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Effect of small bowel preparation with simethicone on capsule endoscopy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第1期10卷 46-51页

作者： You-hong FANG Chun-xiao CHEN bing-ling zhang The Children's Hospital School of Medicine Zhejiang University Hangzhou 310003 China Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Background： Capsule endoscopy is a novel non-invasive method for visualization of the entire small bowel. The diagnostic yield of capsule endoscopy depends on the quality of visualization of the small bowel mucosa and its complete passage through the small bowel. To date, there is no standardized protocol for bowel preparation before capsule endoscopy. The addition of simethicone in the bowel preparation for the purpose of reducing air bubbles in the intestinal lumen had only been studied by a few investigators. Methods： Sixty-four participants were randomly divided into two groups to receive a bowel preparation of polyethylene glycol （PEG） solution （Group 1） and both PEG solution and simethicone （Group 2）. The PEG solution and sime- thicone were taken the night before and 20 rain prior to capsule endoscopy, respectively. Frames taken in the small intestine were examined and scored for luminal bubbles by two professional capsule endoscopists. Gastric emptying time and small bowel transit time were also recorded. Results： Simethicone significantly reduced luminal bubbles both in the proximal and distal small intes- tines. The mean time proportions with slight bubbles in the proximal and distal intestines in Group 2 were 97.1% and 99.0%, respectively, compared with 67.2% （P〈0.001） and 68.8% （P〈0.001） in Group 1. Simethicone had no effect on mean gastric emptying time, 32.08 rain in Group 2 compared with 30.88 min in Group 1 （P=0.868）, but it did increase mean small intestinal transit time from 227.28 to 281.84 rnin （P=0.003）. Conclusion： Bowel preparation with both PEG and simethicone significantly reduced bubbles in the intestinal lumen and improved the visualization of the small bowel by capsule endoscopy without any side effects observed.

关键词： Capsule endoscopy Bowel preparation Simethicone Polyethylene glycol (PEG) Visualization Air bubbles

OMOM capsule endoscopy in diagnosis of small bowel disease

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第11期9卷 857-862页

作者： Chen-yi LI bing-ling zhang Chun-xiao CHEN You-ming LI Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To assess the diagnostic efficiency of OMOM capsule endoscopy （CE） in a group of patients with different indications. Methods： Data from 89 consecutive patients （49 males, 40 females） with suspected small bowel disease who underwent OMOM CE （Jinshan Science and Technology Company, review. The patients＇ indications of the disease consisted of the Chongqing, China） examination were obtained by retrospective following： obscure gastrointestinal bleeding （OGIB）, abdominal pain or diarrhea, partial intestinal obstruction, suspected inflammatory bowel disease, tumor of unknown origin, hypoproteinemia, constipation, weight loss, and elevated tumor markers. Results： CE failed in one patient. Visualization of the entire small bowel was achieved in 75.0%. Capsules were naturally excreted by all patients. The detection rate of abnormalities was 70.5% for patients with suspected small bowel disease, and the diagnostic yield for patients with OGIB was higher than that for patients with abdominal pain or diarrhea （85.7% vs 53.3%, P〈0.005）. Angiodysplasia was the most common small bowel finding. Active bleeding sites were noted in the small intestine in 11 cases. Conclusion： OMOM CE is a useful diagnostic tool for the diagnosis of variably suspected small bowel disease, whose diagnostic efficiency is similar to that of the Pillcam SB （small bowel） CE （Given Imaging, Yoqneam, Israel）.

关键词： OMOM capsule endoscopy (CE) Small bowel disease Obscure gastrointestinal bleeding (OGIB) Diagnosis

The value of endoscopic ultrasonography on diagnosis and treatment of esophageal hamartoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 662-666页

作者： Guo-qiang XU Feng-ling HU Li-hua CHEN Guo-dong SHAN bing-ling zhang Department of Gastroenterology the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective:To examine the values of endoscopic ultrasonography (EUS) on diagnosis and treatment of esophageal hamartoma. Methods:We compared and analyzed various kinds of imaging examinations such as barium esophagram, con-trast-enhanced computed tomography (CT) and conventional gastroscopy in retrospectively reviewing the clinical data of an esophageal hamartoma patient seen in our clinic in the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Having received various imaging examinations, this patient was finally diagnosed with esophageal hamartoma and underwent gastroscopic resection of hamartoma with the diagnostic information obtained from EUS. The patient had been regularly followed up for 13 months after treatment. Results: Barium esophagram, CT and conventional gastroscopy detected the lesion, but were unable to distinguish it from common esophagopolypus and other submucosal lesions, and unable to determine etiopathogenisis. EUS detected the hamartoma and identified its internal structure, echo, exact size, depth of invasion, origin and the relationship between adjacent tissues and organs, differentiating the lesion from other submucosal tumors and clearly defining the diagnosis. EUS-guided fine needle aspiration (FNA) also helped to identify the etiological diagnosis. Conclusion: EUS was superior to other imaging means in diagnosis and treatment of hamartoma.

关键词： Esophageal hamartoma Endoscopic ultrasonography (EUS) Gastroscopic resection

A primary intestinal lymphangiectasia patient diagnosed by capsule endoscopy and confirmed at surgery: A case report

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World Journal of Gastroenterology 2007年第15期13卷 2263-2265页

作者： You-Hong Fang bing-ling zhang Jia-Guo Wu Chun-Xiao Chen The First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China Sir Run Run Shaw hospital of College of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China

Intestinal lymphangiectasia （IL） is a rare disease characterized by dilated lymphatic vessles in the intestinal wall and small bowel mesentery which induce loss of protein and lymphocytes into bowel lumen. Because it most often occurs in the intestine and cannot be detected by upper gastroendoscopy or colonoscopy, and the value of common image examinations such as X-ray and computerized tomography （CT） are limited, the diagnosis of IL is difficult, usually needing the help of surgery. Capsule endoscopy is useful in diagnosing intestinal diseases, such as IL. We here report a case of IL in a female patient who was admitted for the complaint of recurrent edema accompanied with diarrhea and abdominal pain over the last twenty years, and aggravated ten days ago. She was diagnosed by M2A capsule endoscopy as a primary IL and confirmed by surgical and pathological examination.

关键词： Intestinal lymphangiectasia Capsule endoscopy Hypoproteinemia Lymphocytopenia Edema Surgery

Single-center experience of 309 consecutive patients with obscure gastrointestinal bleeding

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World Journal of Gastroenterology 2009年第45期15卷 5740-5745页

作者： bing-ling zhang You-Hong Fang Chun-Xiao Chen You-Ming Li Zun Xiang Department of Gastroenterology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China The Children's Hospital College of MedicineZhejiang University 57 Zhugan Lane Yanan Road Hangzhou 310003 Zhejiang Province China

AIM: To investigate the diagnostic yield of capsule endoscopy (CE) in patients with obscure gastrointestinal bleeding (OGIB), and to determine whether the yield was affected by different bleeding status. METHODS: Three hundred and nine consecutive patients (all with recent negative gastric and colonic endoscopy results) were investigated with CE; 49 cases with massive bleeding and 260 cases with chronic recurrent overt bleeding. Data regarding OGIB were obtained by retrospective chart review and review of an internal database of CE fi ***: Visualization of the entire small intestine was achieved in 81.88% (253/309) of cases. Clinically positive findings occurred in 53.72% (166/309) of cases. The positivity of the massive bleeding group was slightly higher than that of the chronic recurrent overt bleeding group but there was no significant difference (59.18% vs 52.69%, P > 0.05) between the two groups. Small intestinal tumors were the most common fi nding in the entire cohort, these accounted for 30% of clinically signifi cant lesions. In the chronic recurrent overt bleeding group angioectasia incidence reached more than 29%, while in the massive bleedinggroup, small intestinal tumors were the most common finding at an incidence of over 51%. Increasing patient age was associated with positive diagnostic yield of CE and the findings of OGIB were different according to age range. Four cases were compromised due to the capsule remaining in the stomach during the entire test, and another patient underwent emergency surgery for massive bleeding. Therefore, the complication rate was 1.3%. CONCLUSION: In this study CE was proven to be a safe, comfortable, and effective procedure, with a high rate of accuracy for diagnosing OGIB.

关键词： Obscure gastrointestinal bleeding Capsule endoscopy Massive bleeding Chronic recurrent overt occult bleeding

Experimental Study of Thermoelectric Heat Pump Water Heater with Exhaust Heat Recovery from Kitchens

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湖南大学学报（自然科学版） 2009年第S1期36卷 131-135页

作者： LIU Zhong-bing,zhang ling,YANG zhang,XU Ming,HAN Tian-he(College of Civil Engineering,Hunan University,Changsha,Hunan 410082,China) College of Civil Engineering Hunan University Changsha 410082 China

A new kind of thermoelectric heat pump water heater for kitchens exhaust heat recovery was presented,and its performances were investigated under different operating *** experiment results show that the coefficient of performance decreases and the temperature difference between the hot and cold sides becomes larger with the increase of the operating voltage,but the heating time becomes *** higher the temperature of water,the greater the temperature difference between the hot and cold sides,leading to a smaller coefficient of *** an exhaust temperature of 36 ℃,the coefficient of performance decreases from 1.66 to 1.22 when the temperature of water increases from 28 ℃ to 46 ℃ with operating voltage 16 *** tests illustrate that,compared with the conventional electrical water heaters,the new kind of thermoelectric heat pump water heater is more coefficient.

关键词： thermoelectric heat pump kitchens exhaust water heater coefficient of performance

Vitamin D binding protein in psychiatric and neurological disorders:Implications for diagnosis and treatment

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Genes & Diseases 2024年第5期11卷 324-334页

作者： ling Li bing Han Yan Kong Gaojia zhang Zhijun zhang Research Institution of Neuropsychiatry School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalNanjingJiangsu 210009China Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

Vitamin D binding protein(VDBP)serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target *** plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin *** research has shed light on its potential role in various diseases,leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological *** purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric *** examining the intricate interplay between VDBP and these disorders,this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic *** gained from the study of VDBP could pave the way for novel strategies in the diagnosis,prognosis,and treatment of psychiatric and neurological disorders.

关键词： Neurological disorder Polymorphism Psychiatric disorder Structure Vitamin D binding protein

Complex adaptive system theory,agent-based modeling,and simulation in dominant technology formation

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Journal of Systems Engineering and Electronics 2024年第1期35卷 130-153页

作者： zhang Ruihan SUN bing Glorious Sun School of Business and Management Donghua UniversityShanghai 200051China School of Economics and Management Harbin Engineering UniversityHarbin 150001China

Dominant technology formation is the key for the hightech industry to“cross the chasm”and gain an established foothold in the market(and hence disrupt the regime).Therefore,a stimulus-response model is proposed to investigate the dominant technology by exploring its formation process and ***,based on complex adaptive system theory and the basic stimulus-response model,we use a combination of agent-based modeling and system dynamics modeling to capture the interactions between dominant technology and the socio-technical *** results indicate the following:(i)The dynamic interaction is“stimulus-reaction-selection”,which promotes the dominant technology’s formation.(ii)The dominant technology’s formation can be described as a dynamic process in which the adaptation intensity of technology standards increases continuously until it becomes the leading technology under the dual action of internal and external mechanisms.(iii)The dominant technology’s formation in the high-tech industry is influenced by learning ability,the number of adopting users and ***,a“critical scale”of learning ability exists to promote the formation of leading technology:a large number of adopting users can promote the dominant technology’s formation by influencing the adaptive response of technology standards to the socio-technical landscape and the choice of technology standards by the socio-technical *** is a minimum threshold and a maximum threshold for the role of adaptability in the dominant technology’s formation.(iv)The socio-technical landscape can promote the leading technology’s shaping in the high-tech industry,and different elements have different *** study promotes research on the formation mechanism of dominant technology in the high-tech industry,presents new perspectives and methods for researchers,and provides essential enlightenment for managers to formulate technology strategies.

关键词： complex adaptive system theory agent-based modeling and simulation dominant technology socio-technical landscape adaptation-choice

Diagnostic effect of capsule endoscopy in 31 cases of subacute small bowel obstruction

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World Journal of Gastroenterology 2009年第19期15卷 2401-2405页

作者： Xiao-Yun Yang Chun-Xiao Chen bing-ling zhang Li-Ping Yang Hua-Jing Su Li-Song Teng You-Ming Li Department of Gastroenterology The First Affiliated Hospital College of Medicine Zhejiang University #79 Qingchun Road Hangzhou310003 Zhejiang Province China Department of Oncology The First Affiliated Hospital College of Medicine Zhejiang University #79 Qingchun Road Hangzhou 310003 Zhejiang Province China

AIM： TO evaluate the effectiveness and safety of capsule endoscopy （CE） in patients with recurrent subacute small bowel ***： The study was a retrospective analysis of 31 patients referred to hospital from January 2003 to August 2008 for the investigation of subacute small bowel obstruction, who underwent CE. The patients were aged 9-81 years, and all of them had undergone gastroscopy and colonoscopy previously. Some of them received abdominal computed tomography or small bowel ***： CE made a definitive diagnosis in 12 （38.7%） of 31 cases： four Crohn＇s disease （CD）, two carcinomas, one intestinal tuberculosis, one ischemic enteritis, one abdominal cocoon, one duplication of the intestine,one diverticulum and one ileal polypoid tumor. Capsule retention occurred in three （9.7%） of 31 patients, and was caused by CD （2） or tumor （1）. Two with retained capsules were retrieved at surgery, and the other one of the capsules was spontaneously passed the stricture by medical treatment in 6 too. No case had an acute small bowel obstruction caused by performance of ***： CE provided safe and effective visualization to identify the etiology of a subacute small bowel obstruction, especially in patients with suspected intestinal tumors or CD, which are not identified by routine examinations.

关键词： Capsule endoscopy Small bowelobstruction Capsule retention