检索结果-南通市图书馆

High stearic acid diet modulates gut microbiota and aggravates acute graft-versus-host disease

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第8期6卷 2315-2318页

作者： bingyu yang Xianfeng Zhang Huanle Gong Yuhui Huang Chang Wang Haiyan Liu Chen Dong Shoubao Ma Xiaojin Wu Depei Wu National Clinical Research Center for Hematologic Diseases The First Affiliated Hospital of Soochow UniversityJiangsu Institute of HematologyInstitute of Blood and Marrow TransplantationCollaborative Innovation Center of HematologySoochow UniversitySuzhouChina Department of Hematology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxiChina Center for Clinical Laboratory the First Affiliated Hospital of Soochow UniversitySuzhouChina Cyrus Tang Hematology Center Collaborative Innovation Center of Hematologythe Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and the Chinese Ministry of Science and TechnologySoochow UniversitySuzhouChina School of Radiation Medicine and Protection Medical College of Soochow UniversityCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsJiangsu Provincial Key Laboratory of Radiation Medicine and ProtectionSuzhouChina lmmunology Programme Life Sciences Institute and Department of Microbiology and ImmunologyYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Institute for Immunology and School of Medicine Tsinghua UniversityBeijingChina

Dear Editor,Acute graft-versus-host disease(aGVHD)is the leading cause of transplantation-related mortality,and limits therapeutic benefits of allogeneic bone marrow transplantation(allo-BMT).New insight is needed int... 详细信息

关键词： homeostasis Acute mortality

Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2022年第10期7卷 3955-3966页

作者： Huanle Gong Shoubao Ma Jia Chen bingyu yang Shuangzhu Liu Xin Liu Jingjing Han Xiaojin Wu Lei Lei Zhinan Yin Hongjian Sun Di Yu Haiyan Liu yang Xu Depei Wu The First Affiliated Hospital of Soochow University National Clinical Research Center for Hematologic DiseasesJiangsu Institute of HematologyInstitute of Blood and Marrow TransplantationSoochow UniversitySuzhou 215123China Collaborative Innovation Center of Hematology Soochow UniversitySuzhou 215123China Department of Hematology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Zhuhai Precision Medical Center Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Jinan UniversityZhuhai 519000 GuangdongChina The Biomedical Translational Research Institute Faculty of Medical ScienceJinan UniversityGuangzhou 510632 GuangdongChina Shandong Artificial Intelligence Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250200China The University of Queensland Diamantina Institute Faculty of MedicineThe University of QueenslandBrisbaneQLD 4072Australia Immunology Programme Life Sciences InstituteImmunology Translational Research Program and Department of Microbiology and ImmunologyYong Loo Lin School of MedicineNational University of SingaporeSingapore 117456Singapore

Interleukin 27(IL-27),a heterodimeric cytokine composed of Epstein-Barr virus-induced 3 and p28,is a pleiotropic cytokine with both pro-and anti-inflammatory ***,the precise role of IL-27 in acute graft-versus-host disease is not yet fully *** this study,utilizing mice with IL-27 p28 deficiency in dendritic cells(DCs),we demonstrated that IL-27 p28 deficiency resulted in impaired Treg cell function and enhanced effector T cell responses,corresponding to aggravated aGVHD in *** addition,using single-cell RNA sequencing,we found that loss of IL-27 p28 impaired Treg cell generation and promoted IL1R2^(+)TIGIT^(+)pathogenic CD4+T cells in the thymus at a steady ***,IL-27 p28 deficiency promoted STAT1 phosphorylation and Th1 cell responses,leading to the inhibition of Treg cell differentiation and ***,patients with high levels of IL-27 p28 in serum showed a substantially decreased occurrence of grade II-IV aGVHD and more favorable overall survival than those with low levels of IL-27 ***,our results suggest a protective role of DC-derived IL-27 p28 in the pathogenesis of aGVHD through modulation of the Treg/Teff cell balance during thymic ***-27 p28 may be a valuable marker for predicting aGVHD development after transplantation in humans.

关键词： impaired protective graft

Application of Meteorological Data Operation System(MDOS)in Meteorological Operation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meteorological and Environmental Research 2022年第1期13卷 31-34页

作者： bingyu yang Honghong HUANG Qun ZHOU Kangning SHU Yunnan Meteorological Information Center Kunming 650034China COMAC Flight Test Center Shanghai 201323China

Meteorological data operation system(MDOS)is a comprehensive business platform that integrates data transmission and monitoring,quality control,processing,storage and distribution,and data *** operation and implementation of MDOS has further improved the quality control system of meteorological data in Yunnan Province,adjusted the business layout of meteorological data,and made the availability ratio of meteorological data continue to *** availability ratio of meteorological data from national stations rose from 99.68% to 99.96%,and that of regional stations increased from 95.33% to 99.08% from 2016 to *** not only solves the problem of inconsistent data and quality control methods of various business platforms,but also provides guarantees for more refined and accurate weather forecasts and climate predictions.

关键词： MDOS Meteorological data Quality control

Analysis of the Correlation between Middle-season Rice Yield and Meteorological Factors in Jingdong County from 2009 to 2016

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Agricultural Research 2020年第8期12卷 60-64页

作者： bingyu yang Zhengyou WANG Min GAO Baofeng HUANG Data Section of Yunnan Meteorological Information Center Kunming 650034 China Jingdong Meteorological Bureau Jingdong 676299 China Pu'er Coffee Meteorological Service Center Pu'er 665000 China Mojiang Meteorological Bureau Mojiang 654800 China

Middle-season rice is an important food crop in southern rice areas of China,especially in Yunnan,the main rice-producing ***,due to the impact of low temperature at the seedling stage and high or low temperature at the booting and heading stage of middle-season rice,the yield is not *** on the data of yield factors of different middle-season rice varieties planted in the same ecological site in Jingdong County from 2009 to 2016,average development period was calculated using the data of development period measured in field during 2009-2016,and the average of meteorological factors(daily average temperature,daily maximum temperature,daily minimum temperature,and sunshine hours)and total precipitation were *** correlation between meteorological factors in different development periods of each year and corresponding per unit area yield was *** results show that temperature is the most important factor affecting rice *** light is beneficial to the increase in the number of grains per spike and thousand seed weight at the sowing-seedling emergence stage and milk maturity-maturity *** precipitation will reduce the number of grains per spike at the booting-heading *** precipitation decreases the number of filled grains per spike at the jointing-booting stage,and proper drainage helps increase the formation rate of *** study provides scientific reference for rice production and management in this county in future.

关键词： Jingdong County Middle-season rice yield Meteorological factors Correlation analysis

在百姓日常的炊烟里:延安时期科学技术观念的传播实践

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

学海 2019年第3期 94-99页

作者：杨冰郁西北工业大学马克思主义学院

延安时期的科学技术观念,与中国传统“格致”观以及五四科学思潮渊源颇深,并受到马克思主义唯物史观的深刻影响,体现出实用性和大众化的鲜明特征;延安时期的科技观,也与地方的自然和社会环境相辅相成。陕甘宁边区政府通过展览会这一具... 详细信息

延安时期的科学技术观念,与中国传统“格致”观以及五四科学思潮渊源颇深,并受到马克思主义唯物史观的深刻影响,体现出实用性和大众化的鲜明特征;延安时期的科技观,也与地方的自然和社会环境相辅相成。陕甘宁边区政府通过展览会这一具有现场感和仪式感的场所传播了科学技术观念。在展览会召开之际,政府通过奖励工程师等科技人才,改变了知识分子重道轻器的传统观念;展览会还展示了与日常生产、生活贴近的工农业技术改良成果,显示了普通人的智慧;政府还通过展览会宣讲卫生防疫知识,把现代科技常识带到了穷乡僻壤,初步实现了科学技术观念的大众化。

关键词：延安时期科学技术观念展览会传播实践

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

自然辩证法研究在陕甘宁边区的兴起

学海 2021年第4期 205-210页

作者：杨冰郁西北工业大学马克思主义学院陕西西安710072

陕甘宁边区的自然辩证法研究生成于新民主主义文化土壤之中,涉及科学技术与政治、理论与实践、群众科学等议题。与当代科学技术精英化、建制化、专业化特点迥异的是,陕甘宁边区自然辩证法研究是马克思主义中国化的有机组成部分,强调政... 详细信息

陕甘宁边区的自然辩证法研究生成于新民主主义文化土壤之中,涉及科学技术与政治、理论与实践、群众科学等议题。与当代科学技术精英化、建制化、专业化特点迥异的是,陕甘宁边区自然辩证法研究是马克思主义中国化的有机组成部分,强调政治优先性,倡导经世致用,并推行科学大众化,为新中国成立之后自然辩证法学科建制化发展奠定了基础。从现代国家生成的视角,考察其所蕴含的社会政治意义、经济社会功能和文化教育价值,有助于加深理解近现代民族国家建设这一宏大理论,也有利于理解当下围绕科学技术展开的政治、经济与文化关系的讨论。

关键词：陕甘宁边区自然辩证法研究国家政权建设