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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第4期11卷 258-266页

作者： Feng-ying LI Xiao-bin REN En-ping XU Qiong HUANG Hong-qiang SHENG bing-jian lv Mao-de LAI Department of Pathology School of Medicine Zhejiang University Hangzhou 310058 China Clinical Laboratory Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of Epidemiology and Biostatistics School of Medicine Zhejiang University Hangzhou 310058 China Anatomical and Cellular Pathology Women 's Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Regenerating gene IV （RegIV）, a member of the regenerating gene family discovered in 2001, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate, but the overall expression profile of RegIV has not been reported. To learn more about RegIV, we evaluated its distribution by immunohistochemistry （IHC） in a total of 360 samples including 24 types of normal tissue, 40 benign and malignant lesions, and 18 neuroendocrine tumors. We found that in normal tissues, in addition to its relative specificity for the gastrointestinal tract, RegIV was detected in the adrenal gland and mammary gland. Among all the malignancies of various histological types under evaluation, RegIV was found mostly in adenocarcinomas. Studies on additional sets of colorectal tumor samples showed that RegIV expression was predominant in colorectal adenoma （87.5%） and peritumoral tissue （100%） but not in cancer tissue （30.8%）. Among neuroendocrine tumors, Reglv had a relatively restricted expression to those of digestive system.

关键词： Colorectal cancer Expression profile Neuroendocrine tumor Regenerating gene IV (RegIV)

Fractures interaction and propagation mechanism of multi-cluster fracturing on laminated shale oil reservoir

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Petroleum Science 2024年第4期21卷 2600-2613页

作者： Jia-Xin lv bing Hou Key Laboratory of Petroleum Engineering Ministry of Education China University of Petroleum (Beijing) State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum (Beijing) Department of Petroleum Engineering China University of Petroleum (Beijing) at Karamay

The continental shale reservoirs of Jurassic Lianggaoshan Formation in Sichuan Basin contain thin lamina, which is characterized by strong plasticity and developed longitudinal shell limestone *** improve the production efficiency of reservoirs by multi-cluster fracturing, it is necessary to consider the unbalanced propagation of hydraulic fractures and the penetration effect of fractures. This paper constructed a numerical model of multi-fracture propagation and penetration based on the finite element coupling cohesive zone method; considering the construction cluster spacing, pump rate,lamina strength and other parameters studied the influencing factors of multi-cluster fracture interaction propagation; combined with AE energy data and fracture mode reconstruction method, quantitatively characterized the comprehensive impact of the strength of thin interlayer rock interfaces on the initiation and propagation of fractures that penetrate layers, and accurately predicted the propagation pattern of hydraulic fractures through laminated shale oil reservoirs. Simulation results revealed that in the process of multi-cluster fracturing, the proportion of shear damage is low, and mainly occurs in bedding fractures activated by outer fractures. Reducing the cluster spacing enhances the fracture system's penetration ability, though it lowers the activation efficiency of lamina. The high plasticity of the limestone interlayer may impact the vertical propagation distance of the main fracture. Improving the interface strength is beneficial to the reconstruction of the fracture height, but the interface communication effect is limited. Reasonable selection of layers with moderate lamina strength for fracturing stimulation, increasing the pump rate during fracturing and setting the cluster spacing reasonably are beneficial to improve the effect of reservoir stimulation.

关键词： Laminated shale Multi-cluster fracturing Cross-layer Cohesive zone model Acoustic emission technique

Human-Machine Shared Lateral Control Strategy for Intelligent Vehicles Based on Human Driver Risk Perception Reliability

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Automotive Innovation 2024年第1期7卷 102-120页

作者： Dongjian Song bing Zhu jian Zhao Jiayi Han State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China

Intelligent vehicle(Ⅳ)technology has developed rapidly in recent ***,achieving fully unmanned driving still presents numerous challenges,which means that human drivers will continue to play a vital role in vehicle operation for the foreseeable ***-machine shared driving,involving cooperation between a human driver and an automated driving system(AVS),has been widely regarded as a necessary stage for the development of *** onⅣdriving safety,this study proposed a human-machine shared lateral control strategy(HSLCS)based on the reliability of driver risk *** HSLCS starts by identifying the effective areas of driver risk perception based on eye *** establishes an anisotropic driving risk field,which serves as the foundation for the AVS to assess risk *** upon the cumulative and diminishing effects of risk perception,the proposed approach leverages the driver's risk perception effective area and converts the risk field into a representation aligned with the driver's ***,it quantifies the reliability of the driver's risk perception by using area-matching ***,based on the driver’s risk perception reliability and dif-ferences in lateral driving operation between the human driver and the AVS,the dynamic distribution of driving authority is achieved through a fuzzy rule-based system,and the human-machine shared lateral control is completed by using model predictive *** HSLCS was tested across various scenarios on a driver-in-the-loop test *** results show that the HSLCS can realize the synergy and complementarity of human and machine intelligence,effectively ensuring the safety ofⅣoperation.

关键词： Intelligent vehicle Human-machine shared driving Risk perception Driving authority distribution

Ramsey Numbers of Trees Versus Multiple Copies of Books

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 600-612页

作者： Xiao-bing GUO Si-nan HU Yue-jian PENG School of Mathematical Sciences Luoyang Normal UniversityLuoyang 471934China School of Mathematics Hunan UniversityChangsha 410082China

Given two graphs G and H,the Ramsey number R(G,H) is the minimum integer N such that any two-coloring of the edges of K_(N) in red or blue yields a red G or a blue *** v(G) be the number of vertices of G and χ(G) be the chromatic number of *** s(G) denote the chromatic surplus of G,the number of vertices in a minimum color class among all proper χ(G)-colorings of *** showed that R(G,H)≥(v(G)-1)(χ(H)-1)+s(H) if G is connected and v(G)≥s(H).A connected graph G is H-good if R(G,H)=(v(G)-1)(χ(H)-1)+s(H).Let tH denote the disjoint union of t copies of graph H,and let G∨H denote the join of G and *** a complete graph on n vertices by K_(n),and a tree on n vertices by T_(n).Denote a book with n pages by B_(n),i.e.,the join K_(2) ∨■.Erd?s,Faudree,Rousseau and Schelp proved that T_(n) is B_(m)-good if n≥*** this paper,we obtain the exact Ramsey number of T_(n) versus 2B_(2).Our result implies that T_(n) is 2B_(2)-good if n≥5.

关键词： ramsey number ramsey goodness tree book

Inclusions modification by rare earth in steel and the resulting properties: A review

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Journal of Rare Earths 2024年第3期42卷 431-445,I0001页

作者： Xiaoqiang Wang Zhiwei Wu bing Li Wenxiong Chen Jun Zhang jian Mao College of Materials Science and Engineering Sichuan UniversityChengdu610065China Chengdu Advanced Metal Materials Industry Technology Research Institute Co. Ltd.Chengdu610303China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan114009China

Rare earth(RE) elements are excellent modifiers for non-metallic inclusions that inevitably appear in steel and affect steel properties. This paper reviews the research status of inclusions modification by RE elements and the changes it cause on steel properties. First, the inclusion changes caused by RE modification are described. Generally, after adding pure RE, the main evolution of inclusions occurs as M →M + RE-Al-O → RE-Al-O + RE_(2)O_(2)S → RE_(2)O_(2)S + RE—S/RE_(2)O_(2)S + RE-O with an increase in the RE content(M represents the inclusions before RE addition). The type of final inclusion obtained after RE modification is related to the relative contents of S and O in the steel. Moreover, fine, regular, and uniformly distributed inclusions can be obtained with appropriate RE addition. However, the effectiveness of inclusions modification by adding both RE and non-RE elements is closely related to the order of their addition. Second, the applications and advantages of thermodynamic calculations in the study of RE-modified inclusions are introduced. Third, the changes in the corrosion resistance, impact properties,and other properties of steel caused by the modification of inclusions by RE are reviewed. Finally, the perspectives and trends of inclusions modified by RE elements in the steel industry are presented.

关键词： Rare earths Inclusions Modification Thermodynamic calculation Properties change

Permanent lining castable with low bulk density and thermal conductivity:bauxite castable for tundish obtained by adding pearlescent sand

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Journal of Iron and Steel Research International 2024年第3期31卷 634-646页

作者： Yi Wang jian Yang Bao Wang Hai-jun Zhang Juan Han Pei-yan Pei Wen-long lv jian-an Zhou The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Wuhan Research Institute of Metallurgical Construction MCCWuhan 430081HubeiChina

The low thermal conductivity and light mass of castables for tundish permanent linings are crucial for minimizing the heat loss of molten *** consideration of the low bulk density and thermal conductivity of pearlescent sand,the thermal insulation performance of castables was attempted to be improved by adding pearlescent *** sand was modified to prevent the strength of its porous structure from *** modification mechanism of pearlescent sand and the effect of pearlescent sand on the performance of bauxite castables were *** results suggested that the addition of the modified pearlescent sand significantly raised the apparent porosity and decreased the bulk density of bauxite *** 1000℃,the bulk density of more than 60%of the modified pearlescent sand-bauxite castable was only 2.03 g/cm^(3).The mechanical properties and thermal shock resistance of the modified pearlescent sand-bauxite castable were inferior to those of conventional bauxite castable but were adequate to meet the use conditions of casta-bles for tundish permanent *** high temperatures of 200-800℃,the thermal conductivity of more than 60%of the modified pearlescent sand-bauxite castable was smaller than that of conventional bauxite *** addition of the modified pearlescent sand can greatly reduce the thermal conductivity and bulk density of bauxite castable.

关键词： Pearlescent sand-Hydrophobic modification Bauxite castable Thermal insulation performance Mechanical property

Research on Gait Trajectory Planning of Wall-Climbing Robot Based on Improved PSO Algorithm

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Journal of Bionic Engineering 2024年第4期21卷 1747-1760页

作者： jian Li Xianlin Shi Peng Liang Yanjun Li Yilin lv Mingyue Zhong Zezhong Han School of Mechanical and Automotive Engineering Guangxi University of Science and TechnologyLiuzhou545006China

In order to reduce the labor intensity of high-altitude workers and realize the cleaning and maintenance of high-rise building exteriors,this paper proposes a design for a 4-DOF bipedal wall-climbing bionic robot inspired by the inchworm’s *** robot utilizes vacuum adsorption for vertical wall attachment and legged movement for *** enhance the robot’s movement efficiency and reduce wear on the adsorption device,a gait mimicking an inchworm’s movement is planned,and foot trajectory planning is performed using a quintic polynomial *** velocity constraints,foot trajectory optimization is achieved using an improved Particle Swarm Optimization(PSO)algorithm,determining the quintic polynomial function with the best fitness through ***,through comparative experiments,the climbing time of the robot closely matches the simulation results,validating the trajectory planning method’s accuracy.

关键词： Bionic robot Wall-climbing robot PSO Gait planning Trajectory planning

Mesoporous amorphous FeOOH-encapsulated BiO_(2–x) photocatalyst with harnessing broad spectrum toward activation of persulfate for tetracycline degradation

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Chinese Journal of Chemical Engineering 2024年第7期71卷 235-248页

作者： Pengfei Wu Zhaolong Liu Li Wu Yingkun Zhang bing Wang Zhanghao Cheng Wenquan Cui Xiangyang lv Qingling Liu Tianjin Key Laboratory of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin 300350China Hebei Pollution Control Technology Innovation Center of Steel and Coking Industry Department of Environmental and Chemical EngineeringHebei College of Industry and TechnologyShijiazhuang 050091China Hebei Key Laboratory of Environmental Photocatalytic and Electrocatalytic Materials College of Chemical EngineeringNorth China University of Science and TechnologyTangshan 063210China Hebei Academy of Product Quality Supervision&Inspection Shijiazhuang 050227China

With the growing concern about the water environment,the advanced oxidation process of persulfate activation assisted by photocatalysis has attracted considerable attention to decompose dissolved organic *** this work,to overcome the drawbacks of the photocatalytic activity reduction caused by the photo-corrosion of non-stoichiometric BiO_(2–x),a novel material with amorphous FeOOH in situ grown on layered BiO_(2–x) to form a core-shell structure similar to popcorn chicken-like morphology was produced in two simple and environmentally beneficial *** a series of degradation activity tests of hybrid materials under different conditions,the as-prepared materials exhibited remarkable degradation activity and stability toward tetracycline in the FeOOH@BiO_(2–x)/Vis/PS system due to the synergism of photocatalysis and persulfate *** results of XRD,SEM,TEM,XPS,FTIR,and BET show that the loading of FeOOH increases the specific surface area and active sites appreciably;the heterogeneous structure formed by FeOOH and BiO_(2–x) is more favorable to the effective separation of photogenerated *** optimal degradation conditions were at a catalyst addition of 0.7 g·L^(–1),a persulfate concentration of 1.0 g·L^(–1),and an initial pH of 4.5,at which the degradation rate could reach 94.7%after 90 *** influence of typical inorganic anions on degradation was also *** studies and radical quenching experiments revealed that·OH,SO_(4)^(-)·,and·O_(2)^(-)were the principal active species generated during the degradation of *** results of the 1,10-phenanthroline approach proved that the effect of dissolved iron ions on the tetracycline degradation was limited,and the interfacial reaction that occurs on the active sites on the material's surface was a critical *** work provides a novel method for producing efficient broad-spectrum Bismuth-based composite photocatalysts and photocatalytic-activated persulfate synerg

关键词： Amorphous FeOOH BiO_(2–x) Activated persulfate Photocatalytic Tetracycline degradation

How variable progenitor clones construct a largely invariant neocortex

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National Science Review 2024年第1期11卷 129-144页

作者： Zhongfu Shen Jiajun Yang Qiangqiang Zhang Kuiyu Wang Xiaohui lv Xiaolin Hu jian Ma Song-Hai Shi New Cornerstone Science Laboratory IDG/McG overn Institute for Brain Research Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University Department of Computer Sciences Tsinghua University College of Life Sciences Nankai University Chinese Institute for Brain Research

The neocortex contains a vast collection of diverse neurons organized into distinct layers. While nearly all neocortical neurons are generated by radial glial progenitors(RGPs), it remains largely unclear how a complex yet organized neocortex is constructed reliably and robustly. Here, we show that the division behavior and neuronal output of RGPs are highly constrained with patterned variabilities to support the reliable and robust construction of the mouse neocortex. The neurogenic process of RGPs can be well-approximated by a consistent Poisson-like process unfolding over time, producing deep to superficial layer neurons progressively. The exact neuronal outputs regarding layer occupation are variable; yet, this variability is constrained systematically to support all layer formation, largely reflecting the variable intermediate progenitor generation and RGP neurogenic entry and exit timing differences. Together, these results define the fundamental features of neocortical neurogenesis with a balanced reliability and variability for the construction of the complex neocortex.

关键词： neocortex radial glial progenitor intermediate progenitor neurogenesis clonal variability layer formation

Annulation Cascades of Cyclosulfonium Salts and Alkenes towards Sulfur-Containing N-Heterocycles by Visible Light/Copper Catalysis

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Chinese Journal of Chemistry 2024年第14期42卷 1637-1643页

作者： Jie Ma Xufeng Li Yuqing Chen Yongjia Shi Xiuyan Song jian lv Daoshan Yang Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOECollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdaoShandong266042 China Zhejiang Wansheng Co. Ltd.LinhaiZhejiang317000 China National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass Nanjing Forestry UniversityNanjingJiangsu210037 China

Although,great achievements have been made in the synthesis of heterocycles using radical addition/cyclization strategy,developing versatile alkyl radical precursors,especially the non-stabilized long chain alkyl radicals for this strategy still remains a huge ***,we report an efficient annulation cascade reaction between cyclosulfonium salts and alkenes for the synthesis of sulfur-containing N-heterocycles by visible light/copper catalysis under mild *** C—S bond cleavage/radical cascade reaction delivers a variety of corresponding N-heterocycles containing aryl alkyl thioether motifs with good functional group ***,the current system could be used for the late-stage functionalization of complex bioactive molecules.

关键词： Visible light Radical reactions C-C coupling Sulfur heterocycles Photoredox catalysis