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Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China

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Journal of Genetics and Genomics 2011年第4期38卷 165-171页

作者： Yina Cun Jin Li Wenru Tang Xiaozhi Sheng Haijing Yu bingrong zheng Chunjie Xiao Laboratory for Conservation and Utilization of Bio-resources and Human Genetics Center of Yunnan UniversityKunming 650091China

The association of polymorphisms in exon 1 of the WNK1 gene with essential hypertension in the minority groups of Hani and Yi of China was investigated in the case-control *** sequence of 1257 bp containing the WNK1 gene exon 1 was determined in 1307 individuals（649 essential hypertension subjects and 658 controls）to identify SNPs in Hani and Yi minority *** of eleven previously known SNPs （rs3168640,rs11885,rs11554421 and rs34880640）were *** SNP analysis indicated that SNPs rs11885 and rs11554421 were significantly associated with hypertension in both Hani and Yi populations,and rs34880640 was significantly associated with hypertension in Hani but not in Yi population,adjusted for *** analysis indicated that the haplotype H1 significantly decreased the risk of hypertension in both *** results suggested that WNK1 polymorphisms were involved in the predisposition of essential hypertension in Hani and Yi populations and its effects showed a clear population *** finding supported the importance of population specificity in determining the genetic factors associated with diseases and thus disease treatment.

关键词： WNK1 SNPs Haplotype Essential hypertension Hani population Yi population

Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism

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Science China(Life Sciences) 2008年第5期51卷 435-444页

作者： YANG LiuQi, TAN SiJie, YU HaiJing, zheng bingrong, QIAO EnFa, DONG YongLi, ZAN RuiGuang & XIAO ChunJie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China Key Laboratory of Bioresources Conservation Utilization & Human Genetics Center Yunnan University Kunming 650091 China

To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete.

关键词： polymorphism mtDNA gene admixture Gansu Corridor

Polymorphisms in PPARD,PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions

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Journal of Genetics and Genomics 2010年第6期37卷 371-379页

作者： Yanrui Wu Yina Cun Jing Dong Jingru Shao Shengjun Luo Shengjie Nie Haijing Yu bingrong zheng Qi Wang Chunjie Xiao Human Genetics Center of Yunnan University Kunming 650091 China The General Hospital of the Air Force Beijing 100036 China Center for Studies in Constitution Research of Traditional Chinese Medicine Beijing University of Chinese Medicine Beijing 100029 China

Based on the theory of constitution of Traditional Chinese Medicine （TCM）, the human population is divided into nine constitutions including one balanced constitution （Normality） and eight unbalanced constitutions （Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution）. Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classification is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes including PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms （SNPs） in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method. Biased distribution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Prol2Ala in Yin-deficiency and PPARD rs2076167, APMI rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotypel3 （Hapl3） of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hapl4 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be group-associated haplotypes. These results suggested that single SNP and haplotypes ofPPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in TCM.

关键词： Traditional Chinese Medicine constitution classification PPARD PPARG APM1 SNP

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完善南洲水厂排泥水回用系统的研究与设计

城镇供水 2023年第1期 20-24页

作者：郑炳榕广州市广水工程设计有限公司广东广州510160

随着环保要求的不断提高,南洲水厂取水量、供水量提高的同时,生产构筑物的排泥水也随之增长,水厂现有排泥水回用系统暴露出上清液集水池调节和滤液池调节容积偏小、排泥池没有备用无法进行日常定期清洗、斜管浓缩池冲击负荷大、脱水机2... 详细信息

随着环保要求的不断提高,南洲水厂取水量、供水量提高的同时,生产构筑物的排泥水也随之增长,水厂现有排泥水回用系统暴露出上清液集水池调节和滤液池调节容积偏小、排泥池没有备用无法进行日常定期清洗、斜管浓缩池冲击负荷大、脱水机24小时满负荷运行和储泥池停留时间较短等问题。该文介绍的工程针对实际问题,完善现有排泥水回用系统,有效地提升整个排泥水回用系统的稳定性。

关键词：净水厂排泥水处理浓缩池排泥池干化场

多维石墨烯与钼酸铋纳米颗粒复合材料的制备与光催化性能

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大连工业大学学报 2019年第5期38卷 354-359页

作者：刘唱郑炳荣张新欣王宇董晓丽大连工业大学轻工与化学工程学院

以钼酸铋(Bi2MoO6)纳米颗粒和氧化石墨烯(GO)为原料,采用水热法和静电自组装法分别合成了Bi2MoO6/3D rGO和Bi2MoO6/2D rGO光催化材料;通过X射线衍射、扫描电子显微镜、透射电子显微镜、拉曼光谱、红外光谱、荧光光谱、紫外-可见漫反射... 详细信息

以钼酸铋(Bi2MoO6)纳米颗粒和氧化石墨烯(GO)为原料,采用水热法和静电自组装法分别合成了Bi2MoO6/3D rGO和Bi2MoO6/2D rGO光催化材料;通过X射线衍射、扫描电子显微镜、透射电子显微镜、拉曼光谱、红外光谱、荧光光谱、紫外-可见漫反射、氮吸附脱附曲线、光降解罗丹明B曲线对材料进行了表征;考察了石墨烯含量对钼酸铋光催化性能的影响。光降解罗丹明B结果表明,当GO质量分数为0.5%时,Bi2MoO6/2D rGO的光催化活性最高,可见光照射120 min后,罗丹明B的降解率达到90%。氮吸附脱附反应表明,当Bi2MoO6与GO的质量比为1∶5时,所合成的Bi2MoO6/3D rGO光催化材料的比表面积和孔体积均比Bi2MoO6与GO的大。多维石墨烯的引入不仅能提高钼酸铋的光催化性能,也能增大钼酸铋的比表面积和孔体积。

关键词：钼酸铋氧化石墨烯光催化光降解

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重庆回流人口识别方法及其规划响应

规划师 2024年第7期40卷 136-142页

作者：冷炳荣陈俊伊盛佳慧易峥尹珂重庆市规划设计研究院信息数据所空间规划大数据应用重庆市工程研究中心、自然资源部国土空间规划监测评估预警重点实验室重庆市规划设计研究院、空间规划大数据应用重庆市工程研究中心、自然资源部国土空间规划监测评估预警重点实验室重庆市规划设计研究院空间规划大数据应用重庆市工程研究中心重庆师范大学地理与旅游学院

人口回流已成为全国人口流动的一种普遍现象,对于中西部人口净流出地区而言,认识回流人口的空间规律、结构是新时期编制国土空间规划、配置空间资源的重要基础。在总结当前回流人口定义的基础上,提出基于手机大数据的回流人口识别方法,... 详细信息

人口回流已成为全国人口流动的一种普遍现象,对于中西部人口净流出地区而言,认识回流人口的空间规律、结构是新时期编制国土空间规划、配置空间资源的重要基础。在总结当前回流人口定义的基础上,提出基于手机大数据的回流人口识别方法,并将其应用于回流规模、回流来源、回流去向、回流结构等4个方面的研究分析中。在此基础上,以重庆为例验证回流人口的识别方法,并阐释回流人口的基本特征,由此提出中西部地区人口回流地区的空间规划应对策略,以便加快手机大数据在回流人口研究领域的应用进程。

关键词：回流人口手机大数据识别方法规划应用重庆

维普期刊数据库博看期刊

人脐带间充质干细胞神经向分化与去分化基因表达谱分析

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中华细胞与干细胞杂志（电子版） 2017年第1期7卷 29-34页

作者：焦扬赵洪波刘平付旭锋陈国栋罗晓曦桑雄波郑冰蓉云南大学医学院昆明650091 昆明医科大学云南省干细胞与再生医学重点实验室 650500

目的用生物信息学方法从公共基因芯片数据库(GEO)中初步筛选出与人脐带间充质干细胞(h UC-MSCs)神经向分化和去分化相关的生物学功能和对应的信号通路,分析蛋白互作关系,为进一步开展h UC-MSCs神经向分化和去分化的实验研究提供指导信... 详细信息

目的用生物信息学方法从公共基因芯片数据库(GEO)中初步筛选出与人脐带间充质干细胞(h UC-MSCs)神经向分化和去分化相关的生物学功能和对应的信号通路,分析蛋白互作关系,为进一步开展h UC-MSCs神经向分化和去分化的实验研究提供指导信息。方法在公共基因芯片数据库GEO中搜寻h UC-MSCs神经向分化与去分化的基因芯片数据,用R和Bioconductor软件包进行统计学分析,筛选差异基因;用Gene Analytics在线分析工具进行GO分析和通路分析;用STRING数据库进行差异表达基因对应的蛋白互作关系分析。结果共筛选得到影响神经向分化和去分化过程的670个上调基因和1 458个下调基因;进一步对这些差异基因进行功能富集分析,发现上调过程的功能集中表现为促血管生成和细胞黏附,下调的生物学过程则主要和代谢相关;上调通路主要有与细胞增殖、分化、凋亡有关的ERK、血管生成和Akt等通路,下调通路主要有与细胞代谢和生物合成相关的萜类化合物骨架生物合成、Cholesterot Biosynthesis II和磷酸肌醇代谢等通路,其中特别的是,维持胚胎干细胞多能性的Nanog通路出现在下调通路中;蛋白互作网络分析发现,与血管生成、细胞黏附相关的蛋白VEGFA、IL-6、FGF2、MMP和IL-8有较高的degree值。结论影响h UC-MSCs神经向分化和去分化的因素很多,其中,促进血管生成、细胞黏附及细胞繁殖相关的基因、生物反应过程、信号通路及相关蛋白起着重要作用。上述基于生物信息学的筛查分析结果为进一步开展h UC-MSCs神经向分化与去分化实验研究提供了一定的参考信息。

关键词：计算生物学脐带间质干细胞细胞分化细胞去分化基因表达谱

All-optical format conversion from RZ-QPSK to NRZ-QPSK

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Frontiers of Optoelectronics 2012年第3期5卷 330-333页

作者： bingrong ZOU Yu YU WenhanWU Shoujin HU zheng ZHANG Xinliang ZHANG Wuhan National Laboratory for Optoelectronics College of Optoelectonic Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

We proposed and demonstrated an all-optical format conversion fi：om return-to-zero quadrature phase shift keying （RZ-QPSK） to non-return-to-zero QPSK （NRZ-QPSK） at 40 Gb/s using a half bit delay inter- ferometer （DI）. Due to the constructive interference in the DI, the format conversion was achieved with the phase information preserved. Q penalty for the format conversion was less than 1.8 dB for I and Q data.

关键词： format conversion fiber optics communica-tions modulation

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国外城乡统筹规划经验及启示

规划师 2014年第11期30卷 121-126页

作者：冷炳荣易峥钱紫华重庆市规划设计研究院重庆市规划设计研究院城乡发展战略研究所

当前,我国区域发展较不平衡、城乡收入差距较大。面对这一现实,研究选择英国、欧盟和韩国作为研究对象,从规划编制体系、政策设计和组织安排等角度,分析城乡统筹理念下国外地区规划经验及其对我国城乡统筹规划的主要启示,包括采取整体... 详细信息

当前,我国区域发展较不平衡、城乡收入差距较大。面对这一现实,研究选择英国、欧盟和韩国作为研究对象,从规划编制体系、政策设计和组织安排等角度,分析城乡统筹理念下国外地区规划经验及其对我国城乡统筹规划的主要启示,包括采取整体的思维、整合的方法,平等对待、统筹考虑城乡区域;重视空间规划对区域统筹的纲领作用,以空间规划为平台,整合政府政策资源,提高政策的执行力;突出村庄规划的实际运用价值,成果表达应简单明了、通俗易懂,实事求是地满足村民的实际需要。

关键词：城乡统筹空间规划英国欧盟韩国