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Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei

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Cancer Biology & Medicine 2024年第7期21卷 586-605页

作者： Qidi Zhao Tian Wei ru Ma Yubin Fu rui Yang Yandong Su Yang Yu bing Li Yan Li School of Clinical Medicine Tsinghua UniversityBeijing 100084China Department of Surgical Oncology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Peritoneal Cancer Surgery Bejing Shijitan HospitalCapital Medical UniversityBejing 100038China

Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence rate and latent clinical symptoms and signs are major obstacles to further improving clinical outcomes. Moreover, patients in advanced stages receive little benefit from CRS + HIPEC due to widespread intraperitoneal metastases. Another challenge in PMP treatment involves the progressive sclerosis of PMP cell-secreted mucus, which is often increased due to activating mutations in the gene coding for guanine nucleotide-binding protein alpha subunit(GNAS). Consequently, the development of other PMP therapies is urgently needed. Several immune-related therapies have shown promise, including the use of bacterium-derived non-specific immunogenic agents, radioimmunotherapeutic agents, and tumor cell-derived neoantigens, but a well-recognized immunotherapy has not been established. In this review the roles of GNAS mutations in the promotion of mucin secretion and disease development are discussed. In addition, the immunologic features of the PMP microenvironment and immune-associated treatments are discussed to summarize the current understanding of key features of the disease and to facilitate the development of immunotherapies.

关键词： Pseudomyxoma peritonei tumor immuno-microenvironment immune-related therapy mucin 2 GNAS mutation

Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study

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Science China(Life Sciences) 2019年第12期62卷 1617-1629页

作者： Peipei Jiang Xiaoqiu Tang Huiyan wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong ru Yaling Li Jingmei wang Jun Yang bing Chen Jianwu Dai Yali Hu Department of Obstetrics and Gynecology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Center for Reproductive Medicine Department of Obstetrics and GynecologyThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Nanjing Drum Tower Hospital Chinese Academy of Medical Science&Peking Union Medical CollageNanjing 210008China Department of Pathology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100190China

Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were *** study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis.

关键词： intrauterine adhesion CBD-bFGF endometrial scarring uterine infertility thin endometrium endometrial reconstruction

Characteristics of Atmospheric Fine Particulate Matter(PM2.5)Induced Differentially Expressed Proteins Determined by Proteomics and Bioinformatics Analyses

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Biomedical and Environmental Sciences 2020年第8期33卷 583-592页

作者： ZHENG Kai CAI Ying wang bing Yu QIN Shuang Jian LI Bo ru HUANG Hai Yan QIN Xiao Yun LONG Ding Xin ZHANG Zhao Hui XU Xin Yun School of Public Health University of South ChinaHengyang 421001HunanChina Institute of Environment and Health Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Xiangya School of Public Health Central South UniversityChangsha 410078HunanChina

Objective To screen the differentially expressed proteins(DEPs)in human bronchial epithelial cells(HBE)treated with atmospheric fine particulate matter(PM2.5).Methods HBE cells were treated with PM2.5 samples from Shenzhen and Taiyuan for 24 *** detect overall protein expression,the Q Exactive mass spectrometer was *** ontology(GO),Kyoto encyclopedia of genes and genomes(KEGG),and Perseus software were used to screen *** Overall,67 DEPs were screened in the Shenzhen sample-treated group,of which 46 were upregulated and 21 were *** total,252 DEPs were screened in the Taiyuan sampletreated group,of which 134 were upregulated and 118 were *** analysis demonstrated that DEPs were mainly enriched in ubiquitin-mediated proteolysis and HIF-1 signal pathways in Shenzhen PM2.5 samples-treated *** GO analysis demonstrated that Shenzhen sample-induced DEPs were mainly involved in the biological process for absorption of various metal ions and cell *** Taiyuan PM2.5-induced DEPs were mainly involved in biological processes of protein aggregation regulation and molecular function of oxidase ***,three important DEPs,including ANXA2,DIABLO,and AIMP1,were *** Our findings provide a valuable basis for further evaluation of PM2.5-associated carcinogenesis.

关键词： PM2.5 Proteomics Bioinformatics Differentially expressed proteins Weighted correlation network analysis

Preoperative evaluation with T-staging system for hilar cholangiocarcinoma

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World Journal of Gastroenterology 2007年第43期13卷 5754-5759页

作者： ru-Fu Chen Zhi-Hua Li Jia-Jia Zhou Jie wang Ji-Sheng Chen Qing Lin Qi-bing Tang Ning-Fu Peng Zhi-Peng Jiang Quan-Bo Zhou Department of HepatobiliarySurgery the Affiliated Second Hospital Sun Yat-sen University107 Yan-Jiang Xi Road GuangZhou 510120 GuangdongProvince China Department of Oncology the Affiliated SecondHospital Sun Yat-sen University 107 Yan-Jiang Xi RoadGuangZhou 510120 Guangdong Province China Department of Emergency the AffiliatedSecond Hospital Sun Yat-sen University 107 Yan-Jiang Xi RoadGuangZhou 510120 Guangdong Province China

AIM： To investigate the clinical value of T-staging system in the preoperative assessment of hilar cholangiocarcinoma. METHODS： From March 1993 to January 2006, 85 patients who had cholangiocarcinoma diagnosed by operative tissue-biopsy were placed into one of three stages based on the new T-staging system, and it was evaluated the resectability and survival correlated with T-staging. RESULTS： The likelihood of resection and achieving tumor-free margin decreased progressively with increasing T stage （P 〈 0.05）. The cumulative 1-year survival rates of T1, T2 and T3 patients were 71.8%, 50.8% and 12.9% respectively, and the cumulative 3-year survival rate was 34.4%, 18.2% and 0% respectively; the survival of different stage patients differed markedly （P 〈 0.001）. Median survival in the hepatic resection group was greater than in the group that did not undergo hepatic resection （28 mo vs 18 mo; P 〈 0.05）. The overall accuracy for combined MRCP and color Doppler Ultrasonagraphy detecting disease was higher than that of combined using CT and color Doppler Ultrasonagraphy （91.4% vs 68%; P 〈 0.05 ）. And it was also higher in detecting port vein involvement （90% vs 54.5%; P 〈 0.05）.CONCLUSION： The proposed staging system for hilar cholangiocarcinoma can accurately predict resectability, the likelihood of metastatic disease, and survival. A concomitant partial hepatectomy would help to attain curative resection and the possibility of longterm survival. MRCP/MRA coupled with color Doppler UItrasonagraphy was necessary for preoperative evaluation of hilar cholangiocarcinoma.（OR = 2.46, 95% CI = 0.98-6.14）, and a significantly elevated risk of developing esophageal cancer among alcohol drinkers among alcohol drinkers （OR = 9.86, 95% CI = 3.10-31.38）. CONCLUSION： ADH2 and ALDH2 genotypes areassociated with esophageal cancer risk. ADH2＊1 allele and ALDH2＊2 allele carriers have a much higher risk of developing esophageal cancer, especially among alcohol drinkers.

关键词： Hilar cholangiocarcinoma Preoperativestaging Survival rate Surgical treatment

Favorable Lithium Nucleation on Lithiophilic Framework Porphyrin for Dendrite-Free Lithium Metal Anodes

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Research 2019年第1期2019卷 1249-1259页

作者： Bo-Quan Li Xiao-ru Chen Xiang Chen Chang-Xin Zhao rui Zhang Xin-bing Cheng Qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Lithium metal constitutes promising anode materials but sufers from dendrite *** host materials are highly considered for achieving uniform lithium *** construction of lithiophilic sites with desired structure and homogeneous distribution signifcantly promotes the lithiophilicity of lithium hosts but remains a great *** this contribution,a framework porphyrin(POF)material with precisely constructed lithiophilic sites in regard to chemical structure and geometric position is employed as the lithium host to address the above issues for dendrite-free lithium metal *** extraordinary lithiophilicity of POF even beyond lithium nuclei validated by DFT simulations and lithium nucleation overpotentials afords a novel mechanism of favorable lithium nucleation to facilitate uniform nucleation and inhibit dendrite ***,POF-based anodes demonstrate superior electrochemical performances with high Coulombic efciency over 98%,reduced average voltage hysteresis,and excellent stability for 300 cycles at 1.0 mA cm^(−2),1.0 mAh cm^(−2) superior to both Cu and graphene *** favorable lithium nucleation mechanism on POF materials inspires further investigation of lithiophilic electrochemistry and development of lithium metal batteries.

关键词： lithium POF hysteresis

Complete genome sequence of Bacillus amyloliquefaciens YP6, a plant growth rhizobacterium efficiently degrading a wide range of organophosphorus pesticides

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Journal of Integrative Agriculture 2019年第11期18卷 2668-2672页

作者： MENG Di ZHAI Li-xin TIAN Qiao-peng GUAN Zheng-bing CAI Yu-jie LIAO Xiang-ru Key Laboratory of Industrial Biotechnology Ministry of Education School of Biotechnology Jiangnan University

Bacillus amyloliquefaciens YP6,a plant growth promoting rhizobacteria,is capable of efficiently degrading a wide range of organophosphorus pesticides(OPs).Here,we report the complete genome sequence of this bacterium with a genome size of 4009619 bp,4210 protein-coding genes and an average GC content of 45.9%.Based on the genome sequence,several genes previously described as being involved in solubilizing-phosphorus,OPs-degradation,indole-3-acetic acid(IAA)and siderophores ***,compared with the genomes of *** species,strain YP6 had larger genome size and the most protein-coding ***,the four categories of“cell envelope biogenesis,outer membrane(M),”“translation,ribosomal structure and biogenesis(J),”“transcription(K),”and“signal transduction mechanisms(T)”were *** differences may be related to extensive environmental adaptability of the genus *** results expand the application potential of strain YP6 for environmental bioremediation,provide gene resources involved in OPs degradation for biotechnology and gene engineering,and contribute to provide insights into the relationship between microorganism and living environment.

关键词： organophosphorus pesticides genome sequence plant growth promoting rhizobacteria Bacillus amyloliquefaciens

Observation of Electronic Shells and Characteristic Products from Mass Abundance Spectra of Al Cluster and Al-C Cluster Anions

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Chinese Physics Letters 2000年第9期17卷 658-660页

作者： LIU bing-chen ZHAI Hua-Jin ZHOU ru-fang NI Guo-Quan XU Zhi-Zhan Laboratory for Quantum Optics Chinese Academy of SciencesShanghai 201800 Laboratory for High Intensity Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800

Using a laser vaporization/pulsed molecular beam cluster source,Al cluster anions and Al-C mixed cluster anions are produced and recorded by a time of flight mass *** abundance spectra of the Al cluster anions in the size range from Al_(2)^(-)to Al_(42)^(-)show that Al_(13)^(-),Al_(23)^(-),Al_(35)^(-),and slightly,Al_(37)^(-)are local maxima,as predicted by the electronic jellium *** clusters Aln C-and Aln C_(2)^(-)are also shown,among which the most abundant species are Al3 C2,Al6 C_(2)^(-),A_(l7)C^(-)and A_(l7)C_(2)^(-)in the small size *** formation mechanism of these products is discussed.

关键词： cluster slightly anions

The correlation between molecular structure parameters of O-ethyl N-isopropyl phosphoro(thioureido)thioates and their retention data in RP-HPLC

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Chinese Journal of Chemistry 1993年第1期11卷 76-80页

作者： wang,Qin-Sun GAO,ru-Yu YANG,Hua-Zheng YAN,bing-Wen National Laboratory.of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 National Laboratory of Elemento‐Organic Chemistry Namkai University Tianjin 300071

A retention prediction system(RPS)of seven O-ethyl N-isopropyl phosphoro(thioureido)- thioates in reversed phase HPLC was *** system is based on the solvent selectivity triangle *** molecular structure parameters(hydrophobicity Ⅱ,substituent length L, and substituent maximum width B_5)were used to describe the quantitative structure-retention relation- *** these quantitative relationships,the retention behaviours of other eight homologs for different mobile phase composition were *** predicted values were consistent with the measured values within relative error of 10%,which means that it is possible to apply the reported method to predict retention values for qualitative purposes for different mobile phase compositions.

关键词： The correlation between molecular structure parameters of O-ethyl N-isopropyl phosphoro thioureido)thioates and their retention data in RP-HPLC data

Two Types of Mass Abundance Distributions for Anionic Carbon Clusters Investigated by Laser Vaporization and Pulsed Molecular Beam Techniques

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Chinese Physics Letters 2000年第3期17卷 197-199页

作者： ZHAI Hua-Jin LIU bing-Chen ZHOU ru-Fang NI Guo-Quan XU Zhi-Zhan Laboratory for Quantum Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800 Laboratory for High Intensity Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800

Two types of mass spectra for anionic carbon clusters Cn have been revealed using laser vaporization and pulsed molecular beam *** less structured mass spectrum characteristic of the magic-numbers at n=5,8,",15,and 17 is established at the early stage of the cluster formation process,namely,in the laser vaporization,*** more structured one is featured for a regular odd-even alternation and the magic numbers at n=IO,12,16,18j 22j and 28,and has been developed only after extensive clustering and qnenching processes,where low-energy electron attachment plays a vital *** between these two types of mass spectra can be realized by controlling either the strength of the pulsed gas flow or the synchronism between the gas How and the laser vaporization.

关键词： pulsed Transition Molecular