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Neural Regeneration Research 2023年第1期18卷 111-112页

作者： bingwei lu Department of Pathology Stanford University School of MedicineStanfordCAUSA

Proteostasis denotes a cellular state in which protein synthesis,folding,and degradation are maintained at a homeostatic state such that an intact yet dynamic proteome is *** capacity to preserve proteostasis declines with age,which is assumed to contribute to the pathogenesis of age-related *** failure manifested as the formation of aberrant protein aggregates,including the amyloid plaques in Alzheimer’s disease(AD),Lewy bodies in Parkinson’s disease,and TAR DNA binging protein 43 inclusions in amyotrophic lateral sclerosis(ALS),is a defining feature of neurodegenerative diseases.

关键词： stasis degenerative collision

Mechanics of flexible and stretchable piezoelectrics for energy harvesting

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Science China(Physics,Mechanics & Astronomy) 2015年第9期58卷 39-51页

作者： CHEN Ying lu bingwei OU DaPeng FENG Xue Department of Engineering Mechanics Tsinghua University Center for Mechanics and Materials Tsinghua University

As rapid development in wearable/implantable electronic devices benefit human life in daily health monitoring and disease treatment medically, all kinds of flexible and/or stretchable electronic devices are booming, together with which is the demanding of energy supply with similar mechanical property. Due to its ability in converting mechanical energy lying in human body into electric energy, energy harvesters based on piezoelectric materials are promising for applications in wearable/implantable device's energy supply in a renewable, clean and life-long way. Here the mechanics of traditional piezoelectrics in energy harvesting is reviewed, including why piezoelectricity is the choice for minor energy harvesting to power the implantable/wearable electronics and how. Different kinds of up to date flexible piezoelectric devices for energy harvesting are introduced, such as nanogenerators based on Zn O and thin and conformal energy harvester based on PZT. A detailed theoretical model of the flexible thin film energy harvester based on PZT nanoribbons is summarized, together with the in vivo demonstration of energy harvesting by integrating it with swine heart. Then the initial researches on stretchable energy harvesters based on piezoelectric material in wavy or serpentine configuration are introduced as well.

关键词： piezoelectric effect energy harvesting flexible electronics stretchable electronics

Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor

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National Science Review 2020年第5期7卷 849-862页

作者： Haicheng Li Yinji Ma Ziwei Liang Zhouheng Wang Yu Cao Yuan Xu Hua Zhou bingwei lu Ying Chen Zhiyuan Han Shisheng Cai Xue Feng Key Laboratory of Applied Mechanics Department of Engineering Mechanics Tsinghua University Center for Flexible Electronics Technology Tsinghua University Intensive Care Unit Beijing Tsinghua Changgung Hospital Institute of Flexible Electronics Technology of Tsinghua University

According to the statistics of the World Health Organization, an estimated 17.9 million people die from cardiovascular diseases each year, representing 31%of all global deaths. Continuous non-invasive arterial pressure (CNAP) is essential for the management of cardiovascular diseases. However, it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression. Here, we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP. We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts, and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices. We compare the results with the blood pressure acquired by invasive (intra-arterial) blood pressure monitoring for>1500 min in total on 44 subjects in an intensive care unit. The maximum absolute errors of diastolic and systolic blood pressure were±7/±10 mm Hg, respectively, in immobilized, and±10/±14 mm Hg, respectively, in walking scenarios. These strategies provide advanced blood pressure monitoring techniques, which would directly address an unmet clinical need or daily use for a highly vulnerable population.

关键词： skin-like devices optoelectronics blood pressure monitor optical measurement

Studying Alzheimer’s Disease Using Drosophila melanogaster as a Powerful Tool

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Advances in Alzheimer's Disease 2022年第3期11卷 23-37页

作者： Jacob Kasanin Xingjun Wang Wanting Jiao Qiuyu Li bingwei lu Palo Alto High School Palo Alto USA Department of Pathology Stanford University School of Medicine Stanford USA School of Life Science and Technology Tongji University Shanghai China

Background: Alzheimer’s disease (AD) is an increasingly prevalent neurodegenerative disease characterized by protein aggregation in the form of amyloid plaques containing beta-amyloid peptides and neurofibrillary tangles containing hyperphosphorylated tau protein. The central molecular events underlying AD pathogenesis remain controversial and poorly defined. Drosophila melanogaster has emerged as an important genetic resource for studying the pathology of AD. Many AD models have been created using Drosophila, taking advantage of its short generation times, sophisticated genetic tools, and abundance of homologs to human genes. Purpose: This review summarizes different models for studying AD in Drosophila melanogaster, including the full-length APP, C99, Aβ42 and Tau models, explaining how the models were built and what we have learned from them. Conclusion: Four main AD Drosophila models are introduced in this review, which can serve as a future method to investigate genes and drugs that can modify symptoms.

关键词： Drosophila Alzheimer’s Disease APP C99 Aβ42 Tau

High-selectivity electroreduction of low-concentration CO2 with large concentration fluctuation

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Science China Chemistry 2025年

作者： Mengyu Qi Yanbin Ma Chao Zhang bingwei Li Xueqing Yang Zhaolin Shi Simeng Liu Changhua An Jiqing Jiao Tongbu lu MOE International Joint Laboratory of Materials Microstructure Analysis and Testing CenterInstitute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringSchool of Chemistry and Chemical EngineeringTianjin University of Technology Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

Electrochemical CO2reduction reaction（CO2RR） has been regarded as one of the most promising solutions to achieving “zero carbon emission”. In most of the CO2RR-related studies, high-purity CO2has been employed as the feed gas; however, in practice, CO2is generally emitted in low concentrations, so it is of great significance to realize high-selectivity electroreduction of low-concentration CO2with large concentration fluctuation. In this work, we constructed a dual-active-site catalyst and successfully achieved CO2local enrichment and conversion for low-concentration CO2. Operando experiments reveal that the catalyst has one type of site for activating CO2and one type of site for binding the reaction intermediates. The dual-active-site catalyst displays a selectivity for formic acid consistently above 97% over a broad potential window（from-0.9 to-1.6 V ***）. Even when fed with a low-concentration CO2stream（volume ratio from 50% down to 10%）, the dual-active-site catalyst could display high activity and selectivity（>91%）. In particular, the selectivity is still above 85% when the CO2volume ratio is as low as 5%. This work offers a feasible route for converting low-concentration CO2via a synergistic effect for dual-active-site catalysts.

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柔性光学超材料和等离子激元的发展和应用

中国科学：物理学、力学、天文学 2016年第4期46卷 25-36页

作者：高丽陆炳卫徐航勋南京理工大学电子工程和光电技术学院南京210094 清华大学航空航天学院北京100084 中国科学技术大学高分子科学与工程系合肥230026

赋予光学超材料和等离子激元器件弯折、拉伸和卷曲的特性可以开启对电磁波进行调控的新篇章,并实现新颖的器件设计和强大的功能性,例如隐身装置、超级棱镜和变换光学等.本文综述了近年来从微波到可见光不同波段产生响应的柔性光学超材... 详细信息

赋予光学超材料和等离子激元器件弯折、拉伸和卷曲的特性可以开启对电磁波进行调控的新篇章,并实现新颖的器件设计和强大的功能性,例如隐身装置、超级棱镜和变换光学等.本文综述了近年来从微波到可见光不同波段产生响应的柔性光学超材料和等离子激元器件的发展和应用,包括光学结构设计、柔性基底的力学和光学性质、及与其匹配的微纳加工技术.除传统的光刻、电子束曝光、纳米粒子自组装技术外,本文还介绍了新型的纳米掩膜板和纳米压印转移技术.其中,新型低成本的适用于大面积纳米光学结构的纳米压印转移技术具有较大应用前景.文章还将讨论应力作用对不同光子器件产生的性质调控以及实现的滤波器,拉曼信号增强和传感器等方面的应用.

关键词：超材料等离子激元柔性光子器件可调光子器件

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瞬态电子器件研究最新进展

中国科学：物理学、力学、天文学 2016年第4期46卷 37-45页

作者：张颖陆炳卫徐航勋冯雪中国科学技术大学高分子科学与工程系中国科学院软物质化学重点实验室合肥230026 清华大学航空航天学院教育部应用力学重点实验室北京100084 清华大学先进力学与材料中心北京100084

瞬态电子器件是指当所制备的电子功能器件在完成指定功能后,其物理形态和功能可以在外界刺激触发下立即发生部分消失或者完全消失的一种新兴电子器件.传统意义上的电子器件通常非常稳定,甚至需要在极端环境下能够正常工作,但正是这种稳... 详细信息

瞬态电子器件是指当所制备的电子功能器件在完成指定功能后,其物理形态和功能可以在外界刺激触发下立即发生部分消失或者完全消失的一种新兴电子器件.传统意义上的电子器件通常非常稳定,甚至需要在极端环境下能够正常工作,但正是这种稳定性使得当前淘汰或者损毁的电子器件成为污染环境的主要源头之一.相反,具有可降解功能并能够在外界特定刺激作用下发生即时降解的瞬态电子概念的提出很好地解决了这个难题.同时,瞬态电子具有可以补充传统集成电路的能力,并将应用领域扩展至植入式可降解医疗电子器件、安全电子器件、可消失环境传感器和零废物消费电子器件中.本文综述了近几年瞬态电子器件的兴起和发展,阐述了以瞬态技术为基础的各类电子器件的潜在应用.

关键词：瞬态电子柔性电子可降解材料可降解电子器件生物可降解

超声振动辅助磨削CFRP复合材料薄管撕裂损伤研究

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中国机械工程 2024年第3期35卷 524-533,540页

作者：康仁科陆冰伟陈凯良李晟超戴晶滨董志刚鲍岩大连理工大学机械工程学院大连116024 上海复合材料科技有限公司上海201112

针对碳纤维增强复合材料(CFRP)薄管超声振动辅助磨削过程中存在撕裂损伤且形成原因不明确的问题,通过对M55J和T300复合材料薄管开展超声振动辅助磨削试验,探究了超声振幅、进给量及主轴转速对磨削力和撕裂尺寸的影响规律,通过对磨削过... 详细信息

针对碳纤维增强复合材料(CFRP)薄管超声振动辅助磨削过程中存在撕裂损伤且形成原因不明确的问题,通过对M55J和T300复合材料薄管开展超声振动辅助磨削试验,探究了超声振幅、进给量及主轴转速对磨削力和撕裂尺寸的影响规律,通过对磨削过程的受力分析和对最大未变形切屑厚度的计算,分析了撕裂位置的形成原因和撕裂尺寸的变化规律。结果表明:磨削力随超声振幅的增大而减小,随进给量的增大而增大,与主轴转速的关联性较小;撕裂易出现于CFRP薄管内壁,其长度与高度随超声振幅的增大而减小,随进给量的增大而增大,随主轴转速的增大而减小。

关键词：碳纤维增强复合材料薄管超声振动辅助磨削磨削力撕裂

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端面磨削复合材料管毛刺预测及验证

机械工程学报 2022年第15期58卷 63-74页

作者：田俊超鲍岩董志刚陆冰伟康仁科郭东明大连理工大学精密与特种加工教育部重点实验室大连116024

阵列复材管具有优异的性能,可应用于微波反射器夹层。阵列复材管端面磨削过程中易出现规律毛刺且形成过程不明确。研究以阵列复材管的复合材料管胞元为对象,考虑其宏观结构特征和端面磨削特点定义切出角度和砂轮轴线偏移角,并系统研究... 详细信息

阵列复材管具有优异的性能,可应用于微波反射器夹层。阵列复材管端面磨削过程中易出现规律毛刺且形成过程不明确。研究以阵列复材管的复合材料管胞元为对象,考虑其宏观结构特征和端面磨削特点定义切出角度和砂轮轴线偏移角,并系统研究在砂轮倒角参数和工艺参数综合影响下,切削截面内砂轮与纤维相互作用关系,揭示毛刺的形成过程并建立毛刺长度预测模型。结果表明:砂轮轴线偏移角、砂轮倒角共同影响切削截面内的砂轮倒角,而切削截面内砂轮倒角与纤维方向角的大小关系、轴向磨削深度共同影响纤维率先发生断裂的位置,该位置与纤维方向角共同影响毛刺的长度。为获得更好的加工质量应优先选用较大倒角的砂轮、较小的砂轮轴线偏移角或使切出角度接近90°,当毛刺不可避免时,优先选用较小的轴向磨削深度。研究成果可为复合材料管端面磨削过程中刀具轨迹规划、刀具设计和工艺参数选择提供指导。

关键词：碳纤维增强复合材料端面磨削毛刺切出角度砂轮倒角

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陕西省外汇期权发展情况研究

西部金融 2016年第12期 62-65页

作者：章红陆秉炜中国人民银行西安分行陕西西安710075

外汇期权业务是金融衍生品中较为复杂的品种之一,近期陕西省外汇期权零售业务发展迅速,交易量增长态势较为明显。本文从陕西省外汇期权业务发展基本情况入手,详细阐述外汇期权产品类型以及在企业应对汇率风险进行套期保值上的优势。通... 详细信息

外汇期权业务是金融衍生品中较为复杂的品种之一,近期陕西省外汇期权零售业务发展迅速,交易量增长态势较为明显。本文从陕西省外汇期权业务发展基本情况入手,详细阐述外汇期权产品类型以及在企业应对汇率风险进行套期保值上的优势。通过分析产品运行机制,得出外汇期权对近期外汇管理政策存在规避和对冲的结论,最后提出促进外汇期权市场健康发展的相关政策建议。

关键词：买入期权卖出期权汇率风险