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Analysis of temporal and spatial distribution characteristics of ammonium chloride smoke particles in confined spaces

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Defence Technology（防务技术） 2022年第7期18卷 1269-1280页

作者： Chen-youshi Xu bing-ting zha Jia-qian Bao He zhang Hong-xia Li ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyJiangsuNanjing210094China

In response to the demand for short-range detection of anti-smoke environment interference by laser fuzes,this study proposes a smoke environment simulation of non-uniform continuous point source diffusion and investigates an experimental laboratory smoke environment using an ammonium chloride smoke *** particle size distribution,composition,and mass flow distribution of the smoke were *** on a discrete phase model and a kεturbulence model,a numerical simulation was developed to model the smoke generation and diffusion processes of the smoke agent in a confined *** temporal and spatial distribution characteristics of the smoke mass concentration,velocity,and temperature in the space after smoke generation were analyzed,and the motion law governing the smoke diffusion throughout the entire space was *** with the experimental verification of the smoke environment laboratory,the results showed that the smoke plume changed from fan-shaped to umbrella-shaped during smoke generation,and then continued to spread ***,the mass concentration of smoke in the space decreased from the middle outward;the changes in temperature and velocity were small and *** the diffusion stage(after 900 s),the mass concentration of smoke above 0.8 m was relatively uniform across an area of smoke that was 12 m *** concentration decreased over time,following a consistent decreasing trend,and the attenuation was negligible in a very short ***,this system was suitable for conducting experimental research on laser fuzes in a smoke *** to the stability of the equipment and facilities,the setup could reproduce the same experimental smoke environment by artificially controlling the smoke emission of the smoke ***,this work provides a theoretical reference for subsequent research efforts regarding the construction of uniform smoke environments and evaluating laser transmission characteristics in smoky envir

关键词： Laser fuze Smoke environment Temporal distribution Spatial distribution Confined space Smoke agent

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Geometric Error Identification of Gantry-Type CNC Machine Tool Based on Multi-Station Synchronization Laser Tracers

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 150-162页

作者： Jun zha Huijie zhang School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China Xi’an Jiaotong University Suzhou Academy Suzhou 215123China

Laser tracers are a three-dimensional coordinate measurement system that are widely used in industrial *** propose a geometric error identification method based on multi-station synchronization laser tracers to enable the rapid and high-precision measurement of geometric errors for gantry-type computer numerical control(CNC)machine *** method also improves on the existing measurement efficiency issues in the single-base station measurement method and multi-base station time-sharing measurement *** consider a three-axis gantry-type CNC machine tool,and the geometric error mathematical model is derived and established based on the combination of screw theory and a topological analysis of the machine kinematic *** four-station laser tracers position and measurement points are realized based on the multi-point positioning principle.A self-calibration algorithm is proposed for the coordinate calibration process of a laser tracer using the Levenberg-Marquardt nonlinear least squares method,and the geometric error is solved using Taylor’s first-order linearization *** experimental results show that the geometric error calculated based on this modeling method is comparable to the results from the Etalon laser *** a volume of 800 mm×1000 mm×350 mm,the maximum differences of the linear,angular,and spatial position errors were 2.0μm,2.7μrad,and 12.0μm,respectively,which verifies the accuracy of the proposed *** research proposes a modeling method for the precise measurement of errors in machine tools,and the applied nature of this study also makes it relevant both to researchers and those in the industrial sector.

关键词： Multi-point positioning Multi-station synchronization CNC machine tool Geometric error Error separation

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Preparing cyclic polymers at high concentrations via self-folding cyclization technique by adjusting the contents of hydrophilic units in linear precursors

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Chinese Chemical Letters 2024年第2期35卷 283-288页

作者： Hao zha Zuowei Wang Chao Liu Chunyan Hong Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Cyclic polymers are a class of polymers that feature endless topology,and the synthesis of cyclic polymers has attracted the attention of many ***,cyclic polymers were efficiently constructed by self-folding cyclization technique at high *** poly((oligo(ethylene glycol)acrylate)-co-(dodecyl acrylate))(P(OEGA-co-DDA))precursors with different ratios of hydrophilic and hydrophobic moieties were synthesized by reversible addition-fragmentation chain transfer(RAFT)polymerization using a bifunctional chain transfer agent with two anthryl end *** amphiphilic linear precursors underwent the self-folding process to generate polymeric nanoparticles in *** irradiating the aqueous solution of the nanoparticles with 365 nm UV light,cyclic polymers were synthesized successfully via coupling of anthryl *** effects of the ratios of hydrophilic and hydrophobic moieties in linear P(OEGA-co-DDA)copolymers and polymer concentration on the purity of the obtained cyclic polymers were explored in detail via ^(1)H nuclear magnetic resonance(^(1)H NMR),dynamic light scattering(DLS),UV‒visible(vis)analysis,three-detection size exclusion chromatography(TD-SEC)and transmission electron microscopy(TEM).It was found that by adjusting the content of the hydrophilic segments in linear precursors,single chain polymeric nanoparticles(SCPNs)can be generated at high polymer ***,cyclic polymers with high purity can be constructed *** method overcomes the limitation of traditional ring-closure method,which is typically conducted in highly dilute conditions,providing an efficient method for the scalable preparation of cyclic polymers.

关键词： Cyclic polymers Self-folding cyclization technique Single chain polymeric nanoparticles RAFT polymerization Direct visualization

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Acupuncture for cervical dystonia associated with anxiety and depression: A case report

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World Journal of Clinical Cases 2024年第1期12卷 204-209页

作者： Ya-ting zhang Jin-Jing zhang Bi-Xiang zha Yin-Qiu Fan Yuan-Bo Xu Jun Yang Qing-Ping zhang The First School of Clinical Medicine Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Acupuncture and Rehabilitation Department First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina College of Acupuncture and Tuina Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina

BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck *** to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities ***-term abnormal posture or pain can cause negative emotions in patients,which can affect their quality of *** SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental *** two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the negative emotions can be *** This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.

关键词： Cervical dystonia Anxiety and depression Neurological disease Acupuncture Case report

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Efficient synthesis of bottle-brush polymers enabled by selective photoactivation strategy in NIR-induced PET-RAFT polymerization

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Science China Chemistry 2024年第7期67卷 2353-2361页

作者： Hao zha Lin Cheng Zuowei Wang Chao Liu Chunyan Hong Department of Polymer Science and Engineering University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Bottle-brush polymers possessing densely grafted side chains have special properties that are distinct from linear ***,an efficient method for preparing bottle-brush polymers based on a selective photoactivation strategy in the photoinduced electron/energy transfer reversible addition-fragmentation chain transfer(PET-RAFT)polymerization was developed.A methacrylate monomer 2-(2-(dodecylthiocarbonothioylthio)propionate)ethyl methacrylate(DTPEMA)containing a 2-(dodecylthiocarbonothioylthio)propionate(DTP)unit with a secondary R group was *** the unique selectivity of metal naphthalocyanine photocatalyst zinc 2,11,20,29-tetra-tert-butyl-2,3-naphthalocyanine(ZnTtBNc)toward trithiocarbonate with tertiary R group,the PET-RAFT polymerization of DTPEMA catalyzed by ZnTtBNc was performed under near infrared(NIR)light(λ_(max)=760 nm)irradiation at room temperature,using 4-cyano-4-[(dodecylsulfanylthiocarbonyl)-sulfanyl]pentanoic acid(CDTPA)with a tertiary R group as a chain transfer agent(CTA).Proton nuclear magnetic resonance(1H NMR)and gel permeation chromatography(GPC)results demonstrated that the DTP units in the side chains were inert during the *** grafting poly(methyl acrylate)(PMA)from PDTPEMA via thermal-initiated RAFT polymerization,welldefined P(DTPEMA-g-PMA)bottle-brush polymers could be ***,the film prepared from the bottle-brush polymer exhibited excellent scratch self-healing property due to the interlocking of side chains.

关键词： bottle-brush polymers PET-RAFT polymerization selective photoactivation scratch self-healing

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Identification of the Hammerstein nonlinear system with noisy output measurements

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Control Theory and Technology 2024年第2期22卷 203-212页

作者： Qiming zha Feng Li Ranran Liu School of Electrical and Information Engineering Jiangsu University of TechnologyChangzhou213001JiangsuChina School of Automobile and Traffic Engineering Jiangsu University of TechnologyChangzhou213001JiangsuChina

In this research, we present a methodology to identify the Hammerstein nonlinear system with noisy output measurements. The Hammerstein system presented is comprised of neural fuzzy model (NFM) as its static nonlinear block and auto-regressive with extra input (ARX) model as its dynamic linear block, and a two-step procedure is accomplished using signal combination. In the first step, in the case of input–output of Gaussian signals, the correlation function-based least squares (CF-LS) technique is utilized to identify the linear block, solving the problem that the intermediate variable connecting nonlinear and linear blocks cannot be measured. In the second step, to improve the identification accuracy of the nonlinear block parameters, an improved particle swarm optimization technique is developed under input–output of random signals. The validity and accuracy of the presented scheme are verified by a numerical simulation and a practical nonlinear process, and the results illustrate that the proposed methodology can identify well the Hammerstein nonlinear system with noisy output measurements.

关键词： Hammerstein nonlinear system Signal combination Auto-regressive with extra input Improved particle swarm optimization

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Underwater four-quadrant dual-beam circumferential scanning laser fuze using nonlinear adaptive backscatter filter based on pauseable SAF-LMS algorithm

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Defence Technology（防务技术） 2024年第7期37卷 1-13页

作者： Guangbo Xu bingting zha Hailu Yuan Zhen Zheng He zhang Ministerial Key Laboratory of ZNDY Nanjing University of Science and TechnologyNanjing 210094China Science and Technology on Electromechanical Dynamic Control Laboratory Beijing 100081China Shanghai Radio Equipment Research Institute Shanghai 201109China

The phenomenon of a target echo peak overlapping with the backscattered echo peak significantly undermines the detection range and precision of underwater laser *** overcome this issue,we propose a four-quadrant dual-beam circumferential scanning laser fuze to distinguish various interference signals and provide more real-time data for the backscatter filtering *** enhances the algorithm loading capability of the *** order to address the problem of insufficient filtering capacity in existing linear backscatter filtering algorithms,we develop a nonlinear backscattering adaptive filter based on the spline adaptive filter least mean square(SAF-LMS)*** also designed an algorithm pause module to retain the original trend of the target echo peak,improving the time discrimination accuracy and anti-interference capability of the ***,experiments are conducted with varying signal-to-noise ratios of the original underwater target echo *** experimental results show that the average signal-to-noise ratio before and after filtering can be improved by more than31 d B,with an increase of up to 76%in extreme detection distance.

关键词： Laser fuze Underwater laser detection Backscatter adaptive filter Spline least mean square algorithm Nonlinear filtering algorithm

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Myricetin induces M2 macrophage polarization to alleviate renal tubulointerstitial fibrosis in diabetic nephropathy via PI3K/Akt pathway

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World Journal of Diabetes 2024年第1期15卷 105-125页

作者： Wei-Long Xu Pei-Pei Zhou Xu Yu ting Tian Jin-Jing Bao Chang-Rong Ni Min zha Xiao Wu Jiang-Yi Yu Department of Endocrinology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pharmacy Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Pneumology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

BACKGROUND Development of end-stage renal disease is predominantly attributed to diabetic nephropathy(DN).Previous studies have indicated that myricetin possesses the potential to mitigate the pathological alterations observed in renal ***-theless,the precise molecular mechanism through which myricetin influences the progression of DN remains *** To investigate the effects of myricetin on DN and explore its potential therapeutic *** Db/db mice were administered myricetin intragastrically on a daily basis at doses of 50 mg/kg or 100 mg/kg for a duration of 12 ***,blood and urine indexes were assessed,along with examination of renal tissue *** morphology and fibrosis were evaluated using various staining techniques including hematoxylin and eosin,periodic acid–Schiff,Masson’s trichrome,and ***,high-glucose culturing was conducted on the RAW 264.7 cell line,treated with 25 mM myricetin or co-administered with the PI3K/Akt inhibitor LY294002 for a period of 24 *** both in vivo and in vitro settings,quantification of inflammation factor levels was conducted using western blotting,real-time qPCR and *** In db/db mice,administration of myricetin led to a mitigating effect on DN-induced renal dysfunction and ***,we observed a significant reduction in expressions of the kidney injury markers kidney injury molecule-1 and neutrophil gelatinase associated lipocalin,along with a decrease in expressions of inflammatory cytokine-related ***,myricetin treatment effectively inhibited the up-regulation of tumor necrosis factor-alpha,interleukin-6,and interluekin-1βinduced by high glucose in RAW 264.7 ***,myricetin modulated the M1-type polarization of the RAW 264.7 *** docking and bioinformatic analyses revealed Akt as the target of *** protective effect of myricetin was nullified upon blocking the polarization of RAW 264.7 via inh

关键词： Myricetin Diabetic nephropathy PI3K/Akt pathway Renal tubulointerstitial fibrosis Macrophage Polarization

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Simulation Study of Solid Rocket Motor C/C Throat Liner Ablation Based on Two Regions

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Journal of Power and Energy Engineering 2024年第4期12卷 1-19页

作者： Guanneng Chen Yihua Xu Xiaojiang zha Hemeng Shi bing Liu School of Aircraft Engineering Nanchang Hangkong University Nanchang China

Based on the ablation micro-morphological characteristics, thermo-chemical ablation mechanism, and mechanical stripping mechanism, a dual-region solid rocket motor C/C throat liner ablation model and physical model are established. The ablation program was written and the experimental data of 70 lb BATES engine platform was used for model validation. The relative errors between the simulation calculation results and the experimental results were −6.83% - 10.20%. The ablation program was applied to study the effects of combustion chamber temperature, pressure, oxidation component concentration, throat particle concentration and particle scouring angle on the nozzle throat liner, which provides a reference for the design of the nozzle throat liner and the estimation of solid rocket motor ablation.

关键词： Dual-Area Ablation Model C/C Throat Liner Ablation Environment Ablation Program

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Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

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Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI Zhi-feng LI Meng-ya ZHONG Yue-long JIANG Li-ying FENG Jie zha Jing-wei YAO Yin LI Xian-ming DENG bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

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