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Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-Wei Chi Liu-Jian Ouyang Xiao-Qin Xu jing-Nan Chen bing-han jin Rahim Ullah Xue-Lian Zhou Ke Huang Guan-Ping Dong Zhe-Ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

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Identifying and localizing of seismogenic electromagnetic anomalies from data observed by permanent MT stations

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Science China Earth Sciences 2024年第5期67卷 1698-1713页

作者： bing han Wenbao HU Guoze ZHAO Ji TANG State Key Laboratory of Earthquake Dynamics Institute of GeologyBeijing 100029China Key Laboratory of Exploration Technologies for Oil and Gas Resources of Ministry of Education Yangtze UniversityWuhan 430100China

In this research, an arbitrarily oriented electric dipole at subsurface is used to simulate Seismogenic Electromagnetic(SEM) radiation emanating from a seismic zone during its gestation phase. Analytical synthesis of responses at the Lijiang magnetotelluric(MT) station has revealed that SEM radiation could induce identifiable anomalies in the electromagnetic(EM)spectrum, apparent resistivity and phase within specific frequency bands. Background variations were extracted from long-term observation data of Dali and Lijiang MT stations, enabling the identification of SEM anomalies related to the Yunlong and Yangbi earthquakes. Multiple parameters of dipole sources at subsurface were obtained by applying the Differential Ant Colony Optimization(DACO) algorithm to anomalous data of two stations with multi-frequencies and various response functions. The spatial distribution of these predicted dipoles is predominantly clustered in or around the seismogenic area, with their azimuthal orientation aligning towards the seismogenic fault in general. This study has demonstrated the potential of using subsurface electric dipole simulations for SEM radiation analysis, offering a feasible approach for the prediction and understanding of seismogenic zones.

关键词： MT responses Identifying SEM anomaly Vector electric dipole responses Localizing SEM sources by inversion

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Turning point of organoid transplantation:first-in-human trial of iPSC-derived retinal organoid grafting in patients with retinitis pigmentosa

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Science China(Life Sciences) 2024年第5期67卷 1082-1084页

作者： Chang-Jun Zhang Zi-bing jin Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

The discovery of induced pluripotent stem cells(iPSCs)has revolutionized the field of disease research,providing a promising platform for studying various *** the last decade,significant progress has been made in combining iPSCs with other cutting-edge technologies to investigate disease mechanisms and develop potential treatments.

关键词： conditions patients retinitis

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Enhancing whole yeast genome rearrangements through multiple LoxPsym sequences

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Science China(Life Sciences) 2024年第9期67卷 2045-2047页

作者： bing-Zhi Li Ying-jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Frontiers Research Institute for Synthetic Biology Tianjin UniversityTianjin 300072China

Genomic rearrangements play a significant role in disease,evolution,and tumorigenesis(Mani and Chinnaiyan,2010).While single nucleotide polymorphisms(SNPs)and small insertions/deletions contribute substantially to gen... 详细信息

关键词： insertion sequences

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改善空间因子对大豆生长及产量的影响

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作物学报 2006年第7期32卷 1097-1100页

作者：韩秉进中国科学院东北地理与农业生态研究所黑龙江哈尔滨150081

为了从理论上区分土壤因子和空间因子的作用,试验采用框栽的方法控制土壤面积,研究了增大空间因子对生长在不同土壤面积上的大豆植株的影响。结果表明,在大豆有效营养面积范围内,增大空间可以增加大豆产量,单株土壤面积较小时增产作用显... 详细信息

为了从理论上区分土壤因子和空间因子的作用,试验采用框栽的方法控制土壤面积,研究了增大空间因子对生长在不同土壤面积上的大豆植株的影响。结果表明,在大豆有效营养面积范围内,增大空间可以增加大豆产量,单株土壤面积较小时增产作用显著,随着单株土壤面积的增大,空间的增产作用减小。改善(扩大)空间因子明显增加了大豆的单株荚数和百粒重,降低了瘪荚率,增大了单株叶面积和干物质重,降低了株高和结荚部位。因此在土壤肥力水平较高的黑土区,利用和培育株型收敛、高光效大豆品种,在生产中将具更重要的意义。

关键词：空间因子土壤因子大豆

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Non-volatile dynamically switchable color display via chalcogenide stepwise cavity resonators

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Opto-Electronic Advances 2024年第1期7卷 16-27页

作者： Kuan Liu Zhenyuan Lin bing han Minghui Hong Tun Cao School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361102China Institute of Laser Engineering Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China

High-resolution multi-color printing relies upon pixelated optical nanostructures,which is crucial to promote color display by producing nonbleaching colors,yet requires simplicity in fabrication and dynamic *** trisulfide(Sb_(2)S_(3))is a newly rising chalcogenide material that possesses prompt and significant transition of its optical characteristics in the visible region between amorphous and crystalline phases,which holds the key to color-varying ***,we proposed a dynamically switchable color printing method using Sb_(2)S_(3)-based stepwise pixelated Fabry-Pérot(FP)cavities with various cavity *** device was fabricated by employing a direct laser patterning that is a less timeconsuming,more approachable,and low-cost *** switching the state of Sb_(2)S_(3) between amorphous and crystalline,the multi-color of stepwise pixelated FP cavities can be actively *** color variation is due to the profound change in the refractive index of Sb_(2)S_(3) over the visible spectrum during its phase ***,we directly fabricated sub-50 nm nano-grating on ultrathin Sb_(2)S_(3) laminate via microsphere 800-nm femtosecond laser irradiation in far *** minimum feature size can be further decreased down to~45 nm(λ/17)by varying the thickness of Sb_(2)S_(3) *** switchable Sb_(2)S_(3) photonic devices can take one step toward the next generation of inkless erasable papers or displays and enable information encryption,camouflaging surfaces,anticounterfeiting,***,our work explores the prospects of rapid and rewritable fabrication of periodic structures with nano-scale resolution and can serve as a guideline for further development of chalcogenide-based photonics components.

关键词： tunable color displays Fabry-Pérot cavity resonators color printing chalcogenide materials

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A non-probabilistic reliability topology optimization method based on aggregation function and matrix multiplication considering buckling response constraints

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 321-336页

作者： Lei WANG Yingge LIU Juxi HU Weimin CHEN bing han Institute of Solid Mechanics School of Aeronautic Science and EngineeringBeihang UniversityBeijing 100191China Aircraft and Propulsion Laboratory Ningbo Institute of TechnologyBeihang UniversityNingbo 315100Zhejiang ProvinceChina State Key Laboratory of Navigation and Safety Technology Shanghai Ship and Shipping Research InstituteShanghai 200135China National Engineering Research Center of Ship&Shipping Control System Shanghai Ship and Shipping Research InstituteShanghai 200135China

A non-probabilistic reliability topology optimization method is proposed based on the aggregation function and matrix *** expression of the geometric stiffness matrix is derived,the finite element linear buckling analysis is conducted,and the sensitivity solution of the linear buckling factor is *** a specific problem in linear buckling topology optimization,a Heaviside projection function based on the exponential smooth growth is developed to eliminate the gray *** aggregation function method is used to consider the high-order eigenvalues,so as to obtain continuous sensitivity information and refined structural *** cyclic matrix programming,a fast topology optimization method that can be used to efficiently obtain the unit assembly and sensitivity solution is *** maximize the buckling load,under the constraint of the given buckling load,two types of topological optimization columns are *** variable density method is used to achieve the topology optimization solution along with the moving asymptote optimization *** vertex method and the matching point method are used to carry out an uncertainty propagation analysis,and the non-probability reliability topology optimization method considering buckling responses is developed based on the transformation of non-probability reliability indices based on the characteristic ***,the differences in the structural topology optimization under different reliability degrees are illustrated by examples.

关键词： buckling topology optimization aggregation function uncertainty propagation analysis non-probabilistic reliability

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Human-Machine Shared Lateral Control Strategy for Intelligent Vehicles Based on Human Driver Risk Perception Reliability

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Automotive Innovation 2024年第1期7卷 102-120页

作者： Dongjian Song bing Zhu Jian Zhao Jiayi han State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130022China

Intelligent vehicle(Ⅳ)technology has developed rapidly in recent ***,achieving fully unmanned driving still presents numerous challenges,which means that human drivers will continue to play a vital role in vehicle operation for the foreseeable ***-machine shared driving,involving cooperation between a human driver and an automated driving system(AVS),has been widely regarded as a necessary stage for the development of *** onⅣdriving safety,this study proposed a human-machine shared lateral control strategy(HSLCS)based on the reliability of driver risk *** HSLCS starts by identifying the effective areas of driver risk perception based on eye *** establishes an anisotropic driving risk field,which serves as the foundation for the AVS to assess risk *** upon the cumulative and diminishing effects of risk perception,the proposed approach leverages the driver's risk perception effective area and converts the risk field into a representation aligned with the driver's ***,it quantifies the reliability of the driver's risk perception by using area-matching ***,based on the driver’s risk perception reliability and dif-ferences in lateral driving operation between the human driver and the AVS,the dynamic distribution of driving authority is achieved through a fuzzy rule-based system,and the human-machine shared lateral control is completed by using model predictive *** HSLCS was tested across various scenarios on a driver-in-the-loop test *** results show that the HSLCS can realize the synergy and complementarity of human and machine intelligence,effectively ensuring the safety ofⅣoperation.

关键词： Intelligent vehicle Human-machine shared driving Risk perception Driving authority distribution

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Differential Operator Approach to■quantum Groups and Their Oscillator Representations

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1360-1374页

作者： Zhao bing FAN Ji Cheng GENG Shao Long han College of Mathematical Science Harbin Engineering UniversityHarbin 150001P.R.China

For a quasi-split Satake diagram,we define a modified q-Weyl algebra,and show that there is an algebra homomorphism between it and the corresponding■quantum *** other words,we provide a differential operator approach to■quantum ***,the oscillator representations of■quantum groups are *** crystal basis of the irreducible subrepresentations of these oscillator representations are constructed.

关键词： ■quantum group differential operator oscillator representation crystal basis

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Feasibility of medical radioisotope production based on the proton beams at China Spallation Neutron Source

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Nuclear Science and Techniques 2024年第6期35卷 26-39页

作者： bing Jiang Bin-Bin Tian han-Tao jing Qi-Fan Dong Spallation Neutron Source Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The utilization of a proton beam from the China Spallation Neutron Source(CSNS)for producing medical radioisotopes is appealing owing to its high current intensity and high *** medical isotope production based on the proton beam at the CSNS is significant for the development of future radiopharmaceuticals,particularly for theα-emitting *** production yield and activity of typical medical isotopes were estimated using the FLUKA *** results indicate that the 300-MeV proton beam with a power of 100 kW at CSNS-II is highly suitable for proof-of-principle studies of most medical *** particular,this proton beam offers tremendous advantages for the large-scale production of alpha radioisotopes,such as 225Ac,whose theoretical production yield can reach approximately 57 Ci/*** on these results,we provide perspectives on the use of CSNS proton beams to produce radioisotopes for medical applications.

关键词： CSNS proton beam Medical isotope production α-Emitting radionuclides Nuclidic purity analysis

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