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A novel chronic nerve compression model in the rat

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Neural Regeneration Research 2018年第8期13卷 1477-1485页

作者： zhen-Yu Liu zhen-bing chen Jiang-Hai chen Department of Hand Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology

Current animal models of chronic peripheral nerve compression are mainly silicone tube models. However, the cross section of the rat sciatic nerve is not a perfect circle, and there are differences in the diameter of the sciatic nerve due to individual differences. The use of a silicone tube with a uniform internal diameter may not provide a reliable and consistent model. We have established a chronic sciatic nerve compression model that can induce demyelination of the sciatic nerve and lead to atrophy of skeletal muscle. In 3-week-old pups and adult rats, the sciatic nerve of the right hind limb was exposed, and a piece of surgical latex glove was gently placed under the nerve. N-butyl-cyanoacrylate was then placed over the nerve, and after it had set, another piece of glove latex was placed on top of the target area and allowed to adhere to the first piece to form a sandwich-like complex. Thus, a chronic sciatic nerve compression model was produced. Control pups with latex or N-butyl-cyanoacrylate were also prepared. Functional changes to nerves were assessed using the hot plate test and electromyography. Immunofluorescence and electron microscopy analyses of the nerves were performed to quantify the degree of neuropathological change. Masson staining was conducted to assess the degree of fibrosis in the gastrocnemius and intrinsic paw muscles. The pup group rats subjected to nerve compression displayed thermal hypoesthesia and a gradual decrease in nerve conduction velocity at 2 weeks after surgery. Neuropathological studies demonstrated that the model caused nerve demyelination and axonal irregularities and triggered collagen deposition in the epineurium and perineurium of the affected nerve at 8 weeks after surgery. The degree of fibrosis in the gastrocnemius and intrinsic paw muscles was significantly increased at 20 weeks after surgery. In conclusion, our novel model can reproduce the functional and histological changes of chronic nerve compression injury tha

关键词： nerve regeneration chronic nerve compression carpal tunnel syndrome nerve conduction velocity N-butyl-cyanoacrylate hypoesthesia demyelination remyelination intrinsic muscles collagen deposition axonal irregularity neural regeneration

Muscle Fiber Type Changes in Lumbrical Muscles at Early Stages of Chronic Nerve Compression

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Current Medical Science 2019年第1期39卷 59-66页

作者： zhen-yu LIU Jiang-hai chen zhen-bing chen Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Chronic nerve compression(CNC)neuropathy is a common disease in the clinic and provokes paraesthesia,or numbness at early *** changes in muscle fiber composition and motor nerve terminal morphology in distal muscles were studied in this study.A well-established CNC model was used to assess the changes in the *** were measured by von Frey filament test The myosin heavy chain isoforms and neuromuscular junctions(NMJs)were stained by immunofluorescence to show the muscle fiber types composition and motor nerve terminals morphologic changes in the flexor digitorum longus(FDL)and lumbrical *** fiber cross-sectional areas of different muscle fiber types were *** small-fiber degeneration of cutaneous nerve fibers was examined by detecting the protein gene product 9.5(PGP9.5)with *** 2nd month after compression,the proportion of type I and type IIB fibers was markedly decreased,and that of type n A fibers was increased in the lumbrical *** was no significant change in composition of muscle fiber types in FDL and NMJ morphology of FDL and lumbrical ***-epidermal nerve fibre density(IENFD)declined at 2nd month after the *** study reveals the morphological changes of the FDL and lumbrical muscle at an early stage of *** findings may be helpful to understand muscle damage and pathophysiological development of the nerve compression,and provide new evidence for early treatment of CNC.

关键词： chronic nerve compression neuropathy carpal tunnel syndrome lumbrical muscles intra-epidermal nerve fiber density neuromuscular junctions

Use of Muscle Feeding Arteries as Recipient Vessels for Soft Tissue Reconstruction in Lower Extremities

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Current Medical Science 2020年第4期40卷 739-744页

作者： Jia TIAN zhen-bing chen Jin LI Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Summary:Microsurgical free tissue transfer is still playing an important role in lower extremity *** a suitable recipient artery for anastomosis is critical in the microsurgical procedure,especially in an extensive wound,or in a complex trauma combined with vascular *** April 2014 to March 2018,we retrospectively reviewed patients with traumatic/posttraumatic,oncologic,and electrical wounds in the lower *** treated with muscle feeding artery as recipient vessels were *** latissimus dorsi(LD)muscle free flap,anterior lateral thigh(ALT)perforator free flap,and deep inferior epigastric perforator(DIEP)free flap were *** muscle feeding arteries to vastus lateral muscle and to medial head of gastrocnemius muscle,concomitant veins,and great saphenous vein were used as recipient *** included in the study were caused by tumour in 2 cases,car accident in 3 cases,crushing in 3 cases,burns in one case,and electrical injury in one *** wound size varied from 14 cm x 6 cm to 30 cm x 20 ***,ALT,and DIEP free flaps were used in 6,3,and 4 patients,*** muscle feeding arteries to medial head of gastrocnemius muscle,to sartorius muscle,and to vastus lateral muscle were used as recipient arteries in 4,5,and one patient,*** and great saphenous veins were used as recipient veins in 10 and 4 patients,*** the muscle feeding artery is feasible to avoid injury to the main artery and facilitate dissection and anastomoses,particularly when the wound is located proximal to the mid-third of the lower leg.

关键词： muscle feeding artery recipient vessel end-to-end anastomosis end-to-side anastomosis

Application of AlGaInP with Sb Incorporation in Lattice-Matched 5-Junction Tandem Solar Cells

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Chinese Physics Letters 2017年第2期34卷 126-130页

作者： Yang Zhang Qing Wang Xiao-Bin Zhang Na Peng zhen-Qi Liu bing-zhen chen Shan-Shan Huang Zhi-Yong Wang Institute of Laser Engineering Beijing University of TechnologyBeijing 100022 Redsolar New Energy Technology Co.Ltd. Zhongshan 528437

It is well known that conventional CalnP/GMnAs/Ce three-junction （3J） solar cells are difficult to continue to ascend when the effieiencies reach 32% and 42% under AMO and AM1.5D concentrated, respectively. In AlCaInP/AiGMnAs/CalnAs/CalnNAs/Ce five-junction （5,/） solar cells, the performance of the AlGaInP, Al- CalnAs and CalnNAs sub cell is the key factor for conversion efficiency of the 5J solar cell. We investigate the AlCaInP/AlCaInAs/Ge 3J solar cell. By incorporating surfactant trimthylantimony into the AlGaInP material, the crystal quality of AICalnP is improved and the spectrum absorption range of AICalnAs is extended. The current density of each sub cell exceeds ll.3mA/cm2 as is desired. Then we apply this 3J structure to grow the lattice-matched 5J solar ceil and obtain the short circuit current of 134.96 mA, open circuit voltage of 4399.6 m V, fill factor of 81.7% and conversion efficiency of 29.87%.

关键词： Application of AlGaInP with Sb Incorporation in Lattice-Matched 5-Junction Tandem Solar Cells Sb

For Mega-Constellations: Edge Computing and Safety Management Based on Blockchain Technology

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China Communications 2024年第2期21卷 59-73页

作者： zhen Zhang bing Guo chengjie Li College of Computer Science Sichuan UniversityChengdu 610064China The Key Laboratory for Computer Systems of State Ethnic Affairs Commission School of Computer Science and TechnologySouthwest Minzu UniversityChengdu 610225China National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of ChinaChengdu 611731China

In mega-constellation Communication Systems, efficient routing algorithms and data transmission technologies are employed to ensure fast and reliable data transfer. However, the limited computational resources of satellites necessitate the use of edge computing to enhance secure *** edge computing reduces the burden on cloud computing, it introduces security and reliability challenges in open satellite communication channels. To address these challenges, we propose a blockchain architecture specifically designed for edge computing in mega-constellation communication systems. This architecture narrows down the consensus scope of the blockchain to meet the requirements of edge computing while ensuring comprehensive log storage across the network. Additionally, we introduce a reputation management mechanism for nodes within the blockchain, evaluating their trustworthiness, workload, and efficiency. Nodes with higher reputation scores are selected to participate in tasks and are appropriately incentivized. Simulation results demonstrate that our approach achieves a task result reliability of 95% while improving computational speed.

关键词： blockchain consensus mechanism edge computing mega-constellation reputation management

Robust textile-based spoof plasmonic frequency scanning antenna for on-body IoT applications

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Science China(Information Sciences) 2024年第8期67卷 269-284页

作者： Zhao-Min chen Jun-Lin ZHAN Hao chen Ya LI Hongjun HE Wu YANG zhen-Guo LIU Wei-bing LU State Key Lab of Millimeter Waves School of Information Science and EngineeringSoutheast University Center for Flexible RF Technology Frontiers Science Center for Mobile Information Communication and SecuritySoutheast University Future Research Laboratory China Mobile Research Institute Purple Mountain Laboratories

Securing a comfortable, wearable compact frequency beam scanning antenna(FBSA) with robustness to deformation, low specific absorption rate(SAR), and good coverage of the surrounding environment for Internet of Things(IoT) applications, such as on-body navigation and wireless communication is an emerging challenge. In this work, a robust textile-based spoof plasmonic frequency scanning antenna utilizing higher-order modes is presented, which is also robust to deformation caused by the activities of the human body. The innovative design of the element ensures the high-efficiency transmission of the fundamental mode of spoof surface plasmon polaritons(SSPP) structure, providing the potential of being a multifunctional composite device in the compact on-body network. Besides, an artificial magnetic conductor(AMC) is designed underneath the SSPP structure, obtaining a low SAR value(0.113 W/kg), which ensures the safety of users. As a practical realization of this concept, a textile-based spoof plasmonic antenna was fabricated in the microwave regime and the performed experimental results show the proposed antenna has a single-beam radiation characteristic with a 70° beam scanning angle range when the frequency is 4.7–6.0 GHz with a high average realized gain of 13.15 dBi. And it still maintains a steady performance when faced with structure deformation, which proves its robustness. Wireless communication quality experiments are performed to demonstrate the proposed antenna can measure the angles of targets and realize wireless signal transmission to specific targets as the frequency varies, it may find great potential in the field of on-body IoT applications.

关键词： frequency beam scanning antenna (FBSA) Internet of Things (IoT) on-body communication spoof surface plasmon polaritons (SSPP) textile-based antenna

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Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： Yuan Wang bing chen Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly Drug delivery Nanomedicine

Regulation of solvation structure and the cooperation environment of potassium bonds for wider-temperature adaptive potassium storage

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Rare Metals 2024年第4期43卷 1610-1621页

作者： bing-bing Liu Yi-Hui Liu You-Bin Zhang zhen-Guo Qi Guo-Hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China Shandong Synergetic Innovation Center of Ecological and Chemical Engineering Qingdao266042China

Antimony selenide(Sb_(2)Se_(3))is one of the perspective candidates for potassium-ion batteries due to its advanced virtues stem including featured high capacity,fertile reserves and the relative narrow band *** the unique advantages,it is still plagued by the unstable interface compatibility and poor wider-temperature *** optimization of microstructure and the construction of inorganic-organic hybrids with a low desolvation barrier and rapid kinetics behaviors are efficient to address these *** Sb_(2)Se_(3)nanorods enclosed by the S-doped carbon layer(SC),further crosslinked by the poly(N-isopropylacrylamide)(PM)film(PM@Sb_(2)Se_(3)@SC),were artificially fabricated,and it displays the enrichment ion aggregated model as well as contacted ion pair state,the well-tailored cooperation environment of potassium bonds,assuring a homogeneous potassium deposition and an excellent widertemperature *** complicated experimental studies and theoretical calculations authenticate the synergistic effects of geometric conformation and compositional design for the tremendously enhanced potassium ***,the full device over PM@Sb_(2)Se_(3)@SC anode and the potassium Prussian blue cathode manifests impressively durable cycling life and wider-temperature adaptability,verifying the glorious contribution from the finely manipulation in solvation structure and potassium bonds to enhancing the potassium storage behaviors.

关键词： Anode Sb_(2)Se_(3) rods Interface compatibility Inorganic-organic electrode Potassium ion battery

The circ_0002538/miR-138-5p/plasmolipin axis regulates Schwann cell migration and myelination in diabetic peripheral neuropathy

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Neural Regeneration Research 2023年第7期18卷 1591-1600页

作者： Yu-Tian Liu Zhao Xu Wei Liu Sen Ren He-Wei Xiong Tao Jiang Jing chen Yu Kang Qian-Yun Li Zi-Han Wu Hans-GüNther Machens Xiao-Fan Yang zhen-bing chen Department of Hand Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Plastic and Hand Surgery Technical University of MunichMunichGermany

Circular RNAs(circRNAs)play a vital role in diabetic peripheral ***,their expression and function in Schwann cells in individuals with diabetic peripheral neuropathy remain poorly ***,we performed protein profiling and circRNA sequencing of sural nerves in patients with diabetic peripheral neuropathy and *** profiling revealed 265 differentially expressed proteins in the diabetic peripheral neuropathy *** Ontology indicated that differentially expressed proteins were mainly enriched in myelination and mitochondrial oxidative phosphorylation.A real-time polymerase chain reaction assay performed to validate the circRNA sequencing results yielded 11 differentially expressed ***_0002538 was markedly downregulated in patients with diabetic peripheral *** in vitro experiments showed that overexpression of circ_0002538 promoted the migration of Schwann cells by upregulating plasmolipin(PLLP)***,overexpression of circ_0002538 in the sciatic nerve in a streptozotocin-induced mouse model of diabetic peripheral neuropathy alleviated demyelination and improved sciatic nerve *** results of a mechanistic experiment showed that circ_0002538 promotes PLLP expression by sponging miR-138-5p,while a lack of circ_0002538 led to a PLLP deficiency that further suppressed Schwann cell *** findings suggest that the circ_0002538/miR-138-5p/PLLP axis can promote the migration of Schwann cells in diabetic peripheral neuropathy patients,improving myelin sheath structure and nerve ***,this axis is a potential target for therapeutic treatment of diabetic peripheral neuropathy.

关键词： circ_0002538 circRNA sequencing competing endogenous RNAs demyelination diabetic peripheral neuropathy miR-138-5 myelination plasmolipin protein profiling Schwann cells