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A Hybrid and Inexact Algorithm for Nonconvex and Nonsmooth Optimization

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Journal of Systems Science & Complexity 2024年

作者： wang Yiyang SONG Xiaoliang College of Artificial Intelligence Dalian Maritime University School of Mathematical Sciences Dalian University of Technology

The problem of nonconvex and nonsmooth optimization (NNO) has been extensively studied in the machine learning community,leading to the development of numerous fast and convergent numerical *** algorithms typically employ unified iteration schemes and require explicit solutions to subproblems for ensuring ***,these inflexible iteration schemes overlook task-specific details and may encounter difficulties in providing explicit solutions to *** contrast,there is evidence suggesting that practical applications can benefit from approximately solving subproblems;however,many existing works fail to establish the theoretical validity of such *** this paper,the authors propose a hybrid inexact proximal alternating method (hiPAM),which addresses a general NNO problem with coupled terms while overcoming all aforementioned *** proposed hiPAM algorithm offers a flexible yet highly efficient approach by seamlessly integrating any efficient methods for approximate subproblem solving that cater to ***,the authors have devised a simple yet implementable stopping criterion that generates a Cauchy sequence and ultimately converges to a critical point of the original NNO *** proposed numerical experiments using both simulated and real data have demonstrated that hiPAM represents an exceedingly efficient and robust approach to NNO problems.

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The positive energy theorem for weighted asymptotically anti-de Sitter spacetimes

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Science China Mathematics 2024年

作者： Yaohua wang Xiao Zhang School of Mathematics and Statistics Henan University Guangxi Center for Mathematical Research Guangxi University Academy of Mathematics and Systems Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences

The positive energy theorem for weighted asymptotically flat spin manifolds was proved by Baldauf and Ozuch(2022) and for the non-spin case by Chu and Zhu(2024). In this paper, we generalize the positive energy theorem for 3-dimensional asymptotically anti-de Sitter initial data sets to weighted asymptotically anti-de Sitter initial data sets assuming that the weighted dominant energy condition holds.

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A new autophagy-related nomogram and mechanism in multiple myeloma

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Genes & Diseases 2024年第5期11卷 29-32页

作者： Hanying Huang Yang Li Ziang Zhu Yang Liu Weida wang Shuzhao Chen Xiaoping Wu Yun wang Yanzhou Chen Huanxin Lin Yang Liang Lingling Shu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Hematologic Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Department of Radiation Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China Key Laboratory of Neurosurgery in Guangdong Province Southern Medical UniversityGuangzhouGuangdong 510060China Department of Neurosurgery Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510060China State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong Kong 999077China

Multiple myeloma(MM)is the second most common hematological *** is characterized by high drug resistance,easy recurrence,and poor prognosis,and remains *** models or scoring modalities can be used to predict the survival prognosis of MM patients;however,these predictions are still not accurate *** have previously found that scorings related to bone marrow microenvironment metabolism can improve predictive efficacy.

关键词： metabolism prognosis myeloma

Natural long-chain saturated fatty acids doped LNPs enabling spleen selective mRNA translation and potent cancer immunotherapy

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Nano Research 2024年第3期17卷 1804-1817页

作者： Fazhan wang Meng Zhang Meiling Tian Jia Lou Longze Pan Xiaoke Gao Lijing Zhang Xiaohan Lou Linyu Zhu Yuqiao Sheng Ming wang Rui Xue Wenjing Deng Shuai Shao Zhihai Qin Medical Research Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Translational Medical Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052China Department of Neuro-Intensive Care Unit The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450052China

Rationally tailored lipid nanoparticles(LNPs)with efficient and tunable delivery of mRNA in vivo are crucial for mRNA *** expression of antigenic protein in lymphoid tissues/organs could improve the immunostimulatory efficacy and safety of LNPs-based mRNA *** by the metabolic behavior that long-chain saturated fatty acids tending to enter lymphoid tissue rather than the liver,we developed fatty acid-doped LNPs capable of mediating differential protein expressions in the liver and spleen when administered *** the molar ratio of saturated fatty acid located 60%–70%,the doped LNPs achieved the spleen selective mRNA *** mechanism could be attributed to the different cellular uptake behaviors of saturated fatty acids in *** with a model antigen(ovalbumin)mRNA-loaded spleen selective LNPs,we observed enhanced antigen-specific T cell immune responses,and potent immunotherapeutic and immunoprophylactic efficacy in the mouse lymphoma *** natural long-chain saturated fatty acids metabolic characteristics-inspired design of LNPs for spleen-selective mRNA vaccines delivery will provide references for designing mRNA vaccines with high efficacy and safety for tumor immunotherapy.

关键词： mRNA vaccine lipid nanoparticles spleen long-chain saturated fatty acid cancer immunotherapy

Current Immunotherapy Strategies for Rheumatoid Arthritis:The Immunoengineering and Delivery Systems

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Research 2024年第3期2023卷 169-189页

作者： Chenyu Zhang Peixiang Ma An Qin Liao wang Kerong Dai Yuanyuan Liu Jie Zhao Zuyan Lu School of Medicine Shanghai UniversityShanghaiChina Clinical and Translational Research Center for 3D Printing Technology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orthopedic Implants Department of Orthopedic SurgeryShanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System ShanghaiChina.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease accompanied by persistent multiarticular synovitis and cartilage degradation. The present clinical treatments are limited to disease-modifying anti-rheumatic drugs (DMARDs) and aims to relieve pain and control the inflammation of RA. Despite considerable advances in the research of RA, the employment of current clinical procedure is enormous, hindered by systemic side effect, frequent administration, tolerance from long-lasting administration, and high costs. Emerging immunoengineering-based strategies, such as multiple immune-active nanotechnologies via mechanism-based immunology approaches, have been developed to improve specific targeting and to reduce adverse reactions for RA treatments. Here, we review recent studies in immunoengineering for the treatment of RA. The prospect of future immunoengineering treatment for RA has also been discussed.

关键词： drugs Rheumatoid treatment

Research on the navigation method of large-scale differential tail-control improvised guided munitions based on rotational speed constraints

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Defence Technology（防务技术） 2024年第8期38卷 155-170页

作者： Ning Liu Wenjiang Zhao Yao wang Kai Shen Zhong Su Wenhao Qi Yuedong Xie Beijing Key Laboratory of High Dynamic Navigation Technology Beijing Information Science and Technology UniversityBeijing100192China Hua an Industry Group Co. Ltd.Qiqihar161006China Integrated Navigation and Intelligent Navigation Laboratory Beijing Institute of TechnologyBeijing100081China Beijing Institute of Technology Beijing100081China

In the process of launching guided projectile under the conventional system, it is difficult to effectively obtain the precise navigation parameters of the projectile in the high dynamic environment. Aiming at this problem, this paper describes a new system of guided ammunition based on tail spin reduction. After analyzing the mechanism of the ammunition's tail spin reduction, a navigation method of large scale difference tail control simple guided ammunition based on speed constraint is proposed. In this method,the corresponding navigation constraints can be carried out by combining the rotation speed state of the ammunition itself, and the optimal solution of navigation parameters during the flight of the missile can be obtained by Extended Kalman Filter(EKF). Finally, the performance of the proposed method was verified by the simulation environment, and the hardware-in-the-loop simulation test and flight test were carried out to verify the performance of the method in the real environment. The experimental results show that the proposed method can achieve the optimal estimation of navigation parameters for simple guided ammunition with large-scale difference tail control. Under the conditions of simulation test and hardware-in-loop simulation test, the position and velocity errors calculated by the method in this paper converged. Under the condition of flight test, the spatial average error calculated by the method described in this paper is 6.17 m, and the spatial error of the final landing point is 3.50 *** this method, the accurate acquisition of navigation parameters in the process of projectile launching is effectively realized.

关键词： Guided projectiles Tail spin reduction RPM constraints Combined navigation Extended Kalman filter(EKF)

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MTTSNet:Military time-sensitive targets stealth network via real-time mask generation

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Defence Technology（防务技术） 2024年第3期33卷 601-612页

作者： Siyu wang Xiaogang Yang Ruitao Lu Zhengjie Zhu Fangjia Lian Qing-ge Li Jiwei Fan PLA Rocket Force University of Engineering Xi'an 710025China

The automatic stealth task of military time-sensitive targets plays a crucial role in maintaining national military security and mastering battlefield dynamics in military *** propose a novel Military Time-sensitive Targets Stealth Network via Real-time Mask Generation(MTTSNet).According to our knowledge,this is the first technology to automatically remove military targets in real-time from *** critical steps of MTTSNet are as follows:First,we designed a real-time mask generation network based on the encoder-decoder framework,combined with the domain expansion structure,to effectively extract mask ***,the ASPP structure in the encoder could achieve advanced semantic feature *** decoder stacked high-dimensional information with low-dimensional information to obtain an effective mask ***,the domain expansion module guided the adaptive expansion of mask ***,a context adversarial generation network based on gated convolution was constructed to achieve background restoration of mask positions in the original *** addition,our method worked in an end-to-end manner.A particular semantic segmentation dataset for military time-sensitive targets has been constructed,called the Military Time-sensitive Target Masking Dataset(MTMD).The MTMD dataset experiment successfully demonstrated that this method could create a mask that completely occludes the target and that the target could be hidden in real time using this *** demonstrated the concealment performance of our proposed method by comparing it to a number of well-known and highly optimized baselines.

关键词： Deep learning Military application Targets stealth network Mask generation Generative adversarial network

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The interaction between temperature and precipitation on the potential distribution range of Betula ermanii in the alpine treeline ecotone on the Changbai Mountain

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Forest Ecosystems 2024年第1期11卷 42-51页

作者： Yu Cong Yongfeng Gu Wen J.wang Lei wang Zhenshan Xue Yingyi Chen Yinghua Jin Jiawei Xu Mai-He Li Hong S.He Ming Jiang Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China Key Laboratory of Geographical Processes and Ecological Security in Changbai Mountains Ministry of EducationSchool of Geographical SciencesNortheast Normal UniversityChangchun 130024China School of Natural Resources University of MissouriColumbiaMO 65211USA Swiss Federal Institute for Forest Snow and Landscape Research WSLCH-8903 BirmensdorfSwitzerland School of Life Science Hebei UniversityBaoding 071000China

Alpine treeline ecotones are highly sensitive to climate *** low temperature-determined alpine treeline is expected to shift upwards in response to global ***,little is known about how temperature interacts with other important factors to influence the distribution range of tree species within and beyond the alpine treeline ***,we used a GF-2 satellite image,along with bioclimatic and topographic variables,to develop an ensemble suitable habitat model based on the species distribution modeling algorithms in *** investigated the distribution of suitable habitats for *** under three climate change scenarios(i.e.,low(SSP126),moderate(SSP370)and extreme(SSP585)future emission trajectories)between two consecutive time periods(i.e.,current-2055,and 2055-2085).By 2055,the potential distribution range of *** will expand under all three climate *** medium and high suitable areas will decline under SSP370 and SSP585scenarios from 2055 to ***,under the three climate scenarios,the uppermost altitudes of low suitable habitat will rise to 2,329 m a.s.l.,while the altitudes of medium and high suitable habitats will fall to 2,201 and2,051 m *** 2085,*** promotes the expansion of *** distribution range in Changbai Mountain,and this expansion will be modified by precipitation as climate warming *** interaction between temperature and precipitation plays a significant role in shaping the potential distribution range of *** in the alpine treeline *** study reveals the link between environmental factors,habitat distribution,and species distribution in the alpine treeline ecotone,providing valuable insights into the impacts of climate change on high-elevation vegetation,and contributing to mountain biodiversity conservation and sustainable development.

关键词： Biomod2 Birch Climate change Climate scenarios Habitat suitability Range shift Treeline species

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Analytical Solution of a Fractional-slot Double-layer-winding Open-slot Vernier Permanent Magnet Machine with Tooth Tips

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Chinese Journal of Electrical Engineering 2024年第2期10卷 44-58页

作者： Weibing wang Ming Cheng School of Electric Power Engineering Nanjing Institute of TechnologyNanjing 211167China School of Electrical Engineering Southeast UniversityNanjing 210096China

An analytical solution(ANA)for a fractional-slot double-layer-winding open-slot vernier permanent magnet(VPM)machine with tooth tips is *** vector potential equations are analytically solved using the technique of variable separation in four subdomains in a two-dimensional polar coordinate *** on the solved magnetic vector potential,the flux density distribution,torque,flux linkage,inductance,electromotive force(EMF)and power factor are analytically *** 18-slot/32-rotor-pole prototype is analyzed,and the results match well with the finite element analysis(FEA),which validates that the ANA consumes less time than ***,the tooth tips are optimized using the ANA to improve the average ***,the ANA can be used to evaluate the demagnetization withstand capabilities of permanent *** material utilization,slot-filling factor,EMF,and torque are compared between the models with three and four ***,an experimental prototype is constructed and tested,and the results validate the ANA.

关键词： Analytical solution magnetic field vernier permanent magnet machine subdomain optimization demagnetization