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Psychosomatic Medicine Research 2022年第2期4卷 21-26页

作者： Lin Cai Yu Yao Deng-hui Lu Jia-Xin He Yu-Ying Zeng bing-yan hu Yao-Fang Lei School of Marxism Sichuan Institute of Industrial TechnologySichuanChina Research Center of Psychology and Behavior Key Research Base of Humanistic and Social Sciences of DeyangSichuanChina Physical Education College Sichuan Institute of Industrial TechnologySichuanChina

Objective:To explore the influence of physical exercise,psychological resilience,and peer influence on subjective well-being,and then build a model of moderated ***:Physical Activity Rating,Connor Davision Resilience Scale,Peer Influence Scale,and Index of Well-Being were *** paper investigated 790 ***:(1)Physical exercise has a significant positive predictive effect on subjective well-being(β=0.43,P0.05),physical exercise has a stronger positive predictive effect on psychological resilience in college students with high peer influence(β simple=0.87,t=2.07,P<0.05).Conclusion:Physical exercise affects college students'subjective well-being through psychological resilience,and peer influence moderates the mediating effect of psychological resilience.

关键词： Physical exercise subjective well-being psychological resilience peer influence

Relation among Summer Rainfall in South Shandong and High Pressure in South Asia and Atmospheric Circulation

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Meteorological and Environmental Research 2011年第7期2卷 41-46页

作者： GAO An-chun,SHEN Pei-lu,LI bing-wen,hu yan,YU yan-min,Zhu Yi-qing Linyi Meteorological Bureau of Shandong Province,Linyi 276004,China

[Objective] The aim was to study the relation among summer rainfall in south Shandong and high pressure in South Asia and atmospheric circulation.[Method] Taking the precipitation in south Shandong along the Yellow River and huaihe River,using the NCEP/NCAR data and summer rainfall data in south Shandong in summer from 1961 to 2005,the characteristics of high pressure in South Asia and atmospheric circulation in drought year and flood year in summer in south Shandong Province were *** mechanism of 100 hPa pressure in South Asian influencing precipitation in south Shandong Province was *** interaction of different equipment,different altitude and different system of atmosphere circulation in low and high layer was expounded.[Results] The first mode of EOF decomposition of precipitation in summer in south Shandong Province explained above 63% variances and reflected universal form of *** difference of central position of the central position of height field of high pressure in South Asia in drought and flood year was *** the wind field center was *** the area of SAH was smaller and its eastern ridge line stretched to the Western Pacific between the middle of south Shandong and Changjiang Estuary,flood summer occurred when there was an unusual cyclone lied in the east of 90° E and south of Lake *** area of SAH was larger and its eastern ridge line stretching to the Western Pacific over Changjiang Estuary,drought summer occurred,when there was an unusual anticyclone lied in the east of 90° E and south of Lake *** and summer rainfall also had close relationship with Tele-connection Patterns over the Eurasia continent and EAP *** the height anomaly was in '+-+' form in the north of the Caspian Sea,around Lake Baikal and Kamchatka,and when the height anomaly in East Asia-West Pacific area was in '-+' form from low altitude to high altitude,there was much precipitation in summer;and conversel

关键词： Summer rainfall in the south of Shandong Province Drought and flood High pressure in South Asia Atmospheric circulation China

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan bing hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

A Novel Model for Describing Rail Weld Irregularities and Predicting Wheel-Rail Forces Using a Machine Learning Approach

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 555-577页

作者： Linlin Sun Zihui Wang Shukun Cui Ziquan yan Weiping hu Qingchun Meng State Key Laboratory of High-Speed Railway Track System China Academy of Railway Sciences Corporation LimitedBeijing100081China Railway Engineering Research Institute China Academy of Railway Sciences Corporation LimitedBeijing100081China School of Aeronautic Science and Engineering Beihang UniversityBeijing100191China

Rail weld irregularities are one of the primary excitation sources for vehicle-track interaction dynamics in modern high-speed *** can cause significant wheel-rail dynamic interactions,leading to wheel-rail noise,component damage,and *** researchers have employed the vehicle-track interaction dynamic model to study the dynamic interactions between wheel and rail induced by rail weld geometry ***,the cosine wave model used to simulate rail weld irregularities mainly focuses on the maximum value and neglects the geometric *** this study,novel theoretical models were developed for three categories of rail weld irregularities,based on measurements of the high-speed railway from Beijing to *** vertical dynamic forces in the time and frequency domains were compared under different running *** forces generated by the rail weld irregularities that were measured and modeled,respectively,were compared to validate the accuracy of the proposed ***,based on the numerical study,the impact force due to rail weld irrregularity is modeled using an Artificial Neural Network(ANN),and the optimum combination of parameters for this model is *** results showed that the proposed model provided a more accurate wheel/rail dynamic evaluation caused by rail weld irregularities than that established in the *** ANN model used in this paper can effectively predict the impact force due to rail weld irrregularity while reducing the computation time.

关键词： Rail weld irregularity high-speed railway vehicle-track coupled dynamics wheel/rail dynamic vertical force artificial neural networks

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

谷氨酰胺联合脐血间充质干细胞移植在大鼠肠缺血再灌注损伤中的作用

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中国比较医学杂志 2016年第10期26卷 25-31页

作者：王炳杰胡延伟赵叶芳张仕东河北医科大学附属邢台市人民医院肛肠外科邢台054001 河北医科大学附属邢台市人民医院普外科邢台054001 河北医科大学附属邢台市人民医院妇产科邢台054001

目的探讨谷氨酰胺联合脐血间充质干细胞(MSCs)移植在大鼠肠缺血再灌注损伤中作用。方法体外复苏并培养脐血间充质干细胞移植前备用,观察CM-Di I荧光标记后脐血间充质干细胞的去向。80只SD大鼠随机分为正常对照组,缺血再灌注损伤组,谷氨... 详细信息

目的探讨谷氨酰胺联合脐血间充质干细胞(MSCs)移植在大鼠肠缺血再灌注损伤中作用。方法体外复苏并培养脐血间充质干细胞移植前备用,观察CM-Di I荧光标记后脐血间充质干细胞的去向。80只SD大鼠随机分为正常对照组,缺血再灌注损伤组,谷氨酰胺组,MSCs移植组及联合组每组各15只。对照组采用生理盐水灌肠,损伤组采用TNB(S乙醇稀释)灌肠,在TNBS建模后1 h,谷氨酰胺组于尾静脉输入谷氨酰胺0.45 g/kg、MSCs移植组于尾静脉输入1×10^(10)/L脐血间充质干细胞悬液,联合组尾静脉输入谷氨酰胺0.45 g/kg+脐血间充质干细胞悬液1×10^(10)/L。通过ELISA法检测各组大鼠血清中肠脂肪酸结合蛋白(IFABP)、白介素-6(IL-6)、超氧化物歧化酶(SOD)的含量;各组于再灌注1 h、3 h后检测肠组织含水率;通过RT-PCR、Western blot观察大鼠肠黏膜上皮细胞caspase-3、NF-k B、Bcl-2在谷氨酰胺联合MSCs移植后的mRNA和蛋白的表达情况。结果通过荧光示踪法观察到移植的MSCs细胞分布于肠粘膜淋巴组织内和腺上皮细胞间,表明MSCs可能参与了肠缺血再灌注损伤的修复过程。各组大鼠血清中SOD、IFABP、IL-6的含量变化比较,损伤组血清中IFABP、IL-6的含量较对照组显著增加,而谷氨酰胺组,MSCs移植组及联合组与之比较,则显著减少,联合组减少更为明显,损伤组血清中SOD的含量较对照组显著减少,而谷氨酰胺组,MSCs移植组及联合组与之比较,则显著增高,联合组增高更为明显(P0.05)。与对照组比较,损伤组肠黏膜上皮细胞caspase-3、NF-k B的mRNA和蛋白表达明显上调,Bcl-2的mRNA和蛋白表达明显下调(P0.05),但两组与联合组比较,差异明显(P<0.05)。结论谷氨酰胺组及MSCs移植后,明显减轻了大鼠肠缺血再灌注损伤程度,其可能通过抑制caspase-3、NF-k B表达和促进Bcl-2表达减轻肠黏膜缺血再灌注损伤。

关键词：脐血间充质干细胞谷氨酰胺移植大鼠肠道损伤

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi hu Rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

An Experimental Study for Intelligent Logistics:A Middleware Approach

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Chinese Journal of Electronics 2016年第3期25卷 561-569页

作者： yanG Rong LI bing hu yan College of Computer Science and Technology Hubei University of Science and Technology International School of Software Wuhan University Science and Technology on Integrated Information System Laboratory Institute of SoftwareUniversity of Chinese Academy of Sciences

Recent years have witnessed a rapid growth in using Internet of things(Io T), which facilitates and simultaneously raises challenges for the intelligent logistics. The real-world devices can provide their functionality as Web services. Because of the dynamicity and heterogeneity of the target networking environment, the services offered by Io T resources cannot be composed by simply extending existing Service oriented architecture(SOA) approaches. Logistics, which consists of a complex network of organizations and business processes, must be monitored in real time. Based on the proper understanding of the possible exceptions, we propose a middleware approach to solve the logistics service composition in Io T, where a decentralized coordination mechanism is used to monitor the component services with few resources efficiently. Through a set of experiments, the effectiveness and robustness of our approach are evaluated.

关键词： Internet of things(IoT) Intelligent logistics Exceptions Monitoring

社区高血压人群抗高血压药物的利用情况、依从性及影响因素

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复旦学报（医学版） 2001年第5期28卷 425-428页

作者：杜文民王永铭陈斌艳范维琥耿晓芳复旦大学药学院药理学教研室上海200032 复旦大学药学院附属华山医院心内科上海200040 上海市华东医院临床药理室上海200040

目的　了解实际自然人群中抗高血压药物的分布和使用情况。方法　利用抗高血压药物的用药监测系统 ,统计高血压人群中各类抗高血压药物的使用情况和依从性 ;对依从性的影响因素进行非条件logistic回归分析。结果　社区高血压病有 2 5 2 ... 详细信息

目的　了解实际自然人群中抗高血压药物的分布和使用情况。方法　利用抗高血压药物的用药监测系统 ,统计高血压人群中各类抗高血压药物的使用情况和依从性 ;对依从性的影响因素进行非条件logistic回归分析。结果　社区高血压病有 2 5 2 2例 ,未用药 5 39例 (占 2 1.37% ) ,不规则服药 10 5 9例 (占 41.99% ) ,规则服药 92 4例 (占 36 .6 4% ) ,(单一服药 375例 ,联合服药 5 49例 ) ;单独服用复方降压片 173例 ,单独服用硝苯地平10 8例 ,单独服用其他药物 94例 ;复方降压片与硝苯地平联合服用 (复方降压片 +硝苯地平 ) 2 5 2例 ,卡托普利与硝苯地平联合服用 (卡托普利 +硝苯地平 ) 132例 ,其他联合用药 16 5例。结论　社区人群抗高血压药物服药依从性低。吸烟、心脑血管病是主要不规则服药的独立危险因素 ;知识得分、非药物治疗、发病时间长是主要不规则服药的独立保护因素 ;吸烟、心脑血管病是主要未服药的独立危险因素 ;知识得分高、非药物治疗、发病时间长。

关键词：抗高血压药物药物利用药物依从性 logistic回归高血压