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Mendelian Randomization Study of Causal Relationship between Inflammatory Factors and Vascular Dementia and Chinese Herbal Medicines Screening for Prevention and Treatment

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Journal of Biosciences and Medicines 2024年第10期12卷 270-284页

作者： Jinzhi Zhang Wei Chen Guifeng Zhuo Chun Yao Mingyang Su bingmao yuan Xiaomin Zhu Zizhen Zhou Fengyi Lei Yulan Fu Lin Wu Department of Neurology The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning China The First Clinical College of Medicine Guangxi University of Chinese Medicine Nanning China Graduate School Guangxi University of Chinese Medicine Nanning China

Objective: This study aims to examine the causal relationship between inflammatory factors and the probability of developing vascular dementia (VD) using Mendelian Randomization (MR) and Chinese herbal medicine prediction method, and to screen potential Chinese herbal medicines for the prevention and treatment of VD. Methods: Single nucleotide polymorphisms (SNPs) that exhibit a strong association with vascular dementia (VD) were identified as instrumental variables from the summary statistics of genome-wide association studies (GWAS). The primary analytical method employed was inverse variance weighting (IVW), while auxiliary analyses included the MR-Egger method, weighted median method, simple model, and weighted model. A two-way Mendelian randomization analysis was conducted to assess the causal relationship between inflammatory factors and the risk of VD, thereby identifying the key inflammatory factors involved. The MR-Egger intercept test and Cochran’s Q test were employed to assess the horizontal polymorphism and heterogeneity of instrumental variables. A sensitivity analysis was conducted by excluding one method at a time. Ultimately, based on key inflammatory factors, predictions for the prevention and treatment using traditional Chinese medicine were made, along with the screening of homologous herbal remedies. Results: Based on the results of the forward MR, the probability of developing VD was elevated when the inflammatory factors CXCL10 and CXCL5 were expressed at higher levels, whereas the probability of developing VD decreased as the expression levels of IL-13 and IL-20RA increased. These findings were supported by the assessment of pleiotropy, heterogeneity, and sensitivity. The results of the reverse MR analysis showed that there was no causal relationship between VD, as an exposure dataset, and these four inflammatory factors. According to the key inflammatory factors, 37 Chinese herbal medicines such as Siraitia grosvenorii were selected. Their c

关键词： Inflammatory Factors Vascular Dementia Mendelian Randomization Study Causal Association Chinese Medicine Prediction Medicine and Food Homology

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中医药治疗中风后抑郁研究进展

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辽宁中医杂志 2023年第1期50卷 204-207页

作者：陈昭吴林袁炳茂陈炜广西中医药大学第一临床医学院广西南宁530023 广西中医药大学广西南宁530001

随着中风人群的不断增多,作为其重要并发症的中风后抑郁也逐渐走进越来越多人的视线。中风后抑郁给家庭和社会都带来了沉重的负担,中医药治疗中风后抑郁具有明显的优势,能够与现代医学的治疗相辅相成,而具有自身的独特优势,该文就中医... 详细信息

随着中风人群的不断增多,作为其重要并发症的中风后抑郁也逐渐走进越来越多人的视线。中风后抑郁给家庭和社会都带来了沉重的负担,中医药治疗中风后抑郁具有明显的优势,能够与现代医学的治疗相辅相成,而具有自身的独特优势,该文就中医药治疗中风后抑郁展开综述。

关键词：中风后抑郁中医药治疗方法研究进展

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中医药复方干预血管性痴呆的作用及机制

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中华中医药学刊 2023年第6期41卷 111-114页

作者：林龙吴林劳祎林朱健敏匡龙娇袁炳茂陈远亮广西中医药大学广西南宁530200 中山大学南方学院广东广州510970

血管性痴呆(vascular dementia,VaD)患病率高,病理分子机制复杂,现代医学在发病机制、诊断、治疗等方面开展了广泛研究,但目前仍未完全阐明其分子机制,且尚无疗效公认的治疗药物,亟须进一步探索其分子机制及治疗方案。中医治则治法指导... 详细信息

血管性痴呆(vascular dementia,VaD)患病率高,病理分子机制复杂,现代医学在发病机制、诊断、治疗等方面开展了广泛研究,但目前仍未完全阐明其分子机制,且尚无疗效公认的治疗药物,亟须进一步探索其分子机制及治疗方案。中医治则治法指导中药复方广泛应用于血管性痴呆的临床治疗,具有多靶点、多通路、多层次协同治疗的作用机制,与血管性痴呆复杂的分子机制相契合,具有重要研究价值和广阔临床应用前景。系统综述国内外近年中医药复方干预血管性痴呆的实验研究文献,根据不同治疗靶点和分子机制进行分类归纳,以期为血管性痴呆的中医药临床治疗及实验研究提供参考依据并探讨研究展望。

关键词：血管性痴呆中医药方剂作用机制信号通路

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu Zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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小针刀松解头后小直肌治疗颈型颈椎病的临床效果

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广西医学 2023年第22期45卷 2774-2777页

作者：王伟黄永李红波中国人民解放军联勤保障部队第九二三医院康复医学科广西南宁市530000 广西国际壮医医院康复医学科广西南宁市530000

目的观察小针刀松解头后小直肌治疗颈型颈椎病的临床效果。方法选取60例颈型颈椎病患者,按照随机数字表法分为对照组和观察组,每组30例。给予观察组患者小针刀松解头后小直肌治疗,给予对照组患者常规针刺治疗,两组均治疗7 d。分别在... 详细信息

目的观察小针刀松解头后小直肌治疗颈型颈椎病的临床效果。方法选取60例颈型颈椎病患者,按照随机数字表法分为对照组和观察组,每组30例。给予观察组患者小针刀松解头后小直肌治疗,给予对照组患者常规针刺治疗,两组均治疗7 d。分别在治疗前、治疗后4 d和治疗后7 d,比较两组患者疼痛视觉模拟量表(VAS)评分、颈椎功能障碍指数(NDI)量表评分,且治疗后7 d比较两组患者的疗效。结果治疗后4 d和治疗后7 d,两组患者的疼痛VAS评分和NDI量表评分较治疗前降低,且观察组上述评分低于对照组(P<0.05)。治疗后7 d,观察组的疗效优于对照组(P<0.05)。结论相比于常规针刺治疗,小针刀松解头后小直肌治疗更能缓解颈型颈椎病患者的疼痛症状,改善其颈椎功能,疗效确切。

关键词：颈椎病颈型小针刀松解术头后小直肌疗效

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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

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胃癌干细胞研究的文献计量学和可视化分析

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中国组织工程研究 2023年第6期27卷 941-947页

作者：尹硕鑫张涛王舒萍卢鑫黄旭平尹梦影杨玉伟袁炳茂毛志华陈远能广西中医药大学广西壮族自治区南宁市530001 广西中医药大学附属瑞康医院消化内科广西壮族自治区南宁市530011

背景:胃癌干细胞是近年医学领域研究的热点,能够干预胃癌的发生、转移、复发和耐药等,理论上,胃癌干细胞是未来治疗胃癌最有前途的候选靶点,因此研究胃癌干细胞的作用机制不仅能够阐明胃癌的发生发展,而且有助于寻找新的有效分子靶点,... 详细信息

背景:胃癌干细胞是近年医学领域研究的热点,能够干预胃癌的发生、转移、复发和耐药等,理论上,胃癌干细胞是未来治疗胃癌最有前途的候选靶点,因此研究胃癌干细胞的作用机制不仅能够阐明胃癌的发生发展,而且有助于寻找新的有效分子靶点,有着广阔的应用前景。目的:利用文献计量学对胃癌干细胞的研究进行可视化分析,总结研究热点和趋势,为相关领域科研工作者的研究提供参考。方法:基于Web of Science核心数据库,通过CiteSpace对2011-2021年的年度发文量、作者、国家、期刊、被引情况和关键词等进行可视化分析。结果与结论:筛选后共纳入2832篇文献,目前全球胃癌干细胞研究的文献数量呈快速增长趋势;中国和美国是发文量最多的国家。中国学者的总发文量虽然位居世界第一,但中心度和篇均被引频次较低,说明受关注程度及学术影响力不足,在发文质量上还有待提高;《Oncotarget》是国内外学者发文量最多的期刊,《Oncology Letters》是中国学者发文量最多的期刊;胃癌干细胞研究呈现出多学科交叉的发展特点;胃癌干细胞目前的研究热点主要与上皮间质转化、对胃癌细胞生物学功能的影响以及自我更新等有关;胃癌干细胞的可塑性、与脂肪酸氧化和血管内皮生长因子的关系,以及非编码RNA对胃癌干细胞的调控等可能是目前及未来的研究重点。胃癌干细胞研究目前正处于快速上升阶段,近年来胃癌干细胞的作用机制逐渐明朗,未来胃癌干细胞干预将是胃癌患者新的靶向治疗策略。

关键词：胃癌干细胞非编码RNA 上皮间质转化文献计量学可视化分析 Citespace

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Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

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益肺宣肺降浊方通过影响脑源性神经营养因子改善血管痴呆记忆的作用机制

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世界中医药 2024年第12期19卷 1737-1742页

作者：陈炜匡龙娇胡跃强吴林朱健敏袁炳茂洪煌钟朱小敏蒋凌飞江西中医药大学研究生院南昌330004 广西中医药大学第一附属医院脑病科南宁530023 广西中医药大学研究生院南宁530001 广西中医药大学科学实验中心南宁530001

目的:探讨益肺宣肺降浊方及通过影响脑源性神经营养因子(BDNF)改善血管痴呆记忆的作用机制。方法:将Wistar大鼠随机分为假手术组,模型组,益肺宣肺降浊方低剂量组,益肺宣肺降浊方中剂量组,益肺宣肺降浊方高剂量组,石杉碱甲组,每组15只。... 详细信息

目的:探讨益肺宣肺降浊方及通过影响脑源性神经营养因子(BDNF)改善血管痴呆记忆的作用机制。方法:将Wistar大鼠随机分为假手术组,模型组,益肺宣肺降浊方低剂量组,益肺宣肺降浊方中剂量组,益肺宣肺降浊方高剂量组,石杉碱甲组,每组15只。其中除假手术组外均构建大脑中动脉栓塞法(MCAO)大鼠血管性痴呆模型。益肺宣肺降浊方低剂量组、中剂量组、高剂量组分别给予1.25、2.5、5 g/kg的益肺宣肺降浊方灌胃,假手术组和模型组给予同等体积的生理盐水灌胃,石杉碱甲组给予3 mg/kg的石杉碱甲灌胃。各组每日灌胃1次,持续给药4周后,进行Morris水迷宫试验检测动物神经行为学;Morris水迷宫结束后,获取大鼠海马组织,通过TUNEL染色检测海马组织细胞凋亡情况;用免疫组织化学检测海马组织中BDNF表达。结果:Morris水迷宫行为学结果显示,与模型组比较,不同剂量的益肺宣肺降浊方组的逃避潜伏期显著减少(P<0.05),穿越平台次数明显增加(P<0.05);TUNEL结果表明益肺宣肺降浊方可有效抑制海马神经元凋亡(P<0.05);免疫组织化学结果显示益肺宣肺降浊方显著上调大鼠海马组织中BDNF的表达(P<0.05)。结论:益肺宣肺降浊方可改善血管痴呆大鼠的学习和记忆功能障碍,其作用机制与抑制神经元凋亡和上调BDNF表达有关。

关键词：益肺宣肺降浊方血管痴呆脑源性神经营养因子海马神经元凋亡

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Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun yuan Li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

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