute for Molecular Sciences University of Amsterdam

Typically, a Lewis acid and a Lewis base can react with each other and form a classical Lewis adduct. The neutralization reaction can however be prevented by ligating the acid and base with bulky substituents and the resulting complex is known as a "frustrated Lewis pair"(FLP). Since the Lewis acid and base reactivity remains in the formed complex, FLPs can display interesting chemical activities, with promising applications in catalysis. For example, FLPs were shown to function as the first metal-free catalyst for molecular hydrogen activation. This, and other recent applications of FLPs, have opened a new thriving research field. In this short-review, we recapitulate the computational and experimental studies of the H_2 activation by FLPs. We discuss the thus-far uncovered mechanistic aspects, including pre-organization of FLPs,the reaction paths for the activation, the polarization of He H bond and other factors affecting the reactivity. We aim to provide a rather complete mechanistic picture of the H_2 activation by FLPs, which has been under debate for decades since the first discovery of FLPs. This review is meant as a starting point for future studies and a guideline for industrial applications.

关键词： Frustrated Lewis pairs Hydrogen activation Reaction mechanisms Density functional theory Molecular dynamics simulations

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Imaging lexicon for acute pancreatitis:2012 Atlanta Classification revisited

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Gastroenterology Report 2016年第1期4卷 16-23,I0001页

作者： binit Sureka Kalpana Bansal Yashwant Patidar Ankur Arora Department of Radiology/Interventional Radiology Institute of Liver and Biliary SciencesNew DelhiIndia

The original 1992 Atlanta Classification Systemfor acute pancreatitis was revised in 2012 by the Atlanta Working Group,assisted by various national and international societies,through web-based *** revised classification identifies two phases of acute pancreatitis:early and *** pancreatitis can be either oedematous interstitial pancreatitis or necrotizing *** of the disease is categorized into three levels:mild,moderately severe and severe,depending upon organ failure and local/systemic *** to the type of pancreatitis,collections are further divided into acute peripancreatic fluid collection,pseudocyst,acute necrotic collection,and walled-off *** into the revised terminology is essential for accurate communication of imaging *** this review article,we will summarize the updated nomenclature and illustrate corresponding imaging findings using examples.

关键词： acute pancreatitis imaging acute peripancreatic fluid collection pseudocyst walled-off necrosis

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Thoracic perspective revisited in chronic liver disease

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Gastroenterology Report 2015年第3期3卷 194-200页

作者： binit Sureka Kalpana Bansal Yashwant Patidar Sachin Kumar Ankur Arora Department of Radiology/Interventional Radiology Department of Pulmonary Medicine Institute of Liver and Biliary SciencesNew DelhiIndia

A variety of chest manifestations are seen in patients with chronic liver diseases,namely hepatopulmonary syndrome,portopulmonary hypertension,intrathoracic portosystemic collaterals,hepatic hydrothorax,infections,drug-induced changes,manifestations of hepatocellular carcinoma,gynecomastia,acute respiratory distress syndrome,autoimmune changes,aspiration pneumonitis and changes due to a1-antitrypsin *** and radiologists should be aware of these entities;knowledge of the imaging findings specific to each condition is of prime importance for managing such patients.

关键词： cirrhosis infection portosystemic portopulmonary computed tomography

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Spontaneous rupture of intrahepatic pseudocyst into the inferior vena cava

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Gastroenterology Report 2018年第3期6卷 225-227,I0003页

作者： Yashwant Patidar binit Sureka Vaibhav Pratap Singh Kalpana Bansal Rakhi Maiwall Department of Radiology/Interventional Radiology Institute of Liver and Biliary SciencesNew DelhiIndia

We present an extremely rare case of caudate lobe intrahepatic pancreatic pseudocyst with spontaneous rupture into the inferior vena cava(IVC).A 58-year-old male,a chronic alcoholic,presented with features of pancreatitis for which imaging was *** and contrast-enhanced computed tomography were carried out,which revealed intrahepatic pancreatic pseudocyst in the caudate lobe of the *** was suggestion of spontaneous rupture of the pseudocyst into the IVC,which was well delineated on imaging.

关键词： pancreatic pseudocyst spontaneous rupture inferior vena cava

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Imaging panorama in postoperative complications after liver transplantation

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Gastroenterology Report 2016年第2期4卷 96-106,I0001页

作者： binit Sureka Kalpana Bansal S Rajesh Amar Mukund Viniyendra Pamecha Ankur Arora Department of Radiology/Interventional Radiology Institute of Liver and Biliary SciencesVasant KunjNew DelhiIndia Department of Hepatobiliary Surgery Institute of Liver and Biliary SciencesVasant KunjNew DelhiIndia

The liver is the second most-often transplanted solid organ after the kidney,so it is clear that liver disease is a common and serious problem around the *** the advancements in surgical,oncological and imaging techniques,orthotopic liver transplantation has become the first-line treatment for many patients with end-stage liver ***,and Doppler are the most economical and cost-effective imaging modalities for evaluating postoperative fluid collections and vascular *** tomography(CT)is used to confirm the findings of ultrasound and look for pulmonary *** resonance imaging(MRI)is used for the diagnosis of biliary complications,bile leaks and neurological *** article illustrates the imaging options for diagnosing the various complications that can be encountered in the postoperative period after liver transplantation.

关键词： liver transplant postoperative complications imaging

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In vitro antimicrobial effects of grape seed extract on peri-implantitis microflora in craniofacial implants

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Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 822-825页

作者： binit Shrestha M.L.Srithavaj Theerathavaj Sroisiri Thaweboon Boonyanit Thaweboon Maxillofacial Prosthetic Service Faculty of DentistryMahidol University Department of Oral Microbiology Faculty of DentistryMahidol University

Objective:To determine the antimicrobial effects of grape seed on peri-implantitis ***:The grape seed extract was tested against peri-implantitis microflora most commonly found in craniofacial implants including reference strains of Staphylococcus aureus(***),Escherichia coli(***),Candida albicans(***)and clinical strains of ***,Klebsiella pneumonia(***)and Candida parapsilosis(***)by disk diffusion *** inhibitory concentrations(MIC)and minimum cidal concentrations(MCC)were determined using modified agar dilution millpore *** extract was further combined with polyethylene glycol and propylene glycol,and was tested for antimicrobial ***:Grape seed extract showed positive inhibitory effects with *** at MIC of 0.625 mg/mL and MCC of1.25 mg/mL *** the extracts showed minimal or no reactivity against strains of ***,***,*** and *** use of grape seed extract in combination with polyethylene glycol and propylene glycol also showed dose dependent inhibitory effect on ***:The results of the study showed that grape seed has potential antimicrobial effects which can be further studied and developed to be used in the treatment of infected skinabutment interface of craniofacial implants.

关键词： Peri-implantitis Grape seed extract Craniofacial implants Staphylococcus aureus

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In vitro effects of Salvia officinalis *** oil on Candida albicans

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 376-380页

作者： Tularat Sookto Theerathavaj Srithavaj Sroisiri Thaweboon Boonyanit Thaweboon binit Shrestha Maxillofacial Prosthetic Clinic Department of ProsthodonticsFaculty of DentistryMahidol University Department of Oral Microbiology Faculty of DentistryMahidol University

Objective:To determine the anticandidal activities of Salvia officinalis L.(***)essential oil against Candida albicans(***)and the inhibitory effects on the adhesion of *** to polymethyl methacrylate(PMMA)resin ***:Disc diffusion method was first used to test the anticandidal activities of the *** *** oil against the reference strain(ATCC 90028)and 2 clinical strains of *** the minimal inhibitory concentration(MIC)and minimal lethal concentration(MLX)were determined by modified membrane *** adhesion of *** to PMMA resin surface was assessed after immersion with *** *** oil at various concentrations of 1XMIC.0.5XMIC and 0.25XMIC at room temperature for30 ***-way ANOVA was used to compare the Candida cell adhesion with the pretreatment agents and Tukey's test was used for multiple ***:*** *** oil exhibited anticandidal activity against all strains of *** with inhibition zone ranging from 40.5 mm to 19.5 *** MIC and MLC of the oil were determined as 2.780 g/L against all test *** to the effects on *** adhesion to PMMA resin surface,it was found that immersion in the essential oil at concentrations of 1XMIC(2.780 g/L).0.5XMIC(1.390 g/L)and0.25XMIC(0.695 g/L)for 30 min significantly reduced the adhesion of all 3 test strains to PMMA resin surface in a dose dependent manner(P<0.05).Conclusions:*** *** oil exhibited anticandidal activities against *** and had inhibitory effects on the adhesion of the cells to PMMA resin *** further testing and development,*** essential oil may be used as an antifungal denture cleanser to prevent candidal adhesion and thus reduce the risk of candida-associated denture stomatitis.

关键词： Salvia officinalis L. Candida albicans Essential oil PMMA resin Adhesion

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Unified Regional Modeling of GaN HEMTs with the 2DEG and DD Formalism

Unified Regional Modeling of GaN HEMTs with the 2DEG and DD ...

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2012 IEEE 11th International Conference on Solid-State and Integrated Circuit Technology(ICSICT-2012)

作者： Xing Zhou Junbin Zhang binit Syamal Siau Ben Chiah Hongtao Zhou Li Yuan School of Electrical and Electronic Engineering Nanyang Technological University Institute of Microelectronics A*STAR(Agency for ScienceTechnology and Research)

This paper presents the unified regional modeling（URM） approach to developing a compact model（CM）for GaN-based high electron mobility transistors（HEMTs） based on the two-dimensional electron gas（2DEG）and drift-diffusion（DD）*** is shown that through the URM of the 2DEG based on triangular well approximation and surface-potential based DD transport, a CM for generic metal-insulator-semiconductor（MIS） HEMTs can be developed,which is scalable over device physical and structural parameters.

关键词： HEMTs MODFETs Mathematical model Numerical models Gallium nitride Logic gates

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