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Clinical Value of cfDNA Content in Peripheral Blood of Patients with Triple-Negative Breast Cancer

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Proceedings of Anticancer Research 2023年第4期7卷 43-48页

作者： Jirui Sun Qiushuang Ma Hong Chen Xing zhou bingjuan zhou Jinku Zhang Department of Pathology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

Objective:To explore the value of circulating free(cfDNA)content in the clinical diagnosis and treatment of triple-negative breast cancer(TNBC).Methods:A total of 39 TNBC patients,45 non-TNBC patients,and 50 healthy individuals admitted to the Baoding First Central Hospital during 2019-2022 were *** clinical data,peripheral blood cfDNA concentration,and clinicopathological indicators of the patients were observed and ***:The difference in clinical indicators such as age,age range,tumor size,clinical stage,and lymph node metastasis between patients with TNBC and non-TNBC was insignificant(P>0.05).The cfDNA concentrations(ng/mL)of the TNBC group,non-TNBC group,and healthy group were 24.12±4.98,15.36±4.12,and 3.12±1.02,respectively,and they are statistically different(P2 cm(P>0.05)but was significant between TNBC patients with clinical stages I+II and III+IV(P<0.05).The cfDNA concentration in TNBC patients with lymph node metastasis was significantly higher than those without lymph node metastasis(P<0.05).Conclusion:cfDNA has an important application value in the diagnosis and treatment of breast *** detecting the cfDNA level and its gene variation,valuable information about the progress and treatment effects of breast cancer can be *** non-invasive detection method has a wide range of applications and can be used for early screening,auxiliary diagnosis,efficacy evaluation,and recurrence monitoring of breast cancer.

关键词： Triple-negative breast cancer cfDNA Tumor cells

The Role and Mechanism of Unfolded Protein Response Pathway in Tumor Drug Resistance

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Proceedings of Anticancer Research 2023年第6期7卷 65-71页

作者： Yaqi Han bingjuan zhou Haizhi Qiao Lingyan Wang Jinku Zhang Chengde Medical University Chengde 067000China Department of Pathology Baoding First Central HospitalBaoding 071000China Department of Breast Surgery II Baoding First Central HospitalBaoding 071000China Key Laboratory of Molecular Pathology and Early Diagnosis of Tumor in Hebei Province Baoding 071000China

In the process of tumor proliferation and metastasis,tumor cells encounter hypoxia,low glucose,acidosis,and other stressful *** conditions prompt tumor cells to generate endoplasmic reticulum stress(ERS).As a signal mechanism that mitigates ERS in eukaryotic cells,the unfolded protein response(UPR)pathway can activate cells and tissues,regulating pathological activities in various cells,and maintaining ER *** forms the most crucial adaptive and defensive mechanism for ***,under the continuous influence of chemotherapy drugs,the quantity of unfolded proteins and erroneous proteins produced by tumor cells significantly increases,surpassing the normal regulatory range of ***,ERS fails to function properly,fostering tumor cell proliferation and the development of drug *** review delves into the study of three UPR pathways(PERK,IRE1,and ATF6),elucidating the mechanisms of drug resistance and research progress in the signal transduction pathway of UPR related to *** provides a profound understanding of the role and relationship between UPR and anti-tumor drugs,offering a new direction for effective clinical treatment.

关键词： Unfolder protein response(UPR) Tumor resistance Activating transcription factor 6(ATF6) Protein kinase RNA-like endoplasmic reticulum kinase(PERK) Inositol requiring enzyme 1(IRE1)

Adenoid Basal Carcinoma of the Cervix with Squamous Differentiation:A Case Report and Literature Review

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Proceedings of Anticancer Research 2022年第6期6卷 29-35页

作者： Jianhua Hao Yafei Zhao Jinmei Li bingjuan zhou Jirui Sun Qiushuang Ma Department of Pathology Hebei Yixian HospitalBaoding 074200Hebei ProvinceChina Department of Orthopedics Baoding No.1 Hospital of TCMBaoding 071000Hebei ProvinceChina Department of Pathology Baoding No.1 Central HospitalHebei Provincial Key Laboratory of Molecular Pathology and Early Diagnosis of TumorsBaoding 071000Hebei ProvinceChina

Adenoid basal carcinoma(ABC)of the cervix is a rare and low-incidence low-grade cervical *** our practice,we encountered a case of cervical ABC with squamous differentiation and high-grade squamous intraepithelial lesion(HSIL)with gland involvement in the peripheral *** relevant literature and analyzing its clinical manifestations,pathological morphology,and immunohistochemical characteristics would help deepen the understanding of this malignant tumor,so as to make a comprehensive diagnosis with differential diagnosis and prevent misdiagnosis.

关键词： Adenoid basal carcinoma of cervix Squamous differentiation Immunohistochemistry

Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells on Rat Bladder Cancer

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Proceedings of Anticancer Research 2022年第6期6卷 15-20页

作者： Jinmei Li Runfen Cheng bingjuan zhou Zhiqiang Zhang Qiongli Zhai Jinku Zhang Department of Pathology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina The Key Laboratory of Molecular Pathology and Early Diagnosis of Tumor in Hebei Province Baoding 071000Hebei ProvinceChina Department of Pathology Cancer Hospital of Tianjin Medical UniversityNational Clinical Medical Research Center of CancerTianjin Key Laboratory of Cancer Prevention and TreatmentTianjin Clinical Medical Research Center of Malignant CancerTianjin 300060China Department of Thoracic Surgery Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

Objective:To analyze the effect of bone marrow mesenchymal stem cell therapy on rats with bladder cancer and provide a feasible direction for the treatment of human bladder ***:An animal model was constructed,and Model 1 was used as an *** groups of rats were injected with anti-upconversion nanoparticles(UCNPs)(experimental group)and 0.9%normal saline(control group),*** vivo imaging was performed to determine the accuracy of the anti-UCNPs ***:There were 15 rats in the experimental group with obvious bladder *** them,11 rats had cauliflower-like and partially brown bladder tumors,whereas the other four rats had hard,nodular-like protrusions,with indistinct borders and adhesions to the anterior wall of the *** papillary masses were observed in two rats,local mucosal thickening without tumor formation was observed in two rats,and bladder stones were observed in six *** bladder specimens of 15 rats in the control group were pink and shiny,without any *** rats in the experimental group and 12 rats in the control group had bladder cancer lesions,accounting for 93.33%and 80%,*** detection accuracy of the experimental group was significantly better than that of the control ***:Multimodal nanoprobes targeting bladder cancer stem cells in vivo were used to image the orthotopic tumor and lymph node metastasis models of animals by anti-UCNPs imaging to observe the distribution,migration,and differentiation process of bladder cancer stem cells in model *** is clear that rare earth upconversion luminescent nanomaterials,modified by BCMab1 and CD44 monoclonal antibodies,can be used as probes for the detection of bladder cancer,the tracking of lymph node metastasis in bladder cancer,and the comprehensive evaluation of the overall efficacy of nanoprobe-targeted therapy for bladder cancer stem cells.

关键词： Bone marrow Stem cells Bladder cancer

Research Progress of Prostate Stem Cell Antigen in Bladder Cancer Treatment

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Proceedings of Anticancer Research 2022年第5期6卷 51-57页

In order to study the application effect of prostate stem cell antigen in the treatment of bladder cancer,several literatures have been reviewed in this paper,including the predisposition factors of bladder cancer,clinical treatment methods,progress of prostate stem cell antigen,and nanomaterial *** paper presents a feasible method of using luminescent nanomaterials(anti-UCNPs)as biological probes.

关键词： Bladder cancer Prostate stem cells Nanoprobes

Application Experience of Case-Introduction Teaching in the Pathological Regulation Teaching of the Lymphohematopoietic System

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Journal of Contemporary Educational Research 2023年第7期7卷 35-38页

作者： Qiushuang Ma Jirui Sun bingjuan zhou Jinmei Li Wenming Zhao Jinku Zhang Baoding First Central Hospital Hebei Provincial Key Laboratory of Molecular Pathology and Early Diagnosis of TumorsBaoding 071000China

Pathology is the gold standard for clinical diagnosis and an important bridge between clinical work and basic ***,training qualified clinical pathologists is very important for clinical *** is challenging to diagnose lymphohematopoietic diseases in practice since they made up a large percentage of resident doctors’standardized training and there are numerous knowledge nodes associated with ***,this training base adopts the“case-introduction”teaching mode to help resident doctors master the knowledge nodes required by the outline in the study of lymphohematopoietic system pathology.

关键词： Case-introduction teaching mode Lymphohematopoietic system pathology Regulation teaching

Application Experience of Quality Feedback in Standardized Practical Skills Training for Clinicopathology Residents

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Journal of Contemporary Educational Research 2022年第8期6卷 91-95页

作者： Qiushuang Ma bingjuan zhou Jirui Sun Wenming Zhao Jinmei Li Haizhi Qiao Jinku Zhang Department of Pathology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

In recent years,there are increasingly more standardized trainings for doctors based on the standardized training outline that is suitable for different *** training has gradually formed a relatively sound training *** reflecting students’learning effect,there is a need for an ideal quality feedback system in the standardized practical skills training for clinical pathology *** feedback system can help students achieve the training objectives through understanding and grasping the learning content.

关键词： Quality feedback Clinicopathology Residents Standardized practical skills training

Macrophage CCL22 Secretion Under Hypoxic Conditions Promotes the Metastasis of Triple-Negative Breast Cancer

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Proceedings of Anticancer Research 2022年第6期6卷 8-14页

作者： Wenming Zhao bingjuan zhou Jirui Sun Haizhi Qiao Jinmei Li Qiushuang Ma Xu Wang Jinku Zhang Department of Pathology Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

Objective:To explore the mechanism by which macrophages secrete CCL22 to promote the metastasis of triple-negative breast cancer under hypoxic ***:20 ng/mL mass concentration of phorbol 12-myristate 13-acetate(PMA)cell culture medium,4′,6-diamidino-2-phenylindole(DAPI),dimethyl sulfoxide(DMSO),trypsin digestion solution,CCL18 Kit,Interleukin(IL)-10 Kit,CCL17 Kit,CCL22 Kit,TRIzol^(TM)Reagent Reverse Transcriptase Polymerase Chain Reaction(RT-PCR)Kit,triple-negative breast cancer cells MDA-MB-231 and BT-549,as well as other reagents were used to culture triple-negative breast cancer(TNBC)cells MDA-MB-231 and BT-549 as well as human mononuclear cells THP-1,analyze and observe the metastasis of triple-negative breast cancer cells to the lungs,the secretion of CCL22,the migration of triple-negative breast cancer,and the situation of ***:Compared with normal tumor-associated macrophage(TAM),hypoxic TAM further promoted the migration of tumor *** number of tumor metastases in the lungs,induced by hypoxic TAM,was significantly higher than that of normoxic *** can significantly stimulate the expression of ***22 can significantly promote the migration of MDA-MB-231 and BT-549 *** expressions of CCR3,CCR4,and CCR5 in tumor tissues were significantly increased compared with normal tissues,in which CCR4 showed the most significant ***:TAM cultured under hypoxia significantly enhanced the migration ability of TNBC cells and promoted the metastasis of cancer cells to the lungs in *** hypoxic condition induced TAM to secrete CCL22;the expression of CCL22 receptor,CCR4,in breast cancer tissues was significantly higher than that in normal tissues.

关键词： Hypoxia Macrophages Triple-negative breast cancer CCL22

The Expression and Significance of CyclinD2,MPGES-1,Bcl2 in Diffuse Large B-cell Lymphoma

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Proceedings of Anticancer Research 2021年第2期5卷 53-56页

作者： Qiushuang Ma Peng Lin bingjuan zhou Yafei Zhao Ling Li Jinku Zhang Jirui Sun Department of Pathology Baoding First Central HospitalBaoding 071000Hebei provinceChina Department of Hematology Baoding First Central HospitalBaoding 071000Hebei provinceChina Department of Orthopedics Baoding First Hospital of Traditional Chinese MedicineBaoding 071000Hebei provinceChina Department of Dermatology Baoding First Central HospitalBaoding 071000Hebei provinceChina

Objective:To study the expression and significance of cell cycle proteins CyclinD2,mPGES-1,Bcl2 in diffuse large B-cell ***:Choose lymphoma and sexually hyper-plastic lymphoid tissues as ***-hemical methods were used to detect the expression of CyclinD2,mPGES-1,and Bcl2,and to compare the positive expression rates of CyclinD2,MPGES-1 and Bcl2 in diffuse large B-cell lymphoma and reactive proliferative lymphoid tissues to compare their diffusion formation.B-cell lymphoma was analyzed for its clinicopathological ***:The positive expression rate of CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma is higher than that in reactive proliferative lymphoid tissue,and the difference between the two is statistically *** was no statistical difference in CyclinD2,mPGES-1 and Bcl2 in diffuse large B-cell lymphoma between patients according to the age,sex,location,tissue type and degree of ***:CyclinD2,mPGES-1 and Bcl2 are highly expressed in patients with diffuse large B-cell lymphoma,and can be used as reference indicators for evaluating the malignant degree and efficacy of dysplasia.

关键词： CyclinD2 mPGES-1 Bcl2 Diffuse large B-cell lymphoma Clinicopathology