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Design and synthesis of new 7,8-dimethoxy-α-naphthoflavones as CYP1A1 inhibitors

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Chinese Chemical Letters 2013年第3期24卷 215-218页

作者： Jia-Hua Cui Dagula Hu Xu Zhang Zheng Jing Jing Ding ru-bing wang Shao-Shun Li School of Pharmacy Shanghai Jiaotong University

The flavonoids as inhibitors of CYP1A1 exhibit chemopreventive effects against certain procarcinogens and have been considered as the promising cancer preventive agents. A series of novel 7,8-dimethoxy-a- naphthoflavones as the substrate analogs were designed and prepared, The enzyme assay suggested that all of these new flavones were stronger inhibitors of CYP1A1 than the lead compound a-naphthoflavone, Among the tested ones, 3h showed the most potent inhibitory effects,

关键词： a-NaphthoflavoneCYPIA1 inhibitors7 8-Dimethoxy-a-naphthoflavoneFlavonoids

Long-term Integration Ability of the Submillimeter Wave Astronomy Satellite(SWAS)Spectral Line Receivers

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Research in Astronomy and Astrophysics 2024年第6期24卷 315-322页

作者： bing-ru wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai rudolf Schieder Gary J.Melnick National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China KOSMA I.Physik.InstitutUniversität zu KölnZülpicher Str.7750937 KölnGermany Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetMS 66CambridgeMA 02138USA

The Submillimeter Wave Astronomy Satellite(SWAS)was the first space telescope capable of high spectral resolution observations of terahertz spectral *** have investigated the integration ability of its two receivers and spectrometer during five and a half years of on-orbit *** CI,O_(2),H_(2)O,and^(13)CO spectra taken toward all observed Galactic sources were *** present results are based on spectra with a total integration time of up to 2.72×10~4hr(■10~8s).The noise in the spectra is generally consistent with that expected from the radiometer equation,without any sign of approaching a noise *** noise performance reflects the extremely stable performance of the passively cooled front end as well as other relevant components in the SWAS instrument throughout its mission lifetime.

关键词： telescopes space vehicles:instruments instrumentation:miscellaneous ISM:lines and bands

Molecular Oxygen Abundance in Galactic Massive Star Formation Regions Based on SWAS Observations

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Research in Astronomy and Astrophysics 2024年第9期24卷 83-98页

作者： bing-ru wang Di Li Paul F.Goldsmith Jingwen Wu Chao-Wei Tsai Donghui Quan Xia Zhang Junzhi wang Gary J.Melnick Jin-Zeng Li Gary A.Fuller Jinjin Xie National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Tsinghua University Beijing 100084China University of Chinese Academy of Sciences Beijing 100049China Research Center for Astronomical Computing Zhejiang LaboratoryHangzhou 311100China Jet Propulsion Laboratory California Institute of TechnologyPasadenaCA 91109USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Center for Astrophysics Harvard&Smithsonian60 Garden StreetMS 66CambridgeMA 02138USA Jodrell Bank Center for Astrophysics Department of Physics&AstronomyUniversity of ManchesterOxford RoadManchesterM139PLUK I.Physikalisches Institut University of CologneZülpicher Str.7750937 KölnGermany

Molecular oxygen abundance is a key parameter in understanding the chemical network of the interstellar *** estimate the molecular oxygen column density and abundance for a sample of Galactic massive star formation regions based on observations from the Submillimiter Wave Astronomy Satellite(SWAS)*** obtained an averaged O_(2)spectrum based on this sample using the(SWAS)survey data(O_(2),487.249 GHz,N=3-1,J=3-2).No emission or absorption feature is seen around the supposed central velocity with a total integration time of t_(total)=8.67×10^(3)hr and an rms noise per channel of 1.45 m *** a kinetic temperature T_(kin)=30 K,we derive the 3σupper limit of the O_(2)column density to be 3.3×10^(15)cm^(-2),close to the lowest values reported in Galactic massive star formation regions in previous *** corresponding O_(2)abundance upper limit is6.7×10^(-8),lower than all previous results based on SWAS observations and is close to the lowest reported value in massive star formation *** a galactic scale,our statistical results confirm a generally low O_(2)abundance for Galactic massive star formation *** abundance is also lower than results reported in extragalactic sources.

关键词： ISM:molecules galaxies:abundances ISM:lines and bands Galaxy:abundances

Eco-engineering for wastes treatment in process of alcohol production

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Journal of Environmental Sciences 1998年第4期10卷 96-101页

作者： Lu bing you, wang ru song DSE, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Zhang Ren wu Agro Environmental Protection Institute, Tianjin 300191, China Sui Zhi heng Jilin Agro Environ

The strategies of coordination between production activities of alcohol and the comprehensive utilization of its by products was discussed in this paper. It can be concluded from the study that guided by the principles of ecological engineering the purposes of both environment protecting and higher profits gaining can be realized simultaneously with less input than other engineering forms. Within this case, the by products, CO 2,wastewater, distillers' grain, navel and mixed oil were treated as resources for certain purpose such as using as raw materials to produce fuel, forage and fertilizer. The rings earlier broken or given up by human behaviors were connected properly or added, and some high efficient rings were re added. The economic benefits getting from the treatment of by products occupy 10.39% of the total output or 1.17 times of the net output without environmental impacts.

关键词： corn alcohol ecological engineering waste Jilin of China.

波长优选对土壤有机质含量可见光/近红外光谱模型的优化（英文）

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发光学报 2016年第11期37卷 1428-1435页

作者：林志丹汪玉冰王儒敬汪六三鲁翠萍张正勇宋良图刘洋中国科学院合肥智能机械研究所安徽合肥230031 中国科技大学自动化系安徽合肥230026 合肥电子工程学院安徽合肥230037

可见光/近红外光谱模型是土壤属性预测的有效工具。波长优选在光谱建模过程中起着重要作用。文中首先利用从安徽省涡阳县采集的130个砂姜黑土土壤样本获得可见光/近红外光谱,然后利用平滑与多重散射校正联合的光谱预处理方式消除光谱中... 详细信息

可见光/近红外光谱模型是土壤属性预测的有效工具。波长优选在光谱建模过程中起着重要作用。文中首先利用从安徽省涡阳县采集的130个砂姜黑土土壤样本获得可见光/近红外光谱,然后利用平滑与多重散射校正联合的光谱预处理方式消除光谱中的无关变量和冗余信息以提高模型预测结果的相关性,再利用SPXY方法挑选建模集样本,分别利用连续投影算法和遗传算法进行波长优选,最后利用留一法进行交互验证建立有机质含量的主成分回归模型。研究结果显示:连续投影算法和遗传算法都可以有效地减少参与建模的波长数并提高模型的准确度,尤其是遗传算法能够更好地提高土壤有机质含量预测精度,其相关系数、预测均方根误差和相对分析误差分别达到0.931 6,0.214 2和2.319 5。通过合适的特征波长选取,不仅计算量可以大大减少,预测精度也会有效提高。

关键词：可见光/近红外光谱有机质含量光谱预处理样本选择波长优化

基于引力模型的区域农产品物流网络构建研究——以长江三角洲地区为例

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亚热带资源与环境学报 2015年第4期10卷 42-49页

作者：曹炳汝尹娣王静芳江南大学商学院区域发展研究基地江苏无锡214122

构建区域性农产品物流网络,有利于整合区域农产品物流资源,提升区域农产品物流效率,保障城乡农产品供应与安全。研究通过建立区域性农产品物流发展水平评价指标体系,运用因子分析法确定长江三角洲16个城市农产品物流层次体系,运用引力... 详细信息

构建区域性农产品物流网络,有利于整合区域农产品物流资源,提升区域农产品物流效率,保障城乡农产品供应与安全。研究通过建立区域性农产品物流发展水平评价指标体系,运用因子分析法确定长江三角洲16个城市农产品物流层次体系,运用引力模型分析各城市之间的农产品物流引力强度,在此基础上构建了长三角区域农产品物流的网络模型,即以上海为核心,南京、杭州为两翼的区域农产品物流网络体系,为加快长三角地区农产品物流业发展与空间布局优化提供科学依据。

关键词：农产品物流引力模型物流网络长江三角洲地区

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反式白藜芦醇葡萄糖苷在犬体内的药动学研究

中国医院药学杂志 2017年第6期37卷 522-525页

作者：苏美英梅如冰王立强周茂金泰安市中心医院山东泰安271000 华侨大学福建泉州362021

目的:建立Beagle犬血浆中反式白藜芦醇葡萄糖苷(TRG)的测定方法并进行药动学研究。方法:Beagle犬分别灌胃和静脉给予TRG后测定不同时间的血药浓度,运用Topfit 2.0药动学软件计算非房室模型药动学参数。结果:Beagle犬以25,50,100 mg·kg^... 详细信息

目的:建立Beagle犬血浆中反式白藜芦醇葡萄糖苷(TRG)的测定方法并进行药动学研究。方法:Beagle犬分别灌胃和静脉给予TRG后测定不同时间的血药浓度,运用Topfit 2.0药动学软件计算非房室模型药动学参数。结果:Beagle犬以25,50,100 mg·kg^(-1)3个剂量灌胃给予TRG,TRG血浆峰浓度(Cmax)分别为(0.92±0.44),(1.93±0.46),(4.02±1.22)mg·L^(-1);达峰时间(t_(max))分别为(0.83±0.18),(1.19±0.36),(0.78±0.17)h;半衰期(t_(1/2))分别为(0.93±0.16),(1.18±0.19),(1.18±0.29)h;药-时曲线下面积(AUC_(0-t))分别为(1.73±0.77),(4.14±0.52),(8.67±2.95)mg·h·L^(-1)。Beagle犬静脉注射TRG25 mg·kg^(-1)后,TRG的t1/2为(1.72±0.41)h,AUC_(0-t)为(48.9±6.41)mg·h·L^(-1),TRG的绝对生物利用度为3.53%。结论:TRG在25~100 mg·kg^(-1)剂量范围内Cmax和AUC0-t呈线性动力学特征,TRG在Beagle犬体内的绝对生物利用度较低。

关键词：反式白藜芦醇葡萄糖苷犬药动学

基于计算机仿真的被动型氢钟磁屏蔽系统磁场分析

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中国科学院上海天文台年刊 2016年第1期 49-58页

作者：冷如冰王瑞戴家瑜上海大学通信与信息工程学院上海200072 中国科学院上海天文台上海200030

磁屏蔽系统是被动型氢原子钟的重要组成部分，它的好坏直接影响到物理系统输出信号的具体数值，表现为氢钟抵御外界磁场干扰的能力。通过仿真较为直观地展示并分析了特定磁屏蔽系统在特定外界磁场环境中的工作情况，并且通过原理分析，... 详细信息

磁屏蔽系统是被动型氢原子钟的重要组成部分，它的好坏直接影响到物理系统输出信号的具体数值，表现为氢钟抵御外界磁场干扰的能力。通过仿真较为直观地展示并分析了特定磁屏蔽系统在特定外界磁场环境中的工作情况，并且通过原理分析，仿真了在使用特定退磁工艺时磁场在磁屏蔽上的分布情况。根据仿真结果建立了模型，探索了适应于被动型氢原子钟的退磁方法，及相应的结构设计。该方法贴合被动型氢钟磁屏蔽材料的特性，使得退磁工艺的设计有针对性。

关键词：被动氢钟磁屏蔽系统退磁工艺计算机仿真

20年来我国潮土区与黑土区土壤有机质变化的对比研究

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土壤通报 2004年第2期35卷 102-105页

作者：徐艳张凤荣汪景宽王秋兵王茹中国农业大学土地资源与管理系北京100094 沈阳农业大学土地资源与环境学院辽宁沈阳110161 北京市土地整理中心北京100009

对潮土区和黑土区的土壤样品进行采集和分析,结合第二次土壤普查资料,研究潮土区和黑土区土壤有机质的时空变化特征。结果表明潮土区土壤有机质含量呈现提高的趋势,黑土区土壤有机质含量呈现降低的趋势。出现这种变化的结果都与耕作制度... 详细信息

对潮土区和黑土区的土壤样品进行采集和分析,结合第二次土壤普查资料,研究潮土区和黑土区土壤有机质的时空变化特征。结果表明潮土区土壤有机质含量呈现提高的趋势,黑土区土壤有机质含量呈现降低的趋势。出现这种变化的结果都与耕作制度,尤其是施肥管理水平等人为因素有密切的关系。

关键词：潮土区黑土区土壤有机质时空变化施肥管理