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An Improved Method for the Fitting and Prediction of the Number of COVID-19 Confirmed Cases Based on LSTM

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Computers, Materials & Continua 2020年第9期64卷 1473-1490页

作者： bingjie Yan Jun Wang Zhen Zhang Xiangyan Tang Yize Zhou Guopeng Zheng Qi Zou Yao lu Boyi Liu Wenxuan Tu Neal Xiong School of Computer Science and Cyberspace Security Hainan UniversityHaikou570228China College of Humanities and Communication Hainan UniversityHaikou570228China University of Chinese Academy of Science Beijing100049China National University of Defense Technology Changsha410073China Department of Mathematics and Computer Science Northeastern State UniversityTahlequahUSA

New coronavirus disease(COVID-19)has constituted a global pandemic and has spread to most countries and regions in the *** understanding the development trend of confirmed cases in a region,the government can control the pandemic by using the corresponding ***,the common traditional mathematical differential equations and population prediction models have limitations for time series population prediction,and even have large estimation *** address this issue,we propose an improved method for predicting confirmed cases based on LSTM(Long-Short Term Memory)neural *** work compares the deviation between the experimental results of the improved LSTM prediction model and the digital prediction models(such as Logistic and Hill equations)with the real data as ***,this work uses the goodness of fitting to evaluate the fitting effect of the *** show that the proposed approach has a smaller prediction deviation and a better fitting *** with the previous forecasting methods,the contributions of our proposed improvement methods are mainly in the following aspects:1)we have fully considered the spatiotemporal characteristics of the data,rather than single standardized data.2)the improved parameter settings and evaluation indicators are more accurate for fitting and forecasting.3)we consider the impact of the epidemic stage and conduct reasonable data processing for different stage.

关键词： COVID-19 LSTM model predictive analysis

Iridium-Catalyzed asymmetric reduction of α,β-Unsaturated nitriles with water

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第3期5卷 175-179页

作者： Qinli lu Xianming Wang Wanliu Wen Ruifeng Fan Binfeng Zhu bingjie Zhou Jingchao Chen Baomin Fan Key Laboratory of Chemistry in Ethnic Medicinal Resources(Yunnan Minzu University) State Ethnic Affairs Commission&Ministry of EducationYunnan Minzu UniversityKunming650500China Department School of Chemistry and Environment Yunnan Minzu UniversityKunming 650500China School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China

The nitrile compounds are present in a variety of biologically active natural products and pharmaceuticals,and the nitrile groups are versatile synthetic intermediates to other functionalized ***,the asymmetric reduction ofα,β-unsaturated nitriles with water as a hydrogen source is *** reaction is catalyzed by the complex of[Ir(COD)Cl]_(2)and(R_(a),S)-Ph-Bn-SiPhox,and allows the preparation of useful enantioenriched chiral 3,3-disubstituted propionitriles with high optical purities in mild conditions.

关键词： Asymmetric reduction Unsaturated nitriles Water Propionitrile Iridium DIBAL-H

Consistent apparent Young’s modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance

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Cell Regeneration 2020年第1期9卷 155-170页

作者： Anqi Guo bingjie Wang Cheng Lyu Wenjing Li Yaozu Wu lu Zhu Ran Bi Chenyu Huang Jiao Jiao Li Yanan Du Department of Biomedical Engineering Tsinghua-Peking Center for Life SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologySchool of MedicineTsinghua UniversityBeijing 100084China School of Life Sciences Tsinghua UniversityBeijing 100084China Department of Biomedical Engineering McKelvey School of EngineeringWashington University in St.LouisSt.Louis 63130USA Institute of Systems Engineering Academy of Military SciencesBeijing 100071China Department of Dermatology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Kolling Institute University of SydneySydneyNSW 2006Australia

Background:Apparent Young’s modulus(AYM),which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization,has been investigated as potential indicators of cell fate in specific cell ***,applying biophysical cues,such as modulating the substrate stiffness,to regulate AYM and thereby reflect and/or control stem cell lineage specificity for downstream applications,remains a primary challenge during in vitro stem cell ***,substrate stiffness could modulate cell heterogeneity in the single-cell stage and contribute to cell fate regulation,yet the indicative link between AYM and cell fate determination during in vitro dynamic cell expansion(from single-cell stage to multi-cell stage)has not been ***:Here,we show that the AYM of cells changed dynamically during passaging and proliferation on substrates with different ***,the same change in substrate stiffness caused different patterns of AYM change in epithelial and mesenchymal cell *** stem cells and their derived progenitor cells exhibited distinguishing AYM changes in response to different substrate stiffness that had significant effects on their maintenance of pluripotency and/or lineage-specific *** substrates that were too rigid or too soft,fluctuations in AYM occurred during cell passaging and proliferation that led to a loss in lineage *** a substrate with‘optimal’stiffness(i.e.,3.5 kPa),the AYM was maintained at a constant level that was consistent with the parental cells during passaging and proliferation and led to preservation of lineage *** effects of substrate stiffness on AYM and downstream cell fate were correlated with intracellular cytoskeletal organization and nuclear/cytoplasmic localization of ***:In summary,this study suggests that optimal substrate stiffness regulated consi

关键词： Apparent Young’s modulus Human embryonic stem cells Substrate stiffness YAP Cell fate

北京市社区高龄老年人主观身体疲乏感现状及其相关危险因素分析

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中国临床保健杂志 2023年第5期26卷 627-633页

作者：闫瑾胡亦新张天一吴冰杨存美徐秋利王炜韩卫乔鲁冰杰孙沙沙祝志辉底宁范利中国人民解放军总医院第二医学中心心血管内科北京100853 中国人民解放军总医院第二医学中心保健四科北京100853 中国人民解放军总医院管理研究所北京100853 中国人民解放军总医院第二医学中心神经内科国家老年疾病临床医学研究中心北京100853 吉林体育学院宁夏大学体育学院

目的分析北京市社区高龄老年人主观身体疲乏感现状及其相关危险因素。方法选取2019年4月至2022年8月北京市社区415例≥80岁高龄老年人为研究对象。调查临床资料,采用匹兹堡疲乏感量表(PFS)中文版评估主观疲乏感状态,以国际公认标准PFS... 详细信息

目的分析北京市社区高龄老年人主观身体疲乏感现状及其相关危险因素。方法选取2019年4月至2022年8月北京市社区415例≥80岁高龄老年人为研究对象。调查临床资料,采用匹兹堡疲乏感量表(PFS)中文版评估主观疲乏感状态,以国际公认标准PFS-Physical维度得分≥15分为高主观身体疲乏感。采用人体成分分析仪inbody 270分析骨骼肌、脂肪含量等体成分,并测试身体功能。结果基础性日常生活活动能力下降(OR=0.897,95%CI:0.835~0.963,P=0.003)、衰弱(OR=9.177,95%CI:1.961~42.932,P=0.003)、步速下降(OR=3.036,95%CI:1.604~5.622,P<0.001)、握力下降(OR=1.984,95%CI:1.017~3.871,P=0.045)、高内脏脂肪面积(OR=1.014,95%CI:1.002~1.027,P=0.023)是高龄老年人高主观身体疲乏感的独立相关危险因素。结论在高龄老年人衰弱、失能的综合管理中应重视对高主观身体疲乏感的早期筛查。

关键词：疲劳衰弱危险因素健康调查老年人 80以上

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边界约束下的词云拓扑保持算法

计算机辅助设计与图形学学报 2016年第11期28卷 1916-1923页

作者：路强唐靓柴秉捷合肥工业大学计算机与信息学院合肥230009

词云是一种典型的用于文本分析的可视化形式,更美观的可视化效果和更佳的实用性是研究者们研究的主题.针对边界约束下语义聚集的词云在单词发生改变时的紧凑布局和单词间拓扑结构保持的问题,提出一种适用于元组确定式文本的词云布局方式... 详细信息

词云是一种典型的用于文本分析的可视化形式,更美观的可视化效果和更佳的实用性是研究者们研究的主题.针对边界约束下语义聚集的词云在单词发生改变时的紧凑布局和单词间拓扑结构保持的问题,提出一种适用于元组确定式文本的词云布局方式,在确定元组数目的基础上,用Power图剖分显示界面,利用单词间的属性依赖实现词云的初始布局;然后提出边界约束词云的拓扑保持算法,定义了5种约束规则、单词间相对约束力以及边界约束力,规定了词云在布局过程中的约束条件,以保证词云拓扑保持的同时实现单词在确定边界下的无重叠布局.针对词云的不同边界形状详细定义边界约束力,并分别对不同形状的词云进行局部单词放大、删除、缩小实验,结果显示,文中的拓扑保持算法在词云内单词发生变化时较好地保证视觉效果,同时有效地保持了原有的拓扑结构.

关键词：词云布局边界约束 Power图单词变化拓扑保持

On the origin of SARS-CoV-2——The blind watchmaker argument

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Science China(Life Sciences) 2021年第9期64卷 1560-1563页

作者： Chung-I Wu Haijun Wen Jian lu Xiao-dong Su Alice CHughes Weiwei Zhai Chen Chen Hua Chen Mingkun Li Shuhui Song Zhaohui Qian Qihui Wang bingjie Chen Zixiao Guo Yongsen Ruan Xuemei lu Fuwen Wei Li Jin Le Kang Yongbiao Xue Guoping Zhao Ya-Ping Zhang State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Landscape Ecology Group Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Biomedical Innovation Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Beijing Institute of Genomics Chinese Academy of Sciencesand China National Centre for BioinformationBeijing 100101China Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China MOE Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200433China State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China

In the comparison with SARS-CoVof 2003,SARS-CoV-2 is extremely well adapted to the human populations and its adaptive shift from the animal host to humans must have been even more *** the blind watchmaker argument,such an adaptive shift can only happen prior to the onset of the current pandemic and with the aid of step-by-step selection.

关键词： argument origin adapted

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Effect of synergism between sodium alginate and xanthan gum on characteristics of composite film and gloss of areca nut coating

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Food Bioscience 2022年第6期50卷 1083-1091页

作者： Quan Wen Xuejiao Wang bingjie Liu Lin lu Xiaoming Zhang Caleb John Swing Shuqin Xia State Key Laboratory of Food Science and Technology Jiangnan University1800 Lihu RoadWuxiJiangsu214122PR China School of Food Science and Technology Collaborative Innovation Center of Food Safety and Quality ControlJiangnan University1800 Lihu RoadWuxiJiangsu214122PR China Department of Animal Sciences Colorado State University350 W.Pitkin St.Fort Collins CO80523-1171USA

In this study, two polysaccharides of sodium alginate (SA) and xanthan gum (XG) were compounded in proportions of 100:0, 75:25, 50:50, 25:75, 0:100 with 1% total mass concentration and then coated on areca nuts. The effects of their synergistic interactions on the optical appearance of the edible coating were investigated for the first time. Areca nuts coated by 50:50 SA-XG presented the highest gloss (2.69 GU) and maximum spreading coefficient (−33.95 mN/m), indicating the improved wettability of the coating solution on the fruit's surface. The polarized light microscopy exhibited the unique birefringence phenomenon caused by the liquid crystal state, resulting in the better optical properties of the coating. UV–vis transmittance, Fourier transform infrared, and scanning electron microscopy indicated the good compatibility of SA and XG. The SA-XG film was more compactly arranged and had a denser microstructure due to hydrogen bonding. Additionally, the SA-XG combination improved the mechanical properties and water resistance compared to a single polysaccharide films and enhanced the water retention properties for the areca nut coating. Therefore, the SA-XG combination is promising to prepare edible films with improved optical properties for areca nuts.

关键词： Sodium alginate Xanthan gum Composite film Edible coating Gloss Areca nut

Influences of Microbial Oxidation/Reduction on Mineral Transformation in Sulfide Tailings and Environmental Consequence in Shizishan Cu-Au Mine, Tongling, Eastern China

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矿物学报 2013年第S1期33卷 64-64页

作者： lu Xiancai lu Jianjun WANG Rucheng WANG Hongmei LI Juan ZHU Tingting OUYANG bingjie School of Earth Sciences and Engineering State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences

Mining activities have created great wealth, but they have also discharged large quantities of tailings. As an important source of heavy metal contamination, sulfide tailings are usually disposed of in open-air impoundments and thus are exposed to microbial oxidation. Microbial activities greatly enhance sulfide oxidation and result in the release of heavy metals and the precipitation of iron (oxy) hydroxides and sulfates. These secondary minerals in turn influence the mobility of dissolved metals and play important roles in the natural attenuation of heavy metals. Elucidating the microbe–mineral interactions in tailings will improve our understanding of the environmental consequence of mining activities.

关键词： microbial reduction/oxidation sulphide tailings mineralogical composition heavy metals Shizishan Cu-Au mine

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项目管理中任务时间进度不确定性可视化

计算机辅助设计与图形学学报 2018年第6期30卷 1055-1064页

作者：路强毛龙龙柴秉捷谭剑波合肥工业大学计算机与信息学院合肥230009 工业安全与应急技术安徽省重点实验室(合肥工业大学) 合肥230009 中国电子科技集团公司第38研究所合肥230031 孔径阵列与空间探测安徽省重点实验室合肥230031

项目管理中对任务时间进度不确定性的处理是至关重要的.针对现有项目管理软件不能直观地展现项目任务时间进度不确定性和人员协作的问题,提出使用不确定性字形结合时间线法表示任务时间进度不确定性的可视化方法.首先总结项目任务进度... 详细信息

项目管理中对任务时间进度不确定性的处理是至关重要的.针对现有项目管理软件不能直观地展现项目任务时间进度不确定性和人员协作的问题,提出使用不确定性字形结合时间线法表示任务时间进度不确定性的可视化方法.首先总结项目任务进度不确定性特点,对影响项目进度的不确定性因素进行详细定义,建立项目进度不确定性模型;然后使用时间线法可视化项目整体流程,设计不确定性可视化字形隐喻任务时间进度不确定性,并为用户提供多种交互手段和多个视图帮助探索分析项目任务进度不确定性和人员协作情况,根据用户的色彩感知偏好提供多种配色方案.以软件开发项目管理为例,在Program Line可视化系统中验证了文中方法的有效性和实用性.

关键词：项目管理任务时间进度不确定性项目进度不确定性模型不确定性可视化