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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Effect of MgO promoter on Ni-based SBA-15 catalysts for combined steam and carbon dioxide reforming of methane

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Journal of Natural Gas Chemistry 2008年第3期17卷 225-231页

作者： bingyao Huang Xiujin Li Shengfu Ji Bao Lang Fabien Habimana Chengyue Li State Key Laboratoly of Chemical Resource Engineering Beijing University of Chemical Technology. Beijing 100029. China Department of Environmental Engineering Beijing University of Chemical Technology Beijing 100029 China

A series of Ni/SBA-15 catalysts with Ni contents ranging from 5 wt% to 15 wt%, as well as another series of 10%Ni/MgO/SBA-15 catalysts, in which the range of the MgO content was from 1 wt% to 7 wt%, were prepared, and their catalytic performances for the reaction of combined steam and carbon dioxide reforming of methane were investigated in a continuous flow microreactor. The structures of the catalysts were characterized using the XRD, H2-TPR and CO2-TPD techniques. The results indicated that the CO selectivity for this reaction was very close to 100%, and the H2/CO ratio of the product gas could be controlled by changing the H2O/CO2 molar ratio of the feed gas. The simultaneous and plentiful existing of steam and CO2 had a significant influence on the catalytic performance of the 10%Ni/SBA-15 catalyst without modification. After reacting at 850 °C for 120 h over this catalyst, the CH4 conversion dropped from 98% to 85%, and the CO2 conversion decreased from 86% to 53%. However, the 10%Ni/3%MgO/SBA-15 catalyst exhibited a much better catalytic performance, and after reacting for 620 h, the CO2 conversion over this catalyst dropped from 92% to around 77%, while the CH4 conversion was not decreased. Oxidation of the Ni0 species as well as carbon deposition during the reaction were the main reasons for the deactivation of the catalyst without modification. On the other hand, modification by the MgO promoter improved the dispersion of the Ni0 species, and enhanced the CO2 adsorption affinity which in turn depressed the occurring of carbon deposition, and thus retarded the deactivation process.

关键词： MgO promoter Ni-based catalyst SBA-15 methane combined steam carbon dioxide reforming synthesis gas

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Copper-catalyzed C–H bond functionalization enabled by programmed alternating current

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Science China Chemistry 2025年第1期 10-11页

作者： Zhoumei tan Kun Xu Chengchu Zeng Beijing Key Laboratory of Environmental and Viral Oncology College of Chemistry and Life Science Beijing University of Technology

Synthetic electrochemistry has been selected as one of the Top Ten Emerging Technologies in Chemistry in 2023 by International Union of Pure and Applied Chemistry (IUPAC)[1]. It has emerged as a sustainable platform for organic synthesis and has exhibited a wide range of applications from academia to industry [2]. However, electrosynthesis has been predominantly performed by using direct current (DC).

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3D printing of poly(ethyleneimine)-functionalized Mg-Al mixed metal oxide monoliths for direct air capture of CO_(2)

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Journal of Energy Chemistry 2024年第9期96卷 491-500页

作者： Qingyang Shao Zhuozhen Gan bingyao Ge Xuyi Liu Chunping Chen Dermot O’Hare Xuancan Zhu Research Center of Solar Power&Refrigeration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Chemistry Research Laboratory Department of ChemistryUniversity of OxfordOxford OX13TAUK

Direct air capture(DAC)of CO_(2)plays an indispensable role in achieving carbon-neutral goals as one of the key negative emission *** large air flows are required to capture the ultradilute CO_(2)from the air,lab-synthesized adsorbents in powder form may cause unacceptable gas pressure drops and poor heat and mass transfer efficiencies.A structured adsorbent is essential for the implementation of gas-solid contactors for cost-and energy-efficient DAC *** this study,efficient adsorbent poly(ethyleneimine)(PEI)-functionalized Mg-Al-CO_(3)layered double hydroxide(LDH)-derived mixed metal oxides(MMOs)are three-dimensional(3D)printed into monoliths for the first time with more than 90%adsorbent *** printing process has been optimized by initially printing the LDH powder into monoliths followed by calcination into MMO *** structure exhibits a 32.7%higher specific surface area and a 46.1%higher pore volume,as compared to the direct printing of the MMO powder into a *** impregnation of PEI,the monolith demonstrates a large adsorption capacity(1.82 mmol/g)and fast kinetics(0.7 mmol/g/h)using a CO_(2)feed gas at 400 ppm at 25℃,one of the highest values among the shaped DAC *** of the amino-polymers during the post-printing process affects the diffusion of CO_(2),resulting in slower adsorption kinetics of pre-impregnation monoliths compared to post-impregnation *** optimal PEI/MeOH ratio for the post-impregnation solution prevents pores clogging that would affect both adsorption capacity and kinetics.

关键词： 3D printing Mixed metal oxides Amine functionalization Structured adsorbent Direct air capture

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Response of revegetation to climate change with meso- and micro-scale remote sensing in an arid desert of China

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Research in Cold and Arid Regions 2021年第1期13卷 43-52页

作者： Guang Song bingyao Wang JingYao Sun YanLi Wang XinRong Li Shapotou Desert Research and Experimental Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhouGansu 730000China Key Laboratory of Stress Physiology and Ecology in Cold and Arid Regions of Gansu Province Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China

The revegetation protection system(VPS)on the edge of the Tengger Desert can be referred to as a successful model of sand control technology in China and even the world,and there has been a substantial amount of research on revegetation ***,it is unclear how meso-and micro-scale revegetation activity has responded to climatic change over the past *** evaluate the relative influence of climatic variables on revegetation activities in a restored desert ecosystem,we analysed the trend of revegetation change from 2002 to 2015 using a satellite-derived normalized difference vegetation index(NDVI)*** time series of the NDVI data were decomposed into trend,seasonal,and random components using a segmented regression *** results of the segmented regression model indicate a changing trend in the NDVI in the VPS,changing from a decrease(−7×10−3/month)before 2005 to an increase(0.3×10−3/month)after *** found that precipitation was the most important climatic factor influencing the growing season NDVI(Ptance to sand and drought hazards.

关键词： vegetation activity climate change NDVI trend restored ecosystem meso-and micro-scale

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计算机视觉技术赋能大学英语课堂展示中的学习投入研究

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 144-151页

作者：谭苏燕王晋军广州大学外国语学院广东广州510010

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多... 详细信息

学习投入是预测学习者学习效果的重要指标,学术界对其与课堂展示间的相关性研究鲜有涉猎。文本以某综合性大学303名非英语专业本科生为研究对象,采用人工智能与计算机视觉技术模型YOLOv7对大学英语课堂中的课堂展示实录进行学习投入多模态数据分析,并辅以问卷调查,形成双向印证。研究发现,学生课堂展示中的行为投入、认知投入和情感投入值均等于或高于3.78,投入结果均值达4.01,说明学生在课堂展示中的学习投入情况良好。此外,不同时段课堂展示对学生行为投入的影响显著,学生专注度及参与度在课堂前10分钟的课堂展示中效果最佳。文本为课堂展示的有效性提供了智能化、多模态、多维度的实证支持,为课堂教学的数智技术应用提供了新视角。

关键词：大学英语课堂展示学习投入计算机视觉技术展示时段

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非静态4点二重混合细分法

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计算机辅助设计与图形学学报 2019年第4期31卷 629-638页

作者：檀结庆黄丙耀时军合肥工业大学数学学院合肥230601

为了得到插值与逼近相统一的非静态细分法,根据非静态插值4点细分法和三次指数B-样条细分法之间的联系,构造了3类非静态4点二重混合细分法:基于非静态插值细分的非静态逼近细分法,基于非静态逼近细分的非静态插值细分法,非静态插值与逼... 详细信息

为了得到插值与逼近相统一的非静态细分法,根据非静态插值4点细分法和三次指数B-样条细分法之间的联系,构造了3类非静态4点二重混合细分法:基于非静态插值细分的非静态逼近细分法,基于非静态逼近细分的非静态插值细分法,非静态插值与逼近混合细分法.诸多已有的插值细分法和逼近细分法都是所提混合细分法的特例.最后给出了这3类混合细分法的几何解释,分析了其Ck连续性、指数多项式生成性和再生性.数值实例表明,利用文中的混合细分法,通过适当选取参数可以实现对极限曲线的形状控制.

关键词：非静态细分法插值细分法逼近细分法混合细分法指数多项式

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Influence of complicated faults on the differentiation and accumulation of in-situ stress in deep rock mass

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International Journal of Minerals,Metallurgy and Materials 2023年第5期30卷 791-801页

作者： Naigen tan Renshu Yang Zhuoying tan Beijing Key Laboratory of Urban Underground Space Engineering School of Civil and Resource EngineeringUniversity of Science and Technology BeijingBeijing 100083China

High geostress will become a normality in the deep because in-situ stress rises linearly with *** geological structure grows immensely intricate as depth ***,small fractures,and joint fissures are widely *** objective of this paper is to identify geostress anomalies at a variety of locations near faults and to demonstrate their accumulation *** tests were conducted in seven deep *** conducted a test at a drilling depth of over one thousand meters to reveal and quantify the influence of faults on in-situ stresses at the hanging wall,footwall,between faults,end of faults,junction of faults,and far-field of *** effect of fault sites and characteristics on the direction and magnitude of stresses has been investigated and compared to test *** accumulation heterogeneity of stresses near faults was illustrated by a three-dimensional numerical simulation,which is utilized to explain the effect of faults on the accumulation and differentiation of in-situ *** to regional tectonics and faulting,the magnitude,direction,and stress regime are all extremely *** concentration degree of geostress and direction change will vary with the location of faults near faults,but the magnitude and direction of in-situ stress conform to regional tectonic stress at a distance from the *** focal mechanism solution has been verified using historical seismic ground motion *** results demonstrate that the degree of stress differentiation varies according to the fault attribute and its *** in stress differentiation and its ratio from strong to weak occur between faults,intersection,footwall,end of faults,and hanging wall;along with the sequence of orientation is the footwall,between faults,the end of faults,intersection,and hanging *** work sheds new light on the fault-induced stress accumulation and orientation shift mechanisms across the entire cycle.

关键词： fault geostress in deep magnitude and direction of geostress mining dynamic hazards stress accumulation mining optimization

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Multi-physical Modeling and Adjusting for Ultrasonic Assisted Soft Abrasive Flow Processing

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 111-124页

作者： Yesha Ni Yunfeng tan Dapeng tan Key Lab of E&M Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China Collaborative Innovation Center of High-end Laser Manufacturing Equipment Zhejiang Province&Ministry of EducationHangzhou 310014China

The polishing efficiency of the soft abrasive flow(SAF)method is low,which is not in line with the concept of carbon emission reduction in industrial *** address the above issue,a two-phase fluid multi-physics modeling method for ultrasonic-assisted SAF processing is *** acoustics-fluid coupling mechanic model based on the realizable k-ε model and Helmholtz equation is built to analyze the cavitation *** results show that the pro-posed modeling and solution method oriented to ultrasonic-assisted SAF processing have better revealed the flow field evolution *** turbulence kinetic energy at different ultrasonic frequencies and amplitudes is *** results show that the ultrasonic vibration can induce a cavitation effect in the constrained flow chan-nel and promote the turbulence intensity and uniformity of the abrasive flow.A set of comparative polishing experiments with or without ultrasonic vibration are conducted to explore the performance of the proposed *** can be found that the ultrasonic-assisted SAF method can improve the machining efficiency and uniformity,to achieve the purpose of carbon emission *** relevant result can offer a helpful reference for the SAF method.

关键词： Soft abrasive flow Ultrasonic vibration Cavitation effect Polishing efficiency Turbulent kinetic energy

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Circulation background of climate patterns in the past millennium: Uncertainty analysis and re-reconstruction of ENSO-like state

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Science China Earth Sciences 2016年第6期59卷 1225-1241页

作者： tan Ming Key Laboratory of Cenozoic Geology and Environment Institute of Geology and Geophysics Chinese Academy of Sciences

The question of whether or not global warming has paused since more than ten years ago, namely ＂warming hia- tus＂, has attracted the attention of climate science community including the IPCC. Some authors have attributed the ＂warming hiatus＂ to the internal changes in the climate system, i.e., the recombination of ocean-atmosphere circulations. Therefore, it is necessary to propose higher requirements on reconstructing circulation background of climate change for the past millennium. However, the analyses of changes in atmospheric circulation over the last millennium as well as the conclusions of related re- gional climate patterns are so widely different and contradictory, bringing uncertainties to our understanding of regional even global climate change to a great extent. On the other hand, in the last 10 years the high-precision U/Th-dated stalagmite oxygen isotope ratio （δ^18O） sequences provided an accurate chronological frame for the paleoclimate study of the middle and late Pleistocene, in which all authors from China took the Chinese stalagmite δ^18O as the summer monsoon index without excep- tion. However, this point of view misleads the climate scientists into thinking that the stalagmite δ^18O can be as the proxy of precipitation amount. Nevertheless, it is well known that all of these records have a lot in common in the low frequency trend. However, most sequences cannot be calibrated by instrumental precipitation records, and thus the uncertainty of the climate research framework of China and even of the world has increased. Therefore, it is imperative for climatology to clarify the origin of contradiction and to reduce the uncertainty as early as possible. On the basis of analyzing the significance of stalag- mite ~180 in the monsoon regions of China, the author tries to propose a new circulation proxy in this paper： integrating the Chinese stalagmite oxygen isotope sequence to reconstruct the tropical Pacific sea surface temperature gradient, i.e., th

关键词： The past millennium ENSO Circulation background Climate pattern WPSH Stalagmite δ^18O Circulation recombination

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