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Immune microenvironment-reshaping Au@Bi_(2)Te_(3) nanoparticles for spectral computed tomography/photoacoustic imaging-guided synergetic photo/radio/immunotherapy

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Nano Research 2023年第1期16卷 771-781页

作者： Kai Zhu Zede Wu Qiuyu Li Meirong Hou Honglei Hu Shuting Zheng Li Qi Yikai Xu Chenggong Yan bingxia zhao Department of Medical Imaging Center Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangzhou Key Laboratory of Tumor Immunology Research Cancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Medical Image Processing Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic TechnologySchool of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Guangzhou 510515China Experimental Education/Administration Center School of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510515China

Radiotherapy(RT)mediated tumor immunogenicity offers an opportunity for simultaneous RT and immunotherapy via immunogenic cell death(ICD),which releases damaged-associated molecular patterns and generates“eat me”signals for the innate immune system to modulate the ***,tumor hypoxia significantly reduces the therapeutic efficacy of RT and hampers its mediation of ICD ***,Au@Bi_(2)Te_(3)-polyethylene glycol(PEG)was rationally constructed as theranostic nanozymes for mild photothermal therapy,tumor hypoxia modulation,and RT adjuvant cancer *** tumor-specific production of oxygen could not only augment the effects of RT by enhanced reactive oxygen species(ROS)generation,but also reduce hypoxia-related cytokines and downregulate programmed cell death-ligand 1(PD-L1)to unleash immune-enhancing T ***,Au@Bi_(2)Te_(3)-PEG could act as an immune-blocking inhibitor by efficient ICD induction with the combination of mild-photothermal therapy+RT to inhibit the tumor immune escape and improve antitumor immune *** amounts of CD^(4+) and CD^(8+) Tcells and elevated levels of cytokines could be observed that eventually led to effective post-medication inhibition of primary and abscopal *** computed tomography/photoacoustic imaging allowed noninvasive and real-time tracking of nanoparticle(NP)accumulation and oxygenation status at tumor ***,Au@Bi_(2)Te_(3)-PEG NPs could serve as effective theranostic nanoregulators with remarkable synergistic mildphotothermal/RT/immunotherapy effects that helped reshape the immune microenvironment and had remarkable molecular imaging properties.

关键词： radioresistance immunotherapy immunogenic cell death hypoxia programmed cell death-ligand 1(PD-L1) spectral computed tomography(CT)

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Tumor microenvironments self-activated nanoscale metal-organic frameworks for ferroptosis based cancer chemodynamic/photothermal/chemo therapy

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Acta Pharmaceutica Sinica B 2021年第10期11卷 3231-3243页

作者： Yu Liang Li Zhang Chao Peng Shiyu Zhang Siwen Chen Xin Qian Wanxian Luo Qing Dan Yongyan Ren Yingjia Li bingxia zhao Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangzhou Key Laboratory of Tumor Immunology Research Cancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Cerebrovascular Diseases Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519099China Central Laboratory Southern Medical UniversityGuangzhou 510515China

Ferroptosis,as a newly discovered cell death form,has become an attractive target for precision cancer *** ferroptosis therapy strategies based on nanotechnology have been reported by either increasing intracellular iron levels or by inhibition of glutathione(GSH)-dependent lipid hydroperoxidase glutathione peroxidase 4(GPX4).However,the strategy by simultaneous iron delivery and GPX4 inhibition has rarely been ***,novel tumor microenvironments(TME)-activated metal-organic frameworks involving Fe&Cu ions bridged by disulfide bonds with PEGylation(FCSP MOFs)were developed,which would be degraded specifically under the redox TME,simultaneously achieving GSH-depletion induced GPX4 inactivation and releasing Fe ions to produce ROS via Fenton reaction,therefore causing *** ROS could be generated by the acceleration of Fenton reaction due to the released Cu ions and the intrinsic photothermal capability of FCSP *** overexpressed GSH and H2O2 in TME could ensure the specific TME self-activated *** tumor therapeutic efficiency could be achieved by doxorubicin(DOX)loading since it can not only cause apoptosis,but also indirectly produce H2O2 to amplify Fenton *** anti-tumor effect of obtained FCSP@DOX MOFs was verified via both in vitro and in vivo assays.

关键词： Ferroptosis Tumor microenvironments Fenton reaction Metal-organic frameworks(MOFs) GSH depletion Drug delivery

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Recycling arsenic-containing bio-leaching residue after thermal treatment in cemented paste backfill:Structure modification,binder properties and environmental assessment

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2136-2147页

作者： Dengfeng zhao Shiyu Zhang Yingliang zhao Department of Mining Engineering Lyuliang UniversityLvliang 033000China School of Civil and Environmental Engineering University of Science and Technology BeijingBeijing 100083China School of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 00852China

The substantial arsenic(As)content present in arsenic-containing bio-leaching residue(ABR)presents noteworthy environ-mental challenges attributable to its inherent instability and susceptibility to *** its elevated calcium sulfate content,ABR exhibits considerable promise for industrial *** study delved into the feasibility of utilizing ABR as a source of sulfates for producing super sulfated cement(SSC),offering an innovative binder for cemented paste backfill(CPB).Thermal treatment at varying temperatures of 150,350,600,and 800℃ was employed to modify ABR’s *** investigation encompassed the examination of phase transformations and alterations in the chemical composition of As within ***,the hydration characteristics of SSC utilizing ABR,with or without thermal treatment,were studied,encompassing reaction kinetics,setting time,strength development,and *** findings revealed that thermal treatment changed the calcium sulfate structure in ABR,consequently impacting the resultant sample ***,calcination at 600℃ demonstrated optimal modification effects on both early and long-term strength *** enhanced performance can be attributed to the augmented formation of reaction products and a densified ***,the thermal treatment elicited modifications in the chemical As fractions within ABR,with limited impact on the As immobilization capacity of the prepared binders.

关键词： cemented paste backfill bio-leaching residue arsenic immobilization binder hydration calcination

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Automatic modeling algorithm of stochastic error for inertial sensors

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Control Theory and Technology 2024年第1期22卷 81-91页

作者： Luodi zhao Long zhao School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China Digital Navigation Center Beihang UniversityBeijing100191China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing100191China

This paper proposes an automatic algorithm to determine the properties of stochastic processes and their parameters for inertial error. The proposed approach is based on a recently developed method called the generalized method of wavelet moments (GMWM), whose estimator was proven to be consistent and asymptotically normally distributed. This algorithm is suitable mainly (but not only) for the combination of several stochastic processes, where the model identification and parameter estimation are quite difficult for the traditional methods, such as the Allan variance and the power spectral density analysis. This algorithm further explores the complete stochastic error models and the candidate model ranking criterion to realize automatic model identification and determination. The best model is selected by making the trade-off between the model accuracy and the model complexity. The validation of this approach is verified by practical examples of model selection for MEMS-IMUs (micro-electro-mechanical system inertial measurement units) in varying dynamic conditions.

关键词： GMWM Stochastic process Inertial sensor Sensor calibration Error model Allan variance

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Meeting the challenges of invasive alien species

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National Science Review 2024年第3期11卷 296-298页

作者： Weijie zhao NSR news

The Xinjiang Uygur Autonomous Region of China is famous for its tomato production. Abundant sunshine, large day–night temperature difference and the abundant irrigation by snowmelt from the Tianshan Mountains produce...

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Ling-Ling Chen: RNA has its own features;don't study it as a protein

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National Science Review 2024年第2期11卷 301-305页

作者： Weijie zhao NSR

Non-coding RNA(ncRNA) has been a very active research area over the past 30 years. From small nc RNA – the discovery of RNA interference won the lead researchers the Nobel Prize, to long ncRNA(lncRNA), which has attracted much attention in recent years, various nc RNAs participate in all kinds of biological processes and show a variety of biomedical application prospects.

关键词： RNA

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Giant Flexoelectric Effect in Snapping Surfaces Enhanced by Graded Stiffness

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Acta Mechanica Solida Sinica 2024年第4期37卷 528-540页

作者： Chuo zhao Department of Aeronautics Imperial College LondonSouth Kensington CampusLondonSW72AZUK

Flexoelectricity is present in nonuniformly deformed dielectric materials and has size-dependent properties, making it useful for microelectromechanical systems. Flexoelectricity is small compared to piezoelectricity;therefore, producing a large-scale flexoelectric effect is of great interest. In this paper, we explore a way to enhance the flexoelectric effect by utilizing the snap-through instability and a stiffness gradient present along the length of a curved dielectric plate. To analyze the effect of stiffness profiles on the plate, we employ numerical parameter continuation. Our analysis reveals a nonlinear relationship between the effective electromechanical coupling coefficient and the gradient of Young’s modulus. Moreover, we demonstrate that the quadratic profile is more advantageous than the linear profile. For a dielectric plate with a quadratic profile and a modulus gradient of − 0.9, the effective coefficient can reach as high as 15.74 pC/N, which is over three times the conventional coupling coefficient of piezoelectric material. This paper contributes to our understanding of the amplification of flexoelectric effects by harnessing snapping surfaces and stiffness gradient design.

关键词： Functionally graded material Flexoelectricity Numerical continuation Snap-through instability

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One dimensional CeO_(2) nanorods/poly(ethylene oxide) solid composite electrolyte for all-solid-state lithium-ion batteries

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Journal of Rare Earths 2024年第3期42卷 570-577,I0005页

作者： Yudi Guo Erqing zhao Xiaofang zhao Shuailei Liu School of Chemistry and Materials Engineering Xinxiang UniversityXinxiang453003China School of Chemistry and Chemical Engineering Henan Institute of Science and TechnologyXinxiang453003China

The research of poly(ethylene oxide)(PEO)-based solid composite electrolyte with high ionic conductivity and excellent interfacial stability is the key to the development of all-solid-state lithium-ion batteries(ASSLIBs). Herein, uniform nanorod structured CeO_(2) fillers were controllably synthesized by electrospinning, which were subsequently filled into PEO polymer to prepare CeO_(2)/PEO solid composite electrolyte. The addition of CeO_(2) nanorods can reduce both the glass transition temperature and the melting point of PEO polymer, and also interact with PEO and lithium bis(trifluoromethanesulphonyl)imide(LITFSI) by Lewis acid—base reaction. Therefore, the solid composite electrolyte exhibits a high ionic conductivity of 4.52 × 10^(-4)S/cm, a wide electrochemical stability window of about 4.8 V, and a good interfacial stability with Li at 55℃. Moreover, the LiFePO_4/Li ASSLIB divulges the discharging specific capacity of 165, 162, 156 and 146 mA,h/g at 0.2, 0.5, 1 and 2 C, respectively, and achieves the capacity retention of 90.3% after 150 cycles at 0.5 C. Consequently, one dimensional CeO_(2) nanorods can be considered as an alternative filler for polymeric solid electrolyte.

关键词： Poly(ethylene oxide) Solid composite electrolyte CeO_(2)nanorods Ionic conductivity Rare earths

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A DIRECT DISCONTINUOUS GALERKIN METHOD FOR TIME FRACTIONAL DIFFUSION EQUATIONS WITH FRACTIONAL DYNAMIC BOUNDARY CONDITIONS

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Journal of Computational Mathematics 2024年第1期42卷 156-177页

作者： Jingjun zhao Wenjiao zhao Yang Xu School of Mathematics Harbin Institute of TechnologyHarbin 150001China

This paper deals with the numerical approximation for the time fractional diffusion problem with fractional dynamic boundary *** well-posedness for the weak solutions is studied.A direct discontinuous Galerkin approach is used in spatial direction under the uniform meshes,together with a second-order Alikhanov scheme is utilized in temporal direction on the graded mesh,and then the fully discrete scheme is ***,the stability and the error estimate for the full scheme are analyzed in *** experiments are also given to illustrate the effectiveness of the proposed method.

关键词： Time fractional diffusion equation Numerical stability Convergence

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Conformation and Counterion Distribution of Polyelectrolyte in Solution as Viewed from Dielectric Approach

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Chinese Journal of Polymer Science 2024年第9期42卷 1278-1301,I0005页

作者： Kong-Shuang zhao College of Chemistry Beijing Normal UniversityBeijing 100875China

Polyelectrolyte solutions are more variable than uncharged macromolecule due to electrical interaction between charged molecules and surrounding ***,the subject of polyelectrolyte solutions has attracted a wide range of interests in both basic and applied research,and has also been extensively ***,the understanding of the molecular dynamics and conformation of polyelectrolytes in solution remains to be deepened,and universal consensus on some key issues have not been *** methods have contributed to solving the above problems in different ways,including dielectric relaxation spectroscopy(DRS).In this perspective,we briefly reviewed the history of dielectric spectroscopic research on polyelectrolyte solution,with emphasis on summarizing our *** particular,we expound the characteristics of DRS and its ability to obtain the internal information of the system of ***,we evaluate the advantages and limitations of the dielectric method and discussed future prospects of this field.

关键词： Polyelectrolyte Dielectric relaxation spectroscopy Chain conformation Thermosensitive microgel PNIPAM microgel Spherical polyelectrolyte brushes

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